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Dataset results
358 results for “SAR studies”
Study to Evaluate the Performance of the Therma COVID-19 Rapid Antigen Test for Detection of SARS-CoV-2
ClinicalTrials.gov study NCT04878068. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Part 2 on the Study Prevalence of SARS -Cov2 Carriage in Asymptomatic and Mildly-symptomatic Children (COVILLE2) (WHO)
ClinicalTrials.gov study NCT04416893. IPD Sharing: NO. Countries: 0. Publications: 0.
Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Immune-related Myopathy (Myasthenia Gravis and Inflammatory Myopathy) Patients ：a Prospective Observational Study
ClinicalTrials.gov study NCT04941079. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Phase I Dose Escalation SARS-CoV Recombinant S Protein, With and Without Adjuvant, Vaccine Study
ClinicalTrials.gov study NCT01376765. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Study of SARS-CoV-2 Vaccine in Metabolism-related Fatty Liver Disease
ClinicalTrials.gov study NCT05738707. IPD Sharing: Not stated. Countries: 0. Publications: 0.
An Efficacy, Immunogenicity and Safety Study Investigating an Adjuvanted SARS-CoV-2 Influenza Vaccine to Protect Against COVID-19 in Adults Over Aged 18 Years-old and Older
ClinicalTrials.gov study NCT04806529. IPD Sharing: YES. Countries: 0. Publications: 0.
Health outcomes in SARS survivors 18 years after infection: A longitudinal cohort study
GEO Series GSE216357. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
SAR Interferograms for NISAR Quasi-quad pol mode study
This dataset contains a collection of HH and VV interferograms collected with the JPL Airborne system UAVSAR. The interferogram cover various regions: - Winnipeg, Canada -Kenaston, Canada -Stuttgard, Arkansas, USA The data has been used to study the impact of NISAR quasi-quad pol mode on the computation of the ionospheric phase screen. The data are provided in a GDAL format and can be opened and handled using Python. The research was carried out at the Jet Propulsion Laboratory, California Institute of Technology © 2020. All rights reserved, under a contract with the National Aeronautics and Space Administration (80NM0018D0004)
SARS-COV-2 putative mi-RNAs may target host immune system and cellular mechanisms to mediate pathogenesis-an in silico and in vivo study I
GEO Series GSE231528. Homo sapiens. 57 samples. Type: Expression profiling by RT-PCR.
SARS-COV-2 putative mi-RNAs may target host immune system and cellular mechanisms to mediate pathogenesis-an in silico and in vivo study II
GEO Series GSE231529. Homo sapiens. 12 samples. Type: Expression profiling by RT-PCR.
Covid-associated Multisystem Inflammatory Syndrome in Children and Cardiovascular Autonomic Control: a Prospective Cohort Study Nine Months after SARS-CoV-2 Infection. DATASET
<p><span>The data that support the main findings of this study have been uploaded on the Zenodo repository with access granted on justified request to researchers who meet the criteria for access to confidential data due to the restrictions requested for approval by the local ethical committee.</span></p>
A Prospective Study on the Transmission dynamics of Corona virus disease (2019) (COVID-19) among Household contacts in Delhi, India. (SARS CoV-2 HT Study)
<p>This is raw data set for the research on transmission dynamics of COVID-19 among households in Delhi, India.</p>
Clinical Study of SARS in Children
ClinicalTrials.gov study NCT00173576. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Potential Role of Inflammation in SARS-CoV-2 Disease Pathology: A multi-omic study in Type II pneumocytes of A/J mice exposed to Lipopolysaccharide
GEO Series GSE211061. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
SARS-COV-2 putative mi-RNAs may target host immune system and cellular mechanisms to mediate pathogenesis-an in silico and in vivo study
GEO Series GSE231530. Homo sapiens. 69 samples. Type: Expression profiling by RT-PCR.
Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among Hospital Workers – a multicentre cross-sectional study
<p>Variables and baseline data from this cross-sectional study. Manuscript currently available as preprint: https://medrxiv.org/cgi/content/short/2020.11.10.20229005v1.</p>
Serum metabolic disparity between pulmonary Sarcoidosis (SAR) and Tuberculosis (TB) revealed by NMR based metabolomics study
<p>Tuberculosis (TB) -a pulmonary granulomatous disease- is the leading cause of death worldwide from a single infectious disease agent especially in developing countries such as India. Current diagnostic methodologies often lack specificity and sensitivity; therefore, there is an immense clinical interest to investigate alternative biomarker signatures for obtaining a conclusive and suggestive diagnosis of TB. Particular challenge arises for treating physicians while differentiating TB from sarcoidosis (SAR) which is an uncommon granulomatous disease and shares the similar clinical, radiological and pathological features with TB. Symptoms common in TB such as cough, fever, fatigue, and weight-loss are often manifested in sarcoidosis as well. As India accounts for more than 26% of global burden of TB cases and epidemiological data about sarcoidosis is unknown, most of the sarcoidosis patients end up receiving anti tubercular therapy (ATT) erroneously, leading to delayed proper treatment and considerable risk of drug induced toxicity, whereas lung damage continues to progress in this backdrop. Therefore, there is an urgent unmet need to identify non-invasive biomarker(s) for differentiating sarcoidosis from TB. Metabolomics analysis of serum holds great potential to provide distinctive patterns of metabolic profiles relevant to underlying disease processes and thus may aid in rapid clinical diagnosis and guiding appropriate treatment.</p> <p>Starting our efforts in this direction, the serum metabolic profiles of sarcoidosis and active TB patients were measured using 800 MHz NMR Spectroscopy and compared using the multivariate and univariate statistical analysis tools. The partial least square discriminatory analysis (PLS-DA) revealed significant serum metabolic disparity between SAR and TB with respect to normal control subjects [1-5]. Compared to SAR, the sera of TB patients were characterized by (a) elevated levels of lactate, acetate, 3-hydroxybutyrate (3HB), glutamate and succinate (b) decreased levels of glucose, citrate, pyruvate, glutamine, and various lipid and membrane metabolites (such as very-low/low density lipoproteins (VLDL/LDL), polyunsaturated fatty acids, etc.).</p> <p>The altered circulatory levels of glucose (decreased) and lactate (increased) were found well consistent with previous report [6] demonstrating that infection with Mycobacterium tuberculosis (MTb) induces the Warburg effect in mouse lungs. A very recent study reported increased production of glutamate from mitochondrial glutaminolysis and pleiotropic roles of glutamine metabolism in the metabolic reprogramming of MTb infected M1-like macrophages [7]. A previous study published in Science [8] reported the suppression of oxidative stress by 3HB. Another study published in scientific report demonstrated that of <em>Mycobacterium tuberculosis</em> (MTb) secretory protein ESAT-induces GLUT-1 mediated enhanced glucose uptake by macrophages and increased fatty acid biosynthesis (to drive foamy macrophage differentiation) which in turn results in release of 3HB in the extracellular environment [9]. Based on previously reported metabolic derangements in MTb infected systems and our results derived from NMR-based serum metabolomics, the following remarks have been drawn:</p> <ul> <li><strong>Active TB infection </strong>induces Warburg effect as inferred from the decreased serum levels of glucose and elevated levels of lactate</li> <li><strong>Active TB infection </strong>causes increased biosynthesis of fatty acids as inferred from the decreased serum levels of citrate and increased levels of acetate and 3-Hydroxybutyrate (3-HB)</li> <li><strong>Active TB infection </strong>manipulates oxidative stress (OS) induced pathogen