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opennotspecifiedJun 2021View details →

Fig. 1 in Euphorbia ebracteolata Hayata (Euphorbiaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, toxicology, and quality control

Fig. 1. Whole plant (A), the fresh root (B) (Cited from Flora Republicae Populairs Sinicae at http://ppbc.iplant.cn), the dry root (C) and preparation (Youfuning Capsule) (D) (Cited from http://www.nj-tongrentang.com/product/1trt/89.html) of E. ebracteolata.

opennotspecifiedOct 2021View details →

Fig. 6 in Euphorfinoids E-L: Diterpenoids from the roots of Euphorbia fischeriana with acetylcholinesterase inhibitory activity

Fig. 6. Post-docking interactions between active residues of AChE with compound 1. (A) the protein was depicted in surface view and ligands as stick in the binding pocket. (B) schematic drawing of types of interactions of the ligands generated using ligplot.

Fig. 5 in Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots

Fig. 5. Cytotoxic activities of transformed E. lathyris root extract in human carcinoma and embryonic cell lines. a) DU-145 (prostate) b) HeLa (cervix) c) MCF-7 (breast) d) MDA-MB-231 (breast) e) and H2347 (lung) were treated with DMSO (carrier), or increasing concentrations of transformed root MeOH extracts (31.3 μg/ml, 52.5 μg/ml, 125 μg/ml, 250 μg/ml). Titer-Glo® (Promega) was used to count cell lines 48 h post-treatment. Each dose and timepoint was performed in triplicate. Asterisks indicate statistical significance in comparison to carrier (DMSO) control assessed by one-way ANOVA (**,P <0.01; *,P <0.05).

Fig. 1 in Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots

Fig. 1. Establishment and culture maintenance of transformed E. lathyris roots. (a) Stem explants of 3-week-old greenhouse grown plants were used for co-culture with A. rhizogenes. (b) Roots emerged from callus at the site of infection after 2–3 weeks.(c) Adventitious roots displaying the characteristic of the "hairy root" phenotype. (d) Growth characteristics of the isogenic root line used in this study on agar media and in (e) liquid media.

Fig. 2 in Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots

Fig. 2. Base peak chromatograms of transformed E. lathyris roots compared to wild-type plant roots and aerial parts with putatively assigned metabolites that are structurally related to ingenol.

Fig. 4 in Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots

Fig. 4. Bioinformatic analysis and chemical elicitation of early diterpenoid biosynthetic genes expressed in transformed E. lathyris roots. Comparison of the deduced amino acid sequences of (a) ElFPS and (b) ElGGPS highlighting two conserved aspartate-rich domains [DDxx(xx)D]. (c) Comparison of the deduced amino acid sequence of ElCS highlighting a conserved [DDxxD] motif that is essential to the cyclization functionalities of terpene synthases. (d) Time course of E. lathyris diterpenoid biosynthetic gene transcript levels in transformed root cultures treated with 100 μM methyl jasmonate. Asterisks indicate statistical significance in comparison to 0 h control assessed by one-way ANOVA (**,P <0.01; *,P <0.05).

Fig. 3 in Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots

Fig. 3. The MS/MS (fragmentation) data of m/z 477.2732 aided in the putative assignment of compound 8 as 15-O-acetyl-3-O-iso-butyryljolkinol-5β,6β-oxide. The fragmentation structures and m/z values correspond to each other (i.e. structures and peaks A-D).

opennotspecifiedApr 2021View details →

Fig. 1 in Euphorbia helioscopia L.: A phytochemical and pharmacological overview

Fig. 1. The aerial part (a), as well as an illustration (b) of E. helioscopia (A, habit; B, cyathium (Nath s. n., RAW); C, fruit; D, seed (Abedin & Husain 6098, KUH) (www.efloras.org/Flora of Pakistan/Euphorbia helioscopia; eFloras, 2008).

opennotspecifiedMar 2021View details →

Fig. 6 in Eupholides A H, abietane diterpenoids from the roots of Euphorbia fischeriana, and their bioactivities

Fig. 6. The inhibitory effects of diterpenoids 1–15 on HCE 2 (a). The inhibitory effects of diterpenoids 7 (b), 10 (c), and 12 (d) on HCE 2.

Fig. 10 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 10. Binding pose of 15 with human Pgp. The P-gp model was generated based on the PDB structure of human P-gp (Code: 6QEX) and was portrayed as a cartoon (light green). Residues involved in the interaction were colored yellow, while the surfaces of the hydrophobic pocket packing with 15 were colored light brown red. The hydrogen bonds and hydrophobic forces were shown as red dashed lines and yellow dashed lines, respectively. The structural figures were drawn in Accelrys Discovery Studio 2016. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 9 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 9. (A) Inhibitory effects of 15 on the accumulation of rhodamin-123 (Rho-123) in HepG2/DOX. (B) Inhibitory effects of 15 on the efflux of Rho-123 in HepG2/ DOX. Scale bar = 200 μm.

Fig. 7 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 7. Mediated multidrug resistance (MDR)-reversing effects of the compounds on doxorubicin (DOX)-resistant human hepatocellular carcinoma cell line (HepG2/ DOX).

Fig. 6 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 6. Experimental ECD spectrum of 3 (red line) and calculated ECD spectra (200–400 nm) of (3S,4S,5R,8S,10S,11R,13R,14R,15R)-3a (black line) and (3R,4R,5S,8R,10R,11S,13S,14S,15S)-3b (blue line). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 5 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Fig. 5. Experimental CD spectrum (red line) of compound 2, and the Rh2(OCOCF3)4 induced CD spectrum (black line) of 2 in CH2Cl2 for 190–450 nm (left), and the applied bulkiness rule for secondary alcohols (right). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

opennotspecifiedJul 2020View details →

Fig. 5 in Bioactive ent-isopimarane diterpenoids from Euphorbia neriifolia

Fig. 5. Calculated and experimental ECD spectra of 1−5 (a) σ = 0.29 eV; UV shift = 15 nm. (b) σ = 0.30 eV; UV shift = 5 nm. (c) σ = 0.29 eV; UV shift = 10 nm. (d) σ = 0.31 eV; UV shift = 5 nm. (e) σ = 0.32 eV; UV shift = 13 nm.

ClinicalTrials.gov32/100

Euphorbia Kansui and HIV/AIDS Functional Cure

ClinicalTrials.gov study NCT04503928. IPD Sharing: Not stated. Countries: 1. Publications: 2.

restrictedIPD-UNDECIDEDFeb 2026View details →

publicFeb 2021View details →

The impact of a native dominant plant, Euphorbia jolkinii, on plant-flower visitor networks and pollen deposition on stigmas of co-flowering species in sub-alpine meadows of Shangri-La, SW China

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publicMay 2013View details →

Data from: Mitochondrial lineage sorting in action – historical biogeography of the Hyles euphorbiae complex (Sphingidae, Lepidoptera) in Italy

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publicJul 2019View details →

Data from: Convergent evolution in floral morphology in a plant ring species, the Caribbean Euphorbia tithymaloides

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