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opencc-by-4.0Jan 2022View details →

Screening of 67 compounds with predicted biosignature profile similar to remdesivir for anti-SARS-CoV-2 activity

This short report describes the most relevant results of screening compounds with a similar predicted biosignature as remdesivir in a VeroE6 cell-based anti-SARS-CoV-2 assay.

opencc-by-4.0Jan 2022View details →

Screening of ~7000 coronavirus-specific compounds for anti-SARS-CoV-2 activity

This short report describes the most relevant results of screening selected compounds with potential activity against SARS-CoV-2 in a VeroE6 cell-based anti-SARS-CoV-2 assay.

opencc-zeroJan 2022View details →

Theoretical insights into the antiradical activity and copper-catalyzed oxidative damage of mexidol in the physiological environment

This dataset contains data from the calculations described in the paper: "Quan V. Vo*, Nguyen Thi Hoa, Mai Van Bay, Adam Mechler, Theoretical insights into the antiradical activity and copper-catalyzed oxidative damage of mexidol in the physiological environment. Royal Society Open Science. 2021. In this study, the hydroperoxyl radical scavenging activity of MD was studied to establish baseline antioxidant activity, followed by an investigation of the effect of MD on the copper-catalyzed oxidative damage in biological systems, using computational methods. It was found that MD exhibits moderate radical scavenging activity against HOO· in physiological environments. The activity in aqueous solution is defined by the single electron transfer mechanism of the anion state; however in nonpolar environments the formal hydrogen transfer pathway dominates at the O3-H bond. It was also confirmed that MD can chelate Cu (II), forming complexes that are much harder to reduce than free Cu (II): MD chelation completely quenches the Cu (II) reduction by ascorbic acid and suppresses the rate of reduction reaction by O2·- that are the main reductants of Cu (II) in biological environments. Therefore, MD exerts its anti- HO· activity primarily as an OIL-1 inhibitor.

opencc-by-4.0Jan 2022View details →

Knowledge and perception of community on health-related activities of Inclusive Self Help Groups in three regions of Myanmar and ways for strengthening

This data is gathered in 2019.

opencc-zeroJan 2022View details →

Long-term effect of regular physical activity and exercise habits in patients with early parkinson disease

Objective: Owing to the lack of long-term observations and/or comprehensive adjustment for confounding factors, reliable conclusions regarding long-term effects of exercise and regular physical activity in Parkinson's disease (PD) have yet to be drawn. Here, using data from the Parkinson's Progression Markers Initiative study that includes longitudinal and comprehensive evaluations of many clinical parameters, we examined the long-term effects of regular physical activity and exercise habits on the course of PD. Methods: In this observational cohort study, we primarily used the multivariate linear mixed-effects models to analyze the interaction effects of their regular physical activity and moderate-to-vigorous exercise levels, measured through the Physical Activity Scale for the Elderly questionnaire, on the progression of clinical parameters, after adjusting for age, sex, levodopa-equivalent dose, and disease duration. We also calculated bootstrapping 95% confidence intervals (CIs), and conducted sensitivity analyses using the multiple imputation method and subgroup analyses using the propensity score matching to match for all baseline background factors. Results: 237 early PD patients [median (interquartile range); age, 63.0 (56.0–70.0) years; Male, 69.2%; follow-up duration, 5.0 (4.0–6.0) years] were included. Regular physical activity and moderate-to-vigorous exercise levels at the baseline did not significantly affect the subsequent clinical progression of PD. However, average regular overall physical activity levels over time were significantly associated with slower deterioration of postural and gait stability [standardized fixed-effects coefficients of the interaction term (βinteraction) = -0.10 (95% CI, -0.14 to -0.06)], activities of daily living [βinteraction = 0.08 (95% CI, 0.04 to 0.12)], and processing speed [βinteraction = 0.05 (95% CI, 0.03 to 0.08)] in PD patients. Moderate-to-vigorous exercise levels were preferentially associated with slower decline of postural and gait stability [βinteraction = -0.09 (95% CI, -0.13 to -0.05)] and work-related activity levels were primarily associated with slower deterioration of processing speed [βinteraction = 0.07 (95% CI, 0.04 to 0.09)]. Multiple imputation and propensity score matching confirmed the robustness of our results. Conclusions: In the long-term, the maintenance of high regular physical activity levels and exercise habits was robustly associated with better clinical course of PD, with each type of physical activity having different effects.

