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ShareScore release 0.9.0
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853 results for “Knockout mice”
Gene expression profile of spleen B cells from Dock10 knockout mice and its regulation by IL-4
GEO Series GSE73760. Mus musculus. 40 samples. Type: Expression profiling by array.
Liver transcriptomic profile of wild type and hepatocyte-specific ATF6 knockout mice feeding CD-HFD
GEO Series GSE285265. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq of eyes isolated from wildtype and Stra6 knockout mice maintained on either a vitamin A sufficient or deficient diet
GEO Series GSE219252. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Single nucleus RNA-seq analysis of the TA muscles from WT and Dmd Exon 51 Knockout mice
GEO Series GSE156497. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Data from: Comprehensive MicroRNAome analysis of the relationship between Alzheimer disease and cancer in PSEN double-knockout mice
Purpose: Presenilins are functionally important components of γ-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer because both involve substrates of γ-secretase. However, numerous clinical studies have reported an inverse correlation between AD and cancer. Interestingly, AD is a neurodegenerative disorder, whereas cancer is characterized by the proliferation of malignant cells. However, this inverse correlation in the PSEN double-knockout (PSEN dKO) mouse model of AD has been not elucidated, although doing so would shed light onto the relationship between AD and cancer. Methods: To investigate the inverse relationship of AD and cancer under conditions of PSEN loss, we used the hippocampus of 7-month-old and 18-month-old PSEN dKO mice for a microRNA (miRNA) microarray analysis, and explored the tumorsuppressive or oncogenic role of differentially-expressed miRNAs. Results: The total number of miRNAs that showed changes in expression level was greater at 18 months of age than at 7 months. Most of the putative target genes of the differentially-expressed miRNAs involved Cancer pathways. Conclusions: Based on literature reviews, many of the miRNAs involved in Cancer pathways were found to be known tumorsuppressive miRNAs, and their target genes were known or putative oncogenes. In conclusion, the expression levels of known tumor-suppressive miRNAs increased at 7 and 18 months, in the PSEN dKO mouse model of AD, supporting the negative correlation between AD and cancer.
Single-nucleus sequencing of liver cells from hepatocyte-specific Nampt knockout mice and WT littermates reveals major changes to the hepatocyte transcriptome in mice with necrosis
GEO Series GSE174234. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Analysis of transcriptome profiling in liver tissues of wild-type and SREBP1c knockout mice using RNA-seq
GEO Series GSE100827. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
RPB1 ChIP-Seq of NSC from Wild Type (WT) and Armc5 knockout mice
GEO Series GSE169582. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
GSDMD knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
GEO Series GSE241549. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Elucidating the role of glycogen debranching enzyme AGL in bladder carcinogenesis by generation and characterization of knockout mice
GEO Series GSE113158. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Effect of depletion of FXR on gene expression in islets from FXR knockout mice
GEO Series GSE279682. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of Card9 knockout on gene expression in cardiac tissues of mice post myocardial infarction
GEO Series GSE235257. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Signaling protein antibody microarray analyses for islets of control and IFT88 knockout mice [SET100]
GEO Series GSE138885. Mus musculus; Homo sapiens. 4 samples. Type: Protein profiling by protein array.
CRISPR-Cas9 generated SARM1 knockout and epitope tagged mice reveal no role in transcription, despite confirmation of protein expression in macrophages
GEO Series GSE182091. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of 8hr LPS-stimulated bone marrow-derived macrophages from wild type, Ch25h-deficient, and LXRab knockout mice
GEO Series GSE58993. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequencing analysis reveals the different gene expression in male and female wild type and TECRL knockout mice.
GEO Series GSE191112. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Sequencing of Tumor infiltrating macrophages from B16f10 tumors in Wt and IFNγR knockout mice
GEO Series GSE113837. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide maps of chromatin state in KMT2D Knockout and KMT2D WT melanoma in mice
GEO Series GSE116851. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA-seq from adipose and liver tissue in Fam13a knockout and wildtype mice on different diets
GEO Series GSE137022. Mus musculus. 62 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq of femoral shaft RNA from Catalase knockout (KO) and wild-type (WT) male mice at 12 weeks of age given binge ethanol or control PBS for four consecutive days.
GEO Series GSE180304. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.