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478
datasets available to search
ShareScore release 0.9.0
Dataset results
478 results for “Adult Brain”
Measuring Brain Amyloid Plaque Load in Older Adults Using BAY 94-9172
ClinicalTrials.gov study NCT01222351. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Neurobiological Basis of Response to Vyvanse in Adults With ADHD: an fMRI Study of Brain Activation
ClinicalTrials.gov study NCT01924429. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors
ClinicalTrials.gov study NCT06831461. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors
ClinicalTrials.gov study NCT03257631. IPD Sharing: Not stated. Countries: 5. Publications: 2.
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
ClinicalTrials.gov study NCT06669546. IPD Sharing: NO. Countries: 1. Publications: 4.
Brain Dopamine Function in Adults With ADHD
ClinicalTrials.gov study NCT00580814. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Magnetic Brain Stimulation for the Treatment of Adult Depression
ClinicalTrials.gov study NCT00149838. IPD Sharing: YES. Countries: 1. Publications: 2.
Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
ClinicalTrials.gov study NCT03354143. IPD Sharing: YES. Countries: 1. Publications: 1.
Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults
ClinicalTrials.gov study NCT01264614. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neck Cooling as a Non-Invasive Method to Lower Brain Temperature in Healthy Adults
ClinicalTrials.gov study NCT04973085. IPD Sharing: NO. Countries: 1. Publications: 36.
Brain Stimulation and Enhancing Cognition in Older Adults
ClinicalTrials.gov study NCT03653351. IPD Sharing: NO. Countries: 1. Publications: 1.
Problem Solving Training for Care Partners of Adults With Traumatic Brain Injury
ClinicalTrials.gov study NCT03739450. IPD Sharing: YES. Countries: 1. Publications: 26.
Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
ClinicalTrials.gov study NCT04421014. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Thalamic Deep Brain Stimulation for Secondary Dystonia in Children and Young Adults
ClinicalTrials.gov study NCT03078816. IPD Sharing: NO. Countries: 1. Publications: 18.
Data for: Distinct impact modes of polygenic disposition to dyslexia in the adult brain
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Impacts of development and adult sex on brain cell numbers in the Black Soldier Fly, Hermetia illucens L. (Diptera: Stratiomyidae)
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A 3D Adult Zebrafish Brain Atlas (AZBA) for the Digital Age
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Data from: Neuronal migration depends on blood flow in the adult mammalian brain
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Data from: Early life exposure to low levels of AHR agonist PCB126 (3,3',4,4',5-pentachlorobiphenyl) reprograms gene expression in adult brain
Early life exposure to environmental chemicals can have long-term consequences that are not always apparent until later in life. We recently demonstrated that developmental exposure of zebrafish to low, non-embryotoxic levels of 3,3',4,4',5-pentachlorobiphenyl (PCB126) did not affect larval behavior, but caused changes in adult behavior. The objective of this study was to investigate the underlying molecular basis for adult behavioral phenotypes resulting from early life exposure to PCB126. We exposed zebrafish embryos to PCB126 during early development and measured transcriptional profiles in whole embryos, larvae and adult male brains using RNA-sequencing. Early life exposure to 0.3 nM PCB126 induced cyp1a transcript levels in 2-dpf embryos, but not in 5-dpf larvae, suggesting transient activation of aryl hydrocarbon receptor with this treatment. No significant induction of cyp1a was observed in the brains of adults exposed as embryos to PCB126. However, a total of 2209 and 1628 genes were differentially expressed in 0.3 nM and 1.2 nM PCB126-exposed groups, respectively. KEGG pathway analyses of upregulated genes in the brain suggest enrichment of calcium signaling, MAPK and notch signaling, and lysine degradation pathways. Calcium is an important signaling molecule in the brain and altered calcium homeostasis could affect neurobehavior. The downregulated genes in the brain were enriched with oxidative phosphorylation and various metabolic pathways, suggesting that the metabolic capacity of the brain is impaired. Overall, our results suggest that PCB exposure during sensitive periods of early development alters normal development of the brain by reprogramming gene expression patterns, which may result in alterations in adult behavior.
Insecticide exposure during brood or early-adult development reduces brain growth and impairs adult learning in bumblebees
<p>For social bees, an understudied step in evaluating pesticide risk is how contaminated food entering colonies affects residing offspring development and maturation. For instance, neurotoxic insecticide compounds in food could affect central nervous system development predisposing individuals to become poorer task performers later-in-life. Studying bumblebee colonies provisioned with neonicotinoid spiked nectar substitute, we measured brain volume and learning behaviour of 3 or 12-day old adults that had experienced in-hive exposure during brood and/or early-stage adult development. Micro-computed tomography (µCT) scanning and segmentation of multiple brain neuropils showed exposure during either developmental stage caused reduced mushroom body calycal growth relative to unexposed workers. Associated with this, was a lower probability of responding to a sucrose reward and lower learning performance in an olfactory conditioning test. Whilst calycal volume of control workers positively correlated with learning score, this relationship was absent for exposed workers indicating neuropil functional impairment. Comparison of 3 and 12-day adults exposed during brood development showed a similar degree of reduced calycal volume and impaired behaviour highlighting lasting and irrecoverable effects from exposure despite no adult exposure. Our findings help explain how the onset of pesticide exposure to whole colonies can lead to lag-effects on growth and resultant dysfunction.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.