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1,243 results for “Agonist”
Fig. 5 in Description Of The Agonistic Behavior Of Aegla Longirostri (Decapoda: Aeglidae)
Fig. 5. Percentage of the time spent by winners and losers, males of Aegla longirostri, in each of the agonistic acts. The item ''Others'' refers to: BTO, DB, DO, FF, GO, PO, PQ, and TOD, which occurred in low frequency. *Represents a significant difference in the Mann-Whitney Test (P, 0.05). Refer to Table 1 for descriptions of the agonistic acts.
Agonistic Rabbit Action Detection/Classification
<p>Sample data for rabbit doe behavior analysis in group housing.</p> <p>'Raw Video Files' contains 6 hours of continuous video from Camera 1 (6 video files spearated 1h each). </p> <p>'Action Clips' contains segmented agonistic action clips from the raw video files (Camera 1, 6hours only).</p> <p>'COCO Annotations - Rabbits' contains images and the COCO format annotations used to train Keypoint RCNN model.</p> <p>'Model Weights' contains final ANN model weights for both Keypoint RCNN model and Resnet50 (re-identification) model.</p> <p>'Camera 1 - 6h - Agonistic Behaviors' contains agonistic action detections for 6 hours in Camera 1. </p> <p>'<a href="https://zenodo.org/api/files/7ea85db4-619e-4e69-8c12-e08b53c3ee84/Tracker_Cam_11_Action_18.mp4">Tracker_Cam_11_Action_18.mp4</a>' is a random sample of tracked group-housed rabbits.</p>
Fig. 3 in Description Of The Agonistic Behavior Of Aegla Longirostri (Decapoda: Aeglidae)
Fig. 3. Mean duration (in seconds) of time spent by males of Aegla longirostri, in each of the levels of aggression intensity (-2 to 5, see definition in Table 3). *Represents a significant difference in the Mann-Whitney Test (P, 0.05) (Calculation with overall values for each level of intensity).
Fig. 2 in Description Of The Agonistic Behavior Of Aegla Longirostri (Decapoda: Aeglidae)
Fig. 2. Sum of intensities (-2 to 5) of combats between similar-sized males of Aegla longirostri. *Represents significant difference in the x2 Test (P, 0.05). (Size – cephalothorax length in mm of winners ''W'' and losers ''L.'' Pair 1- W = 15.18 X L = 14.27; Pair 2- W = 16.54 X L = 15.78; Pair 3- W = 18.65 X L = 17.71; Pair 4- W = 18.31 X L = 18.73; Pair 5- W = 18.70 X L = 18.64; Pair 6- W = 18.86 X L = 19.27; Pair 7- W = 19.26 X L = 19.09; Pair 8 - W = 19.45 X L = 19.50; Pair 9- W = 20.19 X L = 19.94; and Pair 10- W = 20.84 X L = 20.64).
Fig. 1 in Description Of The Agonistic Behavior Of Aegla Longirostri (Decapoda: Aeglidae)
Fig. 1. Selected frames from the films documenting the agonistic behavior of A. longirostri: A-B: Hitting with chelipeds; C-E-F: Fight and D: Going up the opponent.
Fig. 4 in Description Of The Agonistic Behavior Of Aegla Longirostri (Decapoda: Aeglidae)
Fig. 4. Progression in mean intensity of aggressive combats related to time in encounters, of males of Aegla longirostri.
Consensus recommendations for opioid agonist treatment following the introduction of emergency clinical guidelines in Ireland during the COVID-19 pandemic: A national Delphi study
<p>Anonymous Delphi survey likert scale responses (round 1 (S1-S32) and 2 (R2S1-R2S15)) <a href="https://zenodo.org/api/files/92371fe3-6af6-4044-ba3f-83a26b2fe471/Delphi_likert_responses_ano.csv?versionId=7c3aaa7b-8b43-43da-bfeb-fe644f33d3e2">Delphi_likert_responses_ano.csv</a> and corresponding statements in <a href="https://zenodo.org/api/files/92371fe3-6af6-4044-ba3f-83a26b2fe471/STATEMENTS_REPO.csv?versionId=ada85e7c-ba48-4f61-8e1a-d90dab9b4f05">STATEMENTS_REPO.csv</a>.</p>
Simulation Datasets of 5HT3AR Bound to Two Partial Agonists
<p>Simulation Datasets Reported in the manuscript <strong>Structural Basis for Partial Agonism in 5HT3AR Receptors:</strong></p> <p>1. SMP100 PDB and MOL2 files: SMP.pdb (4.7 KB) and SMP.mol2 (4.7 KB)<br> 2. SMP100 topology and parameter files: SMP.top (2.8 KB) and SMP.prm (4.7 KB)<br> 3. SMP-bound 5-HT3AR initial conformation from cryo-EM and prepared in Maestro: 5HT3AR-SMP_init.pdb (2.7 MB)<br> 4. SMP-bound 5-HT3AR system PDB file and trajectory: 5HT3AR-SMP.pdb (14.4 MB) and 5HT3AR-SMP.xtc (135.7 MB)<br> 5. ALB148471 PDB and MOL2 files: ALB.pdb (4.7 KB) and ALB.mol2 (4.7 KB)<br> 6. ALB148471 topology and parameter files: ALB.top (2.8 KB) and ALB.prm (4.7 KB)<br> 7. ALB-bound 5-HT3AR initial conformation from cryo-EM and prepared in Maestro: 5HT3AR-ALB_init.pdb (2.7 MB)<br> 8. ALB-bound 5-HT3AR system PDB file and trajectory: 5HT3AR-ALB.pdb (14.4 MB) and 5HT3AR-ALB.xtc (135.7 MB)</p>
Pharmacogenomics of GLP1 Receptor Agonists
ClinicalTrials.gov study NCT05762744. IPD Sharing: YES. Countries: 1. Publications: 2.
