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1,870 results for “Adipose tissue”
Data from: Adipose tissue explant culture using PDMS flow chambers: an alternative to static explant culture
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Metabolomics data from: Dietary caloric input and tumor growth accelerate senescence and modulate liver and adipose tissue crosstalk
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Whole mount 3D imaged adipose tissue demonstrating sympathetic neurons and blood vessels during cold exposure and thermoneutrality
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Magnetic resonance imaging reveals human brown adipose tissue is rapidly activated in response to cold
<p class="MsoNoSpacing"><b>Context.</b> In rodents, cold exposure induces the activation of brown adipose tissue (BAT) and the induction of intracellular triacylglycerol (TAG) lipolysis. However, in humans, the kinetics of supraclavicular (SCV) BAT activation and the potential importance of TAG stores remain poorly defined.</p> <p class="MsoNoSpacing"><b>Objective.</b> To determine the time course of BAT activation and changes in intracellular TAG using magnetic resonance imaging (MRI) assessment of the SCV (i.e. BAT depot) and fat in the posterior neck region (i.e. non BAT).</p> <p class="MsoNoSpacing"><b>Design.</b> Cross-sectional.</p> <p class="MsoNoSpacing"><b>Setting.</b> Clinical research centre.</p> <p class="MsoNoSpacing"><b>Patients or Other Participants.</b> Twelve healthy male volunteers ages 18-29 years [BMI=24.7±2.8kg/m<sup>2</sup> and body fat percentage = 25.0±7.4% (both mean±SD)].</p> <p class="MsoNoSpacing"><b>Intervention(s).</b> Standardized whole-body cold exposure (180 minutes at 18<span>°</span>C) and immediate re-warming (30 minutes at 32°C).</p> <p class="MsoNoSpacing"><b>Main Outcome Measure(s).</b> Proton density fat fraction (PDFF) and T2* of the SCV and posterior neck fat pads. Acquisitions occurred at 5-15 minute intervals during cooling and subsequent warming.</p> <p class="MsoNoSpacing"><b>Results.</b> SCV PDFF declined significantly after only 10 minutes of cold exposure [-1.6% (standard error (SE) 0.44%), <i>p</i>=0.007) and continued to decline until 35 minutes after which time it remained stable until 180 minutes. A similar time course was also observed for SCV T2*. In the posterior neck fat (non-BAT) there were no cold-induced changes in PDFF or T2*. Re-warming did not result in a change in SCV PDFF or T2*.</p> <p class="MsoNoSpacing"><b>Conclusions.</b> The rapid cold-induced decline in SCV PDFF suggests that in humans, BAT is activated quickly in response to cold and that TAG is a primary substrate.</p>
The dorsal aortic compartment is a developmental source of brown adipose tissue in mice
<p>We FACS-sorted Osr1-expressing cells (Osr1 GCE/+) from 14 E9.5 and 6 E11.5 mouse embryos and analyzed their gene expression profiles using single-cell RNA sequencing. The data was processed and integrated using Seurat v3. The sample and annotation informations can be accessed via the "<strong>time</strong>" and "<strong>annotations</strong>" columns respectively.</p>
Differences between four skinfold calipers in the assessment of adipose tissue in a healthy young adult population
<p>Database of the paper: Differences between four skinfold calipers in the assessment of adipose tissue in a healthy young adult population</p>
Interrelationship among thigh intermuscular adipose tissue, cross-sectional area, muscle strength and functional mobility in older subjects
<p><strong>Objectives:</strong> The aim of this cross-sectional study was to investigate the association between lower limb strength, muscle mass and composition and balance ability in elders. <strong>Methods:</strong> Thirthy-four older participants (Age: 65.6±4.73 years; male=10 and female=24) were assessed for muscle strength (maximal isometric strength of knee extensors and one repetition maximum by leg press, 1RM), balance and gait capacity (Mini-BESTest), body composition by DXA (obtaining Appendicular Skeletal Muscle Mass Index, ASMMI) and magnetic resonance imaging of thigh to evaluate Intermuscular Adipose Tissue (IMAT) and muscle Cross Sectional Area (CSA). <strong>Results:</strong> Positive correlations between 1RM leg press and ASMMI (r<sub>s</sub>=0.64, P<.0001) and thigh CSA (r<sub>s</sub>=0.52, P=.0017), but not with thigh IMAT, were found. In addition, significant correlations between knee extensors strength and ASMMI (r<sub>s</sub>=0.48, P=.004) and thigh CSA (r<sub>s</sub>=0.49, P=.0033) and IMAT (r<sub>s</sub>=-0.35, P=.043) were observed whereas no significant correlations between the Mini-BESTest with ASMMI, thigh CSA and IMAT were observed. <strong>Discussion:</strong> Lower limb strength positively correlated with appendicular muscle mass. Further, the maximal isometric strength of knee extensors negatively correlated with thigh IMAT in elderly patients whereas the dynamic balance ability did not correlate with any of the morphological variables of the muscle (i.e. ASMMI, CSA and IMAT). A reduced muscle size and strength could affect movement and reduce physical function in older patients. Improving the composition and size of muscle in elder subjects could reduce frailty and risk of falls.</p>
Correlation analysis of epicardial adipose tissue and ventricular myocardial strain in Chinese amateur marathoners using cardiac magnetic resonance
