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674
datasets available to search
ShareScore release 0.9.0
Dataset results
674 results for “brain disease”
Neurodevelopmental Defects and Neurodegenerative Phenotypes in Human Brain Organoids Carrying Parkinson Disease-Linked DNAJC6 Mutations
GEO Series GSE151190. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Single-cell multi-omic and multi-region atlas of the Human Alzheimer's Disease Brain
GEO Series GSE308132. Homo sapiens. 0 samples. Type: Methylation profiling by high throughput sequencing; Other.
Elevated brain manganese induces motor disease by up-regulating the kynurenine pathway of tryptophan metabolism
GEO Series GSE292533. Mus musculus. 44 samples. Type: Expression profiling by high throughput sequencing.
Single nuclei RNA-seq of brain of mouse Alzheimer's disease model
GEO Series GSE143758. Mus musculus. 37 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and epigenomic analyses of transposable elements in the healthy and diseased human brain
GEO Series GSE212090. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Effects of hypoxia on brain gene expression in a mouse model of Parkinson’s disease
GEO Series GSE296779. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Stem cell derived human microglia transplanted in mouse brain to study human disease
GEO Series GSE137444. Homo sapiens; Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
FAD4T mouse model reflects Alzheimer’s disease pathobiology in bone marrow-brain axis
GEO Series GSE214917. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Embryonic exposure to 10 µg/L lead results in male-specific expression changes in genes associated with nervous system development and function and Alzheimer’s disease in aged adult zebrafish brain
GEO Series GSE74038. Danio rerio. 7 samples. Type: Expression profiling by array.
Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons
GEO Series GSE135037. Homo sapiens. 279 samples. Type: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
RNA-Sequencing from ventral mid brain and striatum of paraquat, pyridaben and paraquat+maneb mice models of Parkinson's disease.
GEO Series GSE36232. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Blood-brain barrier dysfunction in response to Alzheimer's disease mutations and aged serum in a tissue-engineered microvascular model
GEO Series GSE272179. Homo sapiens. 54 samples. Type: Expression profiling by high throughput sequencing.
Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking
GEO Series GSE109485. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Data from: Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke
Objective: We assessed the association of baseline imaging markers of cerebral small vessel disease (SVD) and 'brain frailty' with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Methods: ENOS randomised 4011 patients with acute stroke (<48 hours of onset) to transdermal glyceryl trinitrate (GTN) or no GTN for 7 days. The primary outcome was functional outcome (modified Rankin Scale, mRS) at day 90. Cognition was assessed via telephone at day 90. Stroke syndrome was classified using the Oxfordshire Community Stroke Project classification. Brain imaging was adjudicated masked to clinical information and treatment, and assessed SVD (leukoaraiosis, old lacunar infarcts/lacunes, atrophy) and 'brain frailty' (leukoaraiosis, atrophy, old vascular lesions/infarcts). Analyses used ordinal logistic regression adjusted for prognostic variables. Results: In all participants and those with lacunar syndromes (LACS, 1397, 34.8%), baseline CT imaging features of SVD and 'brain frailty' were common and independently associated with unfavourable shifts in mRS at day 90: all participants (SVD score OR 1.15, 95% CI 1.07-1.24; 'brain frailty' score OR 1.25, 95% CI 1.17-1.34); those with LACS (SVD score OR 1.30, 95% CI 1.15-1.47; 'brain frailty' score OR 1.28, 95% CI 1.14-1.44). 'Brain frailty' was associated with worse cognitive scores at 90 days in all and in LACS participants. Conclusions: Baseline imaging features of SVD and 'brain frailty' were common in lacunar stroke and all stroke, predicted worse prognosis after all acute stroke with a stronger effect in lacunar stroke, and may aid future clinical decision-making. Registration: ISRCTN99414122.
Data from: Effects of Lewy body disease and Alzheimer's disease on brain atrophy and cognitive dysfunction
Objectives: We investigated the independent and interaction effects of Alzheimer's disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy. Methods: We consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-Florbetaben PET and 18F-FP-CIT-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment (MCI) and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models. Results: Compared to the controls, pure patients with ADCI group and pure LBCI group had focused cortical thinning in the bilateral entorhinal/right anterior temporal cortices and bilateral anteromedial temporal/basal frontal cortices, respectively, while the mixed disease group had additional cortical thinning in the widespread association cortices. The independent effects of ADCI and LBCI on regional cortical thinning overlapped in the widespread association cortices, especially at the bilateral temporo-parietal junction and parietal cortices. ADCI and LBCI had independent detrimental effects on the copying item of the Rey-Osterrieth Complex Figure Test. Conclusions: Concomitant ADCI and LBCI are associated with the accentuation of neurodegeneration to widespread association cortices, and both diseases contribute to visuospatial dysfunction.
Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer's disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics
<p><span>High-resolution IM-MS-based four-dimensional lipidomics strategy for glycerophospholipid analysis.</span></p>
Effects of Deep Brain Stimulation for the Treatment of Parkinson's Disease
ClinicalTrials.gov study NCT00358189. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease
ClinicalTrials.gov study NCT04222062. IPD Sharing: NO. Countries: 1. Publications: 0.
Remote Programming for Deep Brain Stimulation in Parkinson's Disease.
ClinicalTrials.gov study NCT06078397. IPD Sharing: NO. Countries: 1. Publications: 0.
Brain Imaging and Retreatment Study of Persistent Lyme Disease
ClinicalTrials.gov study NCT00037479. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.