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GEO Series GSE26498. Mus musculus. 0 samples. Type: Expression profiling by array; Third-party reanalysis.
Prognostic and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma
GEO Series GSE113749. Homo sapiens. 95 samples. Type: Non-coding RNA profiling by array.
Dataset related to article "Intramedullary spinal cord tumors: the value of intraoperative neurophysiological monitoring in a series of 57 cases from two Italian centres."
<p>BACKGROUND:</p> <p>Intramedullary spinal cord tumors are rare lesions of the central nervous system. Anatomical, molecular and radiological features are well defined, but correct management is still matter of debate. Pertinent literature has reported conflicting opinions regarding the use of intraoperative electrophysiological monitoring (IONM) in the surgical treatment of this kind of lesions, recently. We report a retrospective study from two Italian centres, in order to highlight the usefulness of IONM in the management of intramedullary lesions.</p> <p>METHODS:</p> <p>We performed a retrospective review of patients with intramedullary spinal tumor who underwent surgical resection from February 2011 to February 2018 in two different institutions. Clinical and radiological data, lesion features, timing of symptom onset and IONM findings were record ed . The IONM includ ed somatosensory-evoked potentials(SSEP), motor-evoked potentials(MEP) and D-Wave whenever possible. We evaluated the outcome according to the Modified McCormick scale. We also evaluated the accuracy and relevance of surgical outcomes for each evoked potential(SSEP, MEP, D-Wave).</p> <p>RESULTS:</p> <p>A total of 57 patients were included. A gross total removal was achieved in 46 cases. Neurological follow-up was assessment at 3 days, and 3 and 6 months after surgery. Comparing the preoperative status and 6 months follow-up: the M-McCormick scale showed a neurological stability for 30 patients (52.63%), a worsening of neurological status for 7 patients (12.28%) and an improvement for 20 patients (35.08%). IONM presented high accuracy (sensibility of 100% and specificity of 95.65%) and significantly pred icted postoperative permanent motor d eficits(P<0.0001; AUC=0.978). D-Wave appeared to have significant greater predictive value than MEP and especially SSEP alone(0.967 vs 0.722 vs 0.542; P = 0.044 and P<0.001 respectively).</p> <p>CONCLUSIONS:</p> <p>The gold standard in the intramedullary lesion treatment is maximal safe resection with good neurological outcome, as shown in our patients. The use of IONM is helpful in intramedullary tumors resection in order to minimize postoperative neurological deficits and our analysis suggests that the use of D-Wave presents a statistically significant higher accuracy for predicting postoperative deficits than SSEP and MEP alone.</p>
Prophesy of Present Value
<p>By applying critical perspectives of colonialism, development theory, and critical work on financial logic to the contemporary socio-economic conditions of Greater Miami, we begin excavating Miami’s transnational colonial heritage to provide insight into the stark socio-economic inequalities Miami exhibits today, and identify emerging forms of climate governance which has roots in social organization and exile since the city’s founding. This is a dance performance film accompanied by compositions of Emahoy Tsegue-Mariam through the waterways of Miami. Emahoy is a Ethiopian composer whose musical compositions speak to her experience in political exile during the colonial Italian-Ethiopian war of the 1930’s. The compositions deeply resonate an emotional landscape of exile and homelessness. Current scholarship on climate and gentrification points to an exile facing future Miami citizens is already and will in the future follow specific racialized patterns of economic violence in Miami, and therefore far from being environmental, remains political. Following the framework of sociologist Randy Martin, we observe the city, in prioritizing short-term economic growth in lieu of other long-term solutions, has confined the movement of bodies through space via financial valuation. In this way, the official city policy creates increasing risk for situated, low-income families of color who do not orient themselves to this slow-rolling disaster to experience a devastating, vulnerable future of homesickness and exile. This performance film emerges in the discrepancy between theory and lived experience: “how do we realize the present value of future risk?”. Just as financial transactions realize future market projections by discounting values to the present rate, we appropriate the same financial logic to take scientific projections and ‘realize’ the human impact into present values based on the current public policy outlook, closing the gap between scientific projections and racialized colonial histories.</p>
