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Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia: A report from the TARGET initiative
<p>Acute myeloid leukemias (AML) are characterized by distinct mutations of tumor suppressor and oncogenes, involving distinct genes in adults and children. While certain mutations have been associated with the increased risk of AML relapse the genomic landscape of primary chemotherapy resistant AML is not well defined. As part of the TARGET initiative, we performed whole-genome DNA sequencing, transcriptome RNA, and miRNA sequencing analysis of pediatric AML with failure of induction chemotherapy. We identified three distinct genetic groups of patients with induction failure, including those with <em>NUP98</em> rearrangements, somatic mutations of <em>WT1</em>, <em>ELF1</em>, <em>KMT2C</em>, <em>MLLT10,</em> and additional recurrent gene mutations, fusions, and structural rearrangements, some of which have been observed in other malignancies. Comparison of specimens before and after chemotherapy revealed distinct and invariant gene expression programs. While exhibiting gross therapy resistance, these leukemias had diverse forms of clonal evolution upon chemotherapy exposure. This included selection for mutant alleles of <em>FRMD8</em>, <em>DHX32</em>, <em>PIK3R1</em>, <em>SHANK3</em>, <em>MKLN1</em>, as well as persistence of <em>WT1</em> and <em>TP53</em> mutant clones, and elimination or contraction of <em>FLT3</em>, <em>PTPN11</em>, and <em>NRAS</em> mutant clones. These findings delineate genetic mechanisms of primary chemotherapy resistance in pediatric AML, which should inform improved approaches for its diagnosis and therapy.</p>
FIGURE 2. Protected areas reporting odonates from 2001 in Odonata from protected areas in Colombia with new records and description of Cora verapax sp. nov. (Zygoptera: Polythoridae)
FIGURE 2. Protected areas reporting odonates from 2001 to 2017 in Colombia. a) Geographical distribution of the sampled areas. Polygons for SFF, RNSC, RFPN and No Register Reserves are too small to be noticed at the map scale. b) Number of sampled areas under the categories recognized by the SINAP.
FIGURES 23 – 28 in Cosmosycanus perelegans (Hemiptera: Reduviidae: Harpactorinae), a new record from China, with report of its female genitalia
FIGURES 23 – 28. Cosmosycanus perelegans (Breddin), ♂, phallus. 23 – 25, China, Guangxi; 26 – 28, Vietnam, Hoa Binh; 23, 26, dorsal view; 24, 27, lateral view; 25, 28, ventral view. Scale bar = 0.5 mm.
Technical Report and Simulation Results for the Paper "It's About Time: On Optimal Virtual Network Embeddings under Temporal Flexibilities"
<p>Archiving the data and the technical report corresponding to our publication "It’s About Time: On Optimal Virtual Network Embeddings under Temporal Flexibilities".<br> The data was previously publicly available at https://net.t-labs.tu-berlin.de/~stefan/tvnep.html.</p>
Dataset for Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling"
<p>All FDA labels and extraction sheets to support our paper, Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling".</p>
FIGURE 8 in A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae) from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
FIGURE 8. Lynchius parkeri in life (QCAZ 61015, adult female, SVL 34.9 mm) from Laguna de Jimbura, Provincia de Loja, Ecuador.
FIGURE 7 in A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae) from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
FIGURE 7. (A) Vertebral column and pelvic griddle, (B) pectoral grid, C) arm and D) foot of the holotype of Lynchius megacephalus, sp. n (adult female).
FIGURE 2 in A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae) from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
FIGURE 2. Map showing the type locality of the new species Lynchius megacephalus (yellow dot) from Ecological Conservation Area Tinajillas Río Gualaceño-Morona Santiago province, Ecuador (elevation: 2800 m), and localities of Lynchius parkeri (red squares) from Yacuri National Park, Laguna Jimbura-Loja province, Ecuador (elevation: 2990–3397 m) and previously known localities from Peru (red squares with a black point). The bold black line represents the boundary between Ecuador, Peru, and Colombia. Locality details are shown in Appendix 2. Abbreviations are Colombia = COL, Ecuador = ECU, Peru = PER.
FIGURE 6 in A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae) from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
FIGURE 6. Skull of holotype of Lynchius megacephalus sp. n. (adult female) in (A) dorsal (B) ventral, and (C) lateral view, with visible exostosis and ornamentation (with wrinkled appearance), and (D) lateral view of the mandible (grey region represents the site of the articulation of the maxilla with the quadratojugal).
FIGURE 5 in A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae) from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
FIGURE 5. Ventral view of A) hand and B) foot of the holotype of Lynchius megacephalus sp. n. (hand length 5.2 mm, foot length 13.4 mm).
