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7,518 results for “screenings”
Scheme 1 from: Voynikov Y, Gevrenova R, Zheleva-Dimitrova D, Balabanova V, Nikolova I, Marinov L, Benbassat I, Momekov G (2023) UHPLC-Orbitrap screening of oleraindoles in hydromethanolic extracts of Portulaca oleracea. Pharmacia 70(4): 1521-1527. https://doi.org/10.3897/pharmacia.70.e113577
Scheme 1 Scheme 1. Common scaffold of an oleraindole.
Figure 2 from: Mateev E, Irfan A, Mateeva A, Kondeva-Burdina M, Georgieva M, Zlatkov A (2024) In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e114120
Figure 2 General core structure of the employed in-house database.
Figure 1 from: Mateev E, Irfan A, Mateeva A, Kondeva-Burdina M, Georgieva M, Zlatkov A (2024) In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e114120
Figure 1 Workflow for identifying novel pyrrole-based acetylcholinesterase inhibitors.
Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library.
<p>Data underlying manuscript Patlewicz G, Paul-Friedman K, Houck K, Zhang L, Huang R, Xia M, Brown J, Simmons SO. Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library. Computational Toxicology https://doi.org/10.1016/j.comtox.2023.100271</p>
Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling
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Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening
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Signature analysis of high-throughput transcriptomics screening data for mechanistic inference and chemical grouping
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Screening of 452 hit enrichment compounds for anti-SARS-CoV-2 activity meta data
<p>This short report describes the most relevant results of screening selected compounds from the Janssen Pharmaceutica compound collection in a VeroE6 cell-based anti-SARS-CoV-2 assay.</p>
High-Content Live-Cell Multiplex Screen for Chemogenomic Compound Annotation based on Nuclear Morphology - Supplemental Material
<p>High-Content Live-Cell Multiplex Screen for Chemogenomic Compound Annotation based on Nuclear Morphology</p> <p>Supplementary Material of linked STAR-protocol</p>
The Nigerian dietary screening tool: A step toward improved patient-clinician communication in Nigerian hospitals: A pilot implementation study
<p>Supplementary Material for the paper "<span>The Nigerian dietary screening tool: A step toward improved patient-clinician communication in Nigerian hospitals: A pilot implementation study"</span></p>
High-throughput screening for cell binding and repulsion peptides on multifunctionalized surfaces
<p><a name="_GoBack"></a>Tables with fluorescent intensity values after cell incubation for each peptide from libraries synthesized on peptide chips. Excel file “Supplementary Data 1.xlsx” represents the numerical source data for graphs Fig 2, Fig3, suppl Fig 1, suppl Fig 2. Excel file “Supplementary Data 2.xlsx” represents the numerical source data for suppl Fig. 3.</p>
Numerical Analysis of Hybrid REBCO-Cu Coatings for the Future Circular Collider Beam Screen
<p>Simulation files and data of the beam screen (BS) of the Hybrid Future Circular Collider (FCC) with a hybrid coating composed of alternating segments of REBCO high temperature superconductor (HTS) and copper.</p> <p>00. All Simulations: All simulation files with no solutions.</p> <p>01. ParametricStudy: Several coating geometries are evaluated in terms of the field quality within the reference radius of the FCC BS. The coatings are defined by the number of segments (n) and the ratio of HTS in the flat portions of the BS (p). The simulation files are generated via COMSOL LiveLink for MATLAB, with the MATLAB script ParSweepAutoSims. </p> <p>02. HspmSims: The experimental setup of a Hall Scan Probe Microscopy measurement of trapped field is replicated with hybrid coatings of different p and n.</p> <p>03. AcDemagnetization: The effect of a perpendicular AC field superimposed to a DC field to the current flowing in a HTS tape is simulated.</p> <p>04. ProposedGeometry: A coating geometry is proposed based on the results of the parametric study.</p> <p>05. MisalignedMultipole: The proposed geometry submitted to other magnetic field configurations as tu study the impact on field harmonics due to a quadrupole field, hysteresis, creep and misalignments. Each study requires different magnetic field inputs, which should be selected appropriately in the definitions tab. The MATLAB script FieldHarmCalc is used to calculate the field harmonics. </p> <p>06. ThermoMechanical: The thermomechanical response of the coated beam screen is investigated. Dipole-induced heat as well as resistive wall heating and synchrotron radiation are considered. </p> <p>07. DipoleQuench: The consequences of a quench of the main dipole magnets is studied. Temperature dependent material properties are taken into account. </p> <p>08. TransverseCurrent: The correlation between transverse current flow and length in electronically coupled HTS segments is analysed in a simplified geometry.</p> <p>09. RebcoProperties: The files containing the material properties used in the simulations. Data from S. Wimbush, N. Strickland, and A. Pantoja. “Critical current characterisation of SuperPower Advanced Pinning 2G HTS superconducting wire”. In: (Mar. 2021). DOI: 10.6084/m9.figshare.4256624.v3. URL: https://figshare.com/articles/dataset/Critical_current_characterisation_of_SuperPower_Advanced_Pinning_2G_HTS_superconducting_wire/4256624.</p> <p>10. MainResults: A summary of the main results obtained with these simulations.</p>
CCogS-Mx/Spanish-lyrics-dataset-for-LGBTQ-phobia-screening: Spanish lyrics dataset for LGBTQ+phobia screening
<p>The development of this corpus includes songs written in Spanish that may contain LGBTQ+phobic text or not, contributor update</p>
Domain-invariant features for mechanism of action prediction in a multi-cell-line drug screen