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period
ClinicalTrials.gov study NCT02787551. IPD Sharing: YES. Countries: 9. Publications: 5.
Study of an Experimental New Drug, PPARγ Agonist Taken by Mouth by Participants With Advanced or Metastatic Cancer
ClinicalTrials.gov study NCT00408434. IPD Sharing: YES. Countries: 1. Publications: 1.
Data and code for: Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist and stimulatory G protein
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Do food distribution and competitor density affect agonistic behaviour within and between clans in a high fission-fusion species?
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A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in a mouse model of tumor associated epilepsy - Thy1-GCaMP Tumor Electrophysiology
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Data from: Agonistic song rate positively correlates with male breeding success and avian malaria infection in Acrocephalus paludicola (Aquatic Warbler), a promiscuous songbird with female-only parental care
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Data from: Agonistic character displacement in social cognition of advertisement signals
Interspecific aggression between sibling species may enhance discrimination of competitors when recognition errors are costly, but proximate mechanisms mediating increased discriminative ability are unclear. We studied behavioral and neural mechanisms underlying responses to conspecific and heterospecific vocalizations in Alston's singing mouse (Scotinomys teguina), a species in which males sing to repel rivals. We performed playback experiments using males in allopatry and sympatry with a dominant heterospecific (Scotinomys xerampelinus) and examined song-evoked induction of egr-1 in the auditory system to examine how neural tuning modulates species-specific responses. Heterospecific songs elicited stronger neural responses in sympatry than in allopatry, despite eliciting less singing in sympatry. Our results refute the traditional neuroethological concept of a matched filter and instead suggest expansion of sensory sensitivity to mediate competitor recognition in sympatry.
Data from: Agonistic character displacement of genetically based male colour patterns across darters
Agonistic character displacement (ACD) occurs when selection to avoid maladaptive interspecific aggression leads to the evolution of agonistic signals and/or associated behavioural biases in sympatry. Here we test for a pattern consistent with ACD in male colour pattern in darters (Percidae: Etheostoma). Male colour pattern has been shown to function in male-male competition rather than female mating preferences in several darter species. Additionally, males bias their aggression towards conspecific over heterospecific males in sympatry but not in allopatry, consistent with divergent ACD in male behavioural biases. We use a common garden approach to show that differences in male colour pattern among four closely related darter species are genetically based. Additionally, we demonstrate that some aspects of male colour pattern exhibit enhanced differences in sympatric compared to allopatric populations of two darter species, consistent with ACD. However, other male colour traits are more similar between species in sympatry compared to allopatry, indicating that not all signal components are under strong divergent selection in sympatry. This study provides evidence that interspecific male-male aggressive interactions alone can promote elaborate male signal evolution both between and within species. We discuss the implications this has for male-driven ACD and cascade ACD.
Molecular Dynamics Trajectories for the D3 receptor (D3R) complexes bound with a GαOβγ heterotrimer and 1) FOB02-04A bitopic agonist; 2) pramipexole.
<p>Molecular Dynamics Data for publication "Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket". Sandra Arroyo-Urea, Antonina L. Nazarova, Ángela Carrión-Antolí et al., Nat. Comm., revision (2024). https://doi.org/10.21203/rs.3.rs-3433207/v1</p> <p><br>This directory includes the PDB (Protein Data Bank) format file detailing the topology and the XTC (eXtended Trajectory) format file outlining the trajectories for two distinct complexes: 1) the FOB02-04A-bound structure of D3 receptor (D3R) complexes in association with a GαOβγ heterotrimer, and 2) the pramipexole-bound structures of D3R complexes also coupled to a GαOβγ heterotrimer. The data is organized in a strided trajectory with a timestep of 0.5 nanoseconds per frame. To reapply periodic boundary conditions, users can employ the standard periodic boundary condition commands available in Visual Molecular Dynamics (VMD) package.</p> <p> </p> <p>The MD trajectory data for this study was acquired as well as uploaded by Antonina L. Nazarova.</p>
Figure 11 in Non-aggressive competition between males of Srilankametrus yaleensis (Kovařík et al., 2019) (Scorpionidae), and other types of agonistic behavior observed in scorpions
Figure 11. Dinorhax rostrumpsittaci (Simon, 1877), two males in threatening condition.
Figure 4 in Non-aggressive competition between males of Srilankametrus yaleensis (Kovařík et al., 2019) (Scorpionidae), and other types of agonistic behavior observed in scorpions
Figure 4. Escaping stage (right male (A2) fled).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.