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829 results for “CRISPR screening”
Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus [Microscope images - Xist act KDs]
<p>Microscope images related to Figure 5 in Schwämmle et al. 2025. </p> <p>The cells are day 2 differentiated TX1072 XX SP427 mESCs with the indicated knockdowns. (-2iLIF)</p> <p>Exonic Xist is stained using Cy5 Stellaris probes. The nuclei are stained using DAPI.</p> <p>These files were used to perform automated image analysis to detect and quantify Xist clouds (https://github.com/EddaSchulz/TFiScreen_Paper).</p>
Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens
Millions of putative transcriptional regulatory elements (TREs) have been cataloged in the human genome, yet their functional relevance in specific pathophysiological settings remains to be determined. This is critical to understand how oncogenic transcription factors (TFs) engage specific TREs to impose transcriptional programs underlying malignant phenotypes. Here, we combine cutting edge CRISPR screens and epigenomic profiling to functionally survey ≈15,000 TREs engaged by estrogen receptor (ER). We show that ER exerts its oncogenic role in breast cancer by engaging TREs enriched in GATA3, TFAP2C, and H3K27Ac signal. These TREs control critical downstream TFs, among which TFAP2C plays an essential role in ER-driven cell proliferation. Together, our work reveals novel insights into a critical oncogenic transcription program and provides a framework to map regulatory networks, enabling to dissect the function of the noncoding genome of cancer cells.
Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance
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Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens
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Mitochondrial and ER membrane protein trafficking CRISPR screens
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Pooled CRISPR Screening of High-content Cellular Phenotypes by Ghost Cytometry_01
<p>Pooled CRISPR screening of high-content cellular phenotypes by ghost cytometry (NFkB NGS data, conventional flow cytometer data, Amnis data)</p>
Pooled CRISPR Screening of High-content Cellular Phenotypes by Ghost Cytometry_02
<p>Pooled CRISPR Screening of High-content Cellular Phenotypes by Ghost Cytometry (Macrophage NGS data)</p>
GeCKO_v2_CRISPR_drug screens in K562 cells
<p>The data contain raw DNA deep sequencing files for GeCKO-v2 genome scale transduced K562 screens with selected drugs (imatinib, dasatinib, asciminib, tivozanib, AZD1775, mepacrine). For all drug except mepacrine the drug, day 0 and day 17 control samples' files are provided. For mepacrine which was screened separately, a triplicate drug, D15 control sample files are provided. The dates are indicated in the file names. </p>
Discovery of target genes and pathways of blood trait loci using pooled CRISPR screens and single cell RNA sequencing
GEO Series GSE171452. Homo sapiens. 28 samples. Type: Other.
Optimized CRISPR guide RNA library cloning reduces skew and enables more compact genetic screens
GEO Series GSE222531. Homo sapiens; synthetic construct. 52 samples. Type: Other.
Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed –1 ribosomal frameshifting
GEO Series GSE223690. Homo sapiens. 24 samples. Type: Other.
Genome-wide CRISPR screen for comprehensive identification of human factors involved in alternative polyadenylation based on differential localization of CD47 protein
GEO Series GSE288919. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Deep sequencing data from PAM screen of Pa83 type IV-A CRISPR-Cas system
GEO Series GSE211446. Escherichia coli. 6 samples. Type: Other.
A secretome CRISPR screen identifies SFRP1 as a regulator of epidermal self-renewal [RNA-seq]
GEO Series GSE269627. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
A functional genomics process for systematic dissection and mutation-specific target discovery in breast cancer PIK3CA hotspot mutations [CRISPR KO Screen Data]
GEO Series GSE248041. Homo sapiens. 6 samples. Type: Other.
In vivo CRISPR screening identifies SAGA complex members as a key regulators of hematopoiesis [scRNA]
GEO Series GSE312125. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide CRISPR inactivation based resistance screens using IMiDs in Primary Effusion Lymphoma (PEL) cells
GEO Series GSE122040. Homo sapiens. 16 samples. Type: Other.
CRISPR-Cas screen in ILC2 identifies Mef2d as a regulator of GATA3 and type-2 immunity [ChIP-Seq]
GEO Series GSE242030. Mus musculus. 17 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CRISPR Screens Identify the ATPase VCP as a Druggable Therapeutic Vulnerability in Cholangiocarcinoma
GEO Series GSE305958. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Functional CRISPR Screen Identifies AP1-associated Enhancer regulating FOXF1 to modulate Oncogene-Induced Senescence
GEO Series GSE112458. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.