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ShareScore release 0.9.0
Dataset results
339 results for “CML”
Gene expression profiling of CD34/CD38 sorted CML cells
GEO Series GSE40721. Homo sapiens. 10 samples. Type: Expression profiling by array.
Expression profiling in extracellular miRNAs of CML patients after imatinib discontinuation (STOP-IM)
GEO Series GSE75392. Homo sapiens. 20 samples. Type: Expression profiling by RT-PCR.
Chronic Myeloid Leukemia (CML), induced pluripotent stem cell (iPSC)-derived lin-CD34+CD45+ (iCD34) cell population
GEO Series GSE60065. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Alternative splicing and the epigenome in CML remission
GEO Series GSE163527. Homo sapiens. 123 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Heterogeneity of CML therapy resistant cells
GEO Series GSE214385. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Sequencing of chronic myeloid leukemia (CML) cell lines upon upregulation or downregulation of G0/G1 switch gene (G0S2)
GEO Series GSE171945. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-seq analysis of the effects of fluphenazine and/or nilotinib on primary CML CD34+CD38- cells
GEO Series GSE247827. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Effect of BCDIN3D knock-out on gene expression in Chronic Myelogenous Leukemia (CML) Hap1 cells.
GEO Series GSE127973. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Heterogeneity of therapy-resistant CML cells
GEO Series GSE206421. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
scRNA+TCRab-seq for CML studies
<p>These data combine two recent publications from CML, where i) patients were treated with dasatinib and interferon-a or ii) imatinib was stopped. </p> <p>i): https://pubmed.ncbi.nlm.nih.gov/36047494/<br>ii): https://pubmed.ncbi.nlm.nih.gov/37919606/</p>
Nilotinib, for Patients With CML-CP or CML-AP
ClinicalTrials.gov study NCT04518644. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effect of knockdown PHF8 on the transcriptional regulation of BCR-ABL1 fusion gene on CML cell line K562
GEO Series GSE235463. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
miRNAs expression profiling in circulating lymphocytes of CML patients after imatinib discontinuation
GEO Series GSE47652. Homo sapiens. 17 samples. Type: Other.
A novel small-molecule inhibitor of STAT5A/STAT5B with therapeutic potential for prostate cancer and CML
GEO Series GSE61312. Homo sapiens. 12 samples. Type: Expression profiling by array.
BCAT1 contributes to the developmentproliferation and leukemogenesis of TKI-resistant CML
GEO Series GSE262421. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile at single cell level of LMPP (lymphoid-primed multipotent progenitor) cells from CP-CML and BC-CML patients.
GEO Series GSE276130. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell CML TKI stop
<p>Data related to single-cell CML TKI stop project:<br><br>https://pubmed.ncbi.nlm.nih.gov/37919606/</p> <div> <div> <p>Immunological control of residual leukemia cells is thought to occur in patients with chronic myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine kinase inhibitor (TKI) discontinuation. To study this, we analyzed 55 single-cell RNA and T cell receptor (TCR) sequenced samples (scRNA+TCRαβ-seq) from patients with CML (n = 13, N = 25), other cancers (n = 28), and healthy (n = 7). The high number and active phenotype of natural killer (NK) cells in CML separated them from healthy and other cancers. Most NK cells in CML belonged to the active CD56<sup>dim</sup> cluster with high expression of GZMA/B, PRF1, CCL3/4, and IFNG, with interactions with leukemic cells via inhibitory LGALS9-TIM3 and PVR-TIGIT interactions. Accordingly, upregulation of LGALS9 was observed in CML target cells and TIM3 in NK cells when co-cultured together. Additionally, we created a classifier to identify TCRs targeting leukemia-associated antigen PR1 and quantified anti-PR1 T cells in 90 CML and 786 healthy TCRβ-sequenced samples. Anti-PR1 T cells were more prevalent in CML, enriched in bone marrow samples, and enriched in the mature, cytotoxic CD8 + T<sub>EMRA</sub> cluster, especially in a patient maintaining TFR. Our results highlight the role of NK cells and anti-PR1 T cells in anti-leukemic immune responses in CML.</p> </div> </div>
Gene expression-based imatinib response prediction in chronic phase CML
GEO Series GSE44589. Homo sapiens. 198 samples. Type: Expression profiling by array.
Goat Model for CML
GEO Series GSE17588. Homo sapiens; Capra hircus. 25 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.