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Figure 3 from: Drapak І, Zimenkovsky B, Perekhoda L, Yeromina H, Lipakova K, Demchuk I, Rakhimova M (2019) QSAR-analysis of 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one's derivatives as potential antioxidants. Pharmacia 66(1): 33-40. https://doi.org/10.3897/pharmacia.66.e35083
Figure 3 The dependence of the observed and predicted antioxidant activity for QSAR-models 5(a) and 15(b) for compounds of the training sample.
Figure 1 from: Drapak І, Zimenkovsky B, Perekhoda L, Yeromina H, Lipakova K, Demchuk I, Rakhimova M (2019) QSAR-analysis of 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one's derivatives as potential antioxidants. Pharmacia 66(1): 33-40. https://doi.org/10.3897/pharmacia.66.e35083
Figure 1 Structure of investigated compounds. R= a) H, b) 2-CH3, c) 2,3-(CH3)2, d) 2,4-(CH3)2, e) 2,6-(CH3)2, f) 3,4-(CH3)2, g) 3,5-(CH3)2, h) 2-OCH3, i) 3-OCH3, j) 4-OCH3, k) 2-Cl, l) 3-Cl, m) 4-Cl.
Scheme 4 from: Chaban T, Ogurtsov V, Chaban I, Myrko I, Harkov S, Lelyukh M (2019) Synthesis of some new 4-iminothiazolidine-2-ones as possible antioxidants agents. Pharmacia 66(1): 27-32. https://doi.org/10.3897/pharmacia.66.e35131
Scheme 4 Synthesis of 4-imino-3-phenyl-thiazolidine-2,5-dione 5-oxime (3) under the nitrosation reaction.
Figure 2 from: Drapak І, Zimenkovsky B, Perekhoda L, Yeromina H, Lipakova K, Demchuk I, Rakhimova M (2019) QSAR-analysis of 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one's derivatives as potential antioxidants. Pharmacia 66(1): 33-40. https://doi.org/10.3897/pharmacia.66.e35083
Figure 2 The dependence of observed and predicted antioxidant activities for QSAR-models 2(a) and 3(b) for compounds of the training sample.
Data from: In vitro cytotoxic, antioxidant, hemolytic and cytoprotective potential of promising ethacrynic acid derivatives
<p><span>Female breast cancer is one of the leading causes of death among patients with cancer and requires a proactive strategy for a cure. Triple-negative breast cancer (</span><span>TNBC) is the most aggressive cancer with a high risk of developing metastases. The purpose of the present study was to screen the pharmacological activities of three promising ethacrynic acid (<strong>EA</strong>) derivatives containing a piperazine moiety (<strong>P3</strong>, <strong>P4</strong>, and <strong>P5</strong>). The <strong>EA</strong> derivatives were tested against MDA-MB-468 cancer cell line as a model for TNBC and MCF7 cancer cell line as a model subtype of luminal breast cancer using the methyl tetrazolium test (MTT). Additionally, the modulation of the glutathione and thioredoxin systems, as well as the antioxidant and cytoprotective potential of each compound, were investigated. Moreover, initial in vitro safety screening was conducted using human blood cells. As a result, <strong>EA</strong> derivatives showed clear dose-dependent antiproliferative activity with high selectivity to cancer cells by orchestrating oxidative stress. Derivative <strong>P3</strong> has the most promising potential for further preclinical investigation, owing to its safety profile and significant cytoprotective and antitumor properties</span><span>.</span></p>
Figure 1 in New antioxidant lauryl-free herbal shampoo formulation with a Brazilian plant extract
Figure 1. Chemical characterization by HPLC of H. speciosa leaf extracts obtained by Soxhlet (L_SOX) and ultrasound (L_US).
Figure 2 in Phytochemical screening and evaluation of antioxidant, total phenolic and flavonoid contents in various weed plants associated with wheat crops
Figure 2. Reducing power assay for Convolvulus arvensis, Chenopodium murale, Avena fatua, Phalaris minor extracts in different solvents.
Figure 5 in Photosynthetic metabolism and antioxidant in Ormosia arborea are modulated by abscisic acid under water deficit?
Figure 5. Enzymatic activity of peroxidase in leaves (POD Leaves) (A) and roots (POD Roots) (B) of Ormosia arborea seedlings irrigated (I and I 10 µM ABA) and submitted to water deficit conditions (SI and SI 10 µM ABA) in the different evaluation periods: zero time (T0), first null photosynthesis (1st P0), second null photosynthesis (2nd P0), recovery (REC) and final evaluation (END). Upper case letters differ between trial times and lowercase letters between treatments.
