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41 results for “Bartonella”
Schizophrenia and Bartonella spp. infection: A pilot case–control study
<p>Recently, infections with emerging zoonotic bacteria of the genus Bartonella have been reported in association with a range of CNS symptoms. Currently, it remains unknown if Bartonella spp. infection is associated with symptoms of schizophrenia/schizoaffective disorder (SCZ/SAD). The objective of this study was to determine if there is an association between Bartonella species infection and SCZ/SAD. A secondary objective was to determine if SCZ/SAD symptoms were more severe among participants with documented Bartonella spp. infection. Using a case–control study design, 17 cases and 13 controls were evaluated with a series of clinical and cognitive assessments. Blood samples were collected and tested for Bartonella spp. infection using serological, microbiological, and molecular techniques. People with SCZ/SAD were more likely than healthy volunteers to have Bartonella spp. DNA in their bloodstream, with 11 of 17 cases (65%) positive by Bartonella spp. droplet digital PCR (ddPCR). In comparison, only one healthy volunteer was Bartonella spp. ddPCR positive (8%, p = 0.0024). Based on serology, Bartonella spp. exposure was common among people with SCZ/SAD (12 of 17) as well as among healthy volunteers (12 of 13), with no significant difference between the groups ( p = 0.196). Within the case group of people with SCZ/SAD, there was no significant difference in SCZ/SAD severity scores between people with and without ddPCR evidence of Bartonella spp. infection. This pilot study provides preliminary evidence in support of future investigations that should examine a potential contribution of Bartonella spp. infection to SCZ/SAD.</p>
Figure 3 in Detection and characterization of zoonotic Bartonella spp. in rodents and shrews ectoparasites from Kigoma and Morogoro regions, Tanzania
Figure 3: Fleas' species identified from rodents, as photographed using a Zeiss Primor Star Axiocam ERc 5S microscope. Source: Authors.
Figure 5 in Detection and characterization of zoonotic Bartonella spp. in rodents and shrews ectoparasites from Kigoma and Morogoro regions, Tanzania
Figure 5: Median-joining network showing the evolutionary relationships and likely ancestral networks among Bartonella haplotypes based on the 379-bp sequence of gltA gene from fleas (FTZ), ticks (TTZ), and lice (LTZ) hosts.
Figure 4 in Detection and characterization of zoonotic Bartonella spp. in rodents and shrews ectoparasites from Kigoma and Morogoro regions, Tanzania
Figure 4: Phylogenetic tree showing the relatedness of the Bartonella gltA gene sequences detected from rodents and shrews ectoparasites; fleas (FTZ), lice (LTZ), and ticks (TTZ) along with reference sequences from the GenBank database. The phylogenetic tree was constructed using the maximum likelihood method. The tree with the highest log likelihood (−1773.15) is shown. Evolutionary analyses were conducted in MEGA 11 (2021). The detected Bartonella genotypes and their sources in this study are indicated by nodes of different colors.
Schizophrenia and Bartonella spp. infection: A pilot case–control study
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Data from: Multihost Bartonella parasites display covert host specificity even when transmitted by generalist vectors
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Data from: Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever
Bartonella quintana is a bacterium that causes a broad spectrum of diseases in humans including trench fever. Humans were previously considered to be the primary, if not the only, reservoir hosts for B. quintana. To identify the animal reservoir and extend our understanding of the ecological and evolutionary history of B. quintana, we examined blood samples from macaques and performed multilocus sequence typing (MLST) analysis. We demonstrated the prevalence of B. quintana infection was common in macaques from main primate centres in mainland China. Overall, 18.0% (59/328) of rhesus macaques and 12.7% (39/308) of cynomolgus macaques were found to be infected with B. quintana by blood culture and/or polymerase chain reaction. The infection was more frequently identified in juvenile and young monkeys compared with adult animals. In contrast with the relatively low level of sequence divergence of B. quintana reported in humans, our investigation revealed much higher genetic diversity in nonhuman primates. We identified 44 new nucleotide variable sites and 14 novel sequence types (STs) among the B. quintana isolates by MLST analysis. Some STs were found only in cynomolgus macaques, while some others were detected only in rhesus macaques, suggesting evidence of host-cospeciation, which were further confirmed by phylogenetic analysis and Splits decomposition analysis. Our findings suggest that trench fever may primarily be a zoonotic disease with macaques as the natural hosts.
Data from: Prevalence, diversity, and host associations of Bartonella strains in bats from Georgia (Caucasus)
Bartonella infections were investigated in seven species of bats from four regions of the Republic of Georgia. Of the 236 bats that were captured, 212 (90%) specimens were tested for Bartonella infection. Colonies identified as Bartonella were isolated from 105 (49.5%) of 212 bats Phylogenetic analysis based on sequence variation of the gltA gene differentiated 22 unique Bartonella genogroups. Genetic distances between these diverse genogroups were at the level of those observed between different Bartonella species described previously. Twenty-one reference strains from 19 representative genogroups were characterized using four additional genetic markers. Host specificity to bat genera or families was reported for several Bartonella genogroups. Some Bartonella genotypes found in bats clustered with those identified in dogs from Thailand and humans from Poland.
