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Dataset results
70 results for “CSF1R”
CSF1R-inhibitor resistant model for CNS-wide microglia replacement strategies
GEO Series GSE311140. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in murine pancreatic tumor tissues in response to the blockade of macrophage colony-stimulating factor receptor (CSF1R) signal
GEO Series GSE57686. Mus musculus. 12 samples. Type: Expression profiling by array.
Single-cell epigenomic analysis of hypodermal macrophages from Csf1r-cre x Igf1-flox mice.
GEO Series GSE227859. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Global N6-methyladenosine RNA profiling reveals CSF1R as a target of METTL14 in non-small cell lung cancer [RIP-seq]
GEO Series GSE179658. Homo sapiens. 2 samples. Type: Other.
Effect of CSF1R targeting on human macrophages in normoxia and hypoxia
GEO Series GSE263919. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide transcriptional profiles of intestinal macrophages from WT and Csf1r-EP4-/- mice during dextran sodium sulfate induced colitis.
GEO Series GSE141093. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Global N6-methyladenosine RNA profiling reveals CSF1R as a target of METTL14 in non-small cell lung cancer.
GEO Series GSE179659. Homo sapiens. 18 samples. Type: Methylation profiling by high throughput sequencing; Other.
CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice.
GEO Series GSE245360. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Microglia in developing retina transition through a disease-like functional state that does not require CSF1R signaling for survival
GEO Series GSE123757. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
High throughput quantitative whole transcriptome analysis of individual macrophages 7 days post-pneumonectomy in a B6 CSF1R-GFP mouse
GEO Series GSE96104. Mus musculus. 73 samples. Type: Expression profiling by high throughput sequencing.
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics
GEO Series GSE198057. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Engineering an inhibitor resistant human CSF1R variant for microglia replacement [InVitro_RNA]
GEO Series GSE220213. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Data from: CSF1R-related leukoencephalopathy: a major player in primary microgliopathies
Since the discovery of CSF1R gene mutations in families with hereditary diffuse leukoencephalopathy with spheroids in 2012, more than 70 different mutations have been identified around the world. Through the analyses of mutation carriers, CSF1R-related leukoencephalopathy has been distinctly characterized clinically, radiologically, and pathologically. Typically, patients present with frontotemporal dementia–like phenotype in their 40s–50s, accompanied by motor symptoms, including pyramidal and extrapyramidal signs. Women tend to develop the clinical symptoms at a younger age than men. On brain imaging, in addition to white matter abnormalities, thinning of the corpus callosum, diffusion-restricted lesions in the white matter, and brain calcifications are hallmarks. Primary axonopathy followed by demyelination was suggested by pathology. Haploinsufficiency of colony-stimulating factor-1 receptor (CSF1R) is evident in a patient with a frameshift mutation, facilitating the establishment of Csf1r haploinsufficient mouse model. These mice develop clinical, radiologic, and pathologic phenotypes consistent with those of human patients with CSF1R mutations. In vitro, perturbation of CSF1R signaling is shown in cultured cells expressing mutant CSF1R. However, the underlying mechanisms by which CSF1R mutations selectively lead to white matter degeneration remains to be elucidated. Given that CSF1R mainly expresses in microglia, CSF1R-related leukoencephalopathy is representative of primary microgliopathies, of which microglia have a pivotal and primary role in pathogenesis. In this review, we address the current knowledge of CSF1R-related leukoencephalopathy and discuss the putative pathophysiology, with a focus on microglia, as well as future research directions.
MIcroglial Colony Stimulating Factor-1 Receptor (CSF1R) in Alzheimer's Disease
ClinicalTrials.gov study NCT04121208. IPD Sharing: NO. Countries: 1. Publications: 0.
CSF1R PET Probe [18F]CSF-23 in Alzheimer's Disease Brain Imaging
ClinicalTrials.gov study NCT06148233. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase I/II Clinical Trial of Axatilimab, a CSF1R Monoclonal Antibody, in Combination With Ruxolitinib as Therapy for Patients With Myelofibrosis (MF) and Chronic Myelomonocytic Leukemia (CMML)
ClinicalTrials.gov study NCT07128381. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Assess CSF1R-related Leukoencephalopathy After Stem Cell Transplantation
ClinicalTrials.gov study NCT04503213. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: CSF1R-related leukoencephalopathy: a major player in primary microgliopathies
Open the record for dataset details and reuse information.
Therapeutic potential of human microglial transplantation in a chimeric model of CSF1R-related leukoencephalopathy
GEO Series GSE253623. Homo sapiens; Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
CSF1R mediates effects of miR-34a loss during intestinal tumorigenesis in ApcMin mice (adenoma)
GEO Series GSE167448. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.