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5,856 results for “B cells”
Peripheral blood DNA methylation profiles predict future development of B-cell Non-Hodgkin Lymphoma
<p>Lack of accurate methods for early lymphoma detection limits the ability to cure patients. Patients with Non-Hodgkin lymphomas (NHL) who present with advanced disease have worse outcomes.</p> <p>We developed a DNA methylation-based prediction tool for NHL, based on blood samples collected prospectively from 278 apparently healthy patients who were followed for up to 16 years to monitor for NHL development. A predictive score was developed using machine learning methods in a robust training/validation framework.</p> <p>Our predictive score incorporates CpG DNA methylation at 135 genomic positions, with higher scores predicting higher risk. It was 85% and 78% accurate for identifying patients at risk of developing future NHL, in patients with high or low epigenetic mitotic clock respectively, in a validation cohort. It was also sensitive at detecting active NHL (96.3% accuracy) and healthy status (95.6% accuracy) in additional independent cohorts. Scores optimized for specific NHL subtypes showed significant but lower accuracy for predicting other subtypes. Our score incorporates hyper-methylation of Polycomb and <em>HOX</em> genes, which have roles in NHL development, as well as <em>PAX5</em> - a master transcriptional regulator of B-cell fate. Subjects with higher risk scores showed higher regulatory T-cells, memory B-cells, but lower naïve T helper lymphocytes fractions in the blood.</p> <p>A score based on DNA methylation in blood is accurate at predicting NHL development with lead time of up to 16 years. Future prospective studies will be required to confirm the utility of our signature for managing patients who are at high risk for developing future NHL.</p>
FIGURE. Metzgeria crassipilis (Lindb.) A. Evans I. (A) Thallus growing on a twig. (B) Thallus cells and gemmae. (C) Thallus margin. (D) Curved marginal hair. (E & F) Gemma. (G) Cross section of thallus. A–G Ruklani & Rubasinghe 117-14SR (PDA). in Thalloid Liverworts (Marchantiopsida) of Sri Lanka
FIGURE. Metzgeria crassipilis (Lindb.) A. Evans I. (A) Thallus growing on a twig. (B) Thallus cells and gemmae. (C) Thallus margin. (D) Curved marginal hair. (E & F) Gemma. (G) Cross section of thallus. A–G Ruklani & Rubasinghe 117-14SR (PDA).
FIGURE. Riccardia multifida (L.) Gray I. (A) Dorsal surface of thallus. (B) Cells of the thallus (branch). (C) Cross section of the thallus. (D) Sporophyte. (E) Light microscope view of spore. A–E Ruklani & Rubasinghe 337-15SR (PDA). in Thalloid Liverworts (Marchantiopsida) of Sri Lanka
FIGURE. Riccardia multifida (L.) Gray I. (A) Dorsal surface of thallus. (B) Cells of the thallus (branch). (C) Cross section of the thallus. (D) Sporophyte. (E) Light microscope view of spore. A–E Ruklani & Rubasinghe 337-15SR (PDA).
FIGURE. Pallavicinia lyellii (Hook.) Gray I. (A) Thallus (B) Cells of thallus (C) Antheridia (D) Female receptacle (E) Cross section of thallus (F) Sporophyte (G) Light microscope view of spore. A–C, E Ruklani & Rubasinghe 275-15SR (PDA); D, F, G Ruklani & Rubasinghe 305-15SR (PDA). in Thalloid Liverworts (Marchantiopsida) of Sri Lanka
FIGURE. Pallavicinia lyellii (Hook.) Gray I. (A) Thallus (B) Cells of thallus (C) Antheridia (D) Female receptacle (E) Cross section of thallus (F) Sporophyte (G) Light microscope view of spore. A–C, E Ruklani & Rubasinghe 275-15SR (PDA); D, F, G Ruklani & Rubasinghe 305-15SR (PDA).
