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Fig. 3 in Biotransformation of betulinic acid by Circinella muscae and Cunninghamella echinulata to discover anti-inflammatory derivatives
Fig. 3. Key NOESY correlationships of metabolites 2 and 8.
Antioxidant and anti-inflammatory function of walnut green husk aqueous extract (WNGH-AE) on human hepatocellular carcinoma cells (HepG2) treated with t-BHP
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Figure 1 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 1 Results of thymol (TML) on: A. Serum creatinine and neutrophil gelatinase-associated lipocalin (NGAL); B. Renal malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC); C. Renal tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18); D. Renal Bax; E. Renal caspase-3, and caspase-9 in gentamicin (GN)-challenged rats. Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs GN.
Figure 2 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 2 H&E (200×) of rat kidneys of: A. Control showing normal renal architecture; B. Gentamicin (GN) group demonstrating marked distortion of kidney architecture, renal tubular necrosis and dilatation, desquamation of lining epithelium (white arrow), cytoplasmic vacuolization (black arrow), interstitial edema, coagulative necrosis (black head), and inflammatory cell infiltration (white head); C. Thymol (TML) + GN showing preservation of the normal kidney histological picture; D. Score of tubular injury. Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Figure 4 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 4 Immunohistochemistry (200×) of kidney injury molecule-1 (KIM-1) of rat kidneys of: A. Control showing no staining (NS); B. Gentamicin (GN) group demonstrating a significant increment of KIM-1 immunopositivity in brown color; C. Thymol (TML) + GN showing a significant decrement of KIM-1 immunoreactivity; D. Immunoreactive area (µm2). Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Figure 3 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 3 Immunohistochemistry (200×) of nuclear factor-κB p65 (NF-κB p65) of rat kidneys of: A. Control showing no staining (NS); B. Gentamicin (GN) group demonstrating a significant increment of NF-κB p65 immunopositivity in brown color; C. Thymol (TML) + GN showing a significant decrement of NF-κB p65 immunoreactivity; D. Immunoreactive area (µm2). Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Figure 2 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 2. Effect of the ethanolic extract of Hymenaea martiana (HmEtOH - 100, 200 and 400 mg.kg-1), indomethacin (20 mg.kg-1) and morphine (10 mg.kg-1) on acetic acid induced writhing test in mice. Values are mean ± S.E.M.*P <0.05,**P <0.01,significantly different from control; one-way ANOVA followed by Tukey's test (n = 6, per group).
Figure 1 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 1. Mass spectrum of astilbin in ESI positive (+MS) and negative (-MS) modes. (A) LC-MS mass spectrum of astilbin in ESI positive molecular ion (+MS); (B) LC-MS mass spectrum of astilbin in ESI negative (-MS) molecular ions.
FMO3 Suppressive Anti-Inflammatory Formula Novelty Report
<p>The WIPO Novelty Report of TR201304603B Patent Number</p> <p>Anti-Inflammatory Formulation currently being co-researched by TUSEB</p> <p>Inventors: Alkoclar , Erdal Can </p> <p> Yesil , Metehan</p>
Data from: New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples.
A magnetic solid-phase extraction (MSPE) procedure on the newly synthesized magnetic β-cyclodextrin functionalized with toluene diisocyanate (TDI) as a linker and was further modified with bio-polymeric spores of sporopollenin (MSp-TDI-βCD) was developed for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs) namely indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP) and fenoprofen (FNP) from water samples prior to their HPLC-DAD determination. The newly synthesised MSp-TDI-βCD was comprehensibly characterized using FT-IR, XRD, SEM-EDX, BET and VSM analyses. The separation of selected NSAIDs on MSp-TDI-βCD from aqueous solution was simply achieved by applying an external magnetic field via a permanent magnet. The MSPE parameters affecting extraction performance i.e., sorbent dosage, sample volume, extraction and desorption time, type of organic eluent and volume and solution pH were investigated and optimized. The proposed method showed linear range between 0.5 - 500 ng/mL, low limit of detection at S/N = 3 (0.16 - 0.37 ng/mL) and limit of quantification at S/N = 10 (0.53 - 1.22 ng/mL). The interday (n = 15) and intraday (n = 5) precision for the proposed methods given by relative standard deviation (RSD%) in the range of 2.5 - 4.0 and 2.1 - 5.5 respectively. The extraction recoveries of NSAIDs from environmental samples (tap, drinking and river water) ranged from 92.5 - 123.6%, with satisfactory precision (RSD% less than 12.4%).
Figure 7 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 7 Microphotograph of the defect of the mandible in a rat of the control group on the 14th day from the beginning of the experiment. There is an inflammatory infiltrate consisting of lymphocytes, leukocytes and macrophages found between the islets of newly formed bone tissue (↑).H&E, Magn.: oc.10, оb. 40.
Figure 6 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 6 Microphotograph of a fragment of the mandible in a rat from control group 14 days after the begining of the experiment. The connective tissue capsule (1) separates the preserved bone (2) from the bone defect (3). H&E, Magn.: oc.10, оb. 40.
Figure 3 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 3 Microphotograph of the adjacent to the site of surgery soft tissues on a fragment of the mandible in a rat from control group 7 days after the begining of the experiment. The blood vessels of the connective tissue (1) appear full of blood (↑). H&E, Magn.: oc.10, оb. 10.
Figure 4 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 4 Microphotograph of a fragment of the mandible in a rat from experimental group 7 days after the begining of the experiment. The bone defect is filled with polymorphonuclear leukocytes (1) with edema of the surrounding tissues (2). H&E, Magn.: oc.10, оb. 40.
Figure 9 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 9 Microphotograph of the defect of the mandible in a rat of the control group on the 28th day from the beginning of the experiment. Newly formed none islands (1) become connected. Inflammatory infiltrate (2) is localized on the periphery of the regeneration zone. H&E, Magn.: oc.10, оb. 10.
Figure 2 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 2 Microphotograph of the adjacent to the site of surgery soft tissues on a fragment of the mandible in an experimental rat 7 days after the begininig of the experiment. The blood vessels of the connective tissue (1) appear full of blood and there is a swelling of the muscle tissue (2). H&E, Magn.: oc. 10, оb. 10.
Figure 10 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 10 Microphotograph of a fragment of the liver in a rat of the experimental group on the 28th day from the beginning of the experiment. The central vein (1) with radially located trabeculae (2) is defined. H&E, Magn.: oc.10, оb. 10.
Figure 1 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 1 Microphotograph of the mandible with an artificial defect around canines that was filled with the recommended paste in a rat of the experimental group on the 7th day since the beginning of the experiment.
Figure 11 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 11 Microphotograph of a fragment of the liver in a rat of the experimental group on the 14th day from the beginning of the experiment. The plethora of arteries (1) and veins (2) in the hepatic triad is determined. H&E, Magn.: oc.10, оb. 40.
Figure 8 from: Kostyiuk I, Kostiuk V, Kimak H, Oktysyuk Y, Tarnavska L (2021) Experimental study the anti-inflammatory and osteo-regenerative qualities of the paste based on symphytum officinale tincture and calcium hydroxide. Pharmacia 68(3): 585-590. https://doi.org/10.3897/pharmacia.68.e67774
Figure 8 Microphotograph of the defect of the mandible in a rat of the experimental group on the 28th day from the beginning of the experiment. Newly formed bone islands (1), separated by connective tissue fibers and fibroblasts (2), displace lymphocytic inflammatory infiltrate from the defect area (3). H&E, Magn.: oc.10, оb. 10.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.