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7,228 results for “Modules”
Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis
<p>This is a dataset for the following paper: doi: 10.1089/thy.2018.0480. PMID: 31426718</p> <p>Each book in the excel file refers to the paper's figure panel specified.</p> <p>For more info do not hesitate to contact me directly at gerasimos.sykiotis@chuv.ch</p>
Raw data related to: Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
<p><strong>Abstract</strong></p> <p>Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the e ective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child.</p> <p><strong>Progetto giovani ricercatori </strong>[GR-2016-02363725] dal titolo: "Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression"</p>
Dataset related to the publication "Optical modulation of coherent phonon emission in optomechanical cavities", DOI: 10.1063/1.5040061
<p>This folder contains the raw data from which the graphs in paper "Optical modulation of coherent phonon emission in optomechanical cavities", DOI: 10.1063/1.5040061, have been obtained.</p> <p> </p>
Extensive Unified Thermo-Electric Module Characterization
<p>Experimental results for the extensive characterization of the low-cost module TES1-12730 by Thermonamic Electronics Corporation, obtained using the Unified Method for Thermo-Electric Module characterization (see references). Data are processed and visualized using MATLAB version 9.7.0.1319299 (R2019b) Update 5.</p> <p>Tests are obtained for 14 operating temperature values with step 3 °C between 10 °C and 49 °C.</p> <p>Datasets include:</p> <ul> <li>Thermocouple-based characterization ( 14 temperature difference values: with step 3 °C between 6 °C and 45 °C )</li> <li>Thermistor-based characterization ( 24 temperature difference values: ten with step 0.3 °C between 0.3 °C and 3 °C and fourteen with step 3 °C between 6 °C and 45 °C )</li> </ul> <p>Softwares include:</p> <ul> <li>importData: function for importing data from files in column vectors</li> <li>analyzeData: script for data processing (suffix _TC and _NTC for thermocouples and thermistor respectively)</li> <li>plotResults: script for extensive plot of parameters mean, relative std and std</li> <li>plotMean: script for quick plot of the parameters mean</li> </ul>
Raw mass spectrometry data for publication "Vertebrate cellular endolysosome modulating pore-forming protein is negatively regulated by its homologue under environmental oxidative conditions"
<p><strong>Abstract</strong>: Endolysosomes are key players in cell physiology, including material exchange, immunity and environmental adaptation etc. Bacterial pore-forming toxin aerolysin-like proteins (ALPs) are widely distributed in animals and plants. βγ-CAT is a complex of an ALP (BmALP1) and a trefoil factor (BmTFF3) in the frog <em>Bombina maxima</em>. It is the first example that a secreted endogenous pore-forming protein modulates the biochemical properties of endolysosomes via pore formation in these vesicles. Here, we report the identification of BmALP3, a homologue of BmALP1 that lacks membrane pore formation capacity. Both BmALP3 and BmALP1 contain a conserved cysteine in their C-terminal regions. BmALP3 was readily oxidized to disulfide bond linked homodimer, and the homodimer could then oxidize BmALP1 via disulfide bond exchange, resulting in the dissociation of βγ-CAT subunits and elimination of its biological activity. Consistent with its behavior <em>in vitro</em>, BmALP3 senses environmental oxygen tension <em>in vivo</em>, leading to modulation of βγ-CAT activity. Interestingly, this C-terminal cysteine site is well conserved in numerous vertebrate ALPs. These findings, for the first time, uncovered the existence of a regulatory ALP (BmALP3) and its modulating action on a cell executive ALP (BmALP1) in a redox-dependent manner, which is completely different from that of bacterial toxin aerolysins.</p>
Phenotypic modulation of biofilm formation in a Staphylococcus epidermidis orthopedic clinical isolate grown under different mechanical stimuli: contribution from a combined proteomic study
<p>One of the major causes of prosthetic joint failure is infection. Recently, coagulase negative <em>Staphylococcus epidermidis</em> has been identified as an emergent, nosocomial pathogen involved in subclinical prosthetic join infections (PJIs). The diagnosis of PJIs mediated by <em>S. epidermidis</em> is usually complex and difficulties due to the absence of acute clinical signs derived from the host immune system response. Therefore, analysis of protein patterns in biofilm-producing <em>S. epidermidis</em> allows for the examination of the molecular basis of biofilm formation. Thus, in the present study, the proteome of a clinical isolate <em>S. epidermidis</em> was analyzed when cultured in its planktonic or sessile form to examine protein expression changes depending on culture conditions. After 24 hours of culture, sessile bacteria exhibited increased gene expression for ribosomal activity and for expression of proteins related to the initial attachment phase, involved in the capsular polysaccharide/adhesin, surface associated proteins and peptidoglycan biosynthesis. Likewise, planktonic <em>S. epidermidis</em> was able to aggregate after 24 hours, synthesizing the accumulation associate protein and cell-wall molecules through the activation of the YycFG and ArlRS, two component regulatory pathways. Prolonged culture under vigorous agitation generated a stressful growing environment triggering aggregation in a biofilm-like matrix as a mechanism to survive harsh conditions.</p> <p>Further studies will be essential to support these findings in order to further delineate the complex mechanisms of biofilm formation of <em>S. epidermidis</em> and they could provide the groundwork for the development of new drugs against biofilm-related infections, as well as the identification of novel biomarkers of subclinical or chronic infections mediated by these emerging, low virulence pathogens.</p>
