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7,518 results for “screenings”
Different sources of natural products from the (a) bacterial, (b) archaeal, (c) fungal, (d) protozoan, (e) chromistan, (f) plant and (g) animal kingdoms, the rationale(s) for screening them for antibacterial activity, and associated advantages and disadvantages
<p>This table of information is from the review article 'Bioprospecting for Antibacterial drugs: A Multidisciplinary Perspective on Natural Product Source Material, Bioassay Selection and Avoidable Pitfalls' (<a href="https://doi.org/10.1007/s11095-020-02849-1">https://doi.org/10.1007/s11095-020-02849-1</a>).</p>
Data from: Computer-aided X-ray screening for tuberculosis and HIV testing among adults with cough in Malawi (the PROSPECT study): a randomized trial and cost-effectiveness analysis
<p>Suboptimal tuberculosis (TB) diagnostics and HIV contribute to the high global burden of TB. We investigated costs and yield from systematic HIV-TB screening, including computer-aided digital chest X-ray (DCXR-CAD). Suboptimal tuberculosis (TB) diagnostics and HIV contribute to the high global burden of TB. We investigated costs and yield from systematic HIV-TB screening, including computer-aided digital chest X-ray (DCXR-CAD).</p> <p>In this open, three-arm randomised trial, adults (≥18 years) with cough attending acute primary services in Malawi were randomised (1:1:1) to standard-of-care (SOC); oral HIV testing (HIV screening) and linkage to care; or HIV testing and linkage to care plus DCXR-CAD with sputum Xpert for high CAD4TBv5 scores (HIV-TB screening). Participants and study staff were not blinded to intervention allocation, but investigator blinding was maintained until final analysis. The primary outcome was time to TB treatment. Secondary outcomes included proportion with same-day TB treatment; prevalence of undiagnosed/untreated bacteriologically-confirmed TB on day 56; and undiagnosed/untreated HIV. Analysis was done on an intention to treat basis. Cost-effectiveness analysis used a health-provider perspective. Between 15/11/2018-27/11/2019, 8236 were screened for eligibility, with 473, 492, and 497 randomly allocated to SOC, HIV, and HIV-TB screening arms; 53 (11%), 52 (9%), and 47 (9%) were lost to follow-up, respectively. At 56 days, TB treatment had been started in 5 (1.1%) SOC, 8 (1.6%) HIV-screening, and 15 (3.0%) HIV-TB screening participants. Median (IQR) time to TB treatment was 11 (6.5-38), 6 (1-22) and 1 (0-3) days (hazard ratio for HIV-TB vs. SOC: 2.86, 1.04-7.87), with same-day treatment of 0/5 (0%) SOC, 1/8 (12.5%) HIV, and 6/15 (40.0%) HIV-TB screening arm TB patients (p=0.03). At day 56, 2 SOC (0.5%), 4 HIV (1.0%), and 2 HIV-TB (0.5%) participants had undiagnosed microbiologically-confirmed TB. HIV screening reduced the proportion with undiagnosed or untreated HIV from 10 (2.7%) in the SOC arm to 2 (0.5%) in the HIV-screening arm (risk ratio [RR]: 0.18, 0.04-0.83), and 1 (0.2%) in the HIV-TB screening arm (RR: 0.09, 0.01-0.71). Incremental costs were US$3.58 and US$19.92 per participant screened for HIV and HIV-TB; the probability of cost-effectiveness at a US$1200/quality-adjusted life-year (QALY) threshold were 83.9% and 0%. Main limitations were the lower than anticipated prevalence of tuberculosis and short participant follow-up period; cost and quality of life benefits of this screening approach may accrue over a longer time horizon.</p> <p>DCXR-CAD with universal HIV screening significantly increased the timeliness and completeness of HIV and TB diagnosis. If implemented at scale this has potential to rapidly and efficiently improve TB and HIV diagnosis and treatment.</p>
Supplementary Information for "Semi-automated high-throughput substrate screening assay for nucleoside kinases
<p>This is the external Supplementary Information for our publication "Semi-automated high-throughput substrate screening assay for nucleoside kinases". Files are to follow soon. We apologize for the delay. Thank you for your patience.</p> <p> </p> <p>The preprint and the Supporting Information are available at ChemRxiv (https://doi.org/10.33774/chemrxiv-2021-k0w7q).</p>
Processed data from Repair-seq screens of double-strand breaks
<p>Processed data from Repair-seq screens of double-strand breaks induced by SpCas9 and AsCas12a in the presence or absence of oligonucleotide homology donors.</p>
High-Throughput-Methyl-Reading (HTMR) assay: A solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases
<p>Epigenetic therapy has significant potential for cancer treatment. However, few small potent molecules have been identified against DNA or RNA modification regulatory proteins. Current approaches for activity detection of DNA/RNA methyltransferases and demethylases are time-consuming and labor-intensive, making it difficult to subject them to high-throughput screening. Here, we developed a fluorescence polarization-based "High-Throughput Methyl Reading" (HTMR) assay to implement large-scale compound screening for DNA/RNA methyltransferases and demethylases-DNMTs, TETs, ALKBH5, and METTL3/METTL14. This assay is simple to perform in a mix-and-read manner by adding the methyl-binding proteins MBD1 or YTHDF1. The proteins can be used to distinguish FAM-labelled substrates or product oligonucleotides with different methylation statuses catalyzed by enzymes. Therefore, the extent of the enzymatic reactions can be coupled with the variation of FP binding signals. Furthermore, this assay can be effectively used to conduct a cofactor competition study. Based on the assay, we identified two natural products as candidate compounds for DNMT1 and ALKBH5. In summary, this study outlines a powerful homogeneous approach for high-throughput screening and evaluating enzymatic activity for DNA/RNA methyltransferases and demethylases that is cheap, easy, quick, and highly sensitive.</p>
Survey of patient advocacy groups regarding the use of AI in cancer screening
<p>This file contains the results of a survey of members of patient advocacy groups affiliated with Washington University in St Louis, Stanford University and Johns Hopkins University. The survey asks about attitudes regarding different ways in which AI could be involved in the process of cancer screening. IRB approval was obtained from Washington University in St Louis.</p>
Long-Term Survival and Curative-Intent Treatment in Hepatitis B or C Virus-Associated Hepatocellular Carcinoma Patients Diagnosed during Screening
<p>We uploaded the image of the mansucript <strong>Long-Term Survival and Curative-Intent Treatment in Hepatitis B or C Virus-Associated Hepatocellular Carcinoma Patients Diagnosed during Screening </strong>accepted on Biology.</p>
Arabidopsis HapMap screen for salt-induced changes in root architecture and root:shoot ratio - images BA1 experiment
<p>Images of scanned agar plates collected for Arabidopsis accessions exposed to salt stress / control treatment. The data was collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink. </p>
Arabidopsis HapMap screen for salt-induced changes in root architecture and root:shoot ratio - images BA2 experiment
<p>Images of scanned agar plates collected for Arabidopsis accessions exposed to salt stress / control treatment. The data were collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink. </p>
Arabidopsis HapMap screen for salt-induced changes in root architecture and root:shoot ratio - images BA7 experiment
<p>Images of scanned agar plates collected for Arabidopsis accessions exposed to salt stress / control treatment. The data were collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink. </p>
Arabidopsis HapMap screen for salt-induced changes in root architecture and root:shoot ratio - images BA3 experiment
<p>Images of scanned agar plates collected for Arabidopsis accessions exposed to salt stress / control treatment. The data were collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink.</p>
Arabidopsis HapMap screen for salt-induced changes in root architecture and root:shoot ratio - images BA6 experiment
<p>Images of scanned agar plates collected for Arabidopsis accessions exposed to salt stress / control treatment. The data were collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink. </p>
Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells
<p>In contrast to the rich single-cell transcriptomic and epigenetic data, the corresponding protein level information of human hematopoietic stem and progenitor cell (HSPC) populations is still missing. We used a highly-multiplexed single-cell screen to quantify the protein expression of 353 surface molecules and 79 functional intracellular molecules (TFs, chromatin regulators, and metabolic enzymes) with mass cytometry. In doing this, we created a core panel with probes against functional protein molecules associated with specific lineage potentials to better illuminate the differentiation potentials of the progenitors. In total, we analyzed 556,226 CD34+ bone marrow HSPCs across three individuals. Our analysis identified ten distinct clusters among HSPCs by unsupervised method and defined their unique proteomic composition. We compare our data-driven populations to the canonical HSPC cell types identified by cell surface proteins and observe discrepancies, especially in the lympho-myeloid axis. Overall, we supply a quantified summary of the proteomes of human HSPCs and create a framework to redefine progenitor populations with unique functional states along hematopoiesis. </p>
PanDDA analysis of PTP1B re-screened against fragment libraries at RT
<p>PTP1B re-screened against multiple fragment libraries with RT crystallography</p>
A QUASI-EXPERIMENTAL STUDY TO IMPROVE DIABETIC CONTROL FOR THE UNDERSERVED POPULATION THROUGH EDUCATION AND SCREENINGS