Dataset related to article "Predictive value of clinical and radiomic features for radiation therapy response in patients with lymph node-positive head and neck cancer"
<p><strong> Abstract</strong></p><p>Background: Prediction of survival and radiation therapy response is challenging in head and neck cancer with metastatic lymph nodes (LNs). Here we developed novel radiomics- and clinical-based predictive models.</p><p>Methods: Volumes of interest of LNs were employed for radiomic features extraction. Radiomic and clinical features were investigated for their predictive value relatively to locoregional failure (LRF), progression-free survival (PFS), and overall survival (OS) and used to build multivariate models.</p><p>Results: Hundred and six subjects were suitable for final analysis. Univariate analysis identified two radiomic features significantly predictive for LRF, and five radiomic features plus two clinical features significantly predictive for both PFS and OS. The area under the curve of receiver operating characteristic curve combining clinical and radiomic predictors for PFS and OS resulted 0.71 (95%CI: 0.60-0.83) and 0.77 (95%CI: 0.64-0.89).</p><p>Conclusions: Radiomic and clinical features resulted to be independent predictive factors, but external independent validation is mandatory to support these findin</p>
Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy
<p>This record contains raw data related to the article “Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy”<br> </p> <p>Abstract</p> <p><strong>Background: </strong>We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved.</p> <p><strong>Methods: </strong>Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 (negative CMR TFC and LV ejection fraction≥55%) and Group2 (positive CMR TFC and/or LVEF<55%) and compared to an age and gender-matched control group. CMR datasets of all patients were analyzed to calculate LV indexed end-diastolic (LVEDi) and end-systolic (LVESi) volumes and RV indexed end-diastolic (RVEDi) and end-systolic (RVESi) volumes, both LV ejection fraction (LVEF) and RV ejection fraction (RVEF). Moreover, LV and RV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were measured.</p> <p><strong>Results: </strong>The AC patients showed both higher LVEDi (p:0.002) and RVEDi (p:0.017) and lower LVEF (p: 0.016) as compared to control patients. Moreover, AC patients showed impaired LV-GLS (p < 0.001), LV-GRS (p < 0.001), LV-GCS (p < 0.001) and RV-GRS (p:0.026) as compared to control subjects. Group1 patients showed a significant reduction of LV-GRS (p < 0.05) and LV-GCS p < 0.01) as compared to control subjects. At univariate analysis LV-GCS was the most discriminatory parameter between Group1 vs heathy subjects with an optimal cut-off of -15.8 (Sensitivity: 74%; Specificity: 10%).</p> <p><strong>Conclusions: </strong>In patients with AC biopsy-proven, CMR-FT could improve the diagnostic yield in the subset of patients who results negative for imaging TFC criteria resulting as useful gatekeeper for indication of myocardial biopsy in case of equivocal clinical and imaging presentation.</p> <p> </p>
A Comparative Study of Multiple Electrode Aggregometry Technologies in Cardiac Surgery: Different Values, Same Clinical Relevance
<p>Baryshnikova E, Di Dedda U, Ranucci M. A Comparative Study of Multiple Electrode Aggregometry Technologies in Cardiac Surgery: Different Values, Same Clinical Relevance. J Cardiothorac Vasc Anesth. 2021 Nov 25:S1053-0770(21)01033-8. doi: 10.1053/j.jvca.2021.11.030. Epub ahead of print. PMID: 34949522.</p> <p><strong>Objectives: </strong>The assessment of platelet function in cardiac surgery patients who recently received dual-antiplatelet therapy is considered in the existing guidelines. Among available devices, Multiplate (MP) and ROTEM Platelet (RP) are both based on electrical impedance. This study aimed to determine the agreement between MP and RP in cardiac surgery patients under dual-antiplatelet therapy discontinued before surgery. Secondarily, it compared the ability of the MP and RP in predicting postoperative bleeding and the need for platelet transfusion.</p> <p><strong>Design: </strong>A prospective cohort study.</p> <p><strong>Setting: </strong>A hospital in Milan, Italy.</p> <p><strong>Participants: </strong>Fifty adult patients preoperatively and postoperatively tested.</p> <p><strong>Interventions: </strong>None.