How to repair a solar module
<p>First video-tutorial shooting at Universidade Evora of an educational series on how to proceed with reparation of solar Photovoltaic modules.</p>
Maternal and cohort effects modulate offspring responses to multiple stressors
Current concerns about climate change has led to intensive research attempting to understand how climate driven stressors affect the performance of organisms, in particular on offspring of many invertebrate and fish. Although stressors are likely to act on several stages of the life cycle, little is known about their action across life phases, for instance how multiple stressors experienced simultaneously in the maternal environment can modulate the responses to the same stressors operating in the offspring environment. Here, we study how performance of offspring of a marine invertebrate (shore crab Carcinus maenas) in response to two stressors (temperature and salinity) changes if the same stressors are experienced at the time of embryogenesis in cohorts of mothers breeding eggs at different seasons. On average, offspring responses were antagonistic: high temperature mitigated the negative effects of low salinity on survival. However, the magnitude of the response was modulated by the temperature and salinity conditions experienced by egg-carrying mothers. Performance also varied among cohorts, suggesting a role for genetic variation, and/or maternal conditions prior to fertilisation. We speculate that similar maternal effects may occur in other brooding organisms, as a consequence of anthropogenic modification of the environment.
Data from: Molecular evolutionary analysis of nematode Zona Pellucida (ZP) modules reveals disulfide-bond reshuffling and standalone ZP-C domains
<p>Zona pellucida (ZP) modules mediate extracellular protein-protein interactions and contribute to important biological processes including syngamy and cellular morphogenesis. While some biomedically-relevant ZP modules are well-studied, little is known about the protein family's broad-scale diversity and evolution. The increasing availability of sequenced genomes from "non-model" systems provides a valuable opportunity to address this issue, and to use comparative approaches to gain new insights into ZP module biology. Here, through phylogenetic and structural exploration of ZP module diversity across the nematode phylum, I report evidence that speaks to two important aspects of ZP module biology. First, I show that ZP-C domains—which in some modules act as regulators of ZP-N domain-mediated polymerization activity, and which have never before been found in isolation—can indeed be found as standalone domains. These standalone ZP-C domain proteins originated in independent (paralogous) lineages prior to the diversification of extant nematodes, after which they evolved under strong stabilizing selection, suggesting the presence of ZP-N domain-independent functionality. Second, I provide a much-needed phylogenetic perspective on disulfide bond variability, uncovering evidence for both convergent evolution and disulfide-bond reshuffling. This result has implications for our evolutionary understanding and classification of ZP module structural diversity and highlights the usefulness of phylogenetics and diverse sampling for protein structural biology. All told, these findings set the stage for broad-scale (cross-phyla) evolutionary analysis of ZP modules and position Caenorhabditis elegans and other nematodes as important experimental systems for exploring the evolution of ZP modules and their constituent domains.</p> <p> </p>
Dataset The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G(α) and G(βγ) Subunits
<p>This dataset is related to the study: </p> <p>"The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G(α) and G(βγ) Subunits" by de Castro Abrantes H, Briquet M, Schmuziger C, Restivo L, Puyal J, Rosenberg N, Rocher AB, Offermanns S, Chatton JY. J Neurosci. 2019 Jun 5;39(23):4422-4433. doi: 10.1523/JNEUROSCI.2092-18.2019. Epub 2019 Mar 29. PubMed PMID: 30926749; PubMed Central PMCID: PMC6554634.</p>
The essential oil of Polygonum minus modulating cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathway
