Find research datasets worth reusing

Carillon Mitral Contour System for Treatment of Exercise Induced Functional Mitral Regurgitation

ClinicalTrials.gov study NCT05040451. IPD Sharing: NO. Countries: 0. Publications: 0.

Cardiac T1 Mapping Enables Risk Prediction of LV Dysfunction After Surgery for Aortic Regurgitation

ClinicalTrials.gov study NCT05332184. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.

Transcatheter Tricuspid Valve Replacement With the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in Severe Tricuspid Regurgitation

ClinicalTrials.gov study NCT07321899. IPD Sharing: NO. Countries: 0. Publications: 0.

The Effect of Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children

ClinicalTrials.gov study NCT04518709. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Effect of Significant Ischemic Mitral Regurgitation on the Outcome of ST Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention

ClinicalTrials.gov study NCT04106648. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Treatment of Functional Mitral Regurgitation in Patients With Atrial Fibrillation

ClinicalTrials.gov study NCT05846412. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Combined Mitral and Tricuspid Versus Isolated Mitral Transcatheter Edge-to-Edge Repair for Mitral Regurgitation With Tricuspid Regurgitation (DUAL-TEER Trial)

ClinicalTrials.gov study NCT07349888. IPD Sharing: Not stated. Countries: 0. Publications: 0.

A Prospective, Multicenter, Randomized Controlled Trial to Evaluate the Efficacy and Safety of the Transcatheter Tricuspid Valvuloplasty System in Patients With Severe or Above Tricuspid Regurgitation

ClinicalTrials.gov study NCT05770648. IPD Sharing: Not stated. Countries: 0. Publications: 0.

EXPLORE DMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation

ClinicalTrials.gov study NCT04679662. IPD Sharing: NO. Countries: 0. Publications: 0.

Outcome of MC3 Ring Annuloplasty for Functional Tricuspid Regurgitation

ClinicalTrials.gov study NCT04078867. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.

MitraClip in Acute Mitral Regurgitation

ClinicalTrials.gov study NCT03107455. IPD Sharing: NO. Countries: 0. Publications: 0.

openGEO-OpenOct 2025View details →

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Transcriptomic analysis of mouse heart after a minimally invasive mitral regurgitation surgery (MiMRS)

GEO Series GSE271640. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.

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Dataset related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling"

This record contains raw data related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling" Abstract: The “ideal” management of asymptomatic severe mitral regurgitation (MR) in valve prolapse (MVP) is still debated. The aims of this study were to identify pre‐operatory parameters predictive of residual MR and of early and long‐term favorable remodeling after MVP repair. We included 295 patients who underwent MV repair for MVP with pre‐operatory two‐ and threedimensional transthoracic echocardiography (2DTTE and 3DTTE) and 6‐months (6M) and 3‐years (3Y) follow‐up 2DTTE. MVP was classified by 3DTTE as simple or complex and surgical procedures as simple or complex. Pre‐operative echo parameters were compared to post‐operative values at 6M and 3Y. Patients were divided into Group 1 (6M‐MR < 2) and Group 2 (6M‐MR ≥ 2), and predictors of MR  2 were investigated. MVP was simple in 178/295 pts, and 94% underwent simple procedures, while in only 42/117 (36%) of complex MVP a simple procedure was performed. A significant relation among prolapse anatomy, surgical procedures and residual MR was found. Postoperative MR ≥ 2 was present in 9.8%: complex MVP undergoing complex procedures had twice the percentage of MR ≥ 2 vs. simple MVP and simple procedures. MVP complexity resulted independent predictor of 6M‐MR ≥ 2. Favorable cardiac remodeling, initially found in all cases, was maintained only in MR < 2 at 3Y. Pre‐operative 3DTTE MVP morphology identifies pts undergoing simple or complex procedures predicting MR recurrence and favorable cardiac remodeling.

restrictedOct 2020View details →

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Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair

This record contains raw data related to the article "Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair" Abstract: Background: Mitral valve regurgitation (MR) is the most common valvular heart disease and current variables associated with MR recurrence are still controversial. We aim to develop a machine learning-based prognostic model to predict causes of mitral valve (MV) repair failure and MR recurrence. Methods: 1000 patients who underwent MV repair at our institution between 2008 and 2018 were enrolled. Patients were followed longitudinally for up to three years. Clinical and echocardiographic data were included in the analysis. Endpoints were MV repair surgical failure with consequent MV replacement or moderate/severe MR (>2+) recurrence at one-month and moderate/severe MR recurrence after three years. Results: 817 patients (DS1) had an echocardiographic examination at one-month while 295 (DS2) also had one at three years. Data were randomly divided into training (DS1: n = 654; DS2: n = 206) and validation (DS1: n = 164; DS2 n = 89) cohorts. For intra-operative or early MV repair failure assessment, the best area under the curve (AUC) was 0.75 and the complexity of mitral valve prolapse was the main predictor. In predicting moderate/severe recurrent MR at three years, the best AUC was 0.92 and residual MR at six months was the most important predictor. Conclusions: Machine learning algorithms may improve prognosis after MV repair procedure, thus improving indications for correct candidate selection for MV surgical repair.

restrictedJan 2022View details →

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ASSESSING RIGHT ATRIAL SIZE IN PATIENTS WITH TRICUSPID REGURGITATION: IMPORTANCE OF THE RIGHT VENTRICULAR-FOCUSED VIEW

AIMS: To assess the accuracy of measuring the right atrial volume (RAV) using two- dimensional echocardiography (2DE) in a right ventricular focused (RVF) view compared to the conventional apical 4-chamber (4Ch) view in patients with secondary tricuspid regurgitation (STR). We also compared the clinical correlates of the measures obtained using different methods. METHODS AND RESULTS: The accuracy of RAV measurements obtained from 2DE- 4Ch and RVF views in 384 patients with STR were compared using three-dimensional echocardiography (3DE) as a reference. We used the analysis of variance to test the differences among RAVs obtained from the different 2DE and 3DE acquisitions and the receiving operating characteristics (ROC) curves to evaluate the association with the composite endpoint of hospitalization for heart failure or death. Compared to 3DE, RAV was significantly more underestimated when measurements were obtained from 4Ch rather than RVF (-24% vs. -14%, respectively, p&lt;0.001 for both). RAV underestimation in 4Ch and RVF view was relatively larger in lower grades of STR (-28% vs. -17% in mild, -23% vs. -14% in moderate, and -19% vs. -11% in severe STR, p=0.001), and in the atrial compared to ventricular (-28% vs. -22%; p=0.002) STR. RAV measured by 3DE and RVF showed the highest area under the curve (AUC=0.67 for 3DE vs 0.64 for RVF, p=0.05), while 4Ch was significantly less related to the outcomes (AUC: 0.61, p=0.021 vs 3DE RAV). CONCLUSIONS. In patients with STR, the use of RVF view improved the accuracy of 2DE RAV measurement as compared to the conventional 4Ch-derived measurements.

restrictedcc-by-4.0Jul 2024View details →

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RNA sequencing of rodent myocardial tissue when subjected to mitral regurgitation (MR) for different time-points, compared to normal Sham tissue.

GEO Series GSE148559. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenNov 2020View details →

restrictedMar 2020View details →

Dataset related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation

This record contains raw data related to the article "Endothelial Dysfunction in Patients with Severe Mitral Regurgitation" Abstract: Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. It has been reported that MVP patients-candidates for mitral valve repair (MVRep)-showed an alteration in the antioxidant defense systems as well as in the L-arginine metabolic pathway. In this study, we investigate if oxidative stress and endothelial dysfunction are an MVP consequence or driving factors. Forty-five patients undergoing MVRep were evaluated before and 6 months post surgery and compared to 29 controls. Oxidized (GSSG) and reduced (GSH) forms of glutathione, and L-arginine metabolic pathway were analyzed using liquid chromatography-tandem mass spectrometry methods while osteoprotegerin (OPG) through the ELISA kit and circulating endothelial microparticles (EMP) by flow cytometry. Six-month post surgery, in MVP patients, the GSSG/GSH ratio decreased while symmetric and asymmetric dimethylarginines levels remained comparable to the baseline. Conversely, OPG levels significantly increased when compared to their baseline. Finally, pre-MVRep EMP levels were significantly higher in patients than in controls and did not change post surgery. Overall, these results highlight that MVRep completely restores the increased oxidative stress levels, as evidenced in MVP patients. Conversely, no amelioration of endothelial dysfunction was evidenced after surgery. Thus, therapies aimed to restore a proper endothelial function before and after surgical repair could benefit MVP patients