</p> <p><strong>Measurements and main results: </strong>Patients were studied with adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP) testing on both of the devices. The mean preoperative ADP tests were below the respective lower limit of the reference value, thus reflecting a good ability of these tests to detect the residual or ongoing effects of antiplatelet drugs acting on the P2Y<sub>12</sub> receptor. The agreement between the 2 methodologies was very poor for both the ADP and TRAP tests, with a percentage error of 80%. The preoperative ADP tests were predictive for the need of platelet concentrate transfusion, with cut-off values at 35 U for the ADP-MP and 60 Ω/min for the ADP-RP. No correlation was found for postoperative bleeding.</p> <p><strong>Conclusion: </strong>Both technologies seemed to offer potential benefits in the surgical approach to patients who preoperatively received antiplatelet drugs. However, the results of these tests are not interchangeable, and different cut-off values should be applied.</p>
Dataset related to article "Prognostic Value of Metabolic Imaging Data of 11 C-choline PET/CT in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma "
<p>This record contains raw data related to article “Prognostic Value of Metabolic Imaging Data of <sup>11</sup> C-choline PET/CT in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma"</p> <p><sup>11</sup>C-choline positron emission tomography/computed tomography (PET/CT) has been used for patients with some types of tumors, but few data are available for hepatocellular carcinoma (HCC). We queried our prospective database for patients with HCC staged with <sup>11</sup>C-choline PET/CT to assess the clinical impact of this imaging modality. Seven parameters were recorded: maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), liver standardized uptake value (SUVliver), metabolic tumor volume (MTV), photopenic area, metabolic tumor burden (MTB = MTVxSUVmean), and SUVratio (SUVmax/SUVliver). Analysis was performed to identify parameters that could be predictors of overall survival (OS). Sixty patients were analyzed: fourteen (23%) were in stage 0-A, 37 (62%) in stage B, and 9 (15%) in stage C of the Barcelona classification. The Cox regression for OS showed that Barcelona stages (HR = 2.94; 95%CI = 1.41-4.51; <em>p</em> = 0.003) and MTV (HR = 2.11; 95%CI = 1.51-3.45; <em>p</em> = 0.026) were the only factors independently associated with OS. Receiver operating characteristics curve analysis revealed MTV ability in discriminating survival (area under the curve (AUC) = 0.77; 95%CI = 0.57-097; <em>p</em> < 0.001: patients with MTV ≥ 380 had worse OS (<em>p</em> = 0.015)). The use of <sup>11</sup>C-choline PET/CT allows for better prognostic refinement in patients undergoing hepatectomy for HCC. Incorporation of such modality into HCC staging system should be considered.</p>
Diagnostic and prognostic value of external anal sphincter EMG patterns in Multiple System Atrophy
<p>This database includes the raw data linked with the paper “Diagnostic and prognostic value of external anal sphincter EMG patterns in multiple system atrophy”.</p> <p>We collected clinical data and external anal sphincter (EAS) EMG findings in 72 patients with multiple system atrophy (MSA) and 21 with Parkinson’s disease (PD). We ascertained the survival times of 49 MSA patients who died during follow-up. We aimed to assess the diagnostic and prognostic value and clinical correlations of a novel classification of EAS electromyography patterns in MSA. We identified four EAS electromyography patterns, ranging from normal findings (pattern I) to mild, moderate or severe neurogenic damage (patterns II, III and IV, respectively).</p> <p>Pattern I was frequently observed in PD patients, while it was associated with prolonged survival when identified in a few MSA patients. Patterns II, III and IV were predominant in MSA. Subjects with MSA and EAS abnormalities often showed fecal incontinence and urogenital symptoms, which were frequently present at disease onset in patients with patterns III and IV. Abnormal EAS patterns correlated with MSA diagnosis. In particular, pattern IV was associated with the highest likelihood of MSA diagnosis and with the worst prognosis in the MSA cohort.</p>
Database for Enhancing Aquatic Invasive Species Outreach Through Values-framed Messages
<p>This database is part of an online survey administered to a Qualtrics panel of Illinois residents from May to June, 2021.</p>
Supplementary phylogenetic trees of Babesia bigemina based on partial sequences of both genes Rap-1a and gp45, with SH-aLRT support values (%), aBayes support, and ultrafast bootstrap support (%).
