Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
6,335
datasets available to search
ShareScore release 0.9.0
Dataset results
6,335 results for “direct”
A Transcription Factor Atlas of Directed Differentiation [10XscRNA_180124_perturb]
GEO Series GSE216595. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing; Other.
SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and interacts directly with mRNAs to impair host stress response (iCLIP-Seq)
GEO Series GSE171008. Homo sapiens. 18 samples. Type: Other.
Direct conversion of mouse fibroblasts into cholangiocyte progenitor cells
GEO Series GSE97507. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Breaking the lineage barrier: Direct induction of trophoblast stem cells from murine fibroblasts
GEO Series GSE64339. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease [T cells]
GEO Series GSE184875. Homo sapiens. 37 samples. Type: Expression profiling by high throughput sequencing.
RNA-directed DNA Methylation is associated with gene expression via chromosomal Interactions
GEO Series GSE64389. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
GEO Series GSE242757. Homo sapiens. 1545 samples. Type: Other; Expression profiling by high throughput sequencing.
Genome-wide analyses of direct target genes of four rice NAC-domain transcription factors involved in drought tolerance [RNA-seq]
GEO Series GSE102919. Oryza sativa. 10 samples. Type: Expression profiling by high throughput sequencing.
Direct control of SPEECHLESS by PIF4 in the high temperature response of stomatal development
GEO Series GSE110302. Arabidopsis thaliana. 16 samples. Type: Expression profiling by high throughput sequencing.
Interplay between calcium cycling and sarcomeres directs cardiomyocyte redifferentiation and maturation during regeneration
GEO Series GSE224156. Danio rerio; Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Innate sensor Dhx9 directly binds to multiple genes related to effector CD8 T cell differentiation [ChIP-Seq]
GEO Series GSE161694. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Calibrated CAR activation potential directs alternative T cell fates and therapeutic potency
GEO Series GSE121226. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Epitope mapping of 4 monoclonal antibodies directed against Neisserial Heparin Binding Antigen by peptide microarray
GEO Series GSE98882. Neisseria meningitidis serogroup B; Homo sapiens. 4 samples. Type: Protein profiling by protein array.
MicroRNA-221 promotes cell proliferation and inhibit apoptosis in osteosarcoma cells via directly targeting FBXW11 and regulating the Wnt signaling
<p><strong>Figure 1.</strong> miR-221 expression is significantly high in human clinical tissues and cell lines of OS. The expression levels of miR-221 in 30 pairs of OS tissues and their adjacent, non-cancerous normal bone tissues (Normal) (A) and the human osteoblastic cell line hFOB 1.19 and OS cell lines (B) are detected by qRT-PCR. U6 is used as the internal control. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 2. </strong>Attenuating miR-221 expression inhibits OS cell proliferation and increase apoptosis. MiR-221 inhibitor is transfected into MG-63-A16 (A) or U2OS cells (B) and induces an obviously lower proliferation rate compared with that in control groups. Further, miR-221 inhibitor is transfected into MG-63-A16 (C) and U2OS cells (D) and triggers a significantly higher apoptosis than controls. And that, the significantly down-regulated Ki67 expression in MG-63-A16 (E) and U2OS cells (F) were observed compared with that in the controls. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 3. </strong>FBXW11 can directly target to miR-221. (A) An potential target of miR-221, called as FBXW11 has been predicted by bioinformatics-based target prediction analysis, and the binding site is on the 3’UTR of FBXW11. (B) RT-PCR analysis of FBXW11 expression in the OS tumor tissues and noncancerous counterparts. (C) The obviously down-regulated expression levels of FBXW11 mRNA are observed in OS cell lines compared with those in hFOB 1.19 cells. (D) A negative Spearman’s correlation between miR-221 and FBXW11 mRNA levels was observed in 30 OS tumor tissues. (E) The significantly decreased luciferase activity driven by 3’UTR of FBXW11 is observed in the miR-211 mimic group and the 3’UTR-MUT group and negative control are as control. (F) The down-regulation of miR-221 induces a dramatic overexpression of FBXW11 protein. (G) A distinctly lower cell proliferation rate is observed in the group of pcDNA-FBXW11 compared with control. (H) An obviously higher apoptosis is observed in the group of pcDNA-FBXW11 than control. (I) The significantly decreased Ki67 expression is detected in the pcDNA-FBXW11 group than control. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 4.</strong> miR-221 and FBXW11 regulate cell proliferation and apoptosis in OS through inhibiting Wnt signaling. (A) The markedly down-regulated expression levels of β-catenin, cyclin D1 and c-myc were detected in the group of miR-221 inhibitor compared with controls. (B) The obviously decreased expression levels of β-catenin, cyclin D1 and c-myc were determined in the pcDNA-FBXW11 group compared with controls. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 5. </strong>The effect of Wnt signaling on the cell proliferation and apoptosis of OS cell lines. A distinctly lower cell proliferation rate (A and B) and an obviously higher apoptosis rate (C and D) were detected in the Wnt1 siRNA groups (siRNA1, siRNA2) than si-control, and similar results were observed in the CGP049090 group. (E and F) The obviously decreased Ki67 expression were detected in the Wnt1 siRNA groups compared with si-control, and similar results were observed in the CGP049090 group. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p>
