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356 results for “Prognostic value”
What is the Prognostic Value of HALP Score, Monocytopenia, Hypofibrinogenemia, and AST/ALT Ratio in Patients With Myelodysplastic Syndromes
ClinicalTrials.gov study NCT07210034. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A compendium of myeloma associated chromosomal copy number abnormalities and their prognostic value
GEO Series GSE21349. Homo sapiens. 491 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array; Expression profiling by array.
Transcriptional analysis of the expression and prognostic value of lipid droplet-localized proteins in hepatocellular carcinoma
GEO Series GSE223446. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The diagnostic and prognostic value of pulmonary virome and its host response for ARDS
GEO Series GSE279069. Homo sapiens. 209 samples. Type: Expression profiling by high throughput sequencing.
Prognostic Values of Immune Landscape in Ras-Mutant Colorectal Cancer Peritoneal Metastases
GEO Series GSE198085. Homo sapiens. 21 samples. Type: Other.
Regional complexity in breast tumors reveals patterns of prognostic value
GEO Series GSE32291. Homo sapiens. 414 samples. Type: Genome variation profiling by genome tiling array.
The diagnostic and prognostic value of hsa_circ_0084927 in colon adenocarcinoma and its ceRNA network construction (miRNA-Seq)
GEO Series GSE189908. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Prognostic and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma
GEO Series GSE113749. Homo sapiens. 95 samples. Type: Non-coding RNA profiling by array.
Dataset related to article "Prognostic Value of Metabolic Imaging Data of 11 C-choline PET/CT in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma "
<p>This record contains raw data related to article “Prognostic Value of Metabolic Imaging Data of <sup>11</sup> C-choline PET/CT in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma"</p> <p><sup>11</sup>C-choline positron emission tomography/computed tomography (PET/CT) has been used for patients with some types of tumors, but few data are available for hepatocellular carcinoma (HCC). We queried our prospective database for patients with HCC staged with <sup>11</sup>C-choline PET/CT to assess the clinical impact of this imaging modality. Seven parameters were recorded: maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), liver standardized uptake value (SUVliver), metabolic tumor volume (MTV), photopenic area, metabolic tumor burden (MTB = MTVxSUVmean), and SUVratio (SUVmax/SUVliver). Analysis was performed to identify parameters that could be predictors of overall survival (OS). Sixty patients were analyzed: fourteen (23%) were in stage 0-A, 37 (62%) in stage B, and 9 (15%) in stage C of the Barcelona classification. The Cox regression for OS showed that Barcelona stages (HR = 2.94; 95%CI = 1.41-4.51; <em>p</em> = 0.003) and MTV (HR = 2.11; 95%CI = 1.51-3.45; <em>p</em> = 0.026) were the only factors independently associated with OS. Receiver operating characteristics curve analysis revealed MTV ability in discriminating survival (area under the curve (AUC) = 0.77; 95%CI = 0.57-097; <em>p</em> < 0.001: patients with MTV ≥ 380 had worse OS (<em>p</em> = 0.015)). The use of <sup>11</sup>C-choline PET/CT allows for better prognostic refinement in patients undergoing hepatectomy for HCC. Incorporation of such modality into HCC staging system should be considered.</p>
Diagnostic and prognostic value of external anal sphincter EMG patterns in Multiple System Atrophy
<p>This database includes the raw data linked with the paper “Diagnostic and prognostic value of external anal sphincter EMG patterns in multiple system atrophy”.</p> <p>We collected clinical data and external anal sphincter (EAS) EMG findings in 72 patients with multiple system atrophy (MSA) and 21 with Parkinson’s disease (PD). We ascertained the survival times of 49 MSA patients who died during follow-up. We aimed to assess the diagnostic and prognostic value and clinical correlations of a novel classification of EAS electromyography patterns in MSA. We identified four EAS electromyography patterns, ranging from normal findings (pattern I) to mild, moderate or severe neurogenic damage (patterns II, III and IV, respectively).</p> <p>Pattern I was frequently observed in PD patients, while it was associated with prolonged survival when identified in a few MSA patients. Patterns II, III and IV were predominant in MSA. Subjects with MSA and EAS abnormalities often showed fecal incontinence and urogenital symptoms, which were frequently present at disease onset in patients with patterns III and IV. Abnormal EAS patterns correlated with MSA diagnosis. In particular, pattern IV was associated with the highest likelihood of MSA diagnosis and with the worst prognosis in the MSA cohort.</p>
