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357
datasets available to search
ShareScore release 0.9.0
Dataset results
357 results for “recession”
A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
ClinicalTrials.gov study NCT04786574. IPD Sharing: NO. Countries: 0. Publications: 0.
Treatment of Gingival Recession-type Defects Using Different Restorative Materials
ClinicalTrials.gov study NCT02788266. IPD Sharing: NO. Countries: 0. Publications: 0.
Clinical Evaluation of (TCAF) Versus (CAF) Combined With Connective Tissue Graft in the Treatment of Multiple RT2 Gingival Recession Sites
ClinicalTrials.gov study NCT07064603. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Growth Factors in the Localized Gingival Recessions Treatment
ClinicalTrials.gov study NCT05188768. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effect of Bristle-less Toothbrush (PeriClean) on Gum Recession
ClinicalTrials.gov study NCT02951065. IPD Sharing: NO. Countries: 0. Publications: 0.
Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession Surgeries
ClinicalTrials.gov study NCT02450162. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Treatment of Miller Class I and II Gingival Recession Using Non- Pedicled Buccal Fat Pad Graft as Compared to Subepithelial Connective Tissue Graft
ClinicalTrials.gov study NCT03543163. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Does Recessive Optic Atrophy Due to WFS1 Exist?
ClinicalTrials.gov study NCT07336966. IPD Sharing: NO. Countries: 0. Publications: 0.
Pathogenic pathways in early onset autosomal recessive Parkinson’s disease discovered using isogenic human dopaminergic neurons
GEO Series GSE140076. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Recessive mutation in EXOSC3 associates with mitochondrial dysfunction and pontocerebellar hypoplasia
GEO Series GSE99715. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing; Third-party reanalysis.
Single cell RNA-seq for a mouse model of recessive dystrophic epidermolysis bullosa
GEO Series GSE181357. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Single cell samples from Recessive Dystrophic Epidermolysis Bullosa (RDEB) patients before and after allogeneic epidermal grafting treatment
GEO Series GSE181227. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome [scRNA-seq]
GEO Series GSE302421. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Autosomal recessive PIK3CD deficiency
GEO Series GSE216493. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Next generation sequencing identifies WNT signalling as a significant pathway in Autosomal Recessive Polycystic Kidney Disease (ARPKD) manifestation and may be linked to disease severity
<p><em>Background: </em>Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a rare paediatric disease primarily caused by mutations in <em>PKHD1</em>. ARPKD presents with considerable clinical variability relating to the type of <em>PKHD1 </em>mutation, but not its position. Animal models of Polycystic Kidney Disease (PKD) suggest that there is a complex genetic landscape, with genetic modifiers as a potential cause of disease variability.</p> <p><em>Methods: </em>To assess this relationship, a Whole Exome Sequencing (WES) and RNA-Sequencing (RNA-Seq) approach was employed on human ARPKD kidneys and age-matched healthy controls, to investigate in an unbiased manner the molecular mechanisms of ARPKD and identify potential markers of disease severity.</p> <p><em>Results: </em>WES confirmed the clinical diagnosis of ARPKD in our patient cohort. Mutation type, nor position of <em>PKHD1 </em>mutations, were linked to disease severity. Mutations in genes associated with other ciliopathies were detected in the ARPKD cohort, but only <em>PKD1</em> could be linked to disease severity. Transcriptomic analysis identified a significant number of genes relating to WNT signalling, cellular metabolism and development. Amongst these genes, increased expression of WNT signalling-related genes was validated by RT-qPCR. In addition, two individuals in our cohort had the same <em>PKHD1</em> mutations but different rates of kidney disease progression. Amongst the transcriptomic differences of these two individuals were differences in the expression of WNT signalling genes.</p> <p><em>Conclusion: </em>ARPKD kidney transcriptomics highlights changes in WNT signalling as potentially significant in ARPKD manifestation and severity and could provide a future therapeutic target for slowing down the progression of ARPKD.</p>
Tofacitinib reduces skin inflammation in a patient with severe autosomal recessive congenital ichthyosis
GEO Series GSE228449. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Kids First: Whole Exome, Genome, and RNA Sequencing in Recessive Structural Brain Defects in Children
Namespace hosted on the Kids First DRC FHIR services at fhir.kidsfirstdrc.org
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.