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10,006 results for “randomness”
A feasibility randomized controlled superiority trial of fluticasone-vilanterol once daily use for the treatment of mild asthma in adults
<p><strong><span>Objectives</span></strong></p> <p><span>Current international guidelines recommend using a combination of Long-Acting Beta-Agonists and Inhaled Corticosteroids (LABA+ICS) therapy for symptomatic mild asthma. However, this change has yet to be widely implemented in the Middle East. The objective of this pilot study is to assess the feasibility (recruitment and retention rates) of conducting a future definitive RCT to investigate the effectiveness of fluticasone-vilanterol (LABA+ICS) in the management of mild asthma in adults, compared with usual care. </span></p> <p><strong><span>Design</span></strong></p> <p><span>This 8-month parallel two-arm pilot trial took place in the Kingdom of Bahrain. We randomly assigned 18 patients with mild asthma in a 1:1 ratio to the treatment (n=10) or usual care (n=8) arms. The treatment group received daily LABA+ICS therapy while the usual care group continued </span><span>as required </span><span>SABA or SABA+ICS combination</span><span>. The main outcome measures were descriptors of study feasibility (recruitment and retention rates). We also compared unblinded outcome assessment of asthma control score, quality of life, and the number of asthma exacerbations experienced by patients in both arms.</span></p> <p><strong><span>Results</span></strong></p> <p><span>A total of 18 patients were recruited from a single primary healthcare center and randomized by remote web-based allocation into intervention (n=10) and usual care (n=8) groups. The baseline characteristics of participants did not differ significantly across the two arms at the start of the trial. Because of slow recruitment and limited funding, the study didn't meet our recruitment target but did successfully meet our retention criteria. At 32 weeks, the analysis indicated significant improvement in asthma control scores in the intervention arm (1.31 vs 2.91; 95% CI </span><span>[0.72, 2.44]; </span><span>P-value=0.003), but no significant differences were noted in quality-of-life scores (P-value=</span><span>0.197) compared to the baseline levels</span><span>. There were no significant differences </span><span>in post-intervention asthma control mean score (</span><span>P-value=</span><span>0.361) or QoL mean score (</span><span>P-value=</span><span>0.337) between the two arms after adjustment for pre-intervention scores. </span></p> <p><strong><span>Conclusions</span></strong></p> <p><span>This pilot RCT indicates that a definitive RCT is feasible in a primary healthcare setting in Bahrain. In a definitive trial, we recommend increasing the recruitment rate by relaxing eligibility criteria, extending the timeline, and increasing the number of sites for recruitment. Additionally, outcomes of this pilot trial suggest that LABA+ICS is a feasible, acceptable, safe, and effective intervention for the management of mild asthma in a Middle Eastern context.</span></p>
Data for: Leveraging spatio-temporal genomic breeding value estimates of dry matter yield and herbage quality in ryegrass via random regression models
<p>Joint modeling of correlated multi-environment and multi-harvest data of perennial crop species may offer advantages in prediction schemes and a better understanding of the underlying dynamics in space and time. The goal of the present study was to investigate the relevance of incorporating the longitudinal dimension of within-season multiple measurements of forage perennial ryegrass traits in a reaction norm model setup that additionally accounts for genotype-environment interactions (G×E). Genetic parameters and accuracy of genomic breeding value (gEBV) predictions were investigated by fitting three random regression models (gRRM) using Legendre polynomial functions to the data. Genomic DNA sequencing of family pools of diploid perennial ryegrass was performed using DNA nanoball-based technology and yielded 56,645 single nucleotide polymorphisms which were used to calculate the allele frequency-based genomic relationship matrix. Biomass yield's estimated additive genetic variance and heritability values were higher in later harvests. The additive genetic correlations were moderate to low