restrictedFeb 2022View details →

Putative Circulating MicroRNAs Are Able to Identify Patients with Mitral Valve Prolapse and Severe Regurgitation

This record contains raw data related to the article “Putative Circulating MicroRNAs Are Able to Identify Patients with Mitral Valve Prolapse and Severe Regurgitation”. Mitral valve prolapse (MVP) associated with severe mitral regurgitation is a debilitating disease with no pharmacological therapies available. MicroRNAs (miRNA) represent an emerging class of circulating biomarkers that have never been evaluated in MVP human plasma. Our aim was to identify a possible miRNA signature that is able to discriminate MVP patients from healthy subjects (CTRL) and to shed light on the putative altered molecular pathways in MVP. We evaluated a plasma miRNA profile using Human MicroRNA Card A followed by real-time PCR validations. In addition, to assess the discriminative power of selected miRNAs, we implemented a machine learning analysis. MiRNA profiling and validations revealed that miR-140-3p, 150-5p, 210-3p, 451a, and 487a-3p were significantly upregulated in MVP, while miR-223-3p, 323a-3p, 340-5p, and 361-5p were significantly downregulated in MVP compared to CTRL (p ≤ 0.01). Functional analysis identified several biological processes possible linked to MVP. In addition, machine learning analysis correctly classified MVP patients from CTRL with high accuracy (0.93) and an area under the receiving operator characteristic curve (AUC) of 0.97. To the best of our knowledge, this is the first study performed on human plasma, showing a strong association between miRNAs and MVP. Thus, a circulating molecular signature could be used as a first-line, fast, and cheap screening tool for MVP identification.

restrictedJan 2023View details →

Partial dataset related to the article "Prognostic Impact of Extra–Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation"

This record contains partial raw data related to the article "Prognostic Impact of Extra–Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation" OBJECTIVES The aim of this study was to evaluate the prognostic impact of the presence of extra–mitral valve cardiac involvement (including known risk factors but also severe left atrial [LA] dilatation and right ventricular [RV] dysfunction) in a large multicenter study of patients with primary mitral regurgitation (MR). BACKGROUND In patients with severe primary MR, the indication for surgery is currently based on the presence of symptoms, left ventricular dilatation and dysfunction, atrial fibrillation, and pulmonary hypertension. METHODS Patients with severe primary MR undergoing surgery were included and categorized according to the extent (highest) of cardiac involvement: group 0, no cardiac involvement; group 1, left ventricular involvement; group 2, LA involvement; group 3, pulmonary vasculature or tricuspid valve involvement; or group 4, RV involvement. The outcome was all-cause mortality. RESULTS A total of 1,106 patients were included (mean age 63 12 years, 68% male). In total, 377 patients (34%) were classified in group 0, 239 (22%) in group 1, 213 (19%) in group 2, 180 (16%) in group 3, and 97 (9%) in group 4. Kaplan-Meier curve analysis revealed significantly worse survival (log-rank chi-square ¼ 43.4; P < 0.001) with higher group. On multivariable analysis, age, male sex, chronic obstructive pulmonary disease, kidney function, and group of cardiac involvement were independently associated with all-cause mortality. For each increase in group, a 17% higher risk for all-cause mortality was observed (95% CI: 1.051-1.313; P ¼ 0.005) during a median follow-up time of 88 months. CONCLUSIONS In patients with severe primary MR, a novel classification system based on extra–mitral valve cardiac involvement may help refine risk stratification and timing of surgery, particularly including severe LA dilatation and RV dysfunction in the assessment.