Figure 2 in Detection and characterization of zoonotic Bartonella spp. in rodents and shrews ectoparasites from Kigoma and Morogoro regions, Tanzania
Figure 2: Map of Kilosa and Morogoro rural Districts in Morogoro region. Source: Authors.
Figure 1 in Detection and characterization of zoonotic Bartonella spp. in rodents and shrews ectoparasites from Kigoma and Morogoro regions, Tanzania
Figure 1: Map of Kakonko and Kibondo Districts in Kigoma region. Source: Authors.
Comparison of serological and molecular assays for Bartonella species in dogs with hemangiosarcoma
<p>Currently, a gold standard diagnostic test for <i>Bartonella </i>infection in dogs is lacking. This represents a critical limitation for the development and evaluation of new diagnostic tests, as well as for the diagnosis of, and research on, bartonellosis in dogs. This retrospective observational study aims to compare the results of commonly performed and newly-reported <i>Bartonella</i> spp. diagnostic tests in banked clinical specimens from 90 dogs with hemangiosarcoma (HSA) using composite reference standard (CRS) and random effects latent class analysis (RE-LCA) techniques. Samples from each dog were tested using six serological or molecular diagnostic assays, including indirect fluorescent antibody (IFA) and Western blot (WB) for the detection of antibodies in serum, and qPCR and droplet digital PCR (ddPCR) in blood and fresh frozen tissue biopsy samples (mainly splenic HSA tumors and histopathologically normal spleen or skin/adipose tissue). <i>Bartonella </i>infection prevalence was estimated to be 78% based on the CRS (parallel testing with all six assays), and 64% based on the RE-LCA model. The assay with the highest diagnostic accuracy was qPCR performed on fresh frozen tissue biopsy samples (sensitivity: 94% by RE-LCA and 80% by CRS; specificity: 100%). When comparing newly-reported to traditional <i>Bartonella </i>diagnostic assays, ddPCR was more sensitive for the detection of <i>Bartonella </i>DNA than qPCR when testing blood samples (36% vs. 0%, <i>p</i> < 0.0001). Dogs that were positive on serological assays alone with negative molecular assays were highly unlikely (<3%) to be classified as infected by the RE-LCA model. These data indicate that <i>Bartonella</i> spp. DNA can be PCR amplified from fresh frozen tissues from a majority of dogs with HSA using both qPCR and ddPCR, supporting the use of these methods for future controlled studies comparing the prevalence of <i>Bartonella </i>spp. DNA in the tissue of dogs with HSA to that of unaffected controls.</p>
Data from: Prevalence, diversity, and host associations of Bartonella strains in bats from Georgia (Caucasus)
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Comparison of serological and molecular assays for Bartonella species in dogs with hemangiosarcoma
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Data from: Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever
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Bartonella spp. infection in nest fleas and arctic foxes from Karrak Lake, NU
<p>PCR results for fleas and foxes tested for Bartonella spp. DNA via conventional and qPCR. </p>
Bartonella in Liver Transplant Patients
ClinicalTrials.gov study NCT02595710. IPD Sharing: YES. Countries: 1. Publications: 0.
Infection of Myeloid Angiogenic Cells (MACs) with Bartonella henselae (B.h.) induces a chord formation phenotype in vitro.
GEO Series GSE55170. Homo sapiens. 7 samples. Type: Expression profiling by array.
Bartonella quintana: growth phase and temperature response
GEO Series GSE42685. Bartonella quintana. 12 samples. Type: Expression profiling by array.
................................................................................................................................................. Fig. 4. DNA fingerprint analysis of the four new isolates and other Bartonella species by ERICPCR. Lanes: M, molecular mass markers; 1, negative control; 2, R1T; 3, R3; 4, R4; 5, R6; 6, Bartonella henselae; 7, Bartonella quintana; 8, Bartonella bacilliformis; 9, Bartonella elizabethae; 10, Bartonella clarridgeiae; 11, Bartonella alsatica; 12, Bartonella tribocorum; 13, Bartonella grahamii; 14, Bartonella doshiae; 15, Bartonella vinsonii spp. arupensis; 16, Bartonella vinsonii spp. berkhoffii; 17, Bartonella vinsonii spp. vinsonii; 18, Bartonella koehlerae. in Bartonella schoenbuchii sp. nov., isolated from the blood of wild roe deer.
................................................................................................................................................. Fig. 4. DNA fingerprint analysis of the four new isolates and other Bartonella species by ERICPCR. Lanes: M, molecular mass markers; 1, negative control; 2, R1T; 3, R3; 4, R4; 5, R6; 6, Bartonella henselae; 7, Bartonella quintana; 8, Bartonella bacilliformis; 9, Bartonella elizabethae; 10, Bartonella clarridgeiae; 11, Bartonella alsatica; 12, Bartonella tribocorum; 13, Bartonella grahamii; 14, Bartonella doshiae; 15, Bartonella vinsonii spp. arupensis; 16, Bartonella vinsonii spp. berkhoffii; 17, Bartonella vinsonii spp. vinsonii; 18, Bartonella koehlerae.
................................................................................................................................................. Fig. 2. Negative staining of strain R1T. Bar, 1 lm. in Bartonella schoenbuchii sp. nov., isolated from the blood of wild roe deer.
................................................................................................................................................. Fig. 2. Negative staining of strain R1T. Bar, 1 lm.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.