FIGURE. Aneura pinguis (L.) Dumort. I (A) Dorsal surface of thallus with archegonia (female receptacles). (B & C) Sporophytes. D) Cells of the capsule wall. (E) Elater (F) Light microscope view of spore. A–F Ruklani & Rubasinghe 47-14SR (PDA). in Thalloid Liverworts (Marchantiopsida) of Sri Lanka
FIGURE. Aneura pinguis (L.) Dumort. I (A) Dorsal surface of thallus with archegonia (female receptacles). (B & C) Sporophytes. D) Cells of the capsule wall. (E) Elater (F) Light microscope view of spore. A–F Ruklani & Rubasinghe 47-14SR (PDA).
FIGURE. Morphology of ventral scales of Sri Lankan Marchantia sp. I (A) Light red laminal scale of M. acaulis (B) Yellowish median scale of M. acaulis boarded by light red to purple cells (C) Laminal scale of M. papillata (D) Purplish coloured median scale of M. papillata (E) Light red coloured laminal scale of M. emarginata with hyaline apical papillae (F) Median scale of M. emarginata. A— Ruklani & Rubasinghe 108-14SR; B—Ruklani & Rubasinghe 108-14SR; C—Ruklani & Rubasinghe 04-14SR; D—Ruklani & Rubasinghe 04-14SR; E—Ruklani & Rubasinghe 169-14SR; F—Ruklani & Rubasinghe 169-14SR. in Thalloid Liverworts (Marchantiopsida) of Sri Lanka
FIGURE. Morphology of ventral scales of Sri Lankan Marchantia sp. I (A) Light red laminal scale of M. acaulis (B) Yellowish median scale of M. acaulis boarded by light red to purple cells (C) Laminal scale of M. papillata (D) Purplish coloured median scale of M. papillata (E) Light red coloured laminal scale of M. emarginata with hyaline apical papillae (F) Median scale of M. emarginata. A— Ruklani & Rubasinghe 108-14SR; B—Ruklani & Rubasinghe 108-14SR; C—Ruklani & Rubasinghe 04-14SR; D—Ruklani & Rubasinghe 04-14SR; E—Ruklani & Rubasinghe 169-14SR; F—Ruklani & Rubasinghe 169-14SR.
FIGURE. Lunularia cruciata (L.) Dumort. ex Lindb. I. (A) Dorsal surface of thallus with gemma cups B) Epidermal pore from dorsal epidermis of thallus (C) Gemma (D) Ventral scale (E) Appendage of ventral scale (F) Cells with oil bodies on ventral scale (G) Cross section of epidermal pore and air chambers. A–G, Ruklani & Rubasinghe 113-14SR (PDA). in Thalloid Liverworts (Marchantiopsida) of Sri Lanka
FIGURE. Lunularia cruciata (L.) Dumort. ex Lindb. I. (A) Dorsal surface of thallus with gemma cups B) Epidermal pore from dorsal epidermis of thallus (C) Gemma (D) Ventral scale (E) Appendage of ventral scale (F) Cells with oil bodies on ventral scale (G) Cross section of epidermal pore and air chambers. A–G, Ruklani & Rubasinghe 113-14SR (PDA).
NanoString dataset for study: Dynamic changes in the NK-, Neutrophil-, and B-cell immunophenotypes relevant in high metastatic risk post neoadjuvant chemotherapy–resistant early breast cancers
<p>Pre-processed DSP and mRNA abundance datasets used in this study.</p>
FIGURE. Cladosporium benschii (VIC 44412, holotype). A–D. Colonies on A. Potato dextrose agar; B. Malt extract agar; C. Oatmeal agar; D. Synthetic nutrient-poor agar, after 14 days at 25 ºC, under near-ultraviolet light, respectively. E–J. Non-geniculate macronematous conidiophores and conidia. K. Conidiogenous cells with slightly protuberant loci. L. Micronematous conidiophores. M. Microcyclic conidiogenesis. Scale bars: E–M = 20 µM. in Six new species of Cladosporium associated with decayed leaves of native bamboo (Bambusoideae) in a fragment of Brazilian Atlantic Forest
FIGURE. Cladosporium benschii (VIC 44412, holotype). A–D. Colonies on A. Potato dextrose agar; B. Malt extract agar; C. Oatmeal agar; D. Synthetic nutrient-poor agar, after 14 days at 25 ºC, under near-ultraviolet light, respectively. E–J. Non-geniculate macronematous conidiophores and conidia. K. Conidiogenous cells with slightly protuberant loci. L. Micronematous conidiophores. M. Microcyclic conidiogenesis. Scale bars: E–M = 20 µM.
