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3,583 results for “elevations”
GS ablation leads to elevated mTORC1 activation in mouse livers harboring c-Met/ΔN90-β-catenin
GEO Series GSE201560. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Physiological and transcriptomic responses in brown trout, Salmo trutta, to multiple stressors: pesticide mixtures, elevated water temperature and the proliferative kidney disease
GEO Series GSE288561. Salmo trutta. 72 samples. Type: Expression profiling by high throughput sequencing.
Gene regulation by elevated c-di-AMP levels in Streptococcus pneumoniae
GEO Series GSE113231. Streptococcus pneumoniae. 6 samples. Type: Expression profiling by high throughput sequencing.
SMARCA4-loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer
GEO Series GSE275694. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Grassland ecosystem responses to elevated CO2 are contingent on nitrogen conditions
GEO Series GSE67531. uncultured bacterium; Bacteria. 48 samples. Type: Other.
Inhibition of AK4 expression increases drug sensitivity and elevates mitochondrial ATP synthesis
GEO Series GSE61843. Homo sapiens. 7 samples. Type: Expression profiling by array.
Persistent epigenetics changes due to elevated temperature during early development in mature zebrafish gonads
GEO Series GSE133088. Danio rerio. 73 samples. Type: Methylation profiling by high throughput sequencing.
Elevation Models for Reproducible Evaluation of Terrain Representation – Multiscale Models – Churfirsten GeoTIFF - Erronous
<p>Multiscale elevation models centered on Churfirsten, Switzerland</p> <p>Resolutions: 30, 60, 120, 250, 500, 1,000, and 2,000 meters, 2,500 x 1,500 height samples each</p> <p>File format: GeoTIFF</p>
in the heterochromatic segment of the short arm in Comparative chromosomal studies in Rhinolophus formosae and R. luctus from China and Vietnam: elevation of R. l. lanosus to species rank
in the heterochromatic segment of the short arm
F — chromosome 1 in Comparative chromosomal studies in Rhinolophus formosae and R. luctus from China and Vietnam: elevation of R. l. lanosus to species rank
F — chromosome 1 of R. formosae showed homology to AST1 (green) and AST12 (red)
indicate the active NORs on pair 8 in Comparative chromosomal studies in Rhinolophus formosae and R. luctus from China and Vietnam: elevation of R. l. lanosus to species rank
indicate the active NORs on pair 8
Fig. 1 in Highest Elevation Recorded for a Nesting Dung Beetle (Coleoptera: Scarabaeidae: Scarabaeinae) in the Americas
Fig. 1. Homocopris achamas, male (minor) habitus. A) Dorsal, B) Ventral, and C) Lateral views.
Enhancing reservoir water level time series in the Mekong river basin by improving area-elevation models and integrating multi-source satellite data
<p>This is a reservoir water surface area and water levels dataset including 32 major reservoirs in Mekong River basin. For all the 32 reservoirs, water levels were inverted by using improved DEM-derived A-E model (combined with actual reservoir parameters limitation), improved DEM-derived A-E model (combined with actual reservoir parameters limitation) or satellite-derived A-E model based on the Landsat-derived surface area. An initial time series was constructed based on the optimal improved A-E model according to their own altimetry data availability. Then all the altimetry water levels (if available) were merged into the initial time series to construct the final time series water levels.Altimetry water level was preferred when the date of two datasets was identical.</p>
Elevated ENSO extremes are reducing tropical forest invertebrate diversity and function
<p>These datasets accompany the article "Elevated ENSO extremes are reducing tropical forest invertebrate diversity and function" and associated Github R code.</p>
Elevated circulatory proline to glutamine ratio (PQR) in Patients with endometriosis revealed by targeted NMR based serum metabolomics
<p>Endometriosis (EM) is a chronic pain condition affecting women in reproductive age and involves the growth of uterine lining (endometrium) outside of the uterus. EM is often associated with altered inflammatory and immune processes and shares some cancer-like characteristics such as activated glutaminolysis. However, preclinical studies suggest mitochondrial dysfunction and decreased energy production in uterine endometriosis tissue. As proline catabolism in mitochondria serve as an important source of energy production and previous transcriptomics studies have demonstrated that there is reduced activity of proline oxidase (POX, a mitochondrial inner-membrane flavoenzyme involved in the catabolic degradation of the proline) due to overexpression of microRNA (known as MiR-23b). Based on this, we hypothesized and demonstrated that circulatory proline to glutamine ratio (PQR) are elevated in the EM patients and may serve as an indicative biomarker to improve the clinical diagnosis of EM. </p>
