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388
datasets available to search
ShareScore release 0.9.0
Dataset results
388 results for “gene loss”
Analysis of gene expression and of H3.3 distribution and abundance in a ATRX loss-of-function line
GEO Series GSE87918. Arabidopsis thaliana. 11 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Discrete chromatin alterations and deregulated gene expression upon PROTAC-induced rapid loss of the trithorax protein ASH2L [Click-it]
GEO Series GSE239789. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene-metabolite network linked to inhibited bioenergetics in association with spaceflight induced loss of quadriceps muscle
Prolonged residence of mice in spaceflight is a scientifically robust and ethically ratified model of muscle atrophy caused by continued unloading. Under the Rodent Research Program of NASA, we assayed the genomic and metabolomics perturbations in the quadriceps of C57BL/6J male mice that lived on the spaceflight (FLT) or at Ground Control (CTR) for approximately four weeks. Wet weight of quadriceps were significantly reduced in FLT mice. Deep next generation sequencing and untargeted mass spectroscopic assay interrogated the gene-metabolite landscape of same tissues. A majority of top ranked differentially suppressed genes in FLT encode proteins from myosin or troponin family suggesting a sarcomere alteration in space. Significantly enriched gene-metabolite networks were found linked to saromeric integrity, immune fitness and oxidative stress response; all inhibited in space as per in silico prediction. A significant loss of FLT mitochondrial DNA copy numbers underlined the energy deprivation associated with spaceflight induced stress, and this hypothesis was reinforced by the omics analysis that showed inhibited networks related to protein, lipid and carbohydrate metabolism, and ATP synthesis and hydrolysis. Finally, we reported a list of upstream regulators, which could be targeted for next generation therapeutic intervention for the betterment of the musculoskeletal system in male mice subjected to chronic disuse. Abbreviation Key: Sham surgical procedure done (Sh); non-surgical control (NS); Ground Control group (G); Flight Group (F); Whole Body frozen as sample on ISS (W).
Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behavior [RNA-Seq]
GEO Series GSE318294. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Weight loss following Roux-en-Y gastric bypass surgery leads to changes in the expression of several miRNAs and their predicted target genes in skeletal muscle
GEO Series GSE87131. Homo sapiens. 50 samples. Type: Expression profiling by RT-PCR.
Effects of Dpy30 loss on gene expression in mouse fetal liver HSCs
GEO Series GSE101856. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq analysis of gene expression changes at 8 hpf induced by miR-34a loss
GEO Series GSE205752. Danio rerio. 8 samples. Type: Expression profiling by high throughput sequencing.
Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes
GEO Series GSE226269. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Loss of PILRB gene at age-related macular degeneration associated PILRB/PILRA locus impairs photoreceptor function in mouse retina
GEO Series GSE264349. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Impact of high fat diet and hepatocyte nuclear factor four alpha loss on hepatic gene expression in mice.
GEO Series GSE137051. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Loss of the Maternal Effect Gene Nlrp2 Impairs Embryonic and Extra-Embryonic Development, Unveiling a Novel Cause of Congenital Anomalies
GEO Series GSE274909. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Cochlear single-cell gene expression profiles in mice with noise-induced hidden hearing loss and noise-induced hearing loss.
GEO Series GSE252285. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq analysis of gene expression changes at 72 hpf induced by miR-34a loss
GEO Series GSE205754. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of subcutaneous fat (SF) loss on gene expression with clear cell renal cell carcinoma
GEO Series GSE215286. Homo sapiens. 57 samples. Type: Expression profiling by high throughput sequencing.
Hippocampus-specific loss of intellectual disability-related gene Brpf1 impaired spatial and contextual learning
GEO Series GSE212983. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome Analyses of Loss of Pitx2 Gene Function at Fetal/Neonatal Mouse Muscle
GEO Series GSE114231. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways
GEO Series GSE137217. Rattus norvegicus. 72 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Recombination suppression on fungal mating-type chromosomes without mating-type loci linkage and with loss of function of HD mating-type genes
GEO Series GSE233508. Microbotryum violaceum. 21 samples. Type: Expression profiling by high throughput sequencing.
Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury
GEO Series GSE176395. Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing.
Loss of self-tolerance leads to altered gene expression and IMD pathway activation in Drosophila melanogaster
GEO Series GSE189383. Drosophila melanogaster. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.