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Distribution. Currently known from three sets of cranial remains found in New Zealand, Chatham, and Juan Fernandez Is and a single stranding consisting of an adult female and ajuvenile male found in New Zealand. It is not known how these records reflect the actual distribution of this species. in Ziphiidae

Distribution. Currently known from three sets of cranial remains found in New Zealand, Chatham, and Juan Fernandez Is and a single stranding consisting of an adult female and ajuvenile male found in New Zealand. It is not known how these records reflect the actual distribution of this species.

Distribution. Poorly known, but it appears to be restricted to cooler waters of the Southern Hemisphere between 32° S and the Antarctic convergence; it has been recorded stranding in New Zealand, Australia, Tristan da Cunha, and Tierra del Fuego. Its distribution may be circumpolar, but it is also possible that there is a gap in its distribution between the Chatham Is and South America. in Ziphiidae

Distribution. Poorly known, but it appears to be restricted to cooler waters of the Southern Hemisphere between 32° S and the Antarctic convergence; it has been recorded stranding in New Zealand, Australia, Tristan da Cunha, and Tierra del Fuego. Its distribution may be circumpolar, but it is also possible that there is a gap in its distribution between the Chatham Is and South America.

Distribution. Warmer waters ofthe Pacific and Indian oceans in an area ranging from E Africa, S India and Sri Lanka to Galapagos Is, and possibly as far as Central and South America. Exact distribution remains unclear due to the small number of known strandings, and the taxonomic confusion between the Deraniyagala's Beaked Whale and the Ginkgo-toothed Beaked Whale (M. ginkgodens). in Ziphiidae

Distribution. Warmer waters ofthe Pacific and Indian oceans in an area ranging from E Africa, S India and Sri Lanka to Galapagos Is, and possibly as far as Central and South America. Exact distribution remains unclear due to the small number of known strandings, and the taxonomic confusion between the Deraniyagala's Beaked Whale and the Ginkgo-toothed Beaked Whale (M. ginkgodens).

Distribution. Most records come from either New Zealand or the Atlantic coast of South America, but also recorded in Tasmania, Western Australia, and South Africa; distribution remains unclear due to the small number of confirmed strandings. There are no records of this species between New Zealand and the Pacific coast of South America, but it is unclear whether this represents a break in distribution or a lack of research activity in this region. Earlier records from the Pacific coast of USA have since been reclassified as Perrin's Beaked Whale (M. perrini). in Ziphiidae

Distribution. Most records come from either New Zealand or the Atlantic coast of South America, but also recorded in Tasmania, Western Australia, and South Africa; distribution remains unclear due to the small number of confirmed strandings. There are no records of this species between New Zealand and the Pacific coast of South America, but it is unclear whether this represents a break in distribution or a lack of research activity in this region. Earlier records from the Pacific coast of USA have since been reclassified as Perrin's Beaked Whale (M. perrini).

Distribution. Ranges from temperate waters of the S Atlantic, Indian, and S Pacific oceans to waters of Antarctica. A single specimen stranded on the Dutch coast is thought to have been a vagrant individual. in Ziphiidae

Distribution. Ranges from temperate waters of the S Atlantic, Indian, and S Pacific oceans to waters of Antarctica. A single specimen stranded on the Dutch coast is thought to have been a vagrant individual.

Distribution. It is known from a handful of strandings on California coast in W USA, and one possible sighting at sea, also off California; it is not known how reflective these records are of the actual distribution of the species at sea. in Ziphiidae

Distribution. It is known from a handful of strandings on California coast in W USA, and one possible sighting at sea, also off California; it is not known how reflective these records are of the actual distribution of the species at sea.