Open the record for dataset details and reuse information.
Supplementary phylogenetic trees of Babesia bigemina based on partial sequences of both genes Rap-1a and gp45, with SH-aLRT support values (%), aBayes support, and ultrafast bootstrap support (%).
Open the record for dataset details and reuse information.
P value
<p>En esta tabla se muestran los Pvalue, ya corregidos</p>
Diagnostic Value of Global Cardiac Strain in Patients With Myocarditis
<p>Dataset from the article Secchi F, Monti CB, Alì M, Carbone FS, Cannaò PM, Sardanelli F. Diagnostic Value of Global Cardiac Strain in Patients With Myocarditis. J Comput Assist Tomogr. 2020 Jul/Aug;44(4):591-598. doi: 10.1097/RCT.0000000000001062. PMID: 32697530.</p> <p><strong>Abstract</strong></p> <p><strong>Background: </strong>Cardiac strain represents an imaging biomarker of contractile dysfunction.</p> <p><strong>Purpose: </strong>The purpose of this study was to investigate the diagnostic value of cardiac strain obtained by feature-tracking cardiac magnetic resonance (MR) in acute myocarditis.</p> <p><strong>Materials and methods: </strong>Cardiac MR examinations of 46 patients with myocarditis and preserved ejection fraction at acute phase and follow-up were analyzed along with cardiac MR of 46 healthy age- and sex-matched controls. Global circumferential strain and global radial strain were calculated for each examination, along with myocardial edema and late gadolinium enhancement, and left ventricle functional parameters, through manual contouring of the myocardium. Correlations were assessed using Spearman ρ. Wilcoxon and Mann-Whitney U test were used to assess differences between data. Receiver operating characteristics curves and reproducibility were obtained to assess the diagnostic role of strain parameters.</p> <p><strong>Results: </strong>Global circumferential strain was significantly lower in controls (median, -20.4%; interquartile range [IQR], -23.4% to -18.7%) than patients in acute phase (-18.4%; IQR, -21.0% to -16.1%; P = 0.001) or at follow-up (-19.2%; IQR, -21.5% to -16.1%; P = 0.020). Global radial strain was significantly higher in controls (82.4%; IQR, 62.8%-104.9%) than in patients during the acute phase (65.8%; IQR, 52.9%-79.5%; P = 0.001). Correlations were found between global circumferential strain and global radial strain in all groups (acute, ρ = -0.580, P < 0.001; follow-up, ρ = -0.399, P = 0.006; controls, ρ = -0.609, P < 0.001), and between global circumferential strain and late gadolinium enhancement only in myocarditis patients (acute, ρ = 0.035, P = 0.024; follow-up, ρ = 0.307, P = 0.038).</p> <p><strong>Conclusions: </strong>Cardiac strain could potentially have a role in detecting acute myocarditis in low-risk acute myocarditis patients where cardiac MR is the main diagnosing technique.</p>
Dataset from: "Prognostic Value of Dynamic Changes in Pulmonary Congestion During Exercise Stress Echocardiography in Heart Failure With Preserved Ejection Fraction"
<p>BACKGROUND: Patients with heart failure (HF) with preserved ejection fraction (HFpEF) typically develop dyspnea and<br> pulmonary congestion upon exercise. Lung ultrasound is a simple diagnostic tool, providing semiquantitative assessment<br> of extravascular lung water through B-lines. It has been shown that patients with HFpEF develop B-lines upon submaximal<br> exercise stress echocardiography; however, whether exercise-induced pulmonary congestion carries prognostic implications<br> is unknown. This study aimed at evaluating the prognostic value of B-line assessment during exercise in patients with HFpEF.