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51 results for “Blood meal”
Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects
ClinicalTrials.gov study NCT00779298. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Blood meal-induced inhibition of vector-borne disease by transgenic microbiota
Open the record for dataset details and reuse information.
Identification of mosquito genes regulated after blood meal with hsa-miR-150-5p antagomir
GEO Series GSE167210. Aedes aegypti. 2 samples. Type: Expression profiling by high throughput sequencing.
RNAseq analysis of blood-meal induced gene-expression changes in Aedes aegypti ovaries
GEO Series GSE152209. Aedes aegypti. 19 samples. Type: Expression profiling by high throughput sequencing.
Data from: Engineered action at a distance: blood-meal-inducible paralysis in Aedes aegypti
Background: Population suppression through mass-release of Aedes aegypti males carrying dominant-lethal transgenes has been demonstrated in the field. Where population dynamics show negative density-dependence, suppression can be enhanced if lethality occurs after the density-dependent (i.e. larval) stage. Existing molecular tools have limited current examples of such Genetic Pest Management (GPM) systems to achieving this through engineering 'cell-autonomous effectors' i.e. where the expressed deleterious protein is restricted to the cells in which it is expressed – usually under the control of the regulatory elements (e.g. promoter regions) used to build the system. This limits the flexibility of these technologies as regulatory regions with useful spatial, temporal or sex-specific expression patterns may only be employed if the cells they direct expression in are simultaneously sensitive to existing effectors, and also precludes the targeting of extracellular regions such as cell-surface receptors. Expanding the toolset to 'non-cell autonomous' effectors would significantly reduce these limitations. Methodology/Principal Findings: We sought to engineer female-specific, late-acting lethality through employing the Ae. aegypti VitellogeninA1 promoter to drive blood-meal-inducible, fat-body specific expression of tTAV. Initial attempts using pro-apoptotic effectors gave no evident phenotype, potentially due to the lower sensitivity of terminally-differentiated fat-body cells to programmed-death signals. Subsequently, we dissociated the temporal and spatial expression of this system by engineering a novel synthetic effector (Scorpion neurotoxin – TetO-gp67.AaHIT) designed to be secreted out of the tissue in which it was expressed (fat-body) and then affect cells elsewhere (neuro-muscular junctions). This resulted in a striking, temporary-paralysis phenotype after blood-feeding. Conclusions/Significance: These results are significant in demonstrating for the first time an engineered 'action at a distance' phenotype in a non-model pest insect. The potential to dissociate temporal and spatial expression patterns of useful endogenous regulatory elements will extend to a variety of other pest insects and effectors.
The Effect of Meal Replacement on the Time to Reach the Blood Glucose Target in Patients With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT05365152. IPD Sharing: NO. Countries: 1. Publications: 0.
Blood Glucose Control With BioChaperone Insulin Lispro Compared to Insulin Lispro (Humalog®) After Ingestion of a Standardized Meal
ClinicalTrials.gov study NCT02344992. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Towards Understanding the Relationship Between Meals and Blood Biomarkers
ClinicalTrials.gov study NCT05295706. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Berry Nectars Sweetened With Inverted Sugar on Post-meal Blood Sugar
ClinicalTrials.gov study NCT02743130. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Fixed Meals With Special Formulated Rice on Blood Glucose Levels of Healthy Volunteers.
ClinicalTrials.gov study NCT03985566. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Effect of Byetta and Symlin on Post-meal Meal Blood Sugar Levels in Children With Type 2 Diabetes
ClinicalTrials.gov study NCT00950677. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal in Healthy Subjects
ClinicalTrials.gov study NCT03255876. IPD Sharing: YES. Countries: 1. Publications: 0.
Daily Physical Activity After Meals -Long Term Effects on Blood Glucose
ClinicalTrials.gov study NCT02536066. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
ClinicalTrials.gov study NCT03504683. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Calcium Over Postprandial Effects of Fatty Meal on Metabolism, Blood Pressure, Oxidative Stress, Endothelial Function.
ClinicalTrials.gov study NCT02137434. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of a Whole Grain Cereal Product on Blood Glucose Response After 3 Consecutive Meals
ClinicalTrials.gov study NCT04888559. IPD Sharing: NO. Countries: 1. Publications: 0.
Alternating Energy Intake and Blood Fat Content After a Meal
ClinicalTrials.gov study NCT04894526. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels
ClinicalTrials.gov study NCT02913079. IPD Sharing: NO. Countries: 1. Publications: 0.
Second Meal Effects of a Wholegrain Cereal Product on Blood Glucose Response
ClinicalTrials.gov study NCT05291806. IPD Sharing: NO. Countries: 1. Publications: 0.
Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal
ClinicalTrials.gov study NCT01995110. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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