Elevated circulatory Glycine to Histidine ratio in Preclinical models of Rheumatoid Arthritis: A Targeted NMR-based metabolomics study
<p><strong>Description:</strong> Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes joint inflammation, bone and cartilage destruction, and sometimes disability. The pathophysiology of RA, on the other hand, is multifactorial and, to a significant extent, unknown. Abnormal glycine metabolism is well established pathophysiological feature in RA [1] and the circulatory levels of glycine are largely reported to be elevated in RA [2]. Further, various clinical studies report the decreased circulatory levels of histidine in RA Patients. The low free serum histidine levels have also been found to be associated with disease activity in RA [3]. Other studies reported higher levels of free histidine in the synovial fluid (SF) compared to that in the patient serum samples of RA (considered to be an inflammatory arthritis condition) but SF histidine levels were significantly lower than corresponding results in patients with osteoarthritis (OA, considered to a non-inflammatory arthritis condition) [4]. Therefore, we hypothesized and demonstrated that the circulatory <strong>glycine to histidine ratio (GHR)</strong> is significantly elevated in RA compared to NC (with p-value <0.0001). For this, fifty (N= 50) serum samples obtained from thirty (N=30) normal control rats and twenty (N=20) rat models of rheumatoid arthritis (RA, induced using Complete Freund's adjuvant (CFA) treatment) were analyzed using high-resolution 800 MHz NMR spectrometer. The serum metabolic profiles were measured using standard 1D-<sup>1</sup>H-CPMG NMR experiments and the concentration levels of selected metabolites (glycine and histidine) were estimated using NMR suite of commercial software CHENOMX following the procedure as described previously from our research group [5]. <strong>The mean values (±standard deviation) of circulatory GHR levels in the serum samples of RA and NC rats were found to be 6.65 ± 2.29 and 3.46 ± 0.93, respectively. </strong>We further performed the receiver operating characteristic (ROC) curve analysis and the resulted area under ROC curve value of <strong>0.97 (with 95% confidence interval 0.92-1.0 and p-value <0.0001) suggested that the circulatory GHR levels have significant potential </strong>to serve as a better preclinical indicator of disease activity in RA and may be a reliable clinical biomarker for monitoring the treatment response in such preclinical models.</p> <p> </p> <p><strong>References:</strong></p> <p>[1] Lemon, H.M., Chasen, W.H. and Looney, J.M., 1952. Abnormal glycine metabolism in rheumatoid arthritis. <em>The Journal of clinical investigation</em>, <em>31</em>(11), pp.993-999.</p> <p>[2] Trang, L.E., Fürst, P., Odeback, A.C. and Lövgren, O., 1985. Plasma amino acids in rheumatoid arthritis. <em>Scandinavian journal of rheumatology</em>, <em>14</em>(4), pp.393-402.</p> <p> </p> <p>[3] Gerber, D.A., 1975. Low free serum histidine concentration in rheumatoid arthritis. A measure of disease activity. <em>The Journal of clinical investigation</em>, <em>55</em>(6), pp.1164-1173.</p> <p> </p> <p>[4] Sitton, N. G., Dixon, J. S., Bird, H. A., & Wright, V. (1986). Serum and synovial fluid histidine: a comparison in rheumatoid arthritis and osteoarthritis. <em>Rheumatology international</em>, <em>6</em>(6), 251-254.</p> <p> </p> <p>[5] Umesh Kumar, Abhai Kumar, Smita Singh, Payal Arya, Sandeep Kumar Singh, Rameshwar Nath Chaurasia, Anup Singh, and Dinesh Kumar, “An elaborative NMR based plasma metabolomics study revealed metabolic derangements in patients with Mild Cognitive Impairment: A study on North Indian Population” <strong>Metabolic Brain Disease</strong> (2021) 36, 957–968. (DOI: 10.1007/s11011-021-00700-z)</p>
Anterior-first Approach for Latissimus Dorsi Myocutaneous flap Breast Reconstruction: A Refined Elevation Method with Detailed Video Instructions
<p>Supplementary video for the article "Anterior-first Approach for Latissimus Dorsi Myocutaneous flap Breast Reconstruction: A Refined Elevation Method with Detailed Video Instructions".</p>
Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure
ClinicalTrials.gov study NCT00359697. IPD Sharing: Not stated. Countries: 0. Publications: 0.
KSRP deficiency attenuates the course of pulmonary aspergil-losis, associated with elevated pathogen-killing activity of in-nate myeloid immune cells
GEO Series GSE280203. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The diatom Thalassiosira pseudonana grown in mesocosms at contemporary and elevated CO2 over the diel cycle
GEO Series GSE168812. Thalassiosira pseudonana. 16 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.