FIGURE. Dothiorella viticola on dead branch of Morus sp. (MFLU 19-0621). a, b. Conidiomata on host substrate. c. Vertical section through conidioma. d. Ostiole. e. Peridium of conidioma. f–j. Conidia attached to conidiogenous cells. k–m. Conidia. n. Germinating conidium. o, p. Colony on PDA (o upper, p lower). Scale bars: a = 1 mm, b = 100 μm, c = 50 μm, d = 20 μm, e–n = 10 μm. in Two new species of Botryosphaeriaceae (Botryosphaeriales) and new host/ geographical records
FIGURE. Dothiorella viticola on dead branch of Morus sp. (MFLU 19-0621). a, b. Conidiomata on host substrate. c. Vertical section through conidioma. d. Ostiole. e. Peridium of conidioma. f–j. Conidia attached to conidiogenous cells. k–m. Conidia. n. Germinating conidium. o, p. Colony on PDA (o upper, p lower). Scale bars: a = 1 mm, b = 100 μm, c = 50 μm, d = 20 μm, e–n = 10 μm.
FIGURE 3. Radula longicarinata. A. Marginal leaf cells. B. Median leaf cells. C. Basal leaf cells. D. Habit with gynoecia. E. Habit. F. Leaves. G in High liverwort diversity in the tropical Andes as evidenced by the discovery of three new species of Radula (Radulaceae)
FIGURE 3. Radula longicarinata. A. Marginal leaf cells. B. Median leaf cells. C. Basal leaf cells. D. Habit with gynoecia. E. Habit. F. Leaves. G. Cross section of stem. H. Cladographs of plants (U = gynoecia without perianth) (A-C, G = 50 µm, D-F = 500 µm; All from the holotype).
FIGURE 1. Radula ilkiuborgesiae. A. Habit with androecia. B. Marginal leaf cells. C. Habit. D. Median leaf cell with oil bodies. E. Median leaf cells. F in High liverwort diversity in the tropical Andes as evidenced by the discovery of three new species of Radula (Radulaceae)
FIGURE 1. Radula ilkiuborgesiae. A. Habit with androecia. B. Marginal leaf cells. C. Habit. D. Median leaf cell with oil bodies. E. Median leaf cells. F. Cladograph of plants. G. Habit. H. Leaves. I. Cross section of stem. J. Habit in dorsal view (A, C, G = 500 µm, B, D, E = 25 µm, H = 100 µm, I = 50 µm, J = 250 µm; All from the holotype).
FIGURE 4. Radula magna. A. Habit. B. Marginal leaf cells. C. Median leaf cells with oil bodies. D. Leaves. E. Habit. F in High liverwort diversity in the tropical Andes as evidenced by the discovery of three new species of Radula (Radulaceae)
FIGURE 4. Radula magna. A. Habit. B. Marginal leaf cells. C. Median leaf cells with oil bodies. D. Leaves. E. Habit. F. Cladograph of plants. G. Cross section of stem (A, D, E = 500 µm, B, C = 25 µm, G = 100 µm; All from the holotype).
Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility - Table S1
<p>This is the supplementary table for the manuscript entitled "Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility"</p>
FIGURE 2. Preussia octocylindrospora A–B. ascomata, C–D. pseudoparaphyses E–G. asci, H–I. ascospores. J in New species of Preussia with 8-celled ascospores (Sporormiaceae, Pleosporales, Ascomycota)
FIGURE 2. Preussia octocylindrospora A–B. ascomata, C–D. pseudoparaphyses E–G. asci, H–I. ascospores. J. part of an ascospore with enhanced germ slits A–J. Coll. F-529978 (UPS). Scale bars: A–B=100 μm, C–D= 10 μm, E–G= 20 μm, H–J=10 μm.
