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Dataset results
4,008 results for “Heart failure”
Transcriptome changes in cardiomyocytes isolated from a rat model of progressive heart failure
GEO Series GSE216263. Rattus norvegicus. 82 samples. Type: Expression profiling by high throughput sequencing.
An inflammatory single-cell RNA sequencing signature driven by metabolic stress in a new mouse model of heart failure with preserved ejection fraction and its reversion by the SGLT2 inhibitor dapaglif
GEO Series GSE208425. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The biological mechanisms related to hub genes in the development of heart failure in dialysis patients were investigated through transcriptome sequencing
GEO Series GSE253498. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
RNA Binding Patterns of Ischemic Heart Failure Prognosis Indicator Eukaryotic Translation Initiation Factor 3m Reveal its Unique Role in Regulation of Nitrative Damage after Myocardial Ischemia-Reperf
GEO Series GSE217296. Homo sapiens; Rattus norvegicus. 20 samples. Type: Expression profiling by high throughput sequencing; Other.
Vagal neuroimmune axis modulates heart failure by limiting monocyte-derived inflammatory CCRL2 macrophage II
GEO Series GSE296255. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic gene-expression links heart failure to memory impairment [chipseq_from_saha_treatment]
GEO Series GSE159475. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic gene-expression links heart failure to memory impairment [rnaseq_tunicamycin_6h]
GEO Series GSE159446. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Secondary hyperparathyroidism and thoracic vertebral fractures in heart failure middle-aged patients: a 3-year prospective study"
<p>This record contains data related to article "Secondary hyperparathyroidism and thoracic vertebral fractures in heart failure middle-aged patients: a 3-year prospective study"</p> <p>Abstract</p> <p><strong>Purpose: </strong>Vertebral fractures (VFs) were described in elderly patients with heart failure (HF) whereas their prevalence and determinants in younger HF patients are still unknown. This study aimed at assessing whether secondary hyperparathyroidism (SHPT) may influence the risk of VFs in middle-aged patients with HF.</p> <p><strong>Methods: </strong>84 patients (44 males, median age 48.5 years, range 43-65) with HF were prospectively evaluated at the baseline and after 36-month follow-up for bone mineral density (BMD) and VFs by quantitative morphometry on chest X-rays. Serum PTH, calcium, 25-hydroxyvitamin D and 24-h-urinary calcium were evaluated at the baseline and every 6-12 months during the study period.</p> <p><strong>Results: </strong>At baseline, SHPT, hypovitaminosis D and VFs were found in 43 patients (51.2%), 73 patients (86.9%) and 29 patients (34.5%), respectively. SHPT was associated with VFs at baseline [inverse probability-weighted (ipw) odds ratio (OR) 12.2, p < 0.001]. Patients were treated with vitamin D3 alone (56%), vitamin D3 plus calcium carbonate (21.4%), calcitriol alone (4.8%), bisphosphonates plus vitamin D3 (8.3%) or a combination of bisphosphonates, vitamin D3 and calcium carbonate (9.5%). At the end of follow-up, hypovitaminosis D was corrected in all patients, whereas 19/84 patients (22.6%) had persistent SHPT. During the follow-up, 16 patients developed incident VFs which resulted to be associated with baseline SHPT (ipw OR 55.7, p < 0.001), even after adjusting from BMD change from baseline to follow-up (ipw OR 46.4, p < 0.001).</p> <p><strong>Conclusions: </strong>This study provides a first evidence that SHPT may be a risk factor for VFs in middle-aged patients with HF.</p>
Ataset of the publication "Is red distribution width a valid tool to predict impaired iron transport in heart failure?"
