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ShareScore release 0.9.0
Dataset results
310 results for “aortic stenosis”
Cardiac Amyloidosis in Patients With Aortic Stenosis
ClinicalTrials.gov study NCT07170306. IPD Sharing: NO. Countries: 0. Publications: 0.
Aortic Valve Replacement for Moderate Aortic Stenosis With Left Ventricular Decompensation Early Feasibility Study
ClinicalTrials.gov study NCT07060183. IPD Sharing: NO. Countries: 0. Publications: 0.
Super-Enhancer-Associated Aortic Valve Stenosis Risk Locus 1p21.2 Alters NFATC2 Binding Site and Promotes Fibrogenesis [ATAC-Seq]
GEO Series GSE154510. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Multiomics coupled with vibrational spectroscopy identify early mechanisms of experimental aortic valve stenosis [RNA]
GEO Series GSE267949. Oryctolagus cuniculus. 27 samples. Type: Expression profiling by high throughput sequencing.
Multiomics coupled with vibrational spectroscopy identify early mechanisms of experimental aortic valve stenosis [miRNA]
GEO Series GSE267951. Oryctolagus cuniculus. 16 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RNA-sequencing of patients with hypertrophic cardiomyopathy or patients with aortic stenosis compared to heart healthy donors
GEO Series GSE230585. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices.
<p>Dataset from Gorla R, Casenghi M, Finotello A, De Marco F, Morganti S, Regazzoli D, Bianchi G, Acerbi E, Popolo Rubbio A, Brambilla N, Testa L, Castriota F, Auricchio F, Reimers B, Bedogni F. Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices. Interact Cardiovasc Thorac Surg. 2021 Jan 1;32(1):20-28. doi: 10.1093/icvts/ivaa231. PMID: 33201993.</p> <p>Abstract</p> <p><strong>Objectives: </strong>To compare device success and paravalvular leak rates of 3 new-generation transcatheter aortic valve replacement devices in patients with bicuspid aortic valve stenosis and to test their biomechanical performance in a computer-based simulation model of aortic root with increasing ellipticity.</p> <p><strong>Methods: </strong>This retrospective multicentre study included 56 bicuspid aortic valve patients undergoing transcatheter aortic valve replacement with new-generation devices: Lotus/Lotus Edge (N = 15; 27%), Evolut-R (N = 20; 36%) and ACURATE neo (N = 21; 37%). Three virtual simulation models of aortic root with increasing index of eccentricity (0-0.25-0.5) were implemented. Stress distribution, stent-root contact area and paravalvular orifice area were computed.</p> <p><strong>Results: </strong>Device success was achieved in 43/56 patients (77%) with comparable rates among Lotus (87%), Evolut-R (60%) and ACURATE neo (86%; P = 0.085). Moderate paravalvular leak rate was significantly lower in the Lotus group as compared to Evolut-R group (0% vs 30%; P = 0.027) and comparable to the ACURATE neo group (0% vs 10%; P = 0.33). By index of eccentricity = 0.5, Lotus showed a uniform and symmetric pattern of stress distribution with absent paravalvular orifice area, ACURATE neo showed a mild asymmetry with small paravalvular orifice area (1.1 mm2), whereas a severely asymmetric pattern was evident with Evolut-R, resulting in a large paravalvular orifice area (12.0 mm2).</p> <p><strong>Conclusions: </strong>Transcatheter aortic valve replacement in bicuspid aortic valve patients with new-generation devices showed comparable device success rates. Lotus showed moderate paravalvular leak rate comparable to that of ACURATE neo and significantly lower than Evolut-R. On simulation, Lotus and ACURATE neo showed optimal adaptability to elliptic anatomies as compared to Evolut-R.</p>
DataSet_Simultaneous versus staged approach in transcatheter aortic valve implantation for severe stenosis and endovascular aortic repair for thoracic and abdominal aortic aneurysm
Open the record for dataset details and reuse information.
