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31
datasets available to search
ShareScore release 0.9.0
Dataset results
31 results for “Cellular microenvironment”
Identifying a high-risk cellular signature in the multiple myeloma bone marrow microenvironment
GEO Series GSE136400. Homo sapiens. 1424 samples. Type: Expression profiling by array.
Identifying a high-risk cellular signature in the multiple myeloma bone marrow microenvironment_1
GEO Series GSE136324. Homo sapiens. 867 samples. Type: Expression profiling by array.
Identifying a high-risk cellular signature in the multiple myeloma bone marrow microenvironment_2
GEO Series GSE136337. Homo sapiens. 426 samples. Type: Expression profiling by array.
Transcriptomic and metabolic effect of immune checkpoint inhibitors on cellular components in renal cell tumor microenvironment and in Sunitinib resistant renal cell carcinoma