<p>Oxidative stress, inflammation and apoptosis are thought as primary mediators of cisplatin-induced hepatotoxicity. The objective of this study was to determine the protective effect of <em>Polygonum minus</em> essential oil in cisplatin-induced hepatotoxicity. A total of forty-two male rats were randomly divided into seven groups: control, cisplatin, positive control β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg + cisplatin (PmEO100CP), PmEO 200 mg/kg + cisplatin (PmEO200CP), PmEO 400 mg/kg + cisplatin (PmEO400CP) and PmEO 400 mg/kg (PmEO400). Rats in the BCP, PmEO100CP, PmEO200CP, PmEO400CP and PmEO400 group received respective treatment orally for 14 consecutive days prior to cisplatin injection. All animals except for those in the control group and PmEO400 were administered with a single dose of cisplatin (10 mg/kg) intraperitoneally on day 15 and were sacrificed on day 18. PmEO100CP pretreatment protected against cisplatin-induced hepatotoxicity by decreasing CYP2E1, malondialdehyde, 8-OHdG and protein carbonyl which was accompanied by increased antioxidant status as compared to cisplatin alone group. PmEO100CP pretreatment also attenuated changes in liver inflammatory markers. PmEO100CP administration also reduced cisplatin-induced apoptosis. In conclusion, our results suggested that <em>P. minus</em> essential oil at a dose of 100 mg/kg may protect against cisplatin-induced hepatotoxicity possibly via inhibition of oxidative stress, inflammation and apoptosis.</p>
Anisotropy-induced spin reorientation in chemically modulated amorphous ferrimagnetic films
<p>Open data for "Anisotropy-induced spin reorientation in chemically modulated amorphous ferrimagnetic films", published in PHYSICAL REVIEW MATERIALS <strong>4</strong>, 074403 (2020)</p> <p> </p>
Modulation of the Tomato Fruit Metabolome by LED Light (GCMS and LCMS datasets)
<p>Metabolic profiles of tomatoes change during ripening and light can modulate the activity of relevant biochemical pathways. We investigated the effects of light directly supplied to the fruits, on the metabolome of the fruit pericarp during ripening. Mature green tomatoes were exposed to well-controlled conditions with light as the only varying factor; control fruits were kept in darkness. In Experiment 1 the fruits were exposed to either white light or darkness for 15 days. In Experiment 2 fruits were exposed to different light spectra (blue, green, red, far-red, white) added to white background light for 7 days. Changes in the global metabolome of the fruit pericarp were monitored using LCMS and GCMS (554 compounds in total). Health-beneficial compounds (carotenoids, flavonoids, tocopherols and phenolic acids) accumulated faster under white light compared to darkness, while alkaloids and chlorophylls decreased faster. Light also changed the levels of taste-related metabolites including glutamate and malate. The light spectrum treatments indicated that the addition of blue light was the most effective treatment in altering the fruit metabolome. We conclude that light during ripening of tomatoes can have various effects on the metabolome and may help shaping the levels of key compounds involved in various fruit quality characteristics.</p>
Data from: Invertebrate phenology modulates the effect of the leaf economics spectrum on litter decomposition rate across 41 subtropical woody plant species
<ol> <li>Litter quality and decomposers are critical to carbon and nutrient cycling through litter decomposition. However, how relationships between litter quality and invertebrate detritivores change litter mass loss through time is poorly known. Species' initial leaf litter quality, as a legacy of their position on the "leaf economics spectrum" (LES), may determine the invertebrate contribution to litter mass loss. This contribution may change through time, as both population peaks of invertebrate detritivores and litter quality of given species will change through time.</li> <li>Here we introduce invertebrate phenology into a conceptual model of drivers of litter mass loss. We hypothesized that in the early decomposition period, LES can predict litter decomposability with or without a strong invertebrate contribution, i.e., litter with higher nutrient content would decompose faster. But in the later decomposition period, when higher quality litter will already have decomposed too much and lower quality litters have still been less degraded, a strong invertebrate peak would coincide with relatively more consumption of initially lower quality litters; this would lead to a hump-back relationship between leaf litter mass loss and initial LES position in this period.</li> <li>We tested our hypothesis through a one-year field decomposition experiment using leaf litter of 41 woody species in each of two sites in subtropical forest in China; only one of these sites had a strong late peak of leaf litter-feeding moth larvae in the litter layer.</li> <li>LES score of litter species had a positive linear relationship with litter mass loss before the key invertebrate consumer peaks in the litter layer. However, with the invertebrates peaking later into the decomposition process, the invertebrate consumption peaked at initially lower quality litters, which altered the species' decomposability trajectory on the LES, consistent with the hypothesized hump-back relationship between leaf litter mass loss and LES. This phenomenon resulted in a strongly reduced slope of cumulative mass loss on initial LES score across species.</li> <li>Our finding highlights the importance of considering interactions between the timing of detritivore activities and the timing of litter quality for better understanding the relationships between soil animals and ecosystem carbon and nutrient cycling.</li> </ol>
Data for "Shallow lower mantle viscosity modulates the pattern of mantle structure"