<p><strong>Motivation: </strong>As a proxy for diseased cells, a cell line cannot be thought of as a perfect model. Many diseases feature an important molecular heterogeneity. Consequently, a drug may be effective against one molecular subtype of a disease, but less so against another. To characterise drugs with respect to their effect not only on one cell line but on a consensus of several is therefore a promising strategy to streamline the drug discovery process.</p> <p><strong>Results: </strong>The contribution of this paper is twofold. First, we investigate whether we can predict MOA at the molecular level without optimisation of the MOA classes to the screen specificities. To this end, we benchmark a set of algorithms within a conventional pipeline, and evaluate their MOA prediction performance according to a statistically rigorous framework. Second, we extend this conventional pipeline to the simultaneous analysis of multiple cell lines, each with potentially different morphological baselines. For this, we propose multitask autoencoders, including a domain-adaptive model used to construct domain-invariant feature representations across cell lines. We apply these methods to a pilot screen of two triple negative breast cancer cell lines as models for two different molecular subtypes of the disease.</p>
Data from: Screen for mitochondrial DNA copy-number maintenance genes reveals essential role for ATP synthase
The machinery of mitochondrial DNA (mtDNA) maintenance is only partially characterized and is of wide interest due to its involvement in disease. To identify novel components of this machinery, plus other cellular pathways required for mtDNA viability, we implemented a genome-wide RNAi screen in Drosophila S2 cells, assaying for loss of fluorescence of mtDNA nucleoids stained with the DNA-intercalating agent PicoGreen. In addition to previously characterized components of the mtDNA replication and transcription machineries, positives included many proteins of the cytosolic proteasome and ribosome (but not the mitoribosome), three proteins involved in vesicle transport, some other factors involved in mitochondrial biogenesis or nuclear gene expression, > 30 mainly uncharacterized proteins and most subunits of ATP synthase (but no other OXPHOS complex). ATP synthase knockdown precipitated a burst of mitochondrial ROS production, followed by copy number depletion involving increased mitochondrial turnover, not dependent on the canonical autophagy machinery. Our findings will inform future studies of the apparatus and regulation of mtDNA maintenance, and the role of mitochondrial bioenergetics and signaling in modulating mtDNA copy number.
CRISPR/Cas9 genome-wide screens for sensitisers and suppressors of AZD6738 efficacy in Atm WT and Atm KO mESCs
<p>The protein kinase ATR plays pivotal roles in DNA repair, cell cycle checkpoint engagement and DNA replication. Consequently, ATR inhibitors (ATRi) are in clinical development for the treatment of cancers, including tumours harbouring mutations in the related kinase ATM. However, it still remains unclear which functions and pathways dominate long-term ATRi efficacy, and how these vary between clinically relevant genetic backgrounds. Elucidating common and genetic-background specific mechanisms of ATRi efficacy could therefore assist patient stratification and pre-empting drug resistance. Here, we use CRISPR-Cas9 genome-wide screening in ATM-deficient and proficient mouse embryonic stem cells to interrogate cell fitness following treatment with the ATRi, ceralasertib (AZD6738). We identify factors that enhance or suppress ATRi efficacy, with a subset of these requiring intact ATM signalling. Overall, our work identifies novel biomarkers of ATRi efficacy in ATM-proficient and ATM-deficient cells, and suggests new ATM-dependent pathways that compensate in the absence of functional ATR.</p>
Effect of neurological screening on early dementia detection in southern Italy
<p>Objective</p> <p>Population screening can facilitate early diagnosis of dementia and improve disease management. This study examined the effects of a screening campaign for neurodegenerative disorders on the early diagnosis of dementia using 2-year follow-up data.</p> <p>Methods</p> <p>A 5-day screening campaign was conducted that comprised neurological, neuropsychological and other specialist examinations. Identification of alterations during the neurological examination was followed-up by further diagnostic examinations to confirm the neurological impairment.</p> <p>Results</p> <p>Neurological alterations were observed in 39% of the screened subjects, who were mostly diagnosed with mild cognitive impairment and referred to a dementia and cognitive disorders centre. Suspicion of neurological impairment was a risk factor for inclusion in a specific neurological ambulatory follow-up and a condition for exemption from payment for medical examinations.</p> <p>Conclusions</p> <p>Neurodegenerative screening initiatives should include subjects selected by general practitioners. It would be useful to create a network including primary care physicians and cognitive disorder centres. Telemedicine tools (e.g., teleconsulting) could also be used to facilitate early diagnosis.</p>
Micelle size screening - Gwalp tail anchor dimer simulation - 60 SDS - Na neutralized - CHARMM36m - 310K - OPC water model
<p>Micelle size screening by varying the amount of SDS to investigate the influence on spin relaxation data with dimers of a given peptide.</p>
Micelle size screening - yFis1 simulation - 45 SDS - Na neutralized - CHARMM36m - 310K - OPC water model
<p>Micelle size screening by varying the amount of SDS to investigate the influence on spin relaxation data.</p>
Dataset of the Distress Screening Scale for the article: Emotional distress, coping, and social support: A network analysis of risk and resources in persons with cancer
<p>Dataset of the Distress Screening System comprises 52 items that relate to six psycho-social domains of human functioning: depression, anxiety, social support, coping efficacy, satisfaction with care, and functional status</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.