<br> METHODS: Sixty-one New York Heart Association class I to II patients with HFpEF underwent standard echocardiography,<br> lung ultrasound (28-scanning point method), and BNP (B-type natriuretic peptide) assessment during supine exercise<br> echocardiography (baseline and peak exercise). The primary end point was a composite of cardiovascular death or HF<br> hospitalization at 1 year.<br> RESULTS: B-lines, E/e′, and BNP significantly increased during exercise (P<0.001 for all). By multivariable analysis, both peak<br> (hazard ratio, 1.50 [95% CI, 1.21–1.85], P<0.001), and change (hazard ratio 1.34 [95% CI, 1.12–1.62], P=0.002) B-lines<br> were retained as independent predictors of outcome (hazard ratios per 1 B-line increment), along with BNP and E/e′ ratio.<br> Importantly, adding peak B-line on top of a clinical model significantly improved prognostic accuracy (C-index increase, 0.157<br> [0.056–0.258], P=0.002) and net reclassification (continuous net reclassification improvement, 0.51 [0.09–0.74], P=0.016),<br> with similar results for B-line change.<br> CONCLUSIONS: Detection of exercise-induced pulmonary congestion by lung ultrasound is an independent predictor of outcome<br> in patients with HFpEF; its use may help refining the routine risk stratification of these patients on top of well-established<br> clinical variables.</p>
A Comparative Study of Multiple Electrode Aggregometry Technologies in Cardiac Surgery: Different Values, Same Clinical Relevance.
<p>Mazzaccaro D, Dolci M, Perego F, Delbue S, Giannetta M, Cardani R, Valentina Renna L, Costa E, Corsi-Romanelli MM, Galli C, Pariani E, Nano G, Clemente C, Basilico N. Viral Agents and Systemic Levels of Inflammatory Cytokines in Vulnerable and Stable Atherosclerotic Carotid Plaques. Ann Vasc Surg. 2022 May;82:325-333. doi: 10.1016/j.avsg.2021.10.070. Epub 2021 Dec 11. PMID: 34902464.</p> <p>Abstract</p> <p><strong>Background: </strong>To investigate the presence of genetic material of viral agents and the serum level of inflammatory cytokines in patients submitted to carotid endarterectomy having vulnerable versus stable atherosclerotic plaques.</p> <p><strong>Methods: </strong>Data of patients consecutively submitted to carotid endarterectomy for a significant stenosis from July 2019 to December 2019 were prospectively collected. The genetic material of Epstein-Barr (EBV), CitoMegalo (CMV), Herpes Simplex (HSV), Varicella-Zoster (VZV) and Influenza (IV) Viruses was searched in the patient's plaques, both in the "mid" of the plaque and in an adjacent lateral portion of no-plaque area. The serum levels of TNF-α, IL-1β, IL-6, IL10 and CCL5 were determined. The obtained results were then correlated to the histologic vulnerability of the removed carotid plaque. P values < 0.05 were considered statistically significant.</p> <p><strong>Results: </strong>Data of 50 patients were analyzed. A vulnerable plaque was found in 31 patients (62%). The genome of CMV, HSV, VZV and IV was not found in any of the vascular samples, while the EBV genome was found in the "mid" of 2 vulnerable plaques, but not in their respective control area. Eighty-two percent of patients who did not receive anti-IV vaccination (23/28) had vulnerable carotid plaque, compared with 36% of vaccinated patients (8/22, P = 0.001). Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque (73.6 ± 238.2 vs. 3.9 ± 13.1 pg/ml, P= 0.01, and 45.9 ± 103.6 vs. 10.1 ± 25.3 pg/ml, P= 0.01, respectively), independent of comorbidities, viral exposure or flu vaccination.</p> <p><strong>Conclusions: </strong>The EBV genome was found in the "core" of 2 vulnerable carotid plaques, but not in their respective adjacent control. Influenza vaccination was associated with a lower incidence of carotid plaque vulnerability. Serum levels of TNF-α and IL-6 were higher in patients with a vulnerable plaque compared to patients with a stable plaque.</p>
Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study.