<p>Data, input files and plotting software for the journal article "Shallow lower mantle viscosity modulates the pattern of mantle structure", published in the journal Geochemistry, Geophysics, Geosystems in 2020.</p> <ol> <li>Simulation-data.tar.gz has information, input files, and data for the last time step of all the simulations run in the study.</li> <li>Post-processing.tar.gz has post-processed data and the scripts used for analysis and plotting of data in the paper.</li> </ol> <p> </p>
Data from: Developmental nutrition modulates metabolic responses to projected climate change
<ol> <li>Current policy has the world on track to experience around 3°C of warming by 2100. The responses of organisms to our warming world will be mediated by changes in physiological processes, including metabolic rate. Metabolic rate represents the energetic cost of living, and is fundamental to understanding the energy required to sustain populations. Current evidence indicates that animals have a limited capacity to adapt to warmer environments by reducing their metabolic rate. Consequently, animals may be more reliant on metabolic plasticity to ameliorate the thermodynamic effect of rising temperatures on physiological rates. However, metabolic plasticity is influenced by other environmental factors, including the nutritional quality of food. Elevated levels of atmospheric CO<sub>2</sub> are expected to reduce the protein and increase the carbohydrate concentration in plants, but we do not know how this will affect the response of metabolic rate to climate warming.</li> <li>Here we test the interactive effects of developmental dietary protein and carbohydrate concentrations on the metabolic plasticity of adult <i>Drosophila melanogaster</i> in response to a 3°C increase in temperature while accounting for variation associated with body mass and activity (resting metabolic rate).</li> <li>We show that the thermal sensitivity of resting metabolic rate is modulated by developmental nutrition with animals reared on nutritionally poor, low-protein diets showing the greatest increase in resting metabolic rate in response to simulated climate warming. We also show that if the nutritional quality of resources is unaffected by climate change, then temperature-induced increases in resting metabolic rate will be offset by decreases in mass, but the absolute energy requirements of animals will be elevated relative to current conditions despite this. If, on the other hand, temperatures rise and resources become more calorie-dense and carbohydrate-rich, then the resting metabolic rate of animals will remain relatively unchanged, but decreases in mass and activity may drive down the absolute energy requirements of animals.</li> <li>In the absence of evolutionary adaptation, these findings suggest that the combined plastic response of physiological, morphological, and behavioural traits to temperature and nutrition may be an important determinant of the ultimate outcome of climate change for populations.</li> </ol>
Data from: Strong effects of lab-to-field environmental transitions on the bacterial intestinal microbiota of Mus musculus are modulated by Trichuris muris infection
<p>Studies of controlled lab animals and natural populations represent two insightful extremes of microbiota research. We bridged these two approaches by transferring lab-bred female C57BL/6 mice from a conventional mouse facility to an acclimation room and then to an outdoor enclosure, to investigate how the gut microbiota changes with environment. Mice residing under constant conditions served as controls. Using 16S rRNA sequencing of fecal samples, we found that the shift in temperature and humidity, as well as exposure to a natural environment, increased microbiota diversity and altered community composition. Community composition in mice exposed to high temperatures and humidity diverged as much from the microbiota of mice housed outdoors as from the microbiota of control mice. Additionally, infection with the nematode <i>Trichuris muris</i> modulated how the microbiota responded to environmental transitions: The dynamics of several families were buffered by the nematodes, while invasion rates of two taxa acquired outdoors were magnified. These findings suggest that gut bacterial communities respond dynamically and simultaneously to changes within the host's body (e.g., the presence of nematodes) and to changes in the wider environment of the host.</p>
Statistical data from: Cholinergic modulation of hippocampally mediated attention and perception
<p>Attention to the relations between visual features modulates hippocampal representations. Moreover, hippocampal damage impairs discrimination of spatial relations. We explore a mechanism by which this might occur: modulation by the acetylcholine system. Acetylcholine enhances afferent input to the hippocampus and suppresses recurrent connections within it. This biases hippocampal processing toward environmental input, and should improve externally-oriented, hippocampally mediated attention and perception. We examined cholinergic modulation on an attention task that recruits the hippocampus. On each trial, participants viewed two images (rooms with paintings). On "similar room" trials, they judged whether the rooms had the same spatial layout from a different perspective. On "similar art" trials, they judged whether the paintings could have been painted by the same artist. On "identical" trials, participants simply had to detect identical paintings or rooms. We predicted that cholinergic modulation would improve performance on the similar room task, given past findings that hippocampal representations predicted, and hippocampal damage impaired, behavior on this task. To test this, nicotine cigarette smokers took part in two sessions: one before which they abstained from nicotine for 12 hours, and one before which they ingested nicotine in the past hour. Individual differences in expired breath carbon monoxide levels — a measure of how recently or how much someone smoked — predicted performance improvements on the similar room task. This finding provides novel support for computational models that propose that acetylcholine enhances externally oriented attentional states in the hippocampus.</p>
