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5,031 results for “MiRNA”
Dataset related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"
<p>This record contains raw data related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aims</p> <p>Calcific <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-stenosis">aortic valve stenosis</a> (CAVS) is the most frequent manifestation of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-disease">aortic valve disease</a> and the third leading cause of cardiovascular disease in the Western countries associated with significant morbidity and mortality. An active biological progression involving inflammation and <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/alpha-oxidation">oxidation</a> leading to valve endothelial damage is considered a hallmark of the early stages of valve degeneration. However, tricuspid (TAV) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/premolar">bicuspid</a> (BAV) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve">aortic valve</a> deterioration are considered to differ only by shear stress. We hypothesized that <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/endothelial-cell">endothelial cells</a> (EC) derived from BAV and TAV patients have different <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNA</a> expression patterns and thus distinct pathways could lead to endothelial damage in BAV than TAV patients.</p> <p>Methods and results</p> <p>We isolated ECs from patients with bicuspid or tricuspid aortic valve, which underwent surgery due to CAVS. MiRNA expression profile by PCR revealed eight upregulated <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNAs</a> between BAV and TAV ECs. Functional analysis identified that BAV ECs presented altered cellular response to <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/oxidative-stress">oxidative stress</a> and DNA damage stimulus <em>via</em> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-p53">p53</a> and alteration in the intrinsic apoptotic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/signal-transduction">signaling pathway</a>. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/gpx3">GPX3</a> and SRXN1 <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/messenger-rna">mRNA</a> were express at lower levels in BAV compared to TAV ECs, leading to an increment of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/double-stranded-dna">DNA double-strand</a> breaks. BAV ECs had a sustained <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/programmed-cell-death">apoptosis</a> activation when compared to TAV ECs. This difference was exacerbated by oxidative stress stimulus leading to a reduced survival rate but completely reverted by miR-328-3p inhibition.</p> <p>Conclusion</p> <p>The present data showed molecular differences in oxidative stress susceptibility, DNA damage magnitude, and apoptosis induction between ECs derived from BAV and TAV patients.</p>
Traits and subtraits in miRNA Database
<p>Traits and subtraits in miRNA Database</p>
miRNA qPCR_Athlete profile
<p>q-PCR validation data of the circulating microRNA profile in athletes compared to sedentary people.</p>
miRNAs targeting AQP3 - Tarbase
<p>This data was collected via the TarBase website when searching for miRNAs that would target AQP3.</p>
Efficacy of a Non-Invasive Endometrial Receptivity Prediction Model Based on Peripheral Blood miRNA Signatures During the Peri-Implantation Period in Improving IVF Outcomes in Patients With Unexplaine
ClinicalTrials.gov study NCT07363018. IPD Sharing: Not stated. Countries: 0. Publications: 0.
miRNA Biomarkers in Multiple Sclerosis
ClinicalTrials.gov study NCT04772495. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Effect of Intravenous Lidocaine on Serum miRNA-135a in Patients Undergoing Non-cardiac Surgery
ClinicalTrials.gov study NCT05503043. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)
ClinicalTrials.gov study NCT05048381. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Association Between VEGF-C and miRNA and Clinical Non-small Cell Lung Cancer and Esophagus Squamous Cell Carcinoma
ClinicalTrials.gov study NCT01240369. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Early Detection and Risk Stratification of Colorectal Cancer Based on miRNA Platform
ClinicalTrials.gov study NCT06351384. IPD Sharing: NO. Countries: 0. Publications: 0.
Effects of Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) Therapy on miRNAs Expression and Absolute Microvascular Resistance by Continuous Thermodilution in ST-segment Elevation Myo
ClinicalTrials.gov study NCT05644925. IPD Sharing: NO. Countries: 0. Publications: 0.
Role of the Serum Exosomal miRNA in Diabetic Retinopathy (DR)
ClinicalTrials.gov study NCT03264976. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Genome-wide miRNA turnover profile after transcription inhibition in HDMYZ cells with biological triplicate
GEO Series GSE60036. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
mRNA and miRNA expression in primary human muscle cells treated with 1,25(OH)2D3 or vehicle
GEO Series GSE70934. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Diagnosis potential of subarachnoid haemorrhage using miRNA signatures isolated plasma-derived extracellular vesicles
GEO Series GSE222980. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
miRNAs in MSCs-exosome compared with NIH3T3-exosome
GEO Series GSE181530. Mus musculus. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Small RNA-seq of human granulosa cells reveals miRNAs in FSHR and aromatase genes
GEO Series GSE46508. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Expression data from miRNAs in colorectal cancer tissues with and without liver metastasis
GEO Series GSE53159. synthetic construct; Homo sapiens. 32 samples. Type: Non-coding RNA profiling by array.
MiRNA and lung cancer (INCA Project) - 16 RNG25k microarrays
GEO Series GSE18695. Homo sapiens. 16 samples. Type: Expression profiling by array.
Transcriptome Analysis of miRNAs in Umbilical cord blood exosomes of Intrauterine Growth Restriction Pigs
GEO Series GSE87111. Sus scrofa. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.