in early measurements and peaked at intermediates, with fairly stable values across the environmental gradient, except for the initial harvest data collection. This led to the conclusion that complex (G×E) arises from spatial and temporal dimensions in the early season, with lower re-ranking trends thereafter. In general, modeling the temporal dimension with a second-order orthogonal polynomial improved the accuracy of gEBV prediction for nutritive quality traits, but no gain in prediction accuracy was detected for dry matter yield. This study leverages the flexibility and usefulness of gRRM models for perennial ryegrass breeding and can be readily extended to other multi-harvest crops.</p>
Cipher Machine TST 0605 Random Noise Generator 970 (Inv. 2017-426)
<p>This dataset represents the computed tomography image acquisition of a historical cipher machine from the collection of the Deutsches Museum. It is composed of CT reconstructed image stacks in the DICOM (.dcm) format.<br> It can be imported in any free or propietary CT-Viewer that supports the DICOM standard to generated 2D and 3D imaging.<br> If segmentations/ROIs are availabe, they are uploaded in a seperate image stacks and are a subset of the scanned cipher machine.</p> <p>object details:<br> name: TST 0605 Random Noise Generator 970<br> Inv.-No. of the Deutsches Museum: 2017-426</p> <p>file object details:<br> file format: image/dcm<br> pixel spacing unit: mm<br> X pixel spacing: 0.181<br> Y pixel spacing: 0.181<br> Z pixel spacing: 0.181<br> grid size x: 1788<br> grid size y: 1176<br> grid size z: 2524<br> color depth: 16Bit</p> <p>ownership & image acquisition:<br> project: <a href="https://digital.deutsches-museum.de/en/projects/3d-cipher">3D-Cipher</a><br> collection: <a href="https://digital.deutsches-museum.de">Deutsches Museum</a><br> IP holder: Deutsches Museum<br> license: <a href="https://creativecommons.org/licenses/by/4.0/deed.en">Creative Commons BY-SA 4.0</a><br> scanning facility: <a href="https://www.iis.fraunhofer.de/en/ff/zfp.html">Fraunhofer Development Center X-ray Technology EZRT/Fraunhofer IIS</a><br> scanning device: High Energy CT XXL-CT<br> Funding attribution: <a href="https://www.bmbf.de/bmbf/en">German Federal Ministry of Education and Research</a><br> acknowledgement: <a href="https://www.cryptomuseum.com">CryptoMuseum</a> (as main source for informations about the cipher machines)</p>
The average transmitted wave in random particulate materials: Monte-Carlo data
<p><em>A Julia repo designed to replicate and validate wave scattering from a plate filled with randomly distributed particles. The code allows you to explore the effects of different parameters such as scatterer type, volume fraction, and frequency on wave scattering behavior.</em></p> <ol> <li> <p>Make sure you have Julia v1.6.7 or later, installed on your system.</p> </li> <li> <p>Open your preferred Julia environment (REPL or Jupyter Notebook).</p> </li> <li> <p>Navigate to the downloaded code directory within Julia.</p> </li> <li> <p>Load the necessary packages included in loaddata.jl.</p> </li> <li> <p>To load the data, modify the code's parameters using the provided flags:</p> </li> </ol> <p> </p> <ul> <li><code><code>is_sound_soft</code><span>: Set to </span><code>true</code><span> for sound-soft scatterers, and </span><code>false</code><span> for hard scatterers.</span></code></li> <li><code><code>is_two_wavenumbers</code><span>: Set to </span><code>true</code><span> for two wavenumbers, and </span><code>false</code><span> for three wavenumbers.</span></code></li> <li><code><code>is_low_freq</code>: Set to <code>true</code> for low frequency ka = 0.04, and <code>false</code> for frequenc ka = 0.36 or ka = 0.62.</code></li> <li><code><code>is_low_volfrac</code>: Set to <code>true</code> for 5% volume fraction, and <code>false</code> for 25% volume fraction.</code></li> </ul> <p> </p> <p>Run the code. The simulation will load the appropriate dataset based on your selected parameters and display the results.</p>
Establishing a new standard of care for calculus using trials with randomized student allocation