An incandescent metasurface for quasimonochromatic polarized Mid-Wave Infrared emission modulated beyond 10 MHz
<p>README :</p> <p>The codes available in this repository are MATLAB scripts.</p> <p>In order to run some of the scripts, users need to download the RETICOLO library available at doi : 10.5281/zenodo.3610175 Light-in-complex-nanostrucutres/RETICOLO and subsequently add this library to their MATLAB search path.</p> <p>4 folders can be found:</p> <ul> <li>EM_simulations: contains scripts to reproduce the electromagnetic simulations presented in the paper. The codes use functions in the RETICOLO library (therefore, please make sure that the folder containing all RETICOLO functions are known to the MATLAB search path).</li> <li>PolarizedFreqResponse: contains raw datasets and ready-to-use analysis scripts to reproduce frequency response curves of the device presented in the paper. The main script to be run is "main.m".</li> <li>EmissivitySpectra: contains raw datasets and ready-to-use analysis scripts to reproduce the emissivity spectrum of the device presented in the paper.</li> <li>Response_to_pulse_simulation: contains raw datasets and ready-to-use analysis scripts to reproduce the pulse response of the device presented in the paper.</li> </ul> <p>===============================</p> <p>DESCRIPTION :</p> <p>This repository contains all datasets and codes used in the following paper :</p> <p>doi :</p> <p>===============================</p> <p>PAPER ABSTRACT:</p> <p>Incandescent sources such as hot membranes and globars are widely used for mid infrared spectroscopic applications. The emission properties of these sources can be tailored by means of resonant metasurfaces: control of the spectrum, polarization and directivity has been reported. For detection or communication applications, fast temperature modulation is desirable but is still a challenge due to thermal inertia. Reducing thermal inertia can be achieved using nanoscale structures at the expense of a low absorption and emission cross section. Here, we introduce a metasurface that combines nanoscale heaters to ensure fast thermal response and nanophotonic resonances to provide large monochromatic and polarized emissivity. The metasurface is based on platinum and silicon nitride and can sustain high temperatures. We report a peak emissivity of 0.8 and an operation up to 20 MHz, six orders of magnitude faster than commercially available hot membranes.</p>
Data from: Anthelmintic drugs modulate the acute phase immune response but not the microbiota in wild Song Sparrows
<p>Co-infection with microparasites (e.g., bacteria) and macroparasites (e.g., helminths) is often the natural state for wild animals. Despite evidence that gut helminths can bias immune responses away from inflammatory processes, few field studies have examined the role that helminths, or their potential interactions with internal microbial communities, play in modulating immunity in free-living, wild birds. Here, we used anthelmintic drugs to treat wild Song Sparrows (<em>Melospiza melodia</em>) for helminth infections and measured markers of systemic inflammation (heterothermia and locomotor activity) in response to an immune challenge with lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria. Using birds from a population that previously showed high helminth prevalence, we monitored skin temperature and activity remotely using automated radio telemetry. We also collected cloacal swabs to determine whether drug treatment was associated with changes in the cloacal microbiota, and whether cloacal microbial community structure was associated with the severity of birds' immune responses. Because helminths can reduce the severity of inflammatory immune responses in other species, we predicted that in comparison with untreated control birds, anthelmintic-treated birds would be more lethargic and display higher fevers when challenged with LPS. Consistent with these predictions, anthelmintic-treated birds expressed higher fevers in response to immune challenge. However, all LPS-challenged birds decreased locomotor activity to a similar degree, regardless of anthelmintic treatment. Although several individual indicator bacterial taxa were strongly associated with anthelmintic treatment, this treatment did not alter overall bacterial alpha- and beta- diversity. Similarly, we did not find evidence that bacterial community diversity influenced the severity of immune responses to LPS. These results suggest that under field conditions, natural helminth infection can reduce the severity of songbirds' thermoregulatory responses (fever) during an immune challenge, without major impacts on internal microbial communities or behavioral responses to infection.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.