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606 results for “association genetics”
Data from: Inbred and furious: negative association between aggression and genetic diversity in highly inbred fish
Aggressive behaviour plays an important role in securing resources, defending against predators and shaping social interactions. Although aggression can have positive effects on growth and reproductive success, it is also energetically costly and may increase injury and compromise survival. Individual genetic diversity has been positively associated with aggression, but the cause for such an association is not clear, and it might be related to the ability to recognize kin. To disentangle the relationships between genetic diversity, kinship and aggression, we quantified aggressive behaviour in a wild, self-fertilizing fish (Kryptolebias marmoratus) with naturally variable degrees of genetic diversity, relatedness and familiarity. We found that in contrast to captive fish, levels of aggression among wild K. marmoratus are positively associated with individual homozygosity, but not with relatedness or familiarity. We suggest that the higher aggression shown by homozygous fish could be related to better kin discrimination and may be facilitated by hermaphrodite competition for scarce males, given the fitness advantages provided by outcrossing in terms of parasite resistance. It seems likely that the relationship between aggression and genetic diversity is largely influenced by both the environment and population history.
Data from: Habitat diversification associated with urban development has a little effect on genetic structure in the annual native plant Commelina communis in an East Asian megacity
<p>Basic statistics for each population and genetic and landscape data between populations.</p>
Figure 3 from: Al-Musawi ZJMA, Al-Juhaishi AMR (2024) Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e111984
Figure 3 The Prevalence of D2 receptor alleles A-241G (rs1799978) among both male and female volunteers.
Fig. 1 in Quantitative genetics of gastrointestinal strongyle burden and associated body condition in feral horses
Fig. 1. Map of Sable Island, Nova Scotia, Canada, showing its position relative to the Canadian mainland and the predominant land cover types.
Genetic diversity of Aedes and Armigeres mosquito vectors and associated Wolbachia pipientis in Khyber Pakhtunkhwa, Pakistan
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Data from: The costs of being dark: the genetic basis of melanism and its association with fitness-related traits in the sand cricket
Melanism is an important component of insect cuticle and serves numerous functions that enhance fitness. Despite its importance, there is little information on its genetic basis or its phenotypic and genetic correlation with fitness-related traits. Here, we examine the heritability of melanism in the wing dimorphic sand cricket and determine its phenotypic and genetic correlation with wing morphology, gonad mass and size of the dorso-longitudinal muscles (the principle flight muscles). Previously demonstrated trade-offs among these traits are significant factors in the evolution of life history variation. Using path analysis, we show that melanization is causally related to gonad mass, but not flight muscle mass. Averaged over the sexes, the heritability of melanism was 0.61, the genetic correlation with gonad mass was −0.36 and with wing morph was 0.51. The path model correctly predicted the ranking of melanization score in lines selected for increased ovary mass, increased flight muscle mass, an index that increased both traits and an unselected control. Our results support the general hypothesis that melanization is costly for insects and negatively impacts investment in early reproduction.
Data from: Cannabis labelling is associated with genetic variation in terpene synthase genes
<p>Genetic data consisting of >100,000 single nucleotide polymorphisms (SNPs) collected using genotype-by-sequencing, from 137 drug-type Cannabis samples from the Netherlands. This genetic data along with terpene and cannabinoid content data collected with GC-FID, was used to analyze Cannabis labelling and to perfom a genome-wide association study.</p>
Population genetic structure associated with a landscape barrier in the Western Grasswren (Amytornis textilis textilis)
<p class="MsoNormal">Dispersal patterns can dictate genetic population structure, and ultimately population resilience, through maintaining gene flow and genetic diversity. However, geographic landforms, such as peninsulas, can impact dispersal patterns and thus be a barrier to gene flow. Here, we use 13,375 genome-wide single-nucleotide polymorphisms (SNPs) to evaluate genetic population structure and infer dispersal patterns of the Western Grasswren (<em>Amytornis textilis textilis</em>; WGW,<em> n </em>= 140)<em> </em>in the Shark Bay region of Western Australia. We found high levels of genetic divergence between subpopulations on the mainland (Hamelin) and narrow peninsula (Peron). In addition, we found evidence of further genetic sub-structuring within the Hamelin subpopulation, with individuals collected from the western and eastern regions of a conservation reserve forming separate genetic clusters. Spatial autocorrelation analysis within each subpopulation revealed significant local-scale genetic structure up to 35 km at Hamelin and 20 km at Peron. In addition, there was evidence of male philopatry in both subpopulations. Our results suggest a narrow strip of land may be acting as a geographic barrier in the WGW, limiting dispersal between a peninsula and mainland subpopulation. In addition, heterogeneous habitat within Hamelin may be restricting dispersal at the local scale. Furthermore, there is evidence to suggest that the limited gene flow is asymmetrical, with directional dispersal occurring from the bounded peninsula subpopulation to the mainland. This study highlights the genetic structure existing within and between some of the few remaining WGW subpopulations, and shows a need for placing equal importance on conservation efforts to maintain them in the future.</p>
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease
ClinicalTrials.gov study NCT00027196. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Genetic Polymorphisms Associated With CAD
ClinicalTrials.gov study NCT02307422. IPD Sharing: YES. Countries: 0. Publications: 1.
Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients.
ClinicalTrials.gov study NCT01104558. IPD Sharing: Not stated. Countries: 1. Publications: 0.
First Year Growth Response Associated Genetic Markers Validation Phase IV Open-label Study in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children: the PREDICT Pharmacogenetics Validatio
ClinicalTrials.gov study NCT01419249. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Diet Quality and Genetic Association With Body Mass Index: Results From Three Observational Studies
ClinicalTrials.gov study NCT03577639. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
The Association of Genetic Polymorphisms With Statin-Induced Myopathy.
ClinicalTrials.gov study NCT00549029. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for T
ClinicalTrials.gov study NCT05519475. IPD Sharing: YES. Countries: 4. Publications: 0.
Data from: Adaptation via pleiotropy and linkage: association mapping reveals a complex genetic architecture within the stickleback Eda locus
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Data from: Genome-wide association analysis for blood lipid traits measured in three pig populations revealed a substantial level of genetic heterogeneity
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Data from: Signatures of polygenic adaptation associated with climate across the range of a threatened fish species with high genetic connectivity
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Data from: Unexpected high genetic diversity in small populations suggests maintenance by associative overdominance
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Data from: Genomic selection and association mapping in rice (Oryza sativa): effect of trait genetic architecture, training population composition, marker number and statistical model on accuracy of rice genomic selection in elite, tropical rice breeding lines
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.