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4,008 results for “Heart failure”
Dataset related to the article "S-Thiolation targets albumin in heart failure"
<p>This record contains raw data related to the article "S-Thiolation targets albumin in heart failure"</p> <p><strong>Abstract. </strong>Human serum albumin (HSA) is associated with several physiological functions, such as maintaining oncotic pressure and microvascular integrity, among others. It also represents the major and predominant antioxidant in plasma due to the presence of the Cys34 sulfhydryl group. In this study we assessed qualitative and quantitative changes in HSA in patients with heart failure (HF) and their relationship with the severity of the disease. We detected by means of mass spectrometry a global decrease of HSA content in the plasma of HF patients in respect to control subjects, a significant increase of thio-HSA with a concomitant decrease in the reduced form of albumin. Cysteine and, at lesser extent homocysteine, represent the most abundant thiol bound to HSA. A strong inverse correlation was also observed between cysteine-HSA and peak VO<sub>2</sub>/Kg, an index of oxygen consumption associated with HF severity. Moreover, in HL-1 cardiomyocytes incubated with H<sub>2</sub>O<sub>2</sub>, we showed a significant decrease of cell viability in cells treated with thio-HSA in respect to restored native-HSA. In conclusion, we found for the first time that S-thiolation of albumin is increased in the plasma of HF patients and induced changes in the structure and antioxidant function of HSA, likely contributing to HF progression.</p>
A matter of sex: persistent predictive value of MECKI score prognostic power in females and males with heart failure and reduced ejection fraction. A multicenter study.
<p>Abstract</p> <p><strong><span>Background:</span></strong><span> A sex-based evaluation of prognosis in heart failure (HF) is lacking.<span> </span></span></p> <p><strong><span>Methods and results: </span></strong><span>We analyzed the MECKI score registry which includes HF with reduced ejection fraction (HFrEF) patients. A cross-validation procedure was performed to estimate weights separately for males and females of all MECKI score parameters: left ventricular ejection fraction (LVEF), hemoglobin, kidney function assessed by MDRD, blood sodium level, ventilation vs. carbon dioxide<sub> </sub>production slope, and peak oxygen consumption (peakVO<sub>2</sub>). The primary outcomes were the composite of all-cause mortality, urgent heart transplant and LVAD implant. </span><span>The difference in predictive ability between the native and sex re-calibrated MECKI (S-MECKI) was calculated with the ROC curve at 2-years and a calibration plot.</span></p> <p><span>We retrospectively analyzed 7900 HFrEF patients included in the MECKI score registry (61±13 years, 6456 M/ 1444 F, LVEF 33±10 %, peakVO<sub>2</sub> </span><span>56.2±17.6 % of predicted</span><span>) with a median follow up of 4.05 years [1.72-7.47]. Our results revealed an unadjusted risk of events doubled in males compared to females (9.7 vs. 4.1) and a significant difference in weight between sexes of most of the parameters included in the MECKI score. S-MECKI showed improved risk classification and accuracy (AUC</span><span> 0.7893 vs. 0.7799, p=0.02 due to prognostication improvement </span><span>in the high-risk settings in both sexes (MECKI score >10 in males and >5 in females).</span></p> <p><strong><span>Conclusions: </span></strong><span>S-MECKI,<strong> </strong>i.e. the re-calibrated MECKI according to sex-specific differences,</span><span> constitutes a further step in the prognostic assessment of patients with severe HFrEF.</span></p>
Comparing Sarcopenia , Physical, Psychological and Social Frailty in Hospitalized Older Women Congestive Heart Failure in Metropolitan and Rural Settings
ClinicalTrials.gov study NCT07100366. IPD Sharing: NO. Countries: 0. Publications: 0.
Ultrasound-guided Treatment in Acute Heart Failure
ClinicalTrials.gov study NCT06181968. IPD Sharing: NO. Countries: 0. Publications: 0.
3-Month Home-based Training With Whole Body Vibration (WBV) Device in Patients With Heart Failure and Preserved Ejection Fraction (GALILEO-HFpEF-HOME) (GALILEOHOME)
ClinicalTrials.gov study NCT04239807. IPD Sharing: NO. Countries: 0. Publications: 0.
Reverse Remodeling Effects of CDR132L in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Cardiac Hypertrophy
ClinicalTrials.gov study NCT05953831. IPD Sharing: NO. Countries: 0. Publications: 0.
Heart Failure Center Accreditation in China (HF-CAP Trial)
ClinicalTrials.gov study NCT07371780. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Monitor Patients With Acute Heart Failure
ClinicalTrials.gov study NCT00919828. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Value of SGLT2 Inhibitor (Dapagliflozin) as an Added Therapy in Diabetic Patients With Heart Failure With Reduced Ejection Fraction; Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT04304560. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass (CPB Pump or Heart L
ClinicalTrials.gov study NCT00530361. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF)
ClinicalTrials.gov study NCT06097481. IPD Sharing: NO. Countries: 0. Publications: 0.
Effects of Phototherapy Associated to Exercise-based Rehabilitation Program in Heart Failure
ClinicalTrials.gov study NCT03119844. IPD Sharing: NO. Countries: 0. Publications: 0.
Investigating the Role of Impella 2.5 System in Acutely Decompensated Chronic Heart Failure Patients
ClinicalTrials.gov study NCT01185691. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Safety of Aerobic Exercise in Acute Heart Failure
ClinicalTrials.gov study NCT02782572. IPD Sharing: NO. Countries: 0. Publications: 0.
Effects of a 20-Minute Mindfulness-Based Breathing Exercise on Dyspnea, Fatigue, and Sleep Quality in Patients With Heart Failure
ClinicalTrials.gov study NCT07046091. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Effect of Nurse-assessed Remote Ischemic Preconditioning on Improving Exercise Capacity, Endothelial Function, and Arterial Stiffness in Patients With Heart Failure With Preserved Ejection Fraction
ClinicalTrials.gov study NCT07024810. IPD Sharing: YES. Countries: 0. Publications: 0.
Growth Hormone and Heart Failure
ClinicalTrials.gov study NCT00190359. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Study to Evaluate the Clinical Epidemiology of Patients With Heart Failure (HF) in India
ClinicalTrials.gov study NCT02047526. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of a Self-regulation Program on Self-care Behaviour of Heart Failure Patients
ClinicalTrials.gov study NCT04228120. IPD Sharing: NO. Countries: 0. Publications: 0.
Training Study to Evaluate the Benefit of Exercise for Patients With Chronic Heart Failure
ClinicalTrials.gov study NCT00934609. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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