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4,008 results for “Heart failure;”
Prediction model of in-hospital mortality in intensive care unit patients with heart failure: machine learning-based, retrospective analysis of the MIMIC-III database
<p><b>Objective:</b> The predictors of in-hospital mortality for intensive care units (ICU)-admitted HF patients remain poorly characterized.We aimed to develop and validate a prediction model for all-cause in-hospital mortality among ICU-admitted HF patients.</p> <p><b>Design: </b>A retrospective cohort study.</p> <p><b>Setting and Participants: </b>Data were extracted from the MIMIC-III database. Data on 1,177 heart failure patients were analysed.</p> <p><strong>Methods</strong>: Patients meeting the inclusion criteria were identified from the MIMIC-III database and randomly divided into derivation and validation groups. Independent risk factors for in-hospital mortality were screened using XGBoost and LASSO regression models in the derivation sample. Multivariable logistic regression analysis was used to build prediction models. Discrimination, calibration, and clinical usefulness of the predicting model were assessed using the C-index, calibration plot, and decision curve analysis. After pairwise comparison, the best performing model was chosen to build a nomogram according to the regression coefficients.</p> <p><b>Results:</b> Among the 1,177 admissions, in-hospital mortality was 13.52%. In both groups, the XGBoost, LASSO regression, and GWTG-HF risk score models showed acceptable discrimination. The XGBoost and LASSO regression models also showed good calibration. In pairwise comparison, the prediction effectiveness was higher with the XGBoost and LASSO regression models than with the GWTG-HF risk score model (P<0.05). The XGBoost model was chosen as our final model for its more concise and wider net benefit threshold probability range and was presented as the nomogram.</p> <p><b>Conclusions</b><b>:</b> Our nomogram enabled good prediction of in-hospital mortality in ICU-admitted HF patients, which may help clinical decision-making for such patients.</p>
Data for: A numerical study of a left ventricular expander for heart failure with preserved ejection fraction
<p><span>Increased cardiac stiffness hinders proper left ventricular (LV) expansion, resulting in decreased volume, delayed filling, and diastolic dysfunction. LV expanders are spring-like devices that aim to improve diastolic function by facilitating mechanical outward expansion. Implantations in animal models and in a few patients have shown promising results, yet further evaluation is needed to assess range of function and the risk of use.</span> <span>In this computational study, the effectiveness and potential use of a generic LV expander were assessed </span><span>by utilising our finite element models of </span><span>HFpEF-induced animal subjects. Following implantation, the treated models were compared to the corresponding untreated and healthy preinduction models. Influence of device orientation and its material properties was also examined. Our results demonstrated a reduction in LV pressure and a volumetric improvement. Computed LV stresses have shown no gross irregularities. The device contributed to stress elevation during diastole while having a minor effect during systole, supporting a basic safety profile. This is the first study to use numerical analysis to assess LV expanders' performance on different HFpEF phenotypes. Improvement in heart function was demonstrated in both subjects, suggesting its potential use in various HFpEF manifestations, yet customisation and optimal deployment are essential to improve heart performance.</span></p>
Sacubitril/valsartan in the treatment of heart failure: Dataset from Systematic Review
<p>Sacubitril/valsartan in the treatment of heart failure: Dataset from Systematic Review</p>
Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure
ClinicalTrials.gov study NCT00733161. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Single Dose Study to Compare the Pharmacodynamics of Torasemide-PR 10 mg,Torasemide-IR 10 mg and Furosemide-IR 40 mg in Patients With Compensated Heart Failure
ClinicalTrials.gov study NCT01549158. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ODYSSEE-vCHAT Mental Health Program for Heart Failure and Kidney Disease Patients
ClinicalTrials.gov study NCT05560737. IPD Sharing: NO. Countries: 1. Publications: 30.
Clinical Efficacy of Remote Monitoring in the Management of Heart Failure
ClinicalTrials.gov study NCT01723865. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Health Literacy, Stress and Quality of Life in Heart Failure Patients
ClinicalTrials.gov study NCT06923514. IPD Sharing: NO. Countries: 1. Publications: 5.
Heart Failure Recorded in Primary Care, Hospital Admissions and National Mortality Registry
ClinicalTrials.gov study NCT02551016. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary Hypertension
ClinicalTrials.gov study NCT00820352. IPD Sharing: Not stated. Countries: 1. Publications: 20.
Danish Pragmatic Randomized Trial to Evaluate the Effect of HeartLogic-Guided Management on Heart Failure Outcomes
ClinicalTrials.gov study NCT06099158. IPD Sharing: YES. Countries: 1. Publications: 0.
Clinical Outcomes of Dapagliflozin in Acute Heart Failure With Reduced Ejection Fraction (CODA-HFrEF)
ClinicalTrials.gov study NCT06012279. IPD Sharing: YES. Countries: 1. Publications: 3.
Functional Parameters Indicative of Heart Failure.
ClinicalTrials.gov study NCT03909919. IPD Sharing: NO. Countries: 1. Publications: 4.
Carmat Total Artificial Heart as a Bridge to Transplant in Patients With Advanced Heart Failure
ClinicalTrials.gov study NCT04475393. IPD Sharing: NO. Countries: 1. Publications: 0.
Serial Measurements of Biomarker in Patients With Acute Decompensated Heart Failure
ClinicalTrials.gov study NCT00514384. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Resynchronization Therapy for Heart Failure
ClinicalTrials.gov study NCT00900549. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
ClinicalTrials.gov study NCT06414759. IPD Sharing: Not stated. Countries: 1. Publications: 22.
Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure
ClinicalTrials.gov study NCT04049045. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effects of Glimepiride in Patients With Type 2 Diabetes and Chronic Heart Failure
ClinicalTrials.gov study NCT05538819. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure
ClinicalTrials.gov study NCT00517426. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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