DATA: A thalamic reticular circuit for head direction cell tuning and spatial navigation
<p>As we navigate in space, external landmarks and internal information guide our movement. Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals remain, however, unclear. We identify an excitatory synaptic projection from the presubiculum (PreS) and the multisensory-associative retrosplenial cortex (RSC) to the anterodorsal thalamic reticular nucleus (TRN), so far classically implied in gating sensory information flow. <em>In vitro</em>, projections to TRN involve AMPA/NMDA-type glutamate receptors that initiate TRN cell burst discharge and feedforward inhibition of anterior thalamic nuclei. <em>In vivo</em>, chemogenetic anterodorsal TRN inhibition modulates PreS/RSC-induced anterior thalamic firing dynamics, broadens the tuning of thalamic HD cells, and lead to preferential use of allo- over egocentric search strategies in the Morris water maze. TRN-dependent thalamic inhibition is thus an integral part of limbic navigational circuits wherein it coordinates external sensory and internal HD signals to regulate the choice of search strategies during spatial navigation.</p>
Data - A floating optical buoy (FOBY) for direct measurements of water-leaving radiance based on the skylight-blocked approach (SBA): An experiment in Honghu Lake, China
<p>Datd for A floating optical buoy (FOBY) for direct measurements of water-leaving radiance based on the skylight-blocked approach (SBA): An experiment in Honghu Lake, China</p>
Artifact for the ICSME 2020 Paper - ifdef Directives and Program Comprehension The Dilemma between Correctness and Preference
<p>Repository of the Replication Package (data.zip) for the Manuscript “#ifdef Directives and Program Comprehension: A Study on Performance versus Perception” by Wolfram Fenske, Jacob Krüger, Maria Kanyshkova, and Sandro Schulze, accepted at ICSME 2020.</p>
A comparative study of the effect of Electroconvulsive therapy and Transcranial direct current stimulation in the treatment of persons suffering from treatment-resistant depression
<p>This study sought to compare the effectiveness of electroconvulsive therapy and transcranial direct current stimulation in the treament of Treatment-resistant depression.</p>
Direct and indirect effects of environmental factors, spatial constraints, and functional traits on shaping the plant diversity of montane forests
Understanding the relative importance of the factors driving the patterns of biodiversity is a key research topic in community ecology and biogeography. However, the main drivers of plant species diversity in montane forests are still not clear. In addition, most existing studies make no distinction between direct and indirect effects of environmental factors, spatial constraints on plant biodiversity. Using data from 107 montane forest plots in Sichuan Giant Panda habitat, China, we quantified the direct and indirect effects of abiotic environmental factors, spatial constraints, and plant functional traits on plant community diversity. Our results showed significant correlations between abiotic environmental factors and trees (r = 0.10, P value = 0.001), shrubs (r = 0.19, P value = 0.001), or overall plant diversity (r = 0.18, P value = 0.001) in montane forests. Spatial constraints also showed significant correlations with trees, and shrubs. However, no significant correlations were found between functional traits and plant community diversity. Moreover, the diversity (richness and abundance) of shrubs, trees, and plant communities was directly affected by precipitation, latitude, and altitude. Mean annual temperature (MAT) had no direct effect on the richness of tree and plant communities. Further, MAT and precipitation indirectly affected plant communities via the tree canopy. The results revealed a stronger direct effect on montane plant diversity than indirect effect, suggesting that single-species models may be adequate for forecasting the impacts of climate factors in these communities. The shifting of tree canopy coverage might be a potential indicator for trends of plant diversity under climate change.
Data from: Non-rhythmic head-direction cells in the parahippocampal region are not constrained by attractor network dynamics
Computational models postulate that HD cells are part of an attractor network integrating angular head turns. This network requires inputs from visual landmarks to anchor the HD signal to the external world. We investigated whether information about HD and visual landmarks is integrated in the medial entorhinal cortex and parasubiculum, resulting in neurons expressing a conjunctive code for HD and visual landmarks. We found that parahippocampal HD cells could be divided into two classes based on their theta-rhythmic activity: non-rhythmic and theta-rhythmic HD cells. Manipulations of the visual landmarks caused tuning curve alterations in most HD cells, with the largest visually driven changes observed in non-rhythmic HD cells. Importantly, the tuning modifications of non-rhythmic HD cells were often non-coherent across cells, refuting the notion that attractor-like dynamics control non-rhythmic HD cells. These findings reveal a new population of non-rhythmic HD cells whose malleable organization is controlled by visual landmarks.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.