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34
datasets available to search
ShareScore release 0.9.0
Dataset results
34 results for “53BP1”
Role of 53BP1 in End Protection and DNA synthesis at DNA breaks [SAR-seq]
GEO Series GSE181667. Mus musculus. 42 samples. Type: Other.
Next Generation Sequencing Analysis of Wild Type and 53BP1-/- Transcriptomes in B lymphocytes
GEO Series GSE42350. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination (ChIP-seq)
GEO Series GSE133805. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination (END-seq)
GEO Series GSE133806. Mus musculus. 8 samples. Type: Other.
TRABID deubiquitinase overexpression enables synthetic lethality to PARP inhibitor via prolonged retention of 53BP1 at DSB sites
GEO Series GSE222267. Homo sapiens. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Role of 53BP1 in End Protection and DNA synthesis at DNA breaks [ChIP-seq]
GEO Series GSE181668. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ATM-ESCO2-SMC3 axis regulates cohesin-dependent chromatin structure dynamics in response to DNA damage and safeguards genome integrity by promoting 53BP1 recruitment
GEO Series GSE221266. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Role of 53BP1 in End Protection and DNA synthesis at DNA breaks
GEO Series GSE181670. Mus musculus. 107 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing.
Role of 53BP1 in End Protection and DNA synthesis at DNA breaks [END-seq]
GEO Series GSE181669. Mus musculus. 49 samples. Type: Other.
A damage independent role for 53BP1 that impacts break order and Igh architecture during CSR
GEO Series GSE81180. Mus musculus. 13 samples. Type: Other.
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination
GEO Series GSE133808. Mus musculus. 17 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids
GEO Series GSE231321. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
ACSL5 Regulated Acetyl-CoA to Promote Bladder Cancer Cellular Senescence via 53BP1 Acetylation
<p><span>Disruption of the fatty acid oxidation process (FAO) significantly affects the tumorigenesis of bladder cancer (BC). Apart from energy regulation, acetyl-CoA from FAO, as an important substrate for protein acetylation, plays an important role in BC. Here, we found that long-chain fatty acid synthase 5 (ACSL5) acting as a key enzyme in the initial stage of <span> </span>FAO, was downregulated in BC, and the decreased level of ACSL5 was strongly associated with a poor prognosis for BC patients. We found that the main reason for the low expression of ACSL5 in BC is the highly methylated CpG islands in its DNA, which is closely regulated by DNA methyltransferase 1 (DNMT1). Upregulating ACSL5 expression in BC cells significantly promoted FAO, and reduces the intracellular lipid content while increasing the level of acetyl-CoA. We demonstrated that restoration of ACSL5 expression promoted K1360 acetylation of TP53-binding protein 1 (53BP1), through posttranslational modification (PTM), subsequently enhancing the recruitment of the P53-P21 senescent signaling axis in the nucleus and promoting cellular senescence. In vivo and in vitro, ACSL5 overexpression promoted BC senescence and inhibited BC cell proliferation, and elaidic acid (EA) feeding further enhanced these effects. In summary, our study revealed that ACSL5-mediated lipid oxidation reduces the intracellular lipid content, promotes cellular senescence, and inhibits the proliferation of BC. The activation of ACSL5-mediated lipid oxidation to regulate cellular senescence may provide an innovative direction for BC therapy.</span></p>
Next Generation Sequencing assesses 53BP1-regulated gene expression profiling in hTRET-RPE1 cells
GEO Series GSE280049. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.