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337
datasets available to search
ShareScore release 0.9.0
Dataset results
337 results for “cell shape”
Multivalent state transitions shape the intratumoral composition of small cell carcinoma
GEO Series GSE221054. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Diverse development potency and metabolic shape of extended pluripotency are faithfully transferred to somatic cells via cell fusion reprogramming
GEO Series GSE210520. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Specific oncogenic drivers differently shaped the composition and functional diversity of immune cells in the microenvironment of experimental gliomas
GEO Series GSE269545. Mus musculus. 4 samples. Type: Other.
Shaping of T cell repertoire and function in murine intestine
GEO Series GSE181681. Mus musculus. 4 samples. Type: Other.
TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [CUT&RUN]
GEO Series GSE275498. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Multivalent state transitions shape the intratumoral composition of small cell carcinoma II
GEO Series GSE221212. Homo sapiens. 64 samples. Type: Expression profiling by high throughput sequencing.
Iron acquisition system and cell shape of host bacteria commonly respond to the carriage of three plasmids belonging to different incompatibility groups.
GEO Series GSE110733. Pseudomonas putida; Pseudomonas putida KT2440. 32 samples. Type: Expression profiling by genome tiling array.
Weaning-Driven Gut Microbiome Shapes Intestinal Stem Cell Epigenetics to Train Immunological Memory (WGS)
GEO Series GSE310995. Mus musculus. 41 samples. Type: Other.
TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [Hi-C]
GEO Series GSE275500. Mus musculus. 8 samples. Type: Other.
Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate [CLIP-seq]
GEO Series GSE267587. Mus musculus. 8 samples. Type: Other.
The EMT-regulator ZEB1 shapes bone marrow immunological niches in AML suppressing T-cell activity and fostering Th17 expansion
GEO Series GSE192473. Mus musculus. 9 samples. Type: Expression profiling by array.
Notch activity in tumor cells shapes interferon-gamma response and immune microenvironment in glioma
GEO Series GSE160715. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Weaning-Driven Gut Microbiome Shapes Intestinal Stem Cell Epigenetics to Train Immunological Memory (WGBS)
GEO Series GSE275219. Mus musculus. 20 samples. Type: Methylation profiling by high throughput sequencing.
IL-21 Shapes the B Cell Response in a Context-Dependent Manner [CUT&RUN]
GEO Series GSE280837. Mus musculus. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [ATAC-seq]
GEO Series GSE275497. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Tra2b's Ultraconserved Poison Exon relays TCR stimulation to shape T cell fate
GEO Series GSE267609. Homo sapiens; Mus musculus. 63 samples. Type: Expression profiling by high throughput sequencing; Other.
Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity
<p><strong>Tumor cell identity is the product of complex interactions between oncogenic drivers and mechanisms regulating normal differentiation pathways. Cell fate transitions observed in embryonic development involve changes in 3D genomic organization that provide proper lineage specification, however, whether similar events also occur within tumor cells and contribute to cancer evolution remains largely unexplored. Here we modeled this process in the pediatric bone cancer Ewing sarcoma and investigated high resolution looping and large-scale 3D nuclear conformation changes associated with EWS-FLI1, the oncogenic fusion protein that drives this tumor. We show that chromatin interactions in Ewing sarcoma cells are dominated by highly connected looping hubs centered on EWS-FLI1 binding sites, which directly control the activity of linked enhancers and promoters to establish oncogenic expression programs. Depletion of EWS-FLI1 led to the loss of looping networks associated with the oncoprotein and, strikingly, also resulted in widespread nuclear reorganization through the establishment of new patterns of looping and large-scale inter-compartment connectivity characteristic of mesenchymal stem cells, a candidate cell of origin for this tumor. </strong><strong>Our data thus demonstrate that major architectural features of nuclear organization in cancer cells can be dependent on a single oncogenic event and readily reversed to re-establish latent differentiation programs.</strong></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.