<p>Frigelli M, Sturla F, Milani V, Ramputi L, Citarella M, Menicanti L, Votta E, Castelvecchio S. Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study. Int J Cardiol. 2022 Sep 1;362:183-189. doi: 10.1016/j.ijcard.2022.04.071. Epub 2022 Apr 30. PMID: 35504452.</p> <p>Abstract</p> <p><strong>Background: </strong>Left atrial (LA) function can be effectively assessed by measuring longitudinal LA strain (LAS) via two-dimensional speckle tracking echocardiography (2DSTE). Here, we test 2DSTE-based LAS as marker of different left ventricle (LV) remodeling patterns and as prognostic index in ischemic heart failure (HF) candidates to surgical ventricular reconstruction.</p> <p><strong>Methods: </strong>We retrospectively considered ischemic HF patients with anterior (group A, n=130) or posterior (group P, n=48) LV remodeling. Based on 2D ultrasound, LV and LA morpho-functional parameters were quantified including reservoir (LAS<sub>Res</sub>), conduit (LAS<sub>Cond</sub>) and booster (LAS<sub>Boost</sub>) LAS. We tested their capability to discriminate between groups A and P, and their group-specific prognostic significance for the composite end-point of death or HF re-hospitalization at follow-up (mean follow-up time=40 months, range 3-101 months).</p> <p><strong>Results: </strong>Group A and group P displayed similar end-diastolic (p=0.89) and end-systolic (p=0.33) LV volume index, and LA volume index LAVi (p=0.44) corrected for the degree of mitral regurgitation. As compared to group P, group A revealed a significant reduction in LAS<sub>Boost</sub> (9.2±0.4% vs. 11.1±0.7%, p=0.04) and a non-significant reduction in LAS<sub>Res</sub> (16.9±0.7% vs. 19.3±1.1%, p=0.06). Kaplan-Meier curves showed that the median LAS<sub>Res</sub> and LAS<sub>Boost</sub> values effectively stratified patients based on their prognosis in the overall study population (Log-rank p=0.002 and Log_rank p<0.0001) and in group A, where the association was stronger for LAS<sub>Boost</sub> (Log-rank p<0.001) than for LAS<sub>Res</sub> (Log-rank p=0.013).</p> <p><strong>Conclusions: </strong>2DSTE-based LAS assessment is affordable, repeatable and non-invasive, and could add clinically-relevant mechanistic insight and prognostic value in the stratification of ischemic HF patients.</p>
Prognostic value of 2D vs 3D LV volumes and ejection fraction
<p>Database of LV volumes and ejecton fraction obtained by 2D and 3D echo in consecutive patients</p>
Data set related to the article: "Gender Differences Associated with the Prognostic Value of BPIFB4 in COVID-19 Patients: A Single-Center Preliminary Study."
<p><strong>Abstract:</strong> In the ongoing global COVID-19 pandemic, male sex is a risk factor for severe disease and death, and the reasons for these clinical discrepancies are largely unknown. The aim of this work is to study the influence of sex on the course of infection and the differences in prognostic markers between genders in COVID-19 patients. Our cohort consisted of 64 adult patients (n = 34 men and n = 30 women) with PCR-proven SARS-CoV-2 infection. Further, a group of patients was characterized by a different severity degree (n = 8 high- and n = 8 low-grade individuals for both male and female patients). As expected, the serum concentrations of LDH, fibrinogen, CRP, and leucocyte count in men were significantly higher than in females. When serum concentrations of the inflammatory cytokines, including IL-6, IL-2, IP-10 and IL-4 and chemokines like MCP-1, were measured with multiplex ELISA, no significant differences between male and female patients were found. In COVID-19 patients, we recently attributed a new prognostic value to BPIFB4, a natural defensin against dysregulation of the immune responses. Here, we clarify that BPIFB4 is inversely related to the disease degree in men but not in women. Indeed, higher levels of BPIFB4 characterized low-grade male patients compared to high-grade ones. On the contrary, no significant difference was reported between low-grade female patients and high-grade ones. In conclusion, the identification of BPIFB4 as a biomarker of mild/moderate disease and its sex-specific activity would open an interesting field for research to underpin gender-related susceptibility to the disease.</p>
Investigation of the Added Value of a Big Toe Hinged Brace for the Treatment of Hallux Rigidus
ClinicalTrials.gov study NCT00284284. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.