Dataset from: "Prognostic Value of Dynamic Changes in Pulmonary Congestion During Exercise Stress Echocardiography in Heart Failure With Preserved Ejection Fraction"
<p>BACKGROUND: Patients with heart failure (HF) with preserved ejection fraction (HFpEF) typically develop dyspnea and<br> pulmonary congestion upon exercise. Lung ultrasound is a simple diagnostic tool, providing semiquantitative assessment<br> of extravascular lung water through B-lines. It has been shown that patients with HFpEF develop B-lines upon submaximal<br> exercise stress echocardiography; however, whether exercise-induced pulmonary congestion carries prognostic implications<br> is unknown. This study aimed at evaluating the prognostic value of B-line assessment during exercise in patients with HFpEF.<br> METHODS: Sixty-one New York Heart Association class I to II patients with HFpEF underwent standard echocardiography,<br> lung ultrasound (28-scanning point method), and BNP (B-type natriuretic peptide) assessment during supine exercise<br> echocardiography (baseline and peak exercise). The primary end point was a composite of cardiovascular death or HF<br> hospitalization at 1 year.<br> RESULTS: B-lines, E/e′, and BNP significantly increased during exercise (P<0.001 for all). By multivariable analysis, both peak<br> (hazard ratio, 1.50 [95% CI, 1.21–1.85], P<0.001), and change (hazard ratio 1.34 [95% CI, 1.12–1.62], P=0.002) B-lines<br> were retained as independent predictors of outcome (hazard ratios per 1 B-line increment), along with BNP and E/e′ ratio.<br> Importantly, adding peak B-line on top of a clinical model significantly improved prognostic accuracy (C-index increase, 0.157<br> [0.056–0.258], P=0.002) and net reclassification (continuous net reclassification improvement, 0.51 [0.09–0.74], P=0.016),<br> with similar results for B-line change.<br> CONCLUSIONS: Detection of exercise-induced pulmonary congestion by lung ultrasound is an independent predictor of outcome<br> in patients with HFpEF; its use may help refining the routine risk stratification of these patients on top of well-established<br> clinical variables.</p>
Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study.
<p>Frigelli M, Sturla F, Milani V, Ramputi L, Citarella M, Menicanti L, Votta E, Castelvecchio S. Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study. Int J Cardiol. 2022 Sep 1;362:183-189. doi: 10.1016/j.ijcard.2022.04.071. Epub 2022 Apr 30. PMID: 35504452.</p> <p>Abstract</p> <p><strong>Background: </strong>Left atrial (LA) function can be effectively assessed by measuring longitudinal LA strain (LAS) via two-dimensional speckle tracking echocardiography (2DSTE). Here, we test 2DSTE-based LAS as marker of different left ventricle (LV) remodeling patterns and as prognostic index in ischemic heart failure (HF) candidates to surgical ventricular reconstruction.</p> <p><strong>Methods: </strong>We retrospectively considered ischemic HF patients with anterior (group A, n=130) or posterior (group P, n=48) LV remodeling. Based on 2D ultrasound, LV and LA morpho-functional parameters were quantified including reservoir (LAS<sub>Res</sub>), conduit (LAS<sub>Cond</sub>) and booster (LAS<sub>Boost</sub>) LAS. We tested their capability to discriminate between groups A and P, and their group-specific prognostic significance for the composite end-point of death or HF re-hospitalization at follow-up (mean follow-up time=40 months, range 3-101 months).</p> <p><strong>Results: </strong>Group A and group P displayed similar end-diastolic (p=0.89) and end-systolic (p=0.33) LV volume index, and LA volume index LAVi (p=0.44) corrected for the degree of mitral regurgitation. As compared to group P, group A revealed a significant reduction in LAS<sub>Boost</sub> (9.2±0.4% vs. 11.1±0.7%, p=0.04) and a non-significant reduction in LAS<sub>Res</sub> (16.9±0.7% vs. 19.3±1.1%, p=0.06). Kaplan-Meier curves showed that the median LAS<sub>Res</sub> and LAS<sub>Boost</sub> values effectively stratified patients based on their prognosis in the overall study population (Log-rank p=0.002 and Log_rank p<0.0001) and in group A, where the association was stronger for LAS<sub>Boost</sub> (Log-rank p<0.001) than for LAS<sub>Res</sub> (Log-rank p=0.013).</p> <p><strong>Conclusions: </strong>2DSTE-based LAS assessment is affordable, repeatable and non-invasive, and could add clinically-relevant mechanistic insight and prognostic value in the stratification of ischemic HF patients.</p>
Prognostic value of 2D vs 3D LV volumes and ejection fraction
<p>Database of LV volumes and ejecton fraction obtained by 2D and 3D echo in consecutive patients</p>
Data set related to the article: "Gender Differences Associated with the Prognostic Value of BPIFB4 in COVID-19 Patients: A Single-Center Preliminary Study."