Figure 1 in Determination of the ursolic and oleanolic acids content with the antioxidant capacity in apple peel extract of various cultivars
Figure 1. Location of the apple collection (indicated in black dot) in Western Cape, South-Western coast part of South Africa.
Figure 2 in Antioxidant status and their enhancements strategies for water stress tolerance in chickpea
Figure 2. (a) Influence of exogenous application of osmoprotectants on relative growth rate (g g-1 day-1) of chickpea genotypes in Bahawalpur; (b) Influence of exogenous application of osmoprotectants on relative growth rate (g g-1 day-1) of chickpea genotypes in Cholistan. Whereas D1= well watered; D2= Drought at flowering+ pod formation + grain filling stage; D3= Drought at flowering stage; DAS, Days after sowing.
Fig. 4 in Antioxidant and anticholinesterase potential of Ferulago cassia with farther bio-guided isolation of active coumarin constituents *
Fig. 4. DPHH free radical scavenging activity of Ferulago cassia methanolic extracts.
Fig. 1 in Antioxidant and anticholinesterase potential of Ferulago cassia with farther bio-guided isolation of active coumarin constituents *
Fig. 1. The isolation procedure of pure compounds from dichloromethane fraction.
Fig. 2 in Antioxidant and anticholinesterase potential of Ferulago cassia with farther bio-guided isolation of active coumarin constituents *
Fig. 2. Chemical structures of coumarins isolated from Ferulago cassia.
Fig. 4 in In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds
Fig. 4. IC50 values of DPPH scavenging activity of isolated compounds and that of standard.
Fig. 3 in In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds
Fig. 3. Structure of isolated compounds from ethyl acetate fraction.
Fig. 1 in Antimicrobial and antioxidant efficacy of Citrus limon L. peel extracts used for skin diseases by Xhosa tribe of Amathole District, Eastern Cape, South Africa
Fig. 1. DPPH scavenging activity of Citrus limon extracts. Results are means of 3 replicates.
Fig. 3 in Antimicrobial and antioxidant efficacy of Citrus limon L. peel extracts used for skin diseases by Xhosa tribe of Amathole District, Eastern Cape, South Africa
Fig. 3. Reducing power of C. limon extracts. Results are means of 3 replicates.
Table 3 in Antioxidant and anticholinesterase potential of Ferulago cassia with farther bio-guided isolation of active coumarin constituents *
<p><b>Table 3</b> In vitro AChE and BuChE inhibitory activities of samples from <i>Ferulago cassia</i> at 20 μg/mL.</p><table><tbody><tr><th>Samples</th><th>Enyzmes</th><th>Percentile of inhibition ± S.E.M a against AChE and BuChE</th></tr></tbody><tbody><tr><th></th><td></td><td>Aerial part</td><td>Root</td><td>Flower</td><td>Fruit</td></tr><tr><th>MeOH</th><td>AChE</td><td>4.78 ± 3.45</td><td>17.21 ± 3.20</td><td>18.35 ± 4.12</td><td>25.01 ± 3.65</td></tr><tr><td>BuChE</td><td>44.23 ± 1.96</td><td>69.22 ± 2.98</td><td>48.11 ± 1.78</td><td>55.41 ± 1.59</td></tr><tr><th>Hexane</th><td>AChE</td><td>b</td><td>3.66 ± 3.43</td><td>c</td><td>b</td></tr><tr><td>BuChE</td><td>27.33 ± 2.55</td><td>45.27 ± 1.87</td><td>40.01 ± 3.59</td><td>38.23 ± 1.78</td></tr><tr><th>CH2Cl2</th><td>AChE</td><td>b</td><td>53.24 ± 1.22</td><td>31.38 ± 5.41</td><td>29.14 ± 2.21</td></tr><tr><td>BuChE</td><td>42.39 ± 3.04</td><td>96.56 ± 2.98</td><td>79.71 ± 1.08</td><td>82.33 ± 2.69</td></tr><tr><th>EtOAc</th><td>AChE</td><td>ND c</td><td>5.98 ± 2.46</td><td>b</td><td>10.57 ± 4.05</td></tr><tr><td>BuChE</td><td>7.67 ± 1.78</td><td>36.43 ± 2.93</td><td>49.18 ± 3.51</td><td>50.61 ± 3.51</td></tr><tr><th>BuOH</th><td>AChE</td><td>b</td><td>c</td><td>c</td><td>b</td></tr><tr><td>BuChE</td><td>17.89 ± 1.41</td><td>19.58 ± 3.76</td><td>41.59 ± 2.05</td><td>b</td></tr><tr><th>Aqueous residue</th><td>AChE</td><td>b</td><td>b</td><td>b</td><td>b</td></tr><tr><td>BuChE</td><td>c</td><td>c</td><td>b</td><td>c</td></tr><tr><th>Lyophilized aqueous</th><td>AChE</td><td>1.45 ± 1.22</td><td>5.66 ± 3.24</td><td>c</td><td>b</td></tr><tr><td>BuChE</td><td>10. 56 ± 3.50</td><td>25.87 ± 4.21</td><td>16.78 ± 2.43</td><td>24.77 ± 2.49</td></tr><tr><th>Peucedanol</th><td>AChE</td><td>50.02 ± 2.09</td><td></td><td></td><td></td></tr><tr><td>BuChE</td><td>76.22 ± 2.13</td><td></td><td></td><td></td></tr><tr><th>Suberosin</th><td>AChE</td><td>17.60 ± 2.05</td><td></td><td></td><td></td></tr><tr><td>BuChE</td><td>71.67 ± 4.67</td><td></td><td></td><td></td></tr><tr><th>Grandivitinol</th><td>AChE</td><td>49.58 ± 5.44</td><td></td><td></td><td></td></tr><tr><td>BuChE</td><td>b</td><td></td><td></td><td></td></tr><tr><th>Umbelliferone</th><td>AChE</td><td>61.09 ± 4.46</td><td></td><td></td><td></td></tr><tr><td>BuChE</td><td>40.99 ± 5.61</td><td></td><td></td><td></td></tr><tr><th>Donepezil</th><td>AChE</td><td>82.45 ± 2.64</td><td></td><td></td><td></td></tr><tr><td>BuChE</td><td>90.33 ± 4.16</td><td></td><td></td><td></td></tr></tbody></table><p><sup>a</sup> Standard error mean.</p><p><sup>b</sup> No activity.</p><p><sup>c</sup> Not detected because of turbidity in the wells of microplates.</p>
Table 2 in Antioxidant and anticholinesterase potential of Ferulago cassia with farther bio-guided isolation of active coumarin constituents *
<p><b>Table 2</b> Antioxidant activities of the samples from <i>Ferulago cassia</i> in TBA test.</p><table><tbody><tr><th>Tested samples</th><th>IC50 values (μg/mL) ± SD*</th></tr></tbody><tbody><tr><th></th><td>Aerial part</td><td>Root</td><td>Flower</td><td>Fruit</td></tr><tr><th>MeOH</th><td>195.42 ± 4.25</td><td>92.21 ± 3.44</td><td>178.31 ± 4.33</td><td>155.67 ± 3.66</td></tr><tr><th>Hexane</th><td>500></td><td>500></td><td>500></td><td>500></td></tr><tr><th>CH2Cl2</th><td>85.66 ± 5.02</td><td>43.10 ± 2.23</td><td>101.13 ± 2.34</td><td>52.45 ± 1.67</td></tr><tr><th>EtOAc</th><td>145.65 ± 2.57</td><td>112.10 ± 3.47</td><td>181.21 ± 1.06</td><td>94.91 ± 3.41</td></tr><tr><th>BuOH</th><td>345.21 ± 4.30</td><td>471.31 ± 4.91</td><td>383.23 ± 2.43</td><td>276.51 ± 1.66</td></tr><tr><th>Aqueous residue</th><td>500></td><td>500></td><td>500></td><td>500></td></tr><tr><th>Lyophilized aqueous</th><td>500></td><td>464.89 ± 2.09</td><td>489 ± 3.28</td><td>356 ± 1.93</td></tr><tr><th>Peucedanol</th><td>18.12 ± 2.80</td><td></td><td></td><td></td></tr><tr><th>Suberosin</th><td>23.54 ± 2.43</td><td></td><td></td><td></td></tr><tr><th>Grandivitinol</th><td>61.11 ± 4.23</td><td></td><td></td><td></td></tr><tr><th>Umbelliferone</th><td>79.53 ± 3.98</td><td></td><td></td><td></td></tr><tr><th>Chlorogenic acid</th><td>12.98 ± 4.89</td><td></td><td></td><td></td></tr><tr><th>Propyl gallate</th><td>3.44 ± 2.05</td><td></td><td></td><td></td></tr><tr><th>Rutin</th><td>9.65 ± 3.09</td><td></td><td></td><td></td></tr></tbody></table><p>* Standard deviation.</p>
Figure 5 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 5 Results of quantification and identification of flavonoids in ethanol extract of Osage Orange.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.