This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis"
<p>This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis"</p> <p><strong>Background:</strong> Aortic stenosis (AS) is the most common valve disorder characterized by fibro-calcific remodeling of leaflets. Recent evidence indicated that there is a sex-related difference in AS development and progression. Fibrotic remodeling is peculiar in women’s aortic valves, while men’s leaflets are more calcified. Our study aimed to assess aortic valve fibrosis (AVF) in a severe AS cohort using non-invasive diagnostic tools and determine whether sex-specific pathological pathways and cell types are associated with severe AS.</p> <p><strong>Materials and Methods:</strong> We have included 28 men and 28 women matched for age with severe AS who underwent echocardiography and cardiac contrast-enhanced computed tomography (CT) before intervention. The calcium and fibrosis volumes were assessed and quantified using the ImageJ thresholding method, indexed calcium and fibrosis volume were calculated by dividing the volume by the aortic annular area. For a deeper understanding of molecular mechanisms characterizing AS disorder, differentially expressed genes and functional inferences between women and men’s aortic valves were carried out on a publicly available microarray-based gene expression dataset (GSE102249). Cell types enrichment analysis in stenotic aortic valve tissues was used to reconstruct the sex-specific cellular composition of stenotic aortic valves.</p> <p><strong>Results:</strong> In agreement with the literature, our CT quantifications showed that women had significantly lower aortic valve calcium content compared to men, while fibrotic tissue composition was significantly higher in women than men. The expression profiles of human stenotic aortic valves confirm sex-dependent processes. Pro-fibrotic processes were prevalent in women, while pro-inflammatory ones, linked to the immune response system, were enhanced in men. Cell-type enrichment analysis showed that mesenchymal cells were over-represented in AS valves of women, whereas signatures for monocytes, macrophages, T and B cells were enriched men ones.</p> <p><strong>Conclusions:</strong> Our data provide the basis that the fibro-calcific process of the aortic valve is sex-specific, both at gene expression and cell type level. The quantification of aortic valve fibrosis by CT could make it possible to perform population-based studies and non-invasive assessment of novel therapies to reduce or halt sex-related calcific aortic valve stenosis (CAVS) progression, acting in an optimal window of opportunity early in the course of the disease.</p>
Incremental prognostic role of left atrial reservoir strain in asymptomatic patients with moderate aortic stenosis
<p>Raw data related to the article</p> <p>Abstract<br> Left atrial (LA) mechanics assessed by two-dimensional speckle tracking echocardiography (2D-STE) have not been extensively<br> studied and clearly characterized in patients with moderate aortic stenosis (AS). Accordingly, we aimed to evaluate<br> the usefulness of LA reservoir strain for risk stratification of asymptomatic patients with moderate AS. This retrospective<br> study included all consecutive asymptomatic patients with moderate AS who underwent transthoracic echocardiography<br> implemented with 2D-STE analysis of LA myocardial strain and strain rate indices at our Institution, between February 2011<br> and September 2019. During the follow-up period, we evaluated the occurrence of any of the following: (1) CV hospitalization;<br> (2) The recourse to AS surgery; (3) Cardiac death or sudden death. A total of 186 patients (mean age 71.9 ± 12.7 years,<br> 61.8% men) were included in the present study. During a mean follow-up of 2.3 ± 1.9 years, no patients died and 63 adverse<br> CV events were recorded: 48 patients were hospitalized because of heart failure (28 patients), acute coronary syndrome (10<br> patients), arrhythmias (10 patients) and 15 patients underwent AS surgery. At the multivariate Cox regression analysis, type 2<br> diabetes mellitus (OR 1.87, 95%CI 1.05–3.34, p = 0.03), NT-proBNP (OR average 1.14, 95%CI 1.02–1.27, p = 0.02), average<br> E/e′ ratio (OR 1.07, 95%CI 1.01–1.15, p = 0.04) and most of all left atrial positive global strain (LA-GSA+) (OR 0.85, 95%CI<br> 0.81–0.90, p < 0.0001) were independently associated with the outcome. LA-GSA+ (optimal cut-off ≤ 19%, AUC = 0.94,<br> 87% sensitivity, 99% specificity, positive predictive value 99%, negative predictive value 88%) showed the highest diagnostic<br> performance. An impaired LA reservoir strain can contribute to identify a subset of asymptomatic patients with moderate<br> AS at higher risk, who may benefit from closer echocardiographic follow-up and/or early surgery.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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