<p>Background: Impaired iron transport (IIT) is a form of iron deficiency (ID) defined as transferrin saturation (TSAT) < 20% irrespective of serum ferritin levels. It is frequently observed in heart failure (HF) where it negatively affects prognosis irrespective of anaemia. Objectives: In this retrospective study we searched for a surrogate biomarker of IIT. Methods: We tested the predictive power of red distribution width (RDW), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC) to detect IIT in 797 non-anaemic HF patients. Results: At ROC analysis, RDW provided the best AUC (0.6928). An RDW cut-off value of 14.2% identified patients with IIT, with positive and negative predictive values of 48 and 80%, respectively. Comparison between the true and false negative groups showed that estimated glomerular filtration rate (eGFR) was significantly higher (p = 0.0092) in the true negative vs. false negative group. Therefore, we divided the study population according to eGFR value: 109 patients with eGFR ≥ 90 ml/min/1.73 m2, 318 patients with eGFR 60-89 ml/min/1.73 m2, 308 patients with eGFR 30-59 ml/min/1.73 m2 and 62 patients with eGFR < 30 ml/min/1.73 m2. In the first group, positive and negative predictive values were 48 and 81% respectively, 51 and 85% in the second group, 48 and 73% in the third group and 43 and 67% in the fourth group. Conclusion: RDW may be seen as a reliable marker to exclude IIT in non-anaemic HF patients with eGFR ≥60 ml/min/1.73 m2.</p>
Dataset related to: The Impact of Cardiac Rehabilitation on Activities of Daily Life in Elderly Patients With Heart Failure
<p>Dataset related to the article:</p> <p>Paneroni M, Scalvini S, Corrà U, Lovagnini M, Maestri R, Mazza A, Raimondo R, Agostoni P, La Rovere MT. The Impact of Cardiac Rehabilitation on Activities of Daily Life in Elderly Patients With Heart Failure. Front Physiol. 2022;12:785501. doi: 10.3389/fphys.2021.785501.</p> <p><strong>Background:</strong> In elderly chronic heart failure (HF) patients, activities of daily living (ADLs) require the use of a high proportion of patients' peak aerobic capacity, heart rate, and ventilation. <strong>Objectives:</strong> To assess the effects of short-term comprehensive cardiac rehabilitation (CR) on the metabolic requirement of ADLs in elderly patients with chronic HF. <strong>Methods:</strong> The study population comprised 99 elderly chronic HF patients (mean age 72 ± 5 years, 80% male, 61% ejection fraction <40%, mean NT-proBNP 2,559 ± 4,511 pg/ml) participating in a short-term (mean days 19 ± 7) residential CR program. Before and after CR, participants, while wearing a portable ergospirometer, performed a standardized ADL battery: ADL1 (getting dressed), ADL2 (folding 8 towels), ADL3 (putting away 6 bottles), ADL4 (making a bed), ADL5 (sweeping the floor for 4 min), ADL6 (climbing 1 flight of stairs carrying a 1.5 Kg load), and ADL7 (a standard 6-min walking test). <strong>Results:</strong> After CR, task-related oxygen uptake did not change in any of the domestic ADLs. Notably, there was a significant decrease in the cumulative time required to perform ADLs (ADL 1-4 and ADL6; from 412 ± 147 to 388 ± 141 s, <em>p</em> = 0.001) and a reduction in maximal heart rate in ADL1 and 3 (<em>p</em> = 0.005 and <em>p</em> = 0.027, respectively). Changes occurred in the 6MWT with an increase in oxygen uptake (<em>p</em> = 0.005) and in the distance covered (<em>p</em> < 0.001) and a significant decrease in the Borg scale of dyspnea (<em>p</em> = 0.004). <strong>Conclusion:</strong> Elderly patients with chronic heart failure who are engaged in a short-term residential CR program improve the performance of routine ADLs.</p>
Study of High Dosage of Losartan in Comparison to Low Dose of Losartan in Heart Failure Patients
ClinicalTrials.gov study NCT02238457. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Congestive Heart Failure Trends in the Elderly 1970-94
ClinicalTrials.gov study NCT00005499. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Levosimendan Compassionate Use in Pediatric Patients With Advanced Decompensated Heart Failure
ClinicalTrials.gov study NCT02973620. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Epidemiology of Depression and Heart Failure in Aging
ClinicalTrials.gov study NCT00241761. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Cannabidiol in Patients With Heart Failure Failure in AHA/ACC Stages A-C
ClinicalTrials.gov study NCT03634189. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Acute Heart Failure Patients With High Copeptin Treated With Tolvaptan Targets Increased AVP Activation for Treatment (ACTIVATE)
ClinicalTrials.gov study NCT01733134. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of Acute L-NMMA Treatment on Renal Hemodynamics and Vasoactive Hormones in Patients With Congestive Heart Failure
ClinicalTrials.gov study NCT00344734. IPD Sharing: Not stated. Countries: 0. Publications: 0.
RNA sequencing reveals the key genes and pathways in a mouse model of heart failure with preserved ejection fraction
GEO Series GSE180065. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Global microRNA profiling of the mouse ventricles during development of severe hypertrophic cardiomyopathy and heart failure
GEO Series GSE37692. Mus musculus. 12 samples. Type: Expression profiling by RT-PCR; Non-coding RNA profiling by array.
Myeloid Cell Derived IL1b Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction
GEO Series GSE244309. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.