Data from: Geographical variation in ant foraging activity and resource use is driven by climate and net primary productivity

Aim: Foraging activity is critical for animal survival. Comprehending how ecological drivers influence foraging behavior would benefit our understanding of the link between animals and ecological processes. Here, we evaluated the influence of ecological drivers on ant foraging activity and relative resource use. Location: Six Brazilian biomes: Amazon, Atlantic rainforest, Caatinga, Cerrado, Pampa and Pantanal. Taxon: Formicidae. Methods: We assessed ant foraging activity and resource use by sampling across 60 sites. We placed baited tubes that contained one of five liquid resources (sugar, lipids, amino acid, sodium and distilled water). We used model selection to assess the influence of ecological drivers (temperature, precipitation, temperature seasonality and net primary productivity) on ant foraging activity and relative resource use. Results: Foraging activity was higher in wetter, more productive and less thermally seasonal environments. The relative use of amino acids increased at higher temperatures while the relative use of lipids decreased. The relative use of sugar increased in drier and less productive environments with high temperature seasonality while the relative use of amino acid and sodium decreased in those environments. The relative use of lipids was complex: increasing with increasing temperature seasonality and decreasing with increasing precipitation. Further, the relative use of sodium was greater where the foraging activity was high. Main Conclusions: We demonstrate how ecological drivers are correlated to ant foraging activity and resource use in the field across large spatial scales. The search for resources encompasses different interactions involving ants with abiotic and biotic components in the ecosystem. Thus, we suggest that changes in climate and NPP, which influence the intensity and the way that ants search for resources, will result in changes in ant-mediated ecological processes.

opencc-by-4.0Nov 2021View details →

Source data for "In-degree centrality in a social network is linked to coordinated neural activity"

The following includes the source data for the manuscript titled "In-degree centrality in a social network is linked to coordinated neural activity". A second version of the source data ("Source Data_updated_011222.xlsx") includes the source data for the figures in the supplementary materials.

Resveratrol loaded chitosan-pectin core-shell nanoparticles as novel drug delivery vehicle for sustained release and improved antioxidant activities

Resveratrol, chemically known as 3, 5, 4'-trihydroxy-trans-stilbene, is a natural polyphenol with promising multi-targeted health benefits. The optimal therapeutic uses of resveratrol are limited due to its poor solubility, rapid metabolism and low bioavailability. To address the issues, we have encapsulated resveratrol inside the nanosized core made of chitosan and coated this core with pectin - shell in order to fabricate a drug delivery vehicle which can entrap resveratrol for a longer period of time. The core - shell nanoparticles fabricated in this way were characterized with the help of Fourier Transform Infrared Spectrometer (FTIR), Field Emission Scanning Electron Microscope (FESEM), Field Emission Transmission electron microscopy/Selected Area Electron Diffraction (FETEM/SAED), High-Resolution Transmission Electron Microscope (HRTEM)), Dynamic Light Scattering (DLS) and Zeta Potential measurements. In vitro drug release study showed the ability of the core-shell nanoparticles to provide sustained release of resveratrol for almost 30 hours. The release efficiency of the drug was found to be pH dependent and a sequential control over drug release can be obtained varying the shell thickness. The resveratrol encapsulated in a nanocarrier was found to have a better in vitro antioxidant activity than free resveratrol as determined by DPPH radical scavenging method. This work finally offers a novel nano-based drug delivery system.

Active Corrosion Control in Wire EDM of carbide punches

The electrical field within the machining area of a WEDM machine was simulated using COMSOL Multiphysics software. In this document, we share the results of this simulation, in particular <ul> <li>the geometry considered</li> <li>Figure 5: Electrical field distribution while machining a) with negative polarity of -10 V, b) with positive polarity of +5 V and c) with positive polarity of +2 V</li> <li>Figure 6: Worktank geometry considered and electrical field distribution during storage with an external applied voltage of -0.5 V. 1) when the WC-Co workpiece is connected to the machine ground with: a) brass wire also connected to the ground and b) wire removed. 2) when the WC-Co workpiece is insulated (floating ground) with the c) wire connected to the ground, d) wire at floating ground and e) wire removed.</li> </ul>

β-glucosidase activity data after interaction with different soil minerals

β-glucosidase activity data after interaction with different soil minerals

Dataset related to: Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis

The file contains all the dataset included in the manuscript, divided by figure in each tab   Abstract Abnormal kidney development leads to lower nephron number, predisposing to renal diseases in adulthood. In embryonic kidneys, nephron endowment is dictated by the availability of nephron progenitors, whose self-renewal and differentiation require a relatively repressed chromatin state. More recently, NAD+-dependent deacetylase sirtuins (SIRTs) have emerged as possible regulators that link epigenetic processes to the metabolism. Here, we discovered a novel role for the NAD+-dependent deacylase SIRT3 in kidney development. In the embryonic kidney, SIRT3 was highly expressed only as a short isoform, with nuclear and extra-nuclear localisation. The nuclear SIRT3 did not act as deacetylase but exerted de-2-hydroxyisobutyrylase activity on lysine residues of histone proteins. Extra-nuclear SIRT3 regulated lysine 2-hydroxyisobutyrylation (Khib) levels of phosphofructokinase (PFK) and Sirt3 deficiency increased PFK Khib levels, inducing a glycolysis boost. This altered Khib landscape in Sirt3-/- metanephroi was associated with decreased nephron progenitors, impaired nephrogenesis and a reduced number of nephrons. These data describe an unprecedented role of SIRT3 in controlling early renal development through the regulation of epigenetics and metabolic processes.

