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45 results for “Antibiotic resistance genes”
Data from: Constitutive presence of antibiotic resistance genes within the bacterial community of a large subalpine lake
The fate of antibiotic resistance genes (ARGs) in environmental microbial communities is of primary concern as prodromal of a potential transfer to pathogenic bacteria. Although of diverse origin, the persistence of ARGs in aquatic environments is highly influenced by anthropic activities, allowing potential control actions in well-studied environments. However, knowledge of abundance and space–time distribution of ARGs in ecosystems is still scarce. Using quantitative real-time PCR, we investigated the presence and the abundance of twelve ARGs (against tetracyclines, β-lactams, aminoglycosides, quinolones and sulphonamides) at different sampling sites, depths and seasons, in Lake Maggiore, a large subalpine lake, and in the area of its watershed. We then evaluated the correlation between each ARG and a number of ecological parameters in the water column in the deepest part of the lake. Our results suggest the constitutive presence of at least four ARGs within the bacterial community with a high proportion of bacteria potentially resistant to tetracyclines and sulphonamides. The presence of these ARGs was independent of the total bacterial density and temperature. The dynamics of tet(A) and sulII genes were, however, positively correlated with dissolved oxygen and negatively to chlorophyll a, suggesting that the resistant microbes inhabit specific niches. These observations indicate that the lake is a reservoir of antibiotic resistances, highlighting the need of a deeper understanding of the sources of ARGs and the factors allowing their persistence in waters.
Data related to the manuscript "Sequence-specific aggregation of magnetic nanoparticles and single-stranded DNA amplification products for detection of antibiotic resistance gene sul1."
<p>Absorbance and AC susceptometry raw and processed excel files used.</p>
Insertion sequences and other mobile elements associated with antibiotic resistance genes in Enterococcus isolates from an inpatient with prolonged bacteremia.
<p>Insertion sequences (ISs) and other transposable elements are associated with the mobilization of antibiotic resistance determinants and the modulation of pathogenic characteristics. In this work, we aimed to investigate the association between ISs and antibiotic resistance genes, and their role in dissemination and modification of the antibiotic resistant phenotype. To that end, we leveraged fully resolved <em>Enterococcus faecium</em> and <em>Enterococcus faecalis</em> genomes of isolates collected over five days from an inpatient with prolonged bacteremia. Isolates from both species harbored similar IS family content but showed significant species-dependent differences in copy number and arrangements of ISs throughout their replicons. Here, we describe two inter-specific IS-mediated recombination events and IS-mediated excision events in plasmids of <em>E. faecium</em> isolates. We also characterize a novel arrangement of the ISs in a Tn1546-like transposon in <em>E. faecalis</em> isolates likely implicated in a vancomycin genotype-phenotype discrepancy. Furthermore, an extended analysis revealed a novel association between daptomycin resistance mutations in <em>liaSR</em> genes and a putative composite transposon in<em> E. faecium</em>, offering a new paradigm for the study of daptomycin resistance and novel insights into the dissemination of daptomycin resistance. In conclusion, our study highlights the role ISs and other transposable elements play in the rapid adaptation and response to clinically relevant stresses such as aggressive antibiotic treatment in enterococci.</p>
Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application
ClinicalTrials.gov study NCT01922024. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Detection of Pathogen and Antibiotic Resistance Genes by Targeted Next-Generation Sequencing in ICU Patients.
ClinicalTrials.gov study NCT06157372. IPD Sharing: NO. Countries: 0. Publications: 6.
Data from: Ecology determines how low antibiotic concentration impacts community composition and horizontal transfer of resistance genes
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Data from: Constitutive presence of antibiotic resistance genes within the bacterial community of a large subalpine lake
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Data from: Phylogenetic relatedness determined between antibiotic resistance and 16S rRNA genes in actinobacteria
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Identification of genes involved with P. aeruginosa biofilm antibiotic resistance by microarray analysis
GEO Series GSE65870. Pseudomonas aeruginosa. 6 samples. Type: Expression profiling by array.
Characterization of antibiotic resistance and host-microbiome interactions in the human upper respiratory tract during influenza infection [16s rRNA gene V4 region]
GEO Series GSE126900. human metagenome. 34 samples. Type: Other.
Global gene expression profiling and antibiotic susceptibility after repeated exposure to the carbon monoxide-releasing molecule-2 (CORM-2) in multidrug-resistant ESBL-producing uropathogenic Escheric
GEO Series GSE87627. Escherichia coli O157:H7 str. Sakai; Escherichia coli CFT073; Escherichia coli; Escherichia coli O157:H7 str. EDL933; Escherichia coli str. K-12 substr. MG1655. 16 samples. Type: Expression profiling by array.
Gender Specific Differences in Expression of Neisseria gonorrhoeae Antibiotic Resistance Genes During Human Mucosal Infection
GEO Series GSE113290. Neisseria gonorrhoeae. 15 samples. Type: Expression profiling by high throughput sequencing.
Data and reproducible scripts for "Distribution of Putative Self-resistance Genes for Antibiotic Biosynthetic Gene Cluster in Actinobacteria"
<p>Data and reproducible scripts for "Distribution of Putative Self-resistance Genes for Antibiotic Biosynthetic Gene Cluster in Actinobacteria"</p>
Penguin-driven dissemination and high enrichment of antibiotic resistance genes in lake sediments across Antarctica
<p>These are Supplementary Information and Supplementary Data to the manuscript entitled Penguin-driven dissemination and high enrichment of antibiotic resistance genes in lake sediments across Antarctica.</p>
Bacterial Gene Profiling to Predict Antibiotic Resistance During Cystic Fibrosis Pulmonary Exacerbations
ClinicalTrials.gov study NCT04341532. IPD Sharing: NO. Countries: 1. Publications: 0.
Detection of Clindamycin Resistance Antibiotic Genes Among Staphylococcus Isolates by Using Real Time PCR
ClinicalTrials.gov study NCT04933019. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Intestinal Microbiota and Their Antibiotic Resistance Genes of ICU Health Care Workers
ClinicalTrials.gov study NCT06524765. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Resistance gene carriage predicts growth of natural and clinical Escherichia coli isolates in the absence of antibiotics
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Detection of antibiotic resistance genes in human gut microbiota
GEO Series GSE54070. human gut metagenome; gut metagenome. 123 samples. Type: Genome variation profiling by array.
Detection of virulence and antibiotic resistance gene families
GEO Series GSE11010. Staphylococcus saprophyticus; Escherichia coli str. K-12 substr. MG1655; Staphylococcus aureus subsp. aureus Mu50; Escherichia coli CFT073; Streptococcus pyogenes MGAS5005; Staphylococcus aureus; Escherichia coli O157:H7 str. EDL933; Enterococcus faecalis V583; Salmonella enterica; unidentified. 12 samples. Type: Other.
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