Distribution. Warmer waters ofthe Pacific and Indian oceans in an area ranging from S India and Sri Lanka to Taiwan, Japan, SE Australia, Galapagos Is, and California. Exact distribution remains unclear due to the small number of known strandings, and the taxonomic confusion between the Ginkgo-toothed Beaked Whale and the Deraniyagala's Beaked Whale (Mesoplodonhotaula). in Ziphiidae

Distribution. Warmer waters ofthe Pacific and Indian oceans in an area ranging from S India and Sri Lanka to Taiwan, Japan, SE Australia, Galapagos Is, and California. Exact distribution remains unclear due to the small number of known strandings, and the taxonomic confusion between the Ginkgo-toothed Beaked Whale and the Deraniyagala's Beaked Whale (Mesoplodonhotaula).

opencc-by-4.0Mar 2021View details →

Gene expression and splicing counts from the Yepez, Gusic et al study - strand-specific

File description: <ol> <li> geneCounts: gene-level counts  </li> <li> k_j: split counts spanning from one exon to another. </li> <li> k_theta: non-split counts covering a splice site </li> <li> n_psi3: total split counts from a given acceptor site </li> <li> n_psi5: total split counts from a given donor site </li> <li> n_theta: total split and non-split counts for a given splice site </li> <li> Sample annotation describing each sample from the dataset </li> <li> Description file with global information from the dataset </li> </ol>   The gene counts were originated using the GTF file from release 34 of GENCODE <a href="https://www.gencodegenes.org/human/release_34">https://www.gencodegenes.org/human/release_34</a>, and the split and non-split counts contain only the annotated junctions from the same release. Use: The count matrices are intended to help researchers that are interested in using RNA-Seq data with the purpose of diagnostics. Researchers can merge their own dataset with the downloaded ones, provided the tissue, genome build, strand, and paired-end specifications match. Afterwards, DROP can be used to compute expression and splicing outliers (<a href="https://github.com/gagneurlab/drop">https://github.com/gagneurlab/drop</a>). Number of samples: 269 Tissue: Fibroblast Organism: Homo sapiens Genome assembly: hg19 Gene annotation: gencode34 Disease (ICD-10: N): E72: 4, E75: 2, E77: 1, E88: 199, F82: 1, F89: 7, G31: 14, G40: 2, G71: 3, G82: 1, G93: 2, I42: 1, K72: 4, NONE: 18, P94: 2, Q02: 1, Q78: 1, R16: 2, R27: 3, R29: 1 Strand specific: TRUE Paired end: TRUE Protocol: poly(A) enrichment Dataset contact: Vicente Yepez, yepez@in.tum.de; Julien Gagneur, gagneur@in.tum.de; Holger Prokisch, prokisch@helmholtz-muenchen.de Citation: Cite both the resource using Zenodo's citation and the publication under References

dryad32/100

Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level

Single-stranded breaks (SSBs) are the most frequent DNA lesions threatening genomic integrity. A highly kinked DNA structure in complex with human PARP-1 domains led to the proposal that SSB sensing in Eukaryotes relies on dynamics of both the broken DNA double helix and PARP-1's multi-domain organization. Here, we directly probe this fundamental yet poorly understood process at the single-molecule level. Quantitative smFRET and structural ensemble calculations reveal how PARP-1's N-terminal zinc fingers convert DNA SSBs from a largely unperturbed conformation, via an intermediate state into the highly kinked DNA conformation. Our data suggest an induced fit mechanism via a multi-domain assembly cascade that drives SSB sensing and stimulates an interplay with the scaffold protein XRCC1 orchestrating subsequent DNA repair events. Interestingly, a clinically used PARP-1 inhibitor Niraparib shifts the equilibrium towards the unkinked DNA conformation, whereas the inhibitor EB47 stabilizes the kinked state.

opencc-zeroOct 2022View details →

opencc-zeroJun 2020View details →

Figuren am Strand

Sculpture "Figures on the beach" by Oskar Bottoli from 1964. Source: Objaverse 1.0 / Sketchfab

opennotspecifiedAug 2017View details →

FIGURES 1–12 in A new Oreonetides Strand, 1901 from the Russian Far East (Araneae, Linyphiidae)

FIGURES 1–12. Oreonetides minimus new species, male and female paratypes from Timiryazevsky (1–10); O. beringianus Eskov, 1991 after Eskov (1991) (11); O. badzhalensis Eskov, 1991, specimen from Bureya River Valley (12). 1, Right palp, retrolateral view. 2, Paracymbium. 3, Embolic division. 4, 5, Lamella characteristica. 6–8, Embolus, different aspects. 9, Epigynum, ventral view. 10, 11, Epigynum, dorsal view. 12, Sketch of epigynum, dorsolateral view. Scale bars, 0.05 mm.