<p>Diabetes is a growing epidemic in the underserved population. Type 2 diabetes is one of the largest health concerns affecting Americans. Over 37 million Americans are diagnosed with diabetes and over 7 million are undiagnosed. One out of three Americans have prediabetes, but only 12% are aware of this condition.<sup>1</sup> Diabetes can lead to serious health conditions including cardiac, renal, retinal and vascular conditions. A step towards controlling diabetes is performing an HbA1C test, but many people are not adequately screened or educated on the risk of diabetes. The American Diabetes Association (ADA) recognizes a HbA1c as an evidence-based tool used in monitoring diabetes and diabetic determination.</p> <p>More than 28 million Americans are considered underserved with approximately 9% of Americans are classified as diabetics.<sup>1</sup> Only 68% of this population are considered compliant with their diabetic treatment.<sup>9</sup> The lack of diabetic control is caused by the inability to seek healthcare and a lack of diabetic supplies, screenings and treatment.<sup>7</sup> The ADA determined that the underserved population suffering with diabetes is impacted 48 times more than any other population.</p>
Cowpea drought stress application at early vegetative stage 2022 - screen 01 - day 13 - raw image data
<p>Cowpea (<em>Vigna unguiculata</em>) miniCore accessions were screened for responses to drought stress at early vegetative stress. The cowpea seedlings were exposed to drought stress at 17 days after germination using the weight of the pot and AAWEsmo device, developed in Julkowska Lab, Boyce Thompson Institute. The seedlings were kept at 60 and 10% of soil water holding capacity for 2 weeks and the data on cowpea shoot size, evapotranspiration and photosystem II efficiency was collected. </p> <p>This dataset represents the images collected for Screen number 01 and day 13 after drought stress application. </p>
Cowpea drought stress application at early vegetative stage 2022 - screen 01 - day 08 - raw image data
<p>Cowpea (<em>Vigna unguiculata</em>) miniCore accessions were screened for responses to drought stress at early vegetative stress. The cowpea seedlings were exposed to drought stress at 17 days after germination using the weight of the pot and AAWEsmo device, developed in Julkowska Lab, Boyce Thompson Institute. The seedlings were kept at 60 and 10% of soil water holding capacity for 2 weeks and the data on cowpea shoot size, evapotranspiration and photosystem II efficiency was collected. </p> <p>This dataset represents the images collected for Screen number 01 and day 8 after drought stress application. </p>
Cowpea drought stress application at early vegetative stage 2022 - screen 01 - day 06 - raw image data
<p>Cowpea (<em>Vigna unguiculata</em>) miniCore accessions were screened for responses to drought stress at early vegetative stress. The cowpea seedlings were exposed to drought stress at 17 days after germination using the weight of the pot and AAWEsmo device, developed in Julkowska Lab, Boyce Thompson Institute. The seedlings were kept at 60 and 10% of soil water holding capacity for 2 weeks and the data on cowpea shoot size, evapotranspiration and photosystem II efficiency was collected. </p> <p>This dataset represents the images collected for Screen number 01 and day 6 after drought stress application. </p>
Cowpea drought stress application at early vegetative stage 2022 - screen 01 - day 04 - raw image data
<p>Cowpea (<em>Vigna unguiculata</em>) miniCore accessions were screened for responses to drought stress at early vegetative stress. The cowpea seedlings were exposed to drought stress at 17 days after germination using the weight of the pot and AAWEsmo device, developed in Julkowska Lab, Boyce Thompson Institute. The seedlings were kept at 60 and 10% of soil water holding capacity for 2 weeks and the data on cowpea shoot size, evapotranspiration and photosystem II efficiency was collected. </p> <p>This dataset represents the images collected for Screen number 01 and day 4 after drought stress application. </p>
Cowpea drought stress application at early vegetative stage 2022 - screen 01 - day 10 - raw image data
<p>Cowpea (<em>Vigna unguiculata</em>) miniCore accessions were screened for responses to drought stress at early vegetative stress. The cowpea seedlings were exposed to drought stress at 17 days after germination using the weight of the pot and AAWEsmo device, developed in Julkowska Lab, Boyce Thompson Institute. The seedlings were kept at 60 and 10% of soil water holding capacity for 2 weeks and the data on cowpea shoot size, evapotranspiration and photosystem II efficiency was collected. </p> <p>This dataset represents the images collected for Screen number 01 and day 10 after drought stress application. </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.