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353
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ShareScore release 0.9.0
Dataset results
353 results for “metabolic pathway”
Antidepressant sertraline biases resistance emergence via stress-driven rewiring of the pentose phosphate pathway: tktA enables metabolic rollback
GEO Series GSE309890. Escherichia coli str. K-12 substr. MG1655. 6 samples. Type: Expression profiling by high throughput sequencing.
Late eating decreases energy expenditure, increases hunger and appetite, and modifies metabolic pathways in adipose tissue [array]
GEO Series GSE190166. Homo sapiens. 12 samples. Type: Expression profiling by array.
Time series transcriptomes resolve metabolic pathways underlying crocin's anti-cancer activity | Dataset: sequencing reads (controls); Kallisto counts/TPMs
<p>This repository is deprecated. Controls are now here: https://zenodo.org/records/13822024 and the Kallisto and ShinyGO analyses are here: https://zenodo.org/records/15804191</p> <p> </p> <p>Liver cancer can be treated with natural products, including saffron. The exact mechanism for the components of saffron, including crocin, to eliminate malignancy in HCC cells is not known. We used response screening from time series transcriptomic datasets to decipher the underlying mechanisms responsible for crocin’s anti-cancer activity. We treated HCC cells with 1 and 2 mM crocin for 2, 6, 12, and 24 hours and examined transcriptomic profiles at each timepoint compared to controls. The effect size was strongest at two hours and 1 mM crocin; later timepoints and the 2 mM dose showed similar responses, but the overall effect was diminished after two hours post-treatment. We observed the upregulation of transcripts for fatty acid oxidation enzymes, mitochondrial carnitine transpoart systems, bile acid synthesis, and cholesterol metabolism to varying degrees at all timepoints tested after crocin treatment. Pathway enrichment analyses showed that pathways for DNA damage checkpoint activation and senescence induction were upregulated while a variety of pro-proliferation pathways were downregulated. We saw 52 genes involved in non-alcoholic fatty liver disease down-regulated after 24 hours post-treatment (enrichment FDR p = 8 x 10<sup>8</sup>), indicating a reversal of many pathways promoting carcinogenesis after crocin treatment. The significant upregulation of senescence and autophagy genes was contrasted with the significant down-regulation of spliceosomal machinery genes at all time points after crocin treatment. Interestingly, the cell fate-protecting PAX transcription factor was significantly upregulated while ELK oncogenes were downregulated after crocin treatment. Overall, the data outline an intricate cellular response leading to HCC spliceosome repression and induced senescence after crocin treatment. Our findings help to explain the cancer-fighting effects of saffron and outline an example of antioxidant ‘swamping’ in cancer cells by natural products.</p>
Novel inhibition of central carbon metabolism pathways by Rac and Cdc42 inhibitorMBQ-167 and paclitaxel
GEO Series GSE272653. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Anaerobic fermentative metabolism of Corynebacterium glutamicum is hampered by a functional oxidative pentose phosphate pathway
GEO Series GSE143977. Corynebacterium glutamicum. 6 samples. Type: Expression profiling by high throughput sequencing.
Reversal of neuronal tau pathology, metabolic dysfunction, and electrophysiological defects via adiponectin pathway-dependent AMPK activation.
GEO Series GSE255813. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
The CD27/CD70 pathway negatively regulates visceral adipose tissue resident Th2 cells and controls metabolic homeostasis
GEO Series GSE253037. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dietary bacteria controls C. elegans lipid metabolism through pathways converging at phosphatidylcholine
GEO Series GSE253268. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway
GEO Series GSE210884. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Global Analysis of the Transcriptional Response of Chinese cabbage (Brassica rapa ssp. pekinensis) to Methyl Jasmonate Reveals JA Signaling on Enhancement of Secondary Metabolism Pathways
GEO Series GSE51363. Brassica rapa subsp. pekinensis. 2 samples. Type: Expression profiling by high throughput sequencing.
Pathways Underlying Impaired Cardiac Preconditioning Potential in Subjects with the Metabolic Syndrome, and its Restoration by ACE-inhibition
GEO Series GSE135198. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome Analysis of Arabidopsis thaliana and Changes of Glucosinolates Metabolism Pathway Induced by Flg22
GEO Series GSE56117. Arabidopsis thaliana. 2 samples. Type: Expression profiling by high throughput sequencing.
Inhibiting FOXM1 Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway [Hi-C]
GEO Series GSE298819. Homo sapiens. 5 samples. Type: Other.
Transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic pathways in mice
GEO Series GSE163294. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Metabolic and transcriptional response to the induction of a heterologous poly-3-hydroxybutyrate pathway in Phaeodactylum tricornutum
GEO Series GSE224880. Phaeodactylum tricornutum CCAP 1055/1. 24 samples. Type: Expression profiling by high throughput sequencing.
Targeting integrated metabolic and epigenetic pathways in lethal childhood ependymomas
GEO Series GSE134572. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
SIRT1-FOXO3 Pathway reprograms fatty acid metabolism to Mitigate Ferroptosis and Fibrosis
GEO Series GSE292618. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Identification of potential pathways whereby dietary high fat induced hepatic lipid metabolic disorder of Oreochromis niloticus through long non-coding RNAs
GEO Series GSE211712. Oreochromis niloticus. 6 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Activation of the ERRα Transcriptional Pathway Alleviates Anthracycline-induced Cardiotoxicity by Improving Mitochondrial Metabolism
GEO Series GSE291450. Sus scrofa. 9 samples. Type: Expression profiling by high throughput sequencing.
Canagliflozin impairs T-cell effector function via metabolic suppression in autoimmunity [Metabolic Pathways]
GEO Series GSE228910. Homo sapiens. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.