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4,004
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4,004 results for “In vivo”
Aspergillus flavus germination, ex vivo
<p>Time-lapse imaging showing intrastromal germination of Aspergillus flavus conidia following intrastromal injection into a porcine cornea. Conidial germination and hyphal elongation can be observed by sixteen hours post-inoculation. </p>
Data from: Phase-dependent differential in vitro and ex vivo susceptibility of Aspergillus flavus and Fusarium keratoplasticum to azole antifungals
<p>Fungal keratitis (FK) is an invasive infection of the cornea primarily associated with <em>Aspergillus</em> and <em>Fusarium</em> species. FK is treated empirically with a limited selection of topical antifungals with varying levels of success. Though clinical infections are typically characterized by a dense network of mature mycelium, traditional models used to test antifungal susceptibility of FK isolates exclusively evaluate susceptibility in fungal cultures derived from asexual spores known as conidia. The purpose of this study was to characterize differences in fungal response when topical antifungal treatment is initiated at progressive phases of fungal development. We compared efficacy of voriconazole and luliconazole against <em>in vitro</em> cultures of <em>A. flavus</em> and <em>F. keratoplasticum</em> at 0, 24, and 48 h of fungal development. Data from this assay is included here, reported as end-point absorbance values. A porcine cadaver corneal model was used to compare antifungal efficacy of voriconazole and luliconazole in <em>ex vivo</em> tissue cultures of <em>A. flavus</em> and <em>F. keratoplasticum</em> at 0, 24, and 48 h of fungal development. Data from this assay may be found here, reported as pixel counts of the determined area.</p>
Human dermal microvascular arterial and venous blood endothelial cells and their use in bioengineered dermo-epidermal skin substitutes in vitro and in vivo
<p>The bio-engineering of vascular networks is pivotal to create complex tissues and</p> <p>organs in vitro for regenerative medicine applications. The vascular plexus is needed for a</p> <p>sufficient and fast blood supply after transplantation, and, thus, required for the survival and</p> <p>function of the engineered tissue or organ. Hence, human endothelial cells are an attractive</p> <p>source for bio-engineering purposes, for example human dermal microvascular endothelial</p> <p>cells (HDMECs).</p> <p>So far, a discrimination between arterial and venous blood endothelial cells after</p> <p>isolation of HDMECs from skin biopsies and if arterial and/or venous capillaries are formed in</p> <p>pre-vascularized bio-engineered substitutes was not investigated.</p> <p>In this study, we investigated employedby single cell sequencing for to</p> <p>investigate/compare human arterial and venous endothelial cell markers in human fetal and</p> <p>juvenile skin. Further, we analyzed if these markers are present after isolation of human skin</p> <p>derived endothelial cells under 2D culture conditions. In additionFinally, we investigated</p> <p>assessed if human endothelial cells form distinct arterial and venous capillaries in 3D</p> <p>collagen type I hydrogels, and if these capillaries retain their identity after transplantation.</p> <p>We determinedOur results showed that arterial and venous endothelial cell markers</p> <p>such as NRP1 and NR2F2 are expressed both in fetal and juvenile skin, and are retained after</p> <p>isolation in culture. We could show demonstrate that arterial and venous endothelial cells</p> <p>maintain their differentiation status and form arterial and venous capillaries in 3D in vitro</p> <p>culture systems and that the capillaries inosculate after transplantation.</p> <p>In summary, we could show that we could bio-engineer human arterial, venous, and</p> <p>lymphatic capillaries in a human skin substitute in view of regenerative medicine approaches</p> <p>for clinical applications.</p>
Supporting data for "A new method for in vivo assessment of corneal transparency using spectral-domain OCT"
<p>Supporting SD-OCT images for PLOS ONE article "<a href="https://doi.org/10.1371/journal.pone.0291613">A new method for <em>in vivo </em>assessment of corneal transparency using spectral-domain OCT</a>" (DOI: 10.1371/journal.pone.0291613). </p>
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells
ClinicalTrials.gov study NCT03384108. IPD Sharing: NO. Countries: 1. Publications: 1.
Ex Vivo Drug Sensitivity Testing and Mutation Profiling
ClinicalTrials.gov study NCT03860376. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Injection of ex Vivo Amplified G-CSF Mobilised Autologous Peripheral Blood Stem Cell Transplantation
ClinicalTrials.gov study NCT00461955. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Ex-vivo Confocal Imaging and Proteomic Profiling to Determine Treatment Response in Children With IBD
ClinicalTrials.gov study NCT07121920. IPD Sharing: NO. Countries: 1. Publications: 14.
In-vivo Behavior of Asqelio Monofocal Biaspheric Intraocular Lens
ClinicalTrials.gov study NCT04971863. IPD Sharing: Not stated. Countries: 1. Publications: 1.
In Vivo EGFR Molecular Classification and Treatment Response
ClinicalTrials.gov study NCT02717221. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects
ClinicalTrials.gov study NCT01565759. IPD Sharing: Not stated. Countries: 1. Publications: 14.
In Vivo Corneal Confocal Microscopy for Non-invasive Assessment of Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT01695629. IPD Sharing: Not stated. Countries: 1. Publications: 1.
MechSens - Dose-response Relationship of in Vivo Ambulatory Load and Mechanosensitive Cartilage Biomarkers
ClinicalTrials.gov study NCT04128566. IPD Sharing: Not stated. Countries: 1. Publications: 2.
In Vivo Liquid Biopsy of Melanoma (Cytophone)
ClinicalTrials.gov study NCT06488365. IPD Sharing: NO. Countries: 1. Publications: 3.
EXplanted LIver and Ex-vivo Pancreatic Specimen Evaluation by 7 TESLA MRI
ClinicalTrials.gov study NCT04012021. IPD Sharing: NO. Countries: 1. Publications: 17.
Investigation of in Vivo Endogenous and/or Exogenous Production of Phenolic Metabolites Using (un)Targeted Metabolomics
ClinicalTrials.gov study NCT06028659. IPD Sharing: YES. Countries: 1. Publications: 1.
Ex Vivo Cultured Bone Marrow Derived Allogenic MSCs in AMI
ClinicalTrials.gov study NCT00883727. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Feasibility and Safety of Normothermic ex Vivo Kidney Perfusion
ClinicalTrials.gov study NCT03136848. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study Comparing ex Vivo MRI Versus Radiography of Breast Specimens
ClinicalTrials.gov study NCT01869335. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Polyphenols Found in Pomegranate Juice on Postprandial Blood Glucose in Vivo
ClinicalTrials.gov study NCT02624609. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.