<p><strong>Abstract:</strong> In the ongoing global COVID-19 pandemic, male sex is a risk factor for severe disease and death, and the reasons for these clinical discrepancies are largely unknown. The aim of this work is to study the influence of sex on the course of infection and the differences in prognostic markers between genders in COVID-19 patients. Our cohort consisted of 64 adult patients (n = 34 men and n = 30 women) with PCR-proven SARS-CoV-2 infection. Further, a group of patients was characterized by a different severity degree (n = 8 high- and n = 8 low-grade individuals for both male and female patients). As expected, the serum concentrations of LDH, fibrinogen, CRP, and leucocyte count in men were significantly higher than in females. When serum concentrations of the inflammatory cytokines, including IL-6, IL-2, IP-10 and IL-4 and chemokines like MCP-1, were measured with multiplex ELISA, no significant differences between male and female patients were found. In COVID-19 patients, we recently attributed a new prognostic value to BPIFB4, a natural defensin against dysregulation of the immune responses. Here, we clarify that BPIFB4 is inversely related to the disease degree in men but not in women. Indeed, higher levels of BPIFB4 characterized low-grade male patients compared to high-grade ones. On the contrary, no significant difference was reported between low-grade female patients and high-grade ones. In conclusion, the identification of BPIFB4 as a biomarker of mild/moderate disease and its sex-specific activity would open an interesting field for research to underpin gender-related susceptibility to the disease.</p>
The prognostic value of the detection of microbial translocation in the blood of colorectal cancer patients
<p>Results of a retrospective analysis aiming to investigate whether microbial translocation occurs in colorectal cancer patients and to evaluate the usefulness of PCR for diagnosis of such translocation in the blood of these patients before treatment initiation. The secondary objective of the study was the correlation of the presence of previously investigated by our group toll-like and vitamin D receptor gene polymorphisms with the detection of microbial DNA fragments in the blood of colorectal cancer patients. </p> <p>The detection of microbial DNA fragments in CRC patients highlights the role of these microbes in cancer development, progression and patients’ survival. Clearly, this increased risk in colorectal patients should be taken into consideration by the clinicians when planning any surgical intervations or during chemotherapy</p>
INCREMENTAL PROGNOSTIC VALUE OF ARTERIAL ELASTANCE IN MILD-TO-MODERATE IDIOPATHIC PULMONARY FIBROSIS
<p><strong>PURPOSE: </strong>Previous reports suggested that poor pulmonary function was associated with increased arterial elastance (Ea) in patients with chronic obstructive pulmonary disease and systemic sclerosis. The mechanisms connecting pulmonary function and Ea have not yet been accurately studied in patients with idiopathic pulmonary fibrosis (IPF). The present study was designed to assess Ea in IPF patients without chronic severe pulmonary hypertension and to determine its prognostic role over a medium-term follow-up.</p> <p><strong>METHODS: </strong>This retrospective study included 60 consecutive patients with mild-to-moderate IPF (73.8±6.6 yrs, 75% males) and 60 controls matched by age, sex and cardiovascular risk factors. All patients underwent physical examination, spirometry, blood tests, modified Haller index (MHI, chest transverse diameter over the distance between sternum and spine) assessment, conventional transthoracic echocardiography implemented with speckle tracking analysis of left atrial positive global strain (LA-GSA+) and finally carotid Doppler ultrasonography, at basal evaluation. The effective arterial elastance index (EaI) was calculated as the ratio of end-systolic pressure to stroke volume index. During follow-up period, we evaluated the composite endpoint of 1) pulmonary or cardiovascular hospitalizations; 2) all-cause mortality.</p> <p><strong>RESULTS: </strong>At baseline, EaI was significantly higher in IPF patients than controls (4.1±1.3 vs 3.5±1.0 mmHg/ml/m<sup>2</sup>, p=0.01). EaI was strongly correlated to the following variables: C-reactive protein (CRP) (r=0.86), forced vital capacity (FVC) (r=-0.91), E/e’ ratio (r=0.91), LA-GSA+ (r=-0.92), common carotid artery-cross sectional area (CCA-CSA) (r=0.89) and MHI (r=0.86), in IPF patients. Mean follow-up time was 2.4±1.3 yrs. During follow-up, 12 patients died and 17 were hospitalized due to major adverse clinical events. At univariate Cox analysis, CRP (HR 1.51, 95%CI 1.25-1.82), FVC (HR 0.88, 95%CI 0.85-0.91), LA-GSA+ (HR 0.85, 95%CI 0.77-0.94), CCA-CSA (HR 1.12, 95%CI 1.03-1.22) and EaI (HR 2.43, 95%CI 1.75-3.37) were significantly associated with outcome. At multivariate Cox analysis, only EaI (HR 1.60, 95%CI 1.03-2.50) retained statistical significance. An EaI ≥4 mmHg/ml/m<sup>2 </sup>showed 100% sensitivity and 99.4% specificity for predicting outcome (AUC=0.98).</p> <p><strong>CONCLUSIONS: </strong>In patients with mild-to-moderate IPF, an EaI ≥4 mmHg/ml/m<sup>2 </sup>is a negative prognostic factor over a medium-term follow-up.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.