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3,508 results for “Observation study”
An Observational Study of TNKase in Patients Enrolled in the National Registry of Myocardial Infarction 4 and 5 (POST)
ClinicalTrials.gov study NCT00669045. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Comparison of Clinical Effect Between Endoscopic and Microscopic Ear Surgery of Cholesteatoma: A Multicenter Retrospective Observational Study
ClinicalTrials.gov study NCT05182268. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Prospective Observational Study on ES-SCLC
ClinicalTrials.gov study NCT07173946. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Post-COVID-19 Condition: Observational Study in Vietnam
ClinicalTrials.gov study NCT06022211. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Management of Surgical Scars Around Knee After Pediatric Orthopedic Surgery: an Observational, Case-control Study
ClinicalTrials.gov study NCT04928443. IPD Sharing: NO. Countries: 0. Publications: 0.
MicroRNAs expression in vulvar lichen sclerosus keratinocytes and fibroblasts: further evidence and possible pathogenetic implications from an observational study
GEO Series GSE249675. Homo sapiens. 19 samples. Type: Non-coding RNA profiling by high throughput sequencing.
CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: a prospective, single-center, observational study
GEO Series GSE254015. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Predicting Physical Activity and Sedentary Behaviors After Cardiac Rehabilitation: An Observational Study
<h2><strong>Note. A non-blind "<em>Version v1"</em> has been published on Zenodo. For a blind peer review, please refer to the current version <em>"Version v2".</em></strong></h2> <p><strong>[Update] Due to an issue with the data files, all files can now be found here: </strong></p> <p>Fessler, L., Maltagliati, S., Meyer, P., Finckh, A., Cullati, S., Sander, D., Friese, M., Wiers, R., Farajzadeh, A., Luthy, C., Sarrazin, P., & Cheval, B. (2025). Anatomy of a Failure: A Retrospective Evaluation of Cognitive Bias Modification to Promote Physical Activity in Cardiac Rehabilitation [Data set]. Zenodo. <a href="https://doi.org/10.5281/zenodo.17189199">https://doi.org/10.5281/zenodo.17189199 </a></p> <p> </p> <blockquote> <p>Data, data management, and analysis R codes related to the study "Predicting Physical Activity and Sedentary Behaviors After Cardiac Rehabilitation: An Observational Study"</p> <p>This study is part of the <em>Improving Physical Activity in Patients Following a Rehabilitation Programme</em> (IMPACT; <a href="https://doi.org/10.1136/bmjopen-2021-053845" target="_blank" rel="noopener">Cheval et al., 2021</a>) project.</p> <p>This Zenodo includes:</p> </blockquote> <ul> <li> <blockquote>The Visual-Approach/Avoidance-by-the-Self-Task (VAAST; <a href="https://doi.org/10.1016/j.jesp.2017.12.004" target="_blank" rel="noopener">Rougier et al., 2018</a>): "Inquisit_VAAST_IMPACT.zip"</blockquote> </li> <li> <blockquote>All the questionnaires used in the study: "Questionnaires_IMPACT.zip"</blockquote> </li> <li> <blockquote>The data and the corresponding codebooks: "Data_and_Codebooks_IMPACT.zip"</blockquote> </li> <li> <blockquote>The R scripts, including the data management and the main analyses: "R_Scripts_IMPACT.zip"</blockquote> </li> </ul>
This record contains raw data related to article: "Effect of Comorbidities in Stage II/III Colorectal Cancer Patients Treated With Surgery and Neoadjuvant/Adjuvant Chemotherapy: A Single-Center, Observational Study"
<p>This record contains raw data related to article "Effect of Comorbidities in Stage II/III Colorectal Cancer Patients Treated With Surgery and Neoadjuvant/Adjuvant Chemotherapy: A Single-Center, Observational Study"</p> <p>Comorbidity has a detrimental effect on cancer survival, however, it is difficult to disentangle its direct effect from its influence on treatment choice. In this study we assessed the effect of comorbidity on survival in patients who received standard treatment for resected stage II and III colorectal cancer (CRC).</p> <p>PATIENTS AND METHODS:</p> <p>In total, 230 CRC patients, 68 rectal (29.6%) and 162 colon cancer (70.4%) treated with surgical resection and neoadjuvant/adjuvant chemotherapy from December 2002 to December 2009 at Humanitas Cancer Center were retrospectively reviewed. The key independent variable was the Charlson Comorbidity Index (CCI) score, measured as a continuous variable. The differences between groups for categorical data were tested using the χ<sup>2</sup> test. Actuarial survival curves were generated using the Kaplan-Meier method.</p> <p>RESULTS:</p> <p>Median follow-up was 113 (range, 8.2-145.0) months. Median age was 63 (range, 37-78) years. In univariate analysis CCI score was significantly associated with poorer disease-free survival (hazard ratio [HR], 1.65; 95% confidence interval [CI], 1.52-1.80; P < .001), and overall survival (OS; HR, 1.55; 95% CI, 1.41-1.71; P < .001). Factors associated with poorer outcome also included (stage III vs. stage II, P < .029) and age (age >70 vs. ≤70 years, P < .001). After adjusting for these factors, a significant negative prognostic role of CCI score was still observed (adjusted HR for OS, 1.59; 95% CI, 1.43-1.76; P < .001).</p> <p>CONCLUSION:</p> <p>Among CRC patients who underwent surgical resection and chemotherapy, a higher CCI score was associated with poorer outcome and might predict long-term survival.</p>
