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752
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ShareScore release 0.9.0
Dataset results
752 results for “Osteoporosis”
Anticholinergic Burden and Osteoporosis in Rheumatoid Arthritis
ClinicalTrials.gov study NCT06812481. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Bonviva/Boniva (Ibandronate) in Biphosphonate-Naïve Women With Post-Menopausal Osteoporosis
ClinicalTrials.gov study NCT01290094. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety Study on Menatetrenone in the Treatment of Postmenopausal Osteoporosis Women
ClinicalTrials.gov study NCT00165698. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Controlled Study of ONO-5920 in Patients With Involutional Osteoporosis in Japan
ClinicalTrials.gov study NCT00212719. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effect of Wii Fit Balance Board Games on Balance in Patients With Osteoporosis Post Mastectomy
ClinicalTrials.gov study NCT07364279. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
3 yr Efficacy & Safety Study of Zoledronic Acid in Post-menopausal Women With Osteoporosis Treated With Zol Acid for 6 Yrs
ClinicalTrials.gov study NCT00718861. IPD Sharing: Not stated. Countries: 18. Publications: 0.
Diagnostic Performances of Mandibular CBCT in Osteoporosis
ClinicalTrials.gov study NCT05721118. IPD Sharing: NO. Countries: 0. Publications: 1.
Effects of Physical Exercise to Prevent Osteoporosis in Postmenopausal Women
ClinicalTrials.gov study NCT03091088. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
A Study and 12 Month Extension to Evaluate Two Investigational Drugs in Postmenopausal Women With Osteoporosis (MK-0217-907)
ClinicalTrials.gov study NCT00092040. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Data from: Prednisolone induces osteoporosis-like phenotypes via focal adhesion signaling pathway in zebrafish larvae
Open the record for dataset details and reuse information.
The Role of PTHrP in Osteoblast Response to Microgravity: Implications for Osteoporosis Development.
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients but with an accelerated timeframe. This rapid effect on weight-bearing bones is also observed in astronauts who lose up to 2% of their bone mass per month spent in Space. Despite important implications for Spaceflight travellers and bedridden patients on Earth the exact mechanisms involved in disuse osteoporosis have not been elucidated. Parathyroid hormone-related protein (PTHrP) regulates many physiological processes including skeletal development and has been proposed as a gravisensor. To investigate the role of PTHrP in microgravity-induced bone loss trabecular osteoblasts (TOs) from Pthrp+/+ and -/- mice were exposed to simulated microgravity for 6 days. Viability of TOs decreased in inverse proportion to PTHrP expression levels. Microarray analysis of Pthrp+/+ TOs after 6 days at 0g revealed expression changes in genes encoding prolactins,apoptosis and survival molecules bone metabolism and extra-cellular matrix composition proteins chemokines IGF family and Wnt-related signalling molecules. Importantly 88% of 0g-induced expression changes in Pthrp+/+ cells overlap those observed in Pthrp-/- cells in normal gravity. Pulsatile treatment with PTHrP1-36 peptide during microgravity exposure reversed a large proportion of 0g-induced changes in Pthrp+/+ TOs. Our results confirm PTHrP efficacy as an anabolic agent to prevent microgravity-induced cell death in TOs. Total RNA samples extracted from Pthrp+/+and -/- trabecular osteoblasts (TOs) exposed for 6 days to simulated 0g in Synthecon rotating cell or left 6 days in culture at 1g. Cells had either been treated with a pulsatile treatment (2 h/day) of PTHrP1-36 peptide (10-8M) or received a change in growth medium. In total: 8 different conditions with 2 replicates each i.e. Pthrp+/+ TOs at 0g or 1g with or without PTHrP1-36 treatment and Pthrp-/- TOs at 0g or 1 g,with or without PTHrP1-36 treatment.
Muscle atrophy osteoporosis prevention in hibernating mammals
Physical inactivity decreases the mechanical load on the skeleton which when prolonged leads to losses of muscle strength and bone mass in humans and most mammalian species. Hibernating mammals show no loss in bone mass and less muscle atrophy than would be anticipated over such a prolonged period of physical inactivity. This suggests that diverse hibernating mammals have evolved natural mechanisms that reduce muscle atrophy and conserve bone mass.
Mitochondrial Transfer Regulates Cell Fate Through Metabolic Remodeling in Osteoporosis
GEO Series GSE198806. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice
GEO Series GSE277491. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
A novel stromal cell source of RANKL during sustained osteoclast activation in disuse osteoporosis
GEO Series GSE289940. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
MiRNA Profiling of Whole Trabecular Bone: Identification of Osteoporosis-Related Changes in MiRNAs in Human Hip Bones
GEO Series GSE74209. Human alphaherpesvirus 2; Human betaherpesvirus 6B; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Betapolyomavirus hominis; human gammaherpesvirus 4; Betapolyomavirus macacae; Macacine alphaherpesvirus 1; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Merkel cell polyomavirus. 12 samples. Type: Non-coding RNA profiling by array.
Gene expression changes in femur tissues of ovariectomy-induced osteoporosis rats
GEO Series GSE201674. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing.
The pivotal role of the Hes1–Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis [human_GIOP]
GEO Series GSE276529. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
GEO Series GSE114933. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Integrative high-throughput enhancer surveying and functional verifying divulges YY2 condensed regulatory axis conferring risk for osteoporosis
GEO Series GSE231932. Homo sapiens. 6 samples. Type: Genome variation profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.