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ShareScore release 0.9.0
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364 results for “breast tissue”
Dataset related to the article "Single- cell profiling defines the prognostic benefit of CD39hi tissue resident memory CD8+ T cells in lumina-like breast cancer"
<p>This record contains data related to the article " Single- cell profiling defines the prognostic benefit of CD39hi tissue resident memory CD8+ T cells in lumina-like breast cancer ".</p> <p>Luminal-like breast cancer (BC) constitutes the majority of BC subtypes, but, differently from highly aggressive triple negative BC, is poorly infiltrated by the immune system. The quality of the immune infiltrate in luminal-like BCs has been poorly studied, thereby limiting further investigation of immunotherapeutic strategies. By using high-dimensional single-cell technologies, we identify heterogeneous behavior within the tissue-resident memory CD8+ T (Trm) cells infiltrating luminal-like tumors. A subset of CD127- CD39<sup>hi</sup> Trm cells, preferentially present in the tumor compared to the adjacent normal breast tissue or peripheral blood, retains enhanced degranulation capacity compared to the CD127+ CD39<sup>lo</sup> Trm counterpart ex vivo, and is specifically associated with positive prognosis. Nevertheless, such prognostic benefit is lost in the presence of highly-suppressive CCR8<sup>hi</sup> ICOS<sup>hi</sup> IRF4+ effector Tregs. Thus, combinatorial strategies aiming at boosting Trm function and infiltration while relieving from Treg-mediated immunosuppression should be investigated to achieve proper tumor control in luminal-like BCs.</p> <p> </p>
CTCF Loss Potentiates P53 Mediated Gene Transcription in Breast Tissue
GEO Series GSE217698. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
MicroRNA profile of breast cancer tissue samples
GEO Series GSE144534. synthetic construct; Homo sapiens. 23 samples. Type: Non-coding RNA profiling by array.
Genome-wide single base resolution profiling of 5-methylcytosine in human breast tissue
GEO Series GSE74214. Homo sapiens. 18 samples. Type: Methylation profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.