killing host-defense mechanism as inferred from decreased circulatory phenylalanine-to-tyrosine ratio (PTR) and 3HB (known to suppress OS)</li> <li><strong>Active TB infection </strong>induces augmented utilization of glutamine (an immunomodulatory nutrient) as inferred from the decreased serum levels of glutamine and increased serum levels of glutamate and succinate</li> <li><strong>Active TB infection </strong>induces dyslipidemia as inferred from the decreased NMR signals of very-low/low density lipoproteins (VLDL/LDL) and polyunsaturated fatty acids (PUFAs)</li> </ul> <p><strong>References:</strong></p> <ol> <li>Dinesh Kumar, Ritu Raj, Avinash Jain , Anupam Guleria, Umesh Kumar, Mohit K Rai, Harshit Singh, Saurabh Chaturvedi, Alok Nath, Durga P Misra and Vikas Agarwal, “Serum based metabolomics analysis revealed highly sensitive and specific panel of metabolic markers for differential diagnosis of Pulmonary Sarcoidosis and Tuberculosis” (Conference paper presented during IRACON-2018). F1000Research 2019, 8:304 (DOI: 10.7490/f1000research.1116481.1)</li> <li>Dinesh Kumar, Avinash Jain, Amit Kumar, Anupam Guleria, Ritu Raj, Harshit Singh, Mohit K Rai, Saurabh Chaturvedi, Alok Nath, Durga P Misra, and Vikas Agarwal, “Targeted nuclear magnetic resonance-based serum metabolomics analysis revealed significantly higher phenylalanine/tyrosine ratio in pulmonary sarcoidosis patients compared to tuberculosis patients”, (Conference Paper selected for Oral Presentation in IRACON 2018: OPC0034) Indian J Rheumatol (2018), vol 13 (Issue 6) Suppl S2:79-92 (DOI: 10.4103/0973-3698.247335)</li> <li>Avinash Jain, Amit Kumar, Harshit Singh, Mohit Kumar Rai, Saurabh Chaturvedi, Anupam Guleria, Alok Nath, Dinesh Kumar, Durga Prasanna Misra, and Vikas Agarwal, “Nuclear magnetic resonance (NMR) based Serum Metabolomics in Sarcoidosis and Tuberculosis – Search for a Biomarker”, (Received Best Oral Award) (Conference Paper selected for Oral Presentation in IRACON 2018: OPC0030) Indian J Rheumatol (2018), vol 13 (Issue 6) Suppl S2:79-92 (DOI: 10.4103/0973-3698.247335).</li> <li>Dinesh Kumar, Avinash Jain, Amit Kumar, Anupam Guleria, Alok Nath, Durga Prasanna Misra, Vikas Agarwal, “Diagnostic panel of biomarkers for the assessment of sarcoidosis and tuberculosis identified using NMR based serum metabolomics approach” (Poster Presented during BSRAC-2018) F1000Research (2018), 7:18 (doi: 10.7490/f1000research.1115194.1)</li> <li>Avinash Jain, Amit Kumar, Harshit Singh, Mohit K Rai, Saurabh Chaturvedi, Anupam Guleria, Alok Nath, Dinesh Kumar, Durga P Misra and Vikas Agarwal, “Nuclear magnetic resonance (NMR) based serum metabolomics in sarcoidosis and tuberculosis: search for a biomarker” (Poster Presentation during British Society for Rheumatology Annual Conference 2018 | BSRAC-2018) Rheumatology (April 2018), Vol 57, Issue suppl_3 (DOI: 10.1093/rheumatology/key075.338).</li> <li>Shi, L., Salamon, H., Eugenin, E.A., Pine, R., Cooper, A. and Gennaro, M.L., 2015. Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs. Scientific reports, 5(1), pp.1-13.</li> <li>Jiang, Qingkui, and Lanbo Shi. "Coordination of the uptake and metabolism of amino acids in Mycobacterium tuberculosis-infected macrophages." Frontiers in Immunology 12 (2021).</li> <li>Shimazu, T., Hirschey, M.D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C.A., Lim, H., Saunders, L.R., Stevens, R.D. and Newgard, C.B., 2013. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. <em>Science</em>, <em>339</em>(6116), pp.211-214.</li> <li>Singh, V., Kaur, C., Chaudhary, V.K., Rao, K.V. and Chatterjee, S., 2015. M. tuberculosis secretory protein ESAT-6 induces metabolic flux perturbations to drive foamy macrophage differentiation. <em>Scientific reports</em>, <em>5</em>(1), pp.1-12.</li> </ol>
Data for the manuscript "Identification and structural studies of the crucial RNAi target of SARS-CoV-2 through molecular dynamics simulations"
<p>Simulation datasets for manuscript titled "<strong>Identification and structural studies of the crucial RNAi target of SARS-CoV-2 through molecular dynamics simulations"</strong></p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.