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2,996 results for “copd”
Lower airway microbiota in COPD and healthy controls
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The airway microbiota and exacerbations of COPD
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Effects of individualized step targets on physical activity in COPD. A randomized study
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Data from: COPD screening using time–frequency features of self-recorded respiratory sounds
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Synthetic LOS and interarrival time data for COPD patients in the Cwm Taf region
<p>This archive contains two artificial datasets for the length of stay (LOS) and interarrival times of patients with COPD. Each dataset is split amongst four clusters as identified in the work that these datasets support. The rest of the associated paper is available at <a href="https://github.com/daffidwilde/copd-paper">https://github.com/daffidwilde/copd-paper</a></p>
Data from: Findings from an exploration of a social network intervention to promote diet quality and health behaviours in older adults with COPD: a feasibility study
<p><span><b>Background: </b>Diet quality in older people with Chronic Obstructive Pulmonary Disease (COPD) is associated with better health and lung function. Social factors, such as social support, social networks and participation in activities, have been linked with diet quality in older age. A social network tool – GENIE (Generating Engagement in Network Involvement) – was implemented in a COPD community care context. The study aimed to assess the feasibility of the GENIE intervention to promote diet quality and other health behaviours in COPD. </span></p> <p><span><b>Methods:</b> Twenty-two community-dwelling older adults with COPD were recruited from a local COPD Service. Participants were offered usual care or the GENIE intervention. Process evaluation methods were used to assess intervention implementation, context and mechanisms of impact; <a name="_Hlk11247522">these included observations of patient interactions with the intervention, documented in observational field notes and in films of a patient group discussion.</a> Diet quality was assessed by food frequency questionnaire; 'prudent' diet scores were used to describe diet quality at baseline and at 3-month follow-up. Change in diet quality was expressed per month, from baseline to follow-up.</span></p> <p><b>Results: </b>Feasibility data showed that the GENIE intervention could be implemented in this sample of community-living older people. The intervention was acceptable to clinicians and older people with COPD, especially for those with less severe disease, when facilitated appropriately and considering the levels of literacy of participants. There was no significant change in diet quality in the intervention group over the follow-up period (median change in prudent diet score per month, (interquartile range (IQR)): 0.03, (-0.24 – 0.07)); whereas an overall fall in diet quality was observed in the control group (-0.15, (-0.24 – 0.03)).</p> <p><span><b>Conclusion: </b>The process evaluation findings suggest that this intervention is feasible and acceptable to both patients and clinicians. Although the sample size achieved in this study was small, findings suggest that the intervention may have a protective effect against declines in diet quality, and other health behaviours, in an older COPD population. Findings from this feasibility study indicate that further evaluation of the GENIE intervention is warranted in a larger study, with a longer follow-up.</span></p> <p> </p> <p> </p>
Data from: Assessment of lung function in successfully treated Tuberculosis reveals high burden of ventilatory defects and COPD
<p>Background: Burden, phenotype and risk-factors of lung function defects in successfully treated tuberculosis cases are unclear. Methods: We performed spirometry with bronchodilators in new drug-sensitive adult (>18 years) pulmonary tuberculosis cases during the 12 months following successful treatment in India. Airflow obstruction was defined as pre-bronchodilator FEV1/FVC<5th percentile of Global Lung Initiative mixed-ethnicity reference (lower limit of normal [LLN]). Chronic obstructive pulmonary disease (COPD) was defined as post-bronchodilator FEV1/FVC</p> <p>Methods: We performed spirometry with bronchodilators in new drug-sensitive adult (≥18 years) pulmonary tuberculosis cases during the 12 months following successful treatment in India. Airflow obstruction was defined as pre-bronchodilator FEV1/FVC<5<sup>th</sup> percentile of Global Lung Initiative mixed-ethnicity reference (lower limit of normal [LLN]). Chronic obstructive pulmonary disease (COPD) was defined as post-bronchodilator FEV1/FVC<LLN among participants with obstruction. Restrictive spirometry pattern was defined as FVC<LLN among participants without obstruction. Multivariable logistic and linear regression was used to identify risk-factors for obstruction, restriction and low lung function despite successful treatment.</p> <p>Results: Of the 172 participants included in the analysis, 82 (48%) were female, 22 (13%) had diabetes and 34 (20%) ever-smoked with a median (IQR) exposure of 3.5 (0.2–9.9) pack-years. Median (IQR) age and body-mass index (BMI) at enrollment was 32 (23–39) years and 18.1 (16.0–20.5) kg/m<sup>2</sup> respectively. Airflow obstruction was detected in 42 (24%) participants; of whom 9 (21%) responded to short-acting bronchodilators and 25 (56%) had COPD; and was associated with duration of illness prior to treatment (aOR = 1.32 per 30-days, 95%CI 1.04–1.68, p = 0.02). A restrictive spirometry pattern was detected in 89 (52%) participants and was associated with female sex (aOR = 3.73, 95%CI 1.51–9.17, p = 0.004) and diabetes (aOR = 4.06, 95%CI 1.14–14.42, p = 0.03). Higher HbA1c at treatment initiation was associated with greater odds of a restrictive spirometry pattern (aOR = 1.29 per unit higher HbA1c, 95%CI 1.04 to 1.60, p = 0.02).</p> <p>We found a high burden of lung function defects and COPD in tuberculosis cases who successfully completed treatment. Screening for chronic lung diseases following treatment and linkage to respiratory health clinics should be included in the routine management plan of all tuberculosis cases in India, regardless of conventional COPD risk-factors such as older age and smoking.</p>
Data from: Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are debilitating events and spur disease progression. Infectious causes are frequent; however, it is unknown to what extent exacerbations are caused by larger shifts in the airways' microbiota. The aim of the current study was to analyse the changes in microbial composition between stable state and during exacerbations, and the corresponding immune response. Methods: The study sample included 36 COPD patients examined at stable state and exacerbation from the Bergen COPD Cohort and Exacerbations studies, and one patient who delivered sputum on 13 different occasions during the three-year study period. A physician examined the patients at all time points, and sputum induction was performed by stringent protocol. Only induced sputum samples were used in the current study, not spontaneously expectorated sputum. Sputum inflammatory markers (IL-6, IL-8, IL-18, IP-10, MIG, TNF-α) and antimicrobial peptides (AMPs, i.e. LL-37/hCAP-18, SLPI) were measured in supernatants, whereas target gene sequencing (16S rRNA) was performed on corresponding cell pellets. The microbiome bioinformatics platform QIIME2TM and the statistics environment R were applied for bioinformatics analyses. Results: Levels of IP-10, MIG, TNF-α and AMPs were significantly different between the two disease states. Of 36 sample pairs, 24 had significant differences in the 12 most abundant genera between disease states. The diversity was significantly different in several individuals, but not when data was analysed on a group level. The one patient case study showed longitudinal dynamics in microbiota unrelated to disease state. Conclusion: Changes in the sputum microbiota with ch anging COPD disease states are common, and are accompanied by changes in inflammatory markers. However, the changes are highly individual and heterogeneous events.
