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Dataset results
673 results for “morphine”
Effects of morphine exposure on the transcriptome of the dorsalmedial prefrontal cortex (dmPFC) in rats
GEO Series GSE233922. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Morphine addiction-NAc_small RNA sequencing
GEO Series GSE199917. Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Transcriptional profiling of Regulatory T cells isolated from mice exposed to Smoke, Morphine and Smoke plus Morphine
GEO Series GSE198210. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
m6a modifications following morphine exposure or Alkbh5 siRNA in primary cortical neuron cultures
GEO Series GSE243685. Rattus norvegicus. 24 samples. Type: Methylation profiling by array.
Evaluation of the effect of morphine and maternal immune activation on pigs
GEO Series GSE209907. Sus scrofa. 57 samples. Type: Expression profiling by high throughput sequencing.
Data from: Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this study was to describe pharmacokinetics of morphine and its metabolites morphine-3-glucuronide and morphine-6-glucuronide in encephalopathic neonates treated with therapeutic hypothermia and to develop pharmacokinetics based dosing guidelines for this population. Study design: Term and near-term encephalopathic neonates treated with therapeutic hypothermia and receiving morphine were included in two multicenter cohort studies between 2008-2010 (SHIVER) and 2010-2014 (PharmaCool). Data were collected during hypothermia and rewarming, including blood samples for quantification of morphine and its metabolites. Parental informed consent was obtained for all participants. Results: 244 patients (GA mean (sd) 39.8 (1.6) weeks, BW mean (sd) 3,428 (613) g, male 61.5%) were included. Morphine clearance was reduced under hypothermia (33.5°C) by 6.89%/°C (95% CI 5.37%/°C – 8.41%/°C, p<0.001) and metabolite clearance by 4.91%/°C (95% CI 3.53%/°C – 6.22%/°C, p<0.001) compared to normothermia (36.5°C). Simulations showed that a loading dose of 50 μg/kg followed by continuous infusion of 5 μg/kg/h resulted in morphine plasma concentrations in the desired range (between 10 and 40 μg/L) during hypothermia. Conclusions: Clearance of morphine and its metabolites in neonates is affected by therapeutic hypothermia. The regimen suggested by the simulations will be sufficient in the majority of patients. However, due to the large interpatient variability a higher dose might be necessary in individual patients to achieve the desired effect.
Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care
ClinicalTrials.gov study NCT05371886. IPD Sharing: NO. Countries: 1. Publications: 0.
Low-dose Spinal Morphine for Post-Thoracotomy Pain After Video-Assisted Thoracoscopic Surgery
ClinicalTrials.gov study NCT01917448. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Taste Acuity and Caloric Intake After Acute Morphine Administration
ClinicalTrials.gov study NCT01763697. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Antiemetic Effect of the Addition of Ondansetron to the Morphine Solution in Patient-Controlled Analgesia (PCA)
ClinicalTrials.gov study NCT00199329. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Intranasal Morphine for Pain After Elective Orthopedic Surgery
ClinicalTrials.gov study NCT00390039. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty
ClinicalTrials.gov study NCT06716749. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy of Topical Morphine in the Treatment of Severe Local Pain of Chronic Wounds
ClinicalTrials.gov study NCT02028923. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Dexamethasone Added to Intra-articular Morphine and Bupivacaine for Post-operative Analgesia After Knee Arthroscopy
ClinicalTrials.gov study NCT04790292. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Morphine on Loading-dose Ticagrelor in Patients With ST-segment Elevation Myocardial Infarction
ClinicalTrials.gov study NCT02913469. IPD Sharing: NO. Countries: 1. Publications: 0.
Preoperative Methadone Single Dose Reduces Postoperative Morphine Consumption.
ClinicalTrials.gov study NCT03529032. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevention of Hyperalgesia With Epidural Morphine
ClinicalTrials.gov study NCT03225690. IPD Sharing: NO. Countries: 1. Publications: 0.
RANDOMISED STUDY OF EPIDURAL VS MPCA MORPHINE VS TAPP IN LAPAROSCOPIC SIGMOIDECTOMY
ClinicalTrials.gov study NCT01825993. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
ClinicalTrials.gov study NCT01897155. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Morphine vs Sufentanil PCA: Same Same or Different?
ClinicalTrials.gov study NCT05259098. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.