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Dataset results
469 results for “Hematopoiesis”
The role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesi
GEO Series GSE43044. Mus musculus. 16 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [II]
GEO Series GSE176036. Danio rerio. 8 samples. Type: Expression profiling by high throughput sequencing.
Interrogation of human hematopoiesis at single-cell and single-variant resolution
GEO Series GSE119453. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
MEIS1 regulates hematopoiesis in hPSCs
GEO Series GSE92245. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
High Glucose Macrophage Exosomes Enhance Atherosclerosis by Driving Cellular Proliferation & Hematopoiesis
GEO Series GSE162962. Mus musculus. 70 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis (1 of 3)
GEO Series GSE92352. Mus musculus. 6 samples. Type: Expression profiling by array.
St. Jude LIFE Hematopoiesis
We present the first comprehensive investigation of clonal hematopoiesis (CH) in 2,860 long-term survivors of pediatric cancer with a median follow-up time of 23.5 years. Deep-sequencing over 39 CH-related genes reveals mutations in 15% of the survivors, significantly higher than the 8.5% in 324 community controls. CH in survivors is associated with exposures to alkylating agents, radiation, and bleomycin. Therapy-related CH shows significant enrichment in STAT3, characterized as a CH-gene specific to Hodgkin lymphoma survivors, and TP53. Single-cell profiling of peripheral blood samples revealed STAT3 mutations predominantly present in T-cells and contributed by SBS25, a mutational signature associated with procarbazine exposure. Serial-sample tracking reveals that larger clone size is a predictor for future expansion of age-related CH clones, while therapy-related CH remains stable decades post-treatment. These data depict the distinct dynamics of these CH subtypes and support the need for longitudinal monitoring to determine the potential contribution to late effects.
ETV6 Represses Inflammatory Response Genes and Regulates HSPC Function During Stress Hematopoiesis in Mice [ATAC-seq]
GEO Series GSE213593. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dynamic DNA methylation reveals novel cis-regulatory elements in murine hematopoiesis
GEO Series GSE201923. Mus musculus. 31 samples. Type: Methylation profiling by array.
The role of histone variant H3.3 regulation by HIRA in hematopoiesis
GEO Series GSE163052. Mus musculus. 52 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Tet2 deficiency mitigates epigenetic aging in clonal hematopoiesis
<p><strong>Github repository</strong></p> <p><a href="https://github.com/LabShengLi/CHIP-DS">https://github.com/LabShengLi/CHIP-DS</a></p> <p><strong>File list</strong></p> <ul> <li><strong>CHIP-DS-main.zip: </strong>all analytical scripts.</li> <li><strong>scRNA_input.rds:</strong> single-cell RNA data for all samples in an R object.</li> <li><strong>scATAC_inputs.tar.gz: </strong>all single-cell ATAC inputs data for analysis scripts.</li> </ul> <p>*Correspondence should be addressed to O.H. (<span><a href="mailto:oguro@uchc.edu"><span>oguro@uchc.edu</span></a></span>) and S.L. (<a href="mailto:sheng.li@jax.org">sheng.li@jax.org</a>).</p>
Metformin Inhibits DNMT3A Clonal Hematopoiesis in Acute Leukemia
ClinicalTrials.gov study NCT07188740. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Clonal Hematopoiesis in Giant Cell Arteritis
ClinicalTrials.gov study NCT06244069. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Single cell RNAseq of engineered human mini bones for the standarized modeling of healthy hematopoiesis, leukemia and solid tumor metastasis
GEO Series GSE201879. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Contribution of PDGFRα Lineage cells in adult mouse hematopoiesis
GEO Series GSE159535. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Hematopoiesis under telomeric attrition at the single-cell resolution [ATAC-seq]
GEO Series GSE171220. Homo sapiens; Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.
GEO Series GSE311225. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
CREB Coactivators CRTC2 and CRTC3 Modulate Bone Marrow Hematopoiesis
GEO Series GSE103999. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Nucleus deformation by microtubules during early steps of hematopoiesis
GEO Series GSE157349. Homo sapiens. 9 samples. Type: Expression profiling by array.
Single cell mRNA sequencing of de novo hematopoiesis from the fetal lung
GEO Series GSE197290. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.