Association of physical activity and APOE genotype with longitudinal cognitive change in early PD

Objective: To determine whether greater physical activity could modify the negative association of APOE ε4 with longitudinal cognitive changes in early Parkinson's disease (PD) and to uncover the disease-specific mechanism for explaining such benefits of physical activity. Methods: We used data from the Parkinson's Progression Markers Initiative cohort. Because self-reported physical activity, measured by the Physical Activity Scale of the Elderly, was initiated at 2 years after enrollment, this longitudinal analysis was based on assessments performed at years 2, 3, and 4. Cognitive function was measured annually with the Montreal Cognitive Assessment (MoCA). Dopamine transporter (DAT) imaging was performed at years 2 and 4. We assessed the interactive associations between physical activity and the APOE ε4 allele on the longitudinal changes in MoCA scores and striatal DAT activities. Results: A total of 173 early PD patients (age 63.3±10.0 years; 27% APOE ε4 carriers) were included. The APOE ε4 allele showed a steeper rate of cognitive decline than the non-APOE ε4 allele (estimate -1.33; 95% CI, -2.12 to -0.47; p=0.002). However, there was a significant interaction between physical activity and APOE ε4, such that higher physical activity was related to slower APOE ε4-related cognitive decline (estimate 0.007; 95% CI, 0.003 to 0.011; p=0.001). No significant interaction was found between physical activity and the APOE ε4 allele regarding the change in striatal DAT activities. Conclusion: Increased physical activity attenuated APOE ε4-related vulnerability to early cognitive decline in PD patients. This protective effect did not appear to be mediated by striatal dopaminergic function. Classification of evidence: This study provides Class II evidence that increased physical activity was associated with decreased APOE ε4-related early cognitive decline in PD patients.

opencc-by-4.0Dec 2021View details →

Functional Ultrasound Localization Microscopy reveals brain-wide neurovascular activity on a microscopic scale

Matlab script to process fULM dynamic maps and compute activation maps. Two dataset are provided : one from a whiskers stimulation experiment in rats and one from a visual stimulation experiment in rats.

opencc-by-4.0Dec 2021View details →

Foreshock Activity Promoted by Locally Elevated Loading Rate on a 4-meter-long Laboratory Fault

Experimental data and event catalog used for the study "Foreshock Activity Promoted by Locally Elevated Loading Rate on a 4-meter-long Laboratory Fault"

Absolute measurement of cellular activities using photochromic single-fluorophore biosensors and intermittent quantification: data and code example

Minimal code example, raw and derived data for the publication on 'Absolute measurement of cellular activities using photochromic single-fluorophore biosensors and intermittent quantification'.

opennotspecifiedMar 2017View details →

Fig. 1. Phylogenetic relationship between strain Gsoil 809T in Arachidicoccus ginsenosidivorans sp. nov., with ginsenosideconverting activity isolated from ginseng cultivating soil

Fig. 1. Phylogenetic relationship between strain Gsoil 809T and other related species of the family Chitinophagaceae. The tree was reconstructed using the maximum-likelihood method based on 16S rRNA gene sequences. Bootstrap values (expressed as percentages of 1000 replications)>60 % are shown at branch points. Filled circles indicate that the corresponding nodes were also recovered in the tree generated with maximum-parsimony and neighbour-joining algorithms. Thermoflavifilum aggregans P373T (GenBank accession number AM749771) was used as an outgroup. Bar, 0.05 substitutions per nucleotide position.

Neuronal activity in sensory cortex predicts the specificity of learning

Learning to avoid dangerous signals while preserving normal responses to safe stimuli is essential for everyday behavior and survival. Following identical experiences, subjects exhibit fear specificity ranging from high (specializing fear to only the dangerous stimulus) to low (generalizing fear to safe stimuli), yet the neuronal basis of fear specificity remains unknown. Here, we identified the neuronal code that underlies inter-subject variability in fear specificity using longitudinal imaging of neuronal activity before and after differential fear conditioning in the auditory cortex of mice. Neuronal activity prior to, but not after learning predicted the level of specificity following fear conditioning across subjects. Stimulus representation in auditory cortex was reorganized following conditioning. However, the reorganized neuronal activity did not relate to the specificity of learning. These results present a novel neuronal code that determines individual patterns in learning. Keywords: fear conditioning, auditory cortex, sensory systems, learning, computational model, imaging, sensory cortex, tuning curve, neurobiology, population coding.

Active sensing in bees through antennal movements is independent of odor molecule (Exemple videos)

Exemple videos demanded by the reviewers to illustrate particular behaviors of the insects or details of the experimental setup. Please see the relevant section in the response document.

opencc-by-4.0Mar 2022View details →

Active sensing in bees through antennal movements is independent of odor molecule (Article videos)

Exemple videos referenced in the paper to illustrate particular behaviors of the insects. Please see the relevant section in the supplementary material.