Dataset related to article: "68Ga-PSMA Positron Emission Tomography/Computerized Tomography for Primary Diagnosis of Prostate Cancer in Men with Contraindications to or Negative Multiparametric Magnetic Resonance Imaging: A Prospective Observational Study"
<p>This record contains raw data related to article 68Ga-PSMA Positron Emission Tomography/Computerized Tomography for Primary Diagnosis of Prostate Cancer in Men with Contraindications to or Negative Multiparametric Magnetic Resonance Imaging: A Prospective Observational Study</p> <p>PURPOSE:</p> <p><sup>68</sup>Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography may represent the most promising imaging modality to identify and risk stratify prostate cancer in patients with contraindications to or negative multiparametric magnetic resonance imaging.</p> <p>MATERIALS AND METHODS:</p> <p>In this prospective observational study we analyzed <sup>68</sup>Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography in a select group of patients with persistently elevated prostate specific antigen and/or Prostate Health Index suspicious for prostate cancer, negative digital rectal examination and at least 1 negative biopsy. The cohort comprised men with equivocal multiparametric magnetic resonance imaging (Prostate Imaging-Reporting and Data System, version 2 score of 2 or less), or an absolute or relative contraindication to multiparametric magnetic resonance imaging. Sensitivity, specificity and CIs were calculated compared to histopathology findings. ROC analysis was applied to determine the optimal cutoff values of <sup>68</sup>Ga labeled prostate specific membrane antigen uptake to identify clinically significant prostate cancer (Gleason score 7 or greater).</p> <p>RESULTS:</p> <p>A total of 45 patients with a median age of 64 years were referred for <sup>68</sup>Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography between January and August 2017. The 25 patients (55.5%) considered to have positive positron emission tomography results underwent software assisted fusion biopsy. We determined the uptake values of regions of interest, including a median maximum standardized uptake value of 5.34 (range 2.25 to 30.41) and a maximum-to-background standardized uptake value ratio of 1.99 (range 1.06 to 14.42). Mean and median uptake values on <sup>68</sup>Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography (ie the maximum standardized uptake value or the maximum-to-background standardized uptake value ratio) were significantly higher for Gleason score 7 lesions than for Gleason score 6 or benign lesions (p <0.001). On ROC analysis a maximum standardized uptake value of 5.4 and a maximum-to-background standardized uptake value ratio of 2 discriminated clinically relevant prostate cancer with 100% overall sensitivity in each case, and 76% and 88% specificity, respectively.</p> <p>CONCLUSIONS:</p> <p>Our findings support the use of <sup>68</sup>Ga labeled prostate specific membrane antigen positron emission tomography/computerized tomography for primary detection of prostate cancer in a specific subset of men.</p>
French Observational Study With Colic Capsule
ClinicalTrials.gov study NCT03533894. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Change of Immune Cell of ARDS Patients：an Observational Study
ClinicalTrials.gov study NCT02958748. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Congenital Esotropia Observational Study (CEOS)
ClinicalTrials.gov study NCT00000163. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Observational Study of Antiretroviral (ARV) Response in a Cohort of African Children Using Viral Load Monitoring
ClinicalTrials.gov study NCT01555723. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Observational Cohort Study of Sodium, Weight and Cardiovascular Disease
ClinicalTrials.gov study NCT00006308. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Monocyte phenotype indicates a poor prognosis in paracetamol (acetaminophen) induced acute liver failure but not in non-ae hepatitis: a prospective observational cohort study
GEO Series GSE80751. Homo sapiens. 22 samples. Type: Expression profiling by array.