Data for "Joint Clinical and Molecular Subtyping of COPD with Variational Autoencoders"
<p>Data for paper "Data for "Joint Clinical and Molecular Subtyping of COPD with Variational Autoencoders", Maiorino et al.</p> <p>The associated code repository is at<a href="https://github.com/reemagit/joint_subtyping_vae"> https://github.com/reemagit/joint_subtyping_vae</a></p>
Data from: Dysphagia Management in COPD: A National Survey
<p><span>Chronic obstructive pulmonary disease (COPD) is a progressive lung disease affecting approximately 300 million people globally. Ireland has the highest hospitalisation for COPD exacerbations in Europe. Dysphagia occurs in 17-85% of people with COPD (PwCOPD) and is a contributory factor to COPD exacerbations. Effective dysphagia management can reduce hospitalisation for PwCOPD. Determining Speech and Language Therapists’ (SLTs) clinical practices and confidence levels when working with PwCOPD and dysphagia is warranted. Following a pilot study, a survey exploring SLTs (<em>n </em>=131) clinical practices and confidence levels prior to and during COVID-19 was issued to SLTs working with PwCOPD and dysphagia in the Republic of Ireland. 88 survey responses were analysed. Survey respondents had up to twenty years plus experience working with PwCOPD across primarily acute and outpatient settings. Self-reported confidence ratings when assessing and treating dysphagia in PwCOPD were mixed, with some statistically significant changes noted during COVID-19. Clinical Bedside Swallow Examinations were routinely used but some components were modified because of<span> </span>COVID-19 infection control guidelines. Routine use of instrumental assessment was conducted by 30% of respondents pre COVID-19 and 39% of respondents during COVID-19. Dysphagia management primarily focused on education and compensatory strategies. Less than 1/3 of respondents used policies, procedures, protocols and guidelines (PPPGs) when managing dysphagia in PwCOPD. Development and dissemination of national PPPGs and education regarding evidence-based management of dysphagia in PwCOPD may support consistent care by SLTs. Further research investigating evidence-based dysphagia management and the impact of PPPGs and education on clinical practice is recommended. </span></p>
Data - Magnetic-field-assisted nanochain formation of intermixed catalytic CoPd nanoparticles
<p>This DOI address contains data regarding the manuscript entitled "Magnetic-field-assisted nanochain formation of intermixed catalytic CoPd nanoparticles", published in TBD</p> <p>Authors: Calle Preger, Lisa Rämisch, Johan Zetterberg, Sara Blomberg and Maria E. Messing</p> <p>This DOI contains:</p> <ul> <li>XEDS results used for histogram in Figure 2</li> <li>SEM images used for data points in Figure 3</li> <li>Results from simulations providing solid line in Figure 3</li> </ul>
Underlying data for Evaluation of the antioxidant and anti-inflammatory effect of sublingual glutathione on COPD patients: an observational study
<p>Underlying data for Evaluation of the antioxidant and anti-inflammatory effect of sublingual glutathione on COPD patients: an observational study</p>
Non-interventional Cross-over Study to Reduce Items of PROactive Tools Measuring Physical Activity in Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT01388218. IPD Sharing: Not stated. Countries: 4. Publications: 2.
The Effects of Different Vibration Exercises on COPD Patients
ClinicalTrials.gov study NCT06413524. IPD Sharing: NO. Countries: 1. Publications: 5.
A Cross-sectional Study on COPD Prevalence
ClinicalTrials.gov study NCT03028207. IPD Sharing: NO. Countries: 1. Publications: 2.
Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial
ClinicalTrials.gov study NCT00120978. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients
ClinicalTrials.gov study NCT05897125. IPD Sharing: YES. Countries: 1. Publications: 6.
The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients
ClinicalTrials.gov study NCT00141440. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT04268823. IPD Sharing: YES. Countries: 4. Publications: 0.
The Use of a Forecasting System for Predicting Exacerbations of COPD
ClinicalTrials.gov study NCT00788645. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.