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7,518 results for “screenings”
CRISPR-Cas9 screen upon Olaparib+CldU treatment
<p>DNA single-strand breaks (SSBs) disrupt DNA replication and induce chromosome breakage. However, whether SSBs induce chromosome breakage when present in nascent strands behind replication forks or template strands ahead of replication forks is unclear. To address this question, we exploited an exquisite sensitivity of SSB repair-defective human cells lacking PARP activity or XRCC1 to the thymidine analog 5-chloro-2'-deoxyuridine (CldU). We show that incubation with CldU in these cells results in chromosome breakage, sister chromatid exchange, and cytotoxicity by a mechanism that depends on the S phase activity of uracil DNA glycosylase (UNG). Importantly, we show that CldU incorporation in one cell cycle is cytotoxic only during the following cell cycle when it is present in template DNA. In agreement with this, while UNG induces SSBs both in nascent strands behind replication forks and in template strands ahead of replication forks, only the latter triggers fork collapse and chromosome breakage. Finally, we show that BRCA-defective cells are hypersensitive to CldU, either alone and/or in combination with PARP inhibitor, suggesting that CldU may have clinical utility.</p>
The docked poses from the docking screens against the AlphaFold2 models of the σ2 and 5HT2A receptors
<p>Though AlphaFold2 (AF2) models have had wide impact, they have had mixed success in retrospective ligand recognition. Here, we prospectively docked large libraries against unrefined AF2 models of the σ2 and 5-HT2A receptors, testing hundreds of new molecules and comparing results to docking against the experimental structures. Hit rates were high and similar for the experimental and the AF2 structures, as were affinities. The success of docking against the AF2 models was achieved despite differences in orthosteric residue conformations versus the experimental structures. Determination of the cryoEM structure for one of the more potent 5HT2A ligands from the AF2 docking revealed residue accommodations that resembled the AF2 prediction. AF2 models may sample conformations that differ from experimental structures but remain low energy and relevant for ligand discovery, extending the domain of structure-based ligand discovery. This repository contains docked poses shown in this study.</p> <p>The data contain:</p> <p>1) AlphaFold2 models of the σ2 and 5HT2A receptors used to generate these two docked poses:</p> <ul> <li>AF-Q5BJF2-F1-model_v1_prep.pdb is the AlphaFold2 model used for docking against the σ2 receptor.</li> <li>AF-P28223-F1-model_v1_prep.pdb is the AlphaFold2 model used for docking against the 5HT2A receptor.</li> </ul> <p>2) Docked poses of ZINC866533340 in the σ2 model and Z7757 (ZINClB000002x4yW) in the 5HT2A model:</p> <ul> <li>ZINC000866533340_af.mol2 is the docked pose of ZINC866533340 in the σ2 model.</li> <li>7757_af.mol2 is the docked pose of Z7757 (ZINClB000002x4yW) in the 5HT2A model.</li> </ul>
Figure 1 in Risk screening of non-native freshwater fishes in Yunnan Province, China
Figure 1. Map of the study (risk screening) area (Yunnan Province in southwest China)
STING OPS: BJ1 Secondary Screen Single-Cell Features
<p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for BJ1 fibroblast secondary screen.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_BJ1.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p>
STING OPS: HeLa cGAMP (6 hours) Secondary Screen Single-Cell Features
<div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, 6 hours post-cGAMP, with or without rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> <p> </p> </div>
Figure 1 in Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening patients with imported malaria in a non-endemic setting
Figure 1. Study flow chart.
STING OPS: HeLa Unstimulated Secondary Screen Single-Cell Features
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, unstimulated, without rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> <p> </p> </div> <p> </p> </div>
STING OPS: HeLa Unstimulated Secondary Screen Single-Cell Features (Background-Subtracted)
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, unstimulated, with rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> <p> </p> </div> <p> </p> </div>
STING OPS: HeLa Genome-wide Screen Single-Cell Features (Part 2/5)
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa genome-wide screen, Zenodo dataset part 2/5.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/GW*.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> </div> </div>
STING OPS: HeLa Genome-wide Screen Single-Cell Features (Part 5/5)
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa genome-wide screen, Zenodo dataset part 5/5.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/GW*.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> </div> </div>
STING OPS: HeLa cGAMP (4 hours) Secondary Screen Single-Cell Features
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa secondary screen, 4 hours post-cGAMP, with or without rolling ball background subtraction.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/SEC_HeLa.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> </div> </div>
STING OPS: HeLa Genome-wide Screen Single-Cell Features (Part 1/5)
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa genome-wide screen, Zenodo dataset part 1/5.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/GW*.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> </div> </div>
STING OPS: HeLa Genome-wide Screen Single-Cell Features (Part 3/5)
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa genome-wide screen, Zenodo dataset part 3/5.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/GW*.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> </div> </div>
STING OPS: HeLa Genome-wide Screen Single-Cell Features (Part 4/5)
<div> <div> <p><strong>Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening</strong></p> <p>Single-cell features and coordinates for HeLa genome-wide screen, Zenodo dataset part 4/5.</p> <p>Images available at gs://opspublic-east1/STINGOpticalPooledScreen/Images/GW*.</p> <p>README for additional image information is at gs://opspublic-east1/STINGOpticalPooledScreen/STING_README.</p> </div> </div>
CHRONIC KIDNEY DISEASE SCREENING IN COMMUNITY PHARMACY: CRIERFAC PROJECT
<p>Chronic kidney disease (CKD) is a major health problem. Early detection improves the prognosis of these patients, but the disease does not show its face until it is more advanced. The aim is to screen for the disease in community pharmacies in order to refer patients to primary care physicians.</p> <p>Data from the 2116 patients recruited are presented in a single Excel table where each line corresponds to one patient. It contains patient demographics data, risk factors for chronic kidney disease, creatinine and glomerular filtration data, pharmacist intervention and physician response.</p>
Fig. 4 in Application of allozyme markers for screening of turbot populations along Western Black Sea coast
Fig. 4. Dendrogram of three turbot populations using PAUP cluster analysis of allozyme data.
Fig.1 in Application of allozyme markers for screening of turbot populations along Western Black Sea coast
Fig.1. Sampling localities of turbot samples
Fig. 2 in Screening of essential oil antifeedants in the elm pest Ambrostoma quadriimpressum (Coleoptera: Chrysomelidae)
Fig. 2. Schematic of Y-tube olfactometer used in Exp. 3 for assaying repellency of cinnamaldehyde.
Machine Learning Guided AQFEP: A Fast & Efficient Absolute Free Energy Perturbation Solution for Virtual Screening
<p>Data to reproduce primary figures in the manuscript titled: Machine Learning Guided AQFEP: A Fast & Efficient Absolute Free Energy Perturbation Solution for Virtual Screening.</p> <p>URL: https://chemrxiv.org/engage/chemrxiv/article-details/6583785e66c1381729ac86f5</p>
Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus [Microscope images - Oct4 KDs]
<p>Microscope images related to Figure 2 in Schwämmle et al. 2025. </p> <p>The cells are undifferentiated or day 2 differentiated TX1072 XX SP427 mESCs with (or without) Oct4 knockdown in the indicated media.</p> <p>Exonic Xist is stained using Cy5 Stellaris probes. The nuclei are stained using DAPI.</p> <p>These files were used to manually count Xist clouds (see fish_sgOct4_manual.txt for counts). For code to visualize the results see https://github.com/EddaSchulz/TFiScreen_Paper. RA samples relate only to the biorXiv release of the manuscript (https://doi.org/10.1101/2024.10.08.617282).</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.