FIGURE 1. Preussia alpina A–B. ascomata, C in New species of Preussia with 8-celled ascospores (Sporormiaceae, Pleosporales, Ascomycota)
FIGURE 1. Preussia alpina A–B. ascomata, C. detail of exoperidium, D. immature ascus, E. ascus, F–G. pseudoparaphyses, H–O. ascospores. A–B, F–H, M. Coll. F-529764 (UPS), C, E, L. Coll. F-529759 (UPS), D, J. Coll. F-529761 (UPS), I. Coll. F-529762 (UPS), K. Coll. F-529758 (UPS), N–O. Coll. F-529760 (UPS). Scale bars: A–B=100 μm, C=10 μm, D–E=20 μm, F–O=10 μm.
FIGURE 2. Schistidium squarrosum. A. Habit. B. Sterile plant. C. Stem section. D–F. Cauline leaves. G–I. Distal leaf sections. J–K. Cauline leaf apices. L. Median marginal laminal cells. M. Basal laminal cells. N. Medial leaf section. O in Two new species of Schistidium (Grimmiaceae, Bryophyta) from western North America
FIGURE 2. Schistidium squarrosum. A. Habit. B. Sterile plant. C. Stem section. D–F. Cauline leaves. G–I. Distal leaf sections. J–K. Cauline leaf apices. L. Median marginal laminal cells. M. Basal laminal cells. N. Medial leaf section. O. Capsule in perichaetium. P. Perichaetial leaf. Q. Capsule. R. Operculum and calyptra. S. Peristome tooth. Scale bar: 4 mm for A; 3 mm for B; 1 mm for O, Q; 100 μm for C, G–N, S; 0.5 mm for D–F, P–R.
FIGURE 1. Schistidium splendens. A. Habit. B. Fertile plant. C. Stem section. D. Cauline leaf. E–F. Leaf sections. G–H. Cauline leaf apices. I. Median marginal laminal cells. J. Basal laminal cells. K in Two new species of Schistidium (Grimmiaceae, Bryophyta) from western North America
FIGURE 1. Schistidium splendens. A. Habit. B. Fertile plant. C. Stem section. D. Cauline leaf. E–F. Leaf sections. G–H. Cauline leaf apices. I. Median marginal laminal cells. J. Basal laminal cells. K. Capsule in perichaetium. L. Perichaetial leaf. M. Capsule, opercula, dry. N. Capsule, wet. O. Cells at capsule mouth. Scale bar: 4 mm for A; 2 mm for B; 0.75 mm for K, M, N; 100 μm for C, E–J, O; 0.5 mm for D, L.
PLATE 5. Notothylas orbicularis. a. Transverse section through the columella. b. Capsule epidermal cells illustrating the elongated thickwalled cells. c–d in Rare and peculiar hornworts: Notothylas orbicularis and N. javanica (Notothyladaceae), new genus and species records for Australia
PLATE 5. Notothylas orbicularis. a. Transverse section through the columella. b. Capsule epidermal cells illustrating the elongated thickwalled cells. c–d. SEM images of proximal and distal views of spores. e. Light microscope image of a spore. f. Pseudoelaters. Images by D. C. Cargill.
FIGURE 1. Didymodon hengduanensis. A. Habit, dry. B–C. Leaves. D. Perichaetial leaf. E. Leaf apex. F. Basal laminal cells. G. Upper laminal cells. H–J in Didymodon hengduanensis (Bryophyta, Pottiaceae), a new species from the Hengduan Mountains, Southwestern China
FIGURE 1. Didymodon hengduanensis. A. Habit, dry. B–C. Leaves. D. Perichaetial leaf. E. Leaf apex. F. Basal laminal cells. G. Upper laminal cells. H–J. Transverse sections of a leaf from apical to basal part. K. Capsule. L. Peristome. Scale bars: A = 2 mm. B–D = 300 μm. E = 30 μm. F, H–J = 40 μm. G = 25 μm. K = 0.6 mm. L = 300 μm. All from holotype.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.