<p><span>The volume of epicardial adipose tissue (EAT) is associated with an increased incidence of cardiovascular disease (CVD); however, only a few studies have examined its effect on the myocardial function of endurance in athletes. The association between the EAT and the variation of myocardial function is still unclear in amateur marathoners. Consequently, by using some sedentary individuals as the control, this study aims to evaluate the correlation between the EAT volume and the myocardial strain in the left and right ventricles of Chinese amateur marathoners by cardiac magnetic resonance (CMR).</span>The volume of epicardial adipose tissue (EAT) is associated with an increased incidence of cardiovascular disease (CVD); however, only a few studies have examined its effect on the myocardial function of endurance in athletes. The association between the EAT and the variation of myocardial function is still unclear in amateur marathoners. Consequently, by using some sedentary individuals as the control, this study aims to evaluate the correlation between the EAT volume and the myocardial strain in the left and right ventricles of Chinese amateur marathoners by cardiac magnetic resonance (CMR).</p>
Supplementary tables- FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery
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Dataset for puplication: Machine Learning in Automated Monitoring of Metabolic Changes Accompanying the Differentiation of Adipose Tissue-Derived Human Mesenchymal Stem cells employing 1H-1H TOCSY NMR
<p>Data set used in the publication: <strong>Machine Learning in Automated Monitoring of Metabolic Changes Accompanying the Differentiation of Adipose Tissue-Derived Human Mesenchymal Stem cells employing <sup>1</sup>H-<sup>1</sup>H TOCSY NMR. </strong></p> <p>Abstract: In this work, the dynamic evolution of adipose tissue-derived human MSCs (AT-derived hMSCs) after fourteen days of cultivation, adiobocytes and osteocytes differentiation has been inspected based on 2D NMR TOCSY using machine learning techniques. Multi-class classification in addition to novelty detection of metabolites was established based on the profile of a control hMSCs sample at four days cultivation and successively detect the absence and the abundance of metabolites in differentiated MSCs following a set of <sup>1</sup>H-<sup>1</sup>H TOCSY profiles. The uploaded files are:</p> <p>File: metabolites_names.xlsx contain the names of the used metabolites.</p> <p>File: metabolites.xlsx</p> <p> column 1: metabolite abbreviation</p> <p>column 2: 2D NMR TOCSY horizontal and vertical frequencies of metabolites in the control group at 4 days cultivation (Ct d4)</p> <p>column 3: 2D NMR TOCSY horizontal and vertical frequencies of metabolites found after 14 days of cultivation (Ct d14)</p> <p>column 4: 2D NMR TOCSY horizontal and vertical frequencies of metabolites found after 14 days of differentiation into adipocytes (AT d14)</p> <p>column 5: 2D NMR TOCSY horizontal and vertical frequencies of metabolites found after14 days of differentiation into osteocytes (OS d14)</p> <p>column 6: 2D NMR TOCSY horizontal and vertical standard frequencies of all metabolites measured at broadband high resolution 600.13 MHz NMR</p>
Supplementary information files: Gene co-expression network and differential expression analyses of subcutaneous white adipose tissue reveal novel insights into the pathological mechanisms underlying ketosis in dairy cows
<p>Supplementary information files: Gene co-expression network and differential expression analyses of subcutaneous white adipose tissue reveal novel insights into the pathological mechanisms underlying ketosis in dairy cows</p>
IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
<p>In the skin, <em>Trypanosoma brucei </em>colonises the subcutaneous white adipose tissue (WAT) and harbours a pool of parasites competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is likely to drive adipose tissue wasting and weight loss observed in cattle and humans infected with <em>T. brucei</em>. However, mechanistically, this process is not fully understood. Here, using several complementary approaches including mass cytometry by time of flight, bulk and single cell transcriptomics, we found that <em>T. brucei</em> infection drives a local expansion of several IL-17A-producing cells in the murine WAT, including T<sub>H</sub>17 and Vg6<sup>+</sup> T cells. We also found that global IL-17 deficiency, or mice lacking IL-17 receptor expression specifically on adipocytes, were protected from infection-induced WAT wasting and weight loss. Unexpectedly, we found that abrogation of IL-17 signalling on adipocytes results in higher burden of extravascular parasites in the WAT. Taken together, our study highlights the central role of IL-17 signalling on adipocytes in controlling WAT responses to infection, suggesting that adipocytes are a critical coordinator of the tissue immune response to <em>T. brucei</em> infection. </p>
Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Degenerative Arthritis
ClinicalTrials.gov study NCT01300598. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vitamin D and Adipose Tissue Inflammation
ClinicalTrials.gov study NCT01477034. IPD Sharing: Not stated. Countries: 1. Publications: 1.
L-arginine and Brown Adipose Tissue
ClinicalTrials.gov study NCT02291458. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Epicardial Adipose Tissue Thickness and the Related Factors in Patients With Ankylosing Spondylitis
ClinicalTrials.gov study NCT06094686. IPD Sharing: NO. Countries: 1. Publications: 3.
The Benefits of the Measureof Epicardial Adipose Tissue During Coronary Calcium Assessment of the Refine Cardiovascular Risk Assessment at Reunion Island.
ClinicalTrials.gov study NCT07090629. IPD Sharing: NO. Countries: 1. Publications: 0.
Reparative Therapy in Acute Ischemic Stroke With Allogenic Mesenchymal Stem Cells From Adipose Tissue, Safety Assessment, a Randomised, Double Blind Placebo Controlled Single Center Pilot Clinical Tri
ClinicalTrials.gov study NCT01678534. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigating the Effect of Obesity on Eosinophil Recruitment in Human Adipose Tissue
ClinicalTrials.gov study NCT04234295. IPD Sharing: NO. Countries: 1. Publications: 1.
Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue
ClinicalTrials.gov study NCT01595373. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.