FIGURES 6A–F in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 6A–F. Synagelides tangi sp. nov. A. Male palp, ventral view. B. Dorsolateral view. C. Prolateral view. D. Retrolateral view. E. Epigyne, ventral view. F. Dorsal view (black arrow shows the small C-shaped sclerotized epigynal loop). Abbreviations: CD, copulatory duct; CO, copulatory opening; Em, embolus; FD, fertilization ducts; GD, glandular duct; HTA, hook-shaped tibial apophysis; MA, median apophysis; PA, posterior cymbial apophysis; Spm, spermatheca. TCA, thumb-like cymbial apophysis. Scale bars: A−D, 0.2 mm; E–F, 0.1 mm.

FIGURES 2A−B in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 2A−B. Synagelides jinggangshanensis sp. nov., female holotype. A. Epigyne, ventral view. B. Dorsal view (black arrows show the strongly enlarged median-posterior part of epigynal loop). Abbreviations: CD, copulatory duct; CO, copulatory opening; FD, fertilization duct; GD, glandular duct; Spm, spermatheca. Scale bars: A, B, 0.1 mm.

FIGURES 7A−D in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 7A−D. Synagelides yinae sp. nov., female holotype. A. Dorsal view. B. Ventral view. C. Epigyne, ventral view. D. Dorsal view. Scale bars: A, B, 1 mm; C, D, 0.1 mm.

FIGURES 5A–G in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 5A–G. Synagelides tangi sp. nov., SEM images of male holotype. A. Dorsal view. B. Chelicera, retrolateral view. C. Palp, prolateral view. D. Same, ventrolateral view. E. Same, dorsal view. F. Same, dorsolateral view. G. Same, retrolateral view. Abbreviations: Em, embolus; HTA, hook-shaped tibial apophysis; MA, median apophysis; PA, posterior cymbial apophysis; PT, promarginal teeth; RT, retromarginal teeth; TCA, thumb-like cymbial apophysis. Scale bars: A, 0.2 mm; B, 20 um; C−G, 0.1 mm.

FIGURES 4A–D in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 4A–D. Synagelides tangi sp. nov., female paratype. A. Dorsal view. B. Ventral view. C. Epigyne, ventral view. D. Dorsal (black arrows show the small C-shaped sclerotized epigynal loop. Scale bars: A, B, 1 mm; C, D, 0.1 mm.

FIGURES 3A–F in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 3A–F. Synagelides tangi sp. nov., male holotype. A. Dorsal view. B. Ventral view. C. Palp, prolateral view. D. Same, dorso-prolateral view. E. Same, ventral view. F. Same, retrolateral view. Scale bars: A, B, 1 mm; C−F, 0.2 mm.

FIGURE 9 in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURE 9. Records of Synagelides jinggangensis sp. nov., S. tangi sp. nov. and S. yinae sp. nov. in Jinggangshan National Natural Reserve, Jiangxi province, China.

FIGURES 1A−D in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 1A−D. Synagelides jinggangshanensis sp. nov., female holotype. A. Dorsal view. B. Ventral view. C. Epigyne, ventral view. D. Dorsal view (black arrows show the strongly enlarged median-posterior part of epigynal loop). Scale bars: A, B, 1 mm; C, D, 0.1 mm.

FIGURES 8A−B in Three new species of Synagelides Strand, 1906 from China (Araneae: Salticidae)

FIGURES 8A−B. Synagelides yinae sp. nov., female holotype. A. Epigyne, ventral view. B. Dorsal view. Abbreviations: CD, copulatory duct; CO, copulatory opening; FD, fertilization ducts; GD, glandular duct; Spm, spermatheca. Scale bars: A, B, 0.1 mm.