<p>Calculus, the study of change in processes and systems, serves as the foundation of many STEM disciplines. Traditional, lecture-based calculus instruction presents a persistent barrier for students seeking STEM degrees, limits access to STEM professions, and blocks their potential to address society's challenges. A large-scale pragmatic trial with randomized student allocation was conducted to compare two calculus instruction styles: active student engagement (treatment condition) versus traditional, lecture-based instruction (control condition). A sample of 811 U.S. university students was studied across 32 sections taught by 19 instructors over three semesters at a large U.S. Hispanic-Serving Institution. Large effect sizes were consistently measured for student learning outcomes in the treatment condition, which demonstrated a new standard for calculus instruction and increased opportunities for completion of STEM degrees.</p>
Effectiveness of self-management of medication and self-monitoring of blood pressure, diet, and physical exercise on blood pressure in patients with poorly controlled hypertension (MEDICHY study): randomized and controlled trial
<p>Dataset study medichy ISRCTN144433778</p>
Activaiton of regions at peaks of global signal and random time points
<p>Seven datasets were collected in the study, including: Sleep dataset, Anesthesia dataset, eyes-open/eyes-closed (EO/EC) dataset, two unresponsive wakefulness syndrome (UWS) dataset, REM sleep dataset, and N3 sleep/UWS dataset. The activation of brain regions during the peaks of global signal and random time points were extracted under different arousal conditions.</p>
Efficient Approximation of Molecular Kinetics using Random Fourier Features
<p>Dataset to accompany the paper "<a href="https://scholar.google.com/citations?view_op=view_citation&hl=en&user=RqvAsE0AAAAJ&sortby=pubdate&citation_for_view=RqvAsE0AAAAJ:ULOm3_A8WrAC">Efficient Approximation of Molecular Kinetics using Random Fourier Features</a>", Journal of Chemical Physics 159, 074105 (2023), <a href="https://doi.org/10.1063/5.0162619">https://doi.org/10.1063/5.0162619</a>. Contains source code, input data, and result files. The data are compressed to a single zip file to preserve directory structure. See README file for detailed description of individual files.</p> <p>To automatically download and create the computational environment, pull the latest docker image from <a href="https://hub.docker.com/r/fnueske/23_jcp_rff_data/">https://hub.docker.com/r/fnueske/23_jcp_rff_data/</a></p> <p>and run the following command in terminal:</p> <p>docker run --rm -p 8888:8888 mk-rff:latest</p>
A random mosaic, acquired from l-space
Roman Mosaic found in Somerset. Each panel tells part of a story. Unfortunately, I don't know that story. Source: Objaverse 1.0 / Sketchfab
TIME™ at Home Randomized Controlled Trial
ClinicalTrials.gov study NCT06245135. IPD Sharing: YES. Countries: 1. Publications: 1.
Believing People Can Change: A Randomized Controlled Trial of an Incremental Theory Intervention in Adolescence
ClinicalTrials.gov study NCT04133389. IPD Sharing: NO. Countries: 1. Publications: 8.
Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusio
ClinicalTrials.gov study NCT04792970. IPD Sharing: NO. Countries: 1. Publications: 2.
IMPROVE AKI Cluster-Randomized Trial
ClinicalTrials.gov study NCT03556293. IPD Sharing: YES. Countries: 1. Publications: 2.
The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation
ClinicalTrials.gov study NCT03020407. IPD Sharing: NO. Countries: 1. Publications: 1.
A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease
ClinicalTrials.gov study NCT03404115. IPD Sharing: NO. Countries: 1. Publications: 1.
Randomized Controlled Trial of Subcuticular Skin Closure Versus Steri-strip S Closure
ClinicalTrials.gov study NCT00727025. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prospective Randomized Endovascular Therapy in Multiple Sclerosis - PREMiSE
ClinicalTrials.gov study NCT01450072. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Randomized Cross-Over Study of Self-Insertion of Two Placebo Vaginal Film Formulations
ClinicalTrials.gov study NCT04391036. IPD Sharing: NO. Countries: 1. Publications: 3.
Evaluation of Bioflex and Zirconia Crowns Versus Stainless Steel Crowns on Primary Molars: Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT07156838. IPD Sharing: NO. Countries: 1. Publications: 3.
Randomized Evaluation of Strategic Intervention in Multidrug Resistant Patients With Tipranavir (RESIST)
ClinicalTrials.gov study NCT00054717. IPD Sharing: Not stated. Countries: 4. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.