FIGURE 1 in A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae) from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
FIGURE 1. Phylogenetic relationships of Lynchius species. Maximum-likelihood tree obtained from analyses of mitochondrial (12S, 16S, and ND1) and nuclear (RAG and Tyr) DNA sequences from 14 specimens of Lynchius (excluding outgroup taxa). Numbers before slashes correspond to Bayesian posterior probabilities (PP); asterisks (*) represent PP = 1.0. Numbers after slashes are ML bootstrap support (BB) values; asterisks (*) represent BB = 100. PP and BB values <0.50 or 50, respectively are not shown. Museum number and country are shown for each specimen. Locality is also shown for L. megacephalus sp. n. and L. parkeri. Locality details, as well as voucher, GenBank accession numbers, and literature references are provided in Appendix 2.
FIGURE 4 in A bizarre new species of Lynchius (Amphibia, Anura, Strabomantidae) from the Andes of Ecuador and first report of Lynchius parkeri in Ecuador
FIGURE 4. Holotype of Lynchius megacephalus sp. n. in preservative. (A) Dorsal view, (B) ventral view, (C) profile view of the head, (D) lateral view.
Capturing and Reporting Provenance Information of Simulation Studies Based on an Artifact-Based Workflow Approach - Appendix Provenance Graph
<p>Provenance graph for a fictional ecological simulation study</p>
FIGURE 3. Caridina babaulti Bouvier,1918 in Report of Caridina babaulti Bouvier, 1918 (Crustacea: Decapoda: Caridea: Atyidae) and description of a new species Caridina kutchi sp. nov. from Gujarat, India
FIGURE 3. Caridina babaulti Bouvier,1918.RRLC/Bio-SH/04, ♀: a) First pereiopod; b) Second pereiopod; c) Third pereiopod; d) Dactylus of third pereiopod; e) Fifth pereiopod; f) Dactylus of fifth pereiopod; MNHN IU 2013-11292 (=MNHN Na 668), ♀: g) First female pleopod; MNHN IU 2013-11292 (=MNHN Na 668), ♀ovig., h) Egg; MNHN IU 2013- 11295(=MNHN Na 670), ♂: i) Endopod of first male pleopod; j) Appendix masculina; RRLC/Bio-SH/04, ♀: k) Telson; l) posterior margin of telson; MNHN IU 2013-11292 (=MNHN Na 668), ♀:m) Posterior margin of telson; MNHN IU 2013-11292 (=MNHN Na 668), ♀: n) Posterior margin of telson; RRLC/Bio-SH/04, ♀: o) Uropod diaeresis spinules; p) Preanal carina. Scale bar a, b, c, e, k 31 mm=0.5 mm; g, h 51mm=1mm; d, f, i, j, l, m, n, o 38 mm = 0.25 mm; p 25 mm = 0.25mm.
FIGURE 2. Caridina babaulti Bouvier, 1918 in Report of Caridina babaulti Bouvier, 1918 (Crustacea: Decapoda: Caridea: Atyidae) and description of a new species Caridina kutchi sp. nov. from Gujarat, India
FIGURE 2. Caridina babaulti Bouvier, 1918, RRLC/Bio-SH/04, ♀: a) Anterior region of cephalothorax; MNHN IU 2013- 11292 (=MNHN Na 668), ♀ ovig.: b) Anterior region of cephalothorax. Scale bar a, b 51 mm = 1 mm.
FIGURE 4 in Report of Caridina babaulti Bouvier, 1918 (Crustacea: Decapoda: Caridea: Atyidae) and description of a new species Caridina kutchi sp. nov. from Gujarat, India
FIGURE 4. Caridina kutchi sp. nov., RRLC/BIO-SH/02, ♂: a) Entire; b) Rostrum anterior region; c) Anterior region of cephalothorax. Scale bar a 17 mm = 1 mm; b 38 mm = 0.25 mm; c 51 mm = 1 mm.
FIGURE 1 in Report of Frank Balfour-Browne's collecting in Gran Canaria and Madeira (1932 - 1933), with the description of Ochthebius (Cobalius) lanthanus sp. nov. (Coleoptera, Hydraenidae)
FIGURE 1. One of the two trays with Balfour-Browne specimens of "Ochthebius lejolisii" collected in Gran Canaria deposited in the Royal Scottish Museum (RSM), containing 15 paratypes of O. lanthanus sp. nov.
FIGURES 8–9 in Report of Frank Balfour-Browne's collecting in Gran Canaria and Madeira (1932 - 1933), with the description of Ochthebius (Cobalius) lanthanus sp. nov. (Coleoptera, Hydraenidae)
FIGURES 8–9. Habitat of Ochthebius (Cobalius) lanthanus sp. nov. 8) rockpools in Taliarte; 9) rockpools in Arucas (Gran Canaria) (photos: IR).
FIGURES 3–6 in Report of Frank Balfour-Browne's collecting in Gran Canaria and Madeira (1932 - 1933), with the description of Ochthebius (Cobalius) lanthanus sp. nov. (Coleoptera, Hydraenidae)
FIGURES 3–6. SEM photographs of Ochthebius (Cobalius) lanthanus sp. nov., paratype voucher IBE-AV169. 3) head; 4) pronotum; 5) elytral disc; 6) abdominal ventrites.
Report user data
<p>This dataset contains the relation between users, instruments, elapsed time, result and status_code.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.