Characterization and utilization of an international neurofibromatosis web-based, patient-entered registry: An observational study
In 2012, the Children's Tumor Foundation (CTF) created a web-based patient-entered database, the NF Registry, to inform patients of research opportunities for which they fit general eligibility criteria and enable patients to contact investigators who are seeking to enroll patients in approved trials. Registrants were recruited through CTF-affiliated NF clinics and conferences, through its website, and by word-of-mouth and social media. Following online consent, demographic information and details regarding manifestations of NF were solicited on the Registry website. Statistical analyses were performed on data from a cohort of 4,680 registrants (the number of registrants as of October 9, 2015) who met diagnostic criteria for one of the three NF conditions.
Dataset related to article "p2PSA for predicting biochemical recurrence of prostate cancer earlier than total prostate-specific antigen after radical prostatectomy: an observational prospective cohort study."
<p>BACKGROUND:</p> <p>There is an unmet clinical need for more biochemical specific tests that may detect clinically significant recurrent PCa at an early stage after radical prostatectomy (RP). Our purpose is to test the hypothesis that p2PSA (Index test) detects prostate cancer relapse (BCR) earlier than the current Reference Standard Test (total prostate-specific antigen [tPSA]) in patients who underwent RP for localized PCa.</p> <p>METHODS:</p> <p>This is an observational, prospective, cohort, follow-up study in patients subjected to RALP (robotic assisted laparoscopic radical prostatectomy) for clinically localized PCa from January 2013 to July 2013 at a high-volume Institution (450 average RP/year). A blood sample, for tPSA and p2PSA, was prospectively drawn after 3, 6, and 12 months and then every 6 months during the following two years. The primary outcome is to determine whether or not kinetics in rising of p2PSA significantly anticipates the tPSA kinetics. Exploratory data analysis was used to identify relationship between different variables.</p> <p>RESULTS:</p> <p>Over 134 patients 20 BCRs were detected according to tPSA cut-off. Five patients showed a contemporary increase of tPSA and p2PSA, 11 presented a p2PSA increase earlier than tPSA increase (13.9 months ±9.7). In four patients, the increase of PSA was not associated with a p2PSA>0.8 pg/mL. The correlation between tPSA and p2PSA according to Sperman's rho coefficient was statistically significant at 3, 6, 18 and 30 months: 0.416 (P<0.01), 0.255 (P<0.01), 0.359 (P<0.01) and 0.413 (P<0.01) respectively. When subjects were stratified according to stage/grade and margins (positive vs. negative), patients with higher stage and positive surgical margins could be considered the target categories. The low rate of observed BCR and high rate of p2PSA false positive are the main limitations.</p> <p>CONCLUSIONS:</p> <p>The current findings showed that p2PSA might be more sensitive than tPSA in detecting earlier BCR within 3-year follow-up. Further studies with a longer follow-up and larger population remain mandatory before considering p2PSA for clinical decision-making.</p>
Observing actual evapotranspiration within a hilly watershed: case study of the Kamech site, Cap Bon peninsula, Tunisia
<p>Surface-atmosphere flux data acquired by the Kamech flux tower (Environmental Research Observatory OMERE) between March 2010 and August 2013</p> <p>A single data file (csv format) containing :</p> <ul> <li>quality controlled surface-atmosphere fluxes (friction velocity, sensible heat flux, latent heat flux)</li> <li>meteorological data required to gap fill them with REddyProc (incoming solar radiation, air temperature, air humidity)</li> <li>wind direction (sectors NW or S)</li> </ul> <p>More details (names of the variables, units) are given in the readme.first.txt file</p>
Psychopharmacological treatment in borderline personality disorder: A pilot observational study in a real-world setting
<p>Psychopharmacological treatment in borderline personality disorder: A<br> pilot observational study in a real-world setting</p> <p>Psychotherapy is the cornerstone of treatment for borderline personality disorder (BPD) while pharmacotherapy<br> should be considered only as an adjunctive intervention. In clinical practice, however, most of BPD patients only<br> receive medication. The aim of the study is to first describe pharmacological treatment in BPD patients in Italy<br> and secondly to evaluate if comorbidity or illness severity are associated with the prescription of different class<br> compounds.<br> Data on pharmacological treatment and clinical evaluation of 75 BPD patients were collected in 5 clinical<br> settings. The association between comorbidity and medication was assessed. Moreover, we evaluated the association<br> between pharmacotherapy and severity, defined by a cluster analysis aimed at detecting different groups<br> of patients.<br> Most of the participants (82.7%) were characterized by polypharmacy, with a mean of 2.4 medications per<br> person. Interestingly, the prescription didn’t seem to depend on/be based on the severity of the disorder and was<br> only partially determined by the presence of comorbidity.<br> In conclusion, our findings are similar to what described in other clinical studies, supporting the idea that<br> medication management for BPD is only partially coherent with international guidelines. This pilot study confirms<br> the need for more rigorous studies to gain greater understanding of this topic and diminish the gap between<br> guidelines and the real clinical world.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.