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16,682 results for “Lung.”
Figure 10 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 10 Normalize of transform of A. ZSM-5 Carrier only; B. Free GEF, and C. GEF-ZSM-5 loaded prepared by kneading method (ratio 1:1).
Figure 7 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 7 Drug release profile of free GEF and GEF from the loaded NPs for 60 min, phosphate buffer pH 6.8, apparatus II (paddle), 50 rpm, and 37 °C.
Figure 11 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 11 Control migration testing Treatment of A-549 cells with: Half-Maximal Inhibitory Concentration (IC50), IC50, 2 IC50, Double-Maximal.
Figure 8 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 8 Drug release profile of free GEF and GEF from the loaded NPs for 12 hr, phosphate buffer pH 6.8, apparatus II(paddle), 50 rpm, and 37 °C.
Figure 12 from: Al-Sahlawi F, Al-Ani I, El-Tanani M, Farooq HA (2024) Preparation and evaluation of biological activity of ZSM-5 nanoparticles loaded with gefitinib for the treatment of non-small cell lung carcinoma. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e112449
Figure 12 Colony test of untreated A-549 cells in a control. utilizing free gefitinib and ZSM- 5-gefitinib-loaded utilizing kneading technique 1:1 w/w, 12 IC50 stands for half dosage of the half maximum inhibitory concentration, IC50 for the half maximum inhibitory concentration, and 2 IC50 for double dose of the half maximum inhibitory concentration. Comparisons between each dosage and the control were made. The findings were shown as mean SD. The signs for statistical significance were *P 0.05, **P 0.01, and ***P 0.001.
Figure 1 from: Zlatanova T, Arabadjiev J (2024) The prognostic role of markers of systemic inflammation in patients with metastatic lung cancer receiving immunotherapy: A comprehensive review of the literature. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e115558
Figure 1 Biological Hallmarks of Cancer, Source: Adapted from Hallmarks of Cancer: The Next Generation, Hanahan D., Weinberg R.A. , Cell, Volume 144, ISSUE 5, P646-674, March 04, 2011, https://doi.org/10.1016/j.cell.2011.02.013.
DIFFERENTIAL EXPRESS DIAGNOSIS OF ECHINOCOCCOSIS AND PECILOMYCOSIS OF THE LUNGS
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Lung CT Path2
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NLSTseg: A Pixel-level Lung Cancer Dataset Based on NLST LDCT Images
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Data from: Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p
<p>Circular RNAs (circRNAs) participate in the occurrence and progression of many cancers. CircRNA ataxin 7 (circATXN7) (circBase ID: hsa_circ_0066436) plays a promoting influence on gastric cancer progression. However, the biological role of circATXN7 in non-small cell lung cancer (NSCLC) is indistinct. CircATXN7 and PFN2 were highly expressed in NSCLC, whereas miR-7-5p expression had the opposite trend. CircATXN7 overexpression constrained apoptosis and promoted proliferation, metastasis, invasion, and epithelial-mesenchymal transition (EMT) of NSCLC cells, but circATXN7 silencing played the opposing influence and repressed xenograft tumor growth <i>in vivo</i>. CircATXN7 served as a miR-7-5p sponge, and circATXN7 regulated malignant behaviors of NSCLC cells through sponging miR-7-5p. PFN2 acted as a miR-7-5p target. PFN2 silencing overturned the promoting effect of miR-7-5p inhibitor on NSCLC cell malignancy, while PFN2 overexpression reversed the inhibitory impact of miR-7-5p mimic on NSCLC cell malignancy. CircATXN7 accelerated the malignancy of NSCLC cells through adsorbing miR-7-5p and upregulating PFN2, offering evidence to support circATXN7 as a might target for NSCLC treatment.</p>
Berberine protects against sepsis-related acute lung injury in rats via the upregulation of the PPAR - Υ signaling pathway, with amelioration at the cellular level - A functional, immune-histological and biochemical study
<p>Aim: To assess the therapeutic effects of berberine in experimentally induced lung sepsis. Examining its effects on selected cytokines, gene and protein expression and the histopathological findings.</p> <p>Results: Berberine significantly reduced the wet/dry lung ratio, the BALF protein, cell, and neutrophils percentage & the BALF cytokines levels. In addition, pretreatment with berberine decreases the myeloperoxidase and MDA levels and decreases gene expression of NFKB, MCP -1 and the ICAM - 1 by RT - PCR analysis. Thus, suggesting an antioxidant and anti-inflammatory mode of the action. Western blot analysis revealed increased PPAR – Υ expression in the berberine pretreated group compared to the CLP group. Histopathological examination revealed improved histopathological parameters, in the berberine pretreated group, compared to the CLP group.</p> <p>Conclusion: Berberine improves the outcome in sepsis via antioxidant and anti-inflammatory effects, modulation of cytokine levels, upregulation of PPAR - Υ protein expression, and histopathological amelioration.</p>
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 04
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 04 contains a stitched image montage of the first and of the last semithin section from the analysis of patient C06, which was acquired by bright-field light microscopy.</p>
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 16
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 16 contains stitched image montages of a thin section through the lung of patient C06 which were acquired by scanning electron microscopy. The file “Data_set_16.tif” contains a montage of the entire thin section while the other files contain selected areas of the section recorded at higher resolution.</p>
Role of Point-of-care lung ultrasound in neonatal lung diseases: a review of current evidences
<p>Point-of-care Lung ultrasound (POC-LUS) as the most widely used POCUS which already developed the guidelines has been applied to diagnosis and differential diagnosis neonatal respiratory distress in NICU for many years</p>
Targeted gene expression profiling of human myeloid cells from blood and lung compartments of patients with Tuberculosis and other lung diseases
<p>This dataset comprises expression profiles of 43 genes related to MSDC functioning and 5 reference genes in 8 blood samples and 8 brochio-alveolar lavage fluid (BALF) samples from TB patients. Also included are results from blood and BALF of 2 'other lung disease' patients each.</p>
RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
<p><span>Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity <em>in vitro</em>, and is upregulated in asymptomatic patients during early IAV infection. We therefore hypothesized that FGF9 would protect the lungs from respiratory virus infection and evaluated IAV pathogenesis in mice that overexpress FGF9 in club cells in the conducting airway epithelium (FGF9-OE mice). However, we found that FGF9-OE mice were highly susceptible to IAV and Sendai virus infection compared to control mice. FGF9-OE mice displayed elevated and persistent viral loads, increased expression of cytokines and chemokines, and increased numbers of infiltrating immune cells as early as 1 day post-infection (dpi). Gene expression analysis showed an elevated type I interferon (IFN) signature in the conducting airway epithelium and analysis of IAV tropism uncovered a dramatic shift in infection from the conducting airway epithelium to the alveolar epithelium in FGF9-OE lungs. These results demonstrate that FGF9 signaling primes the conducting airway epithelium to rapidly induce a localized, protective IFN and proinflammatory cytokine response during viral infection. Although this response protects the airway epithelial cells from IAV infection, it allows for early and enhanced infection of the alveolar epithelium, ultimately leading to increased morbidity and mortality. Our study illuminates a novel role for FGF9 in regulating respiratory virus infection and pathogenesis.</span></p>
Single-Cell ALRA-imputed Rat Lung Data
<p>ALRA-imputed Rat Lung Data from Raredon 2019 (10.1126/sciadv.aaw3851) </p>
Dataset from: Lung evolution in vertebrates and the water-to-land transition
<p><span>A </span><span>crucial evolutionary change</span> <span>in vertebrate history was the Palaeozoic (Devonian ~400 million years</span><span> ago</span><span>) water-to-land transition, allowed by key morphological and physiological modifications including the acquisition of lungs. Nonetheless, the origin and early evolution of vertebrate lungs remain highly controversial, particularly whether the ancestral state was paired or unpaired. Due to the rarity of fossil soft tissue preservation, lung evolution can only be traced based on the extant phylogenetic bracket.<strong> </strong>Here we investigate, for the first time, lung morphology in extensive developmental series of key living lunged osteichthyans using synchrotron X-ray microtomography and histology. Our results shed light on the primitive state of vertebrate lungs as unpaired, evolving to be truly paired in the lineage towards the tetrapods. The water-to-land transition confronted</span> <span>profound physiological </span><span>challenges and paired lungs were decisive </span><span>for increasing</span> <span>the surface area and the pulmonary compliance and volume, especially during the air-breathing on land. </span></p>
TotalSegmentator weights - Task 258 - lung vessels
<p>nnU-Net weights for TotalSegmentator lung vessels model (Task 258). See <a href="https://github.com/wasserth/TotalSegmentator">https://github.com/wasserth/TotalSegmentator</a> for more details.</p>
Supplementary material 2 from: Chen R, Shen T, Tsai K, Hu C (2016) Pericardial window operation for malignant pericardial effusion may have worse outcomes for lung cancer than the other cancers. Research Ideas and Outcomes 2: e8758. https://doi.org/10.3897/rio.2.e8758
Stata/MP 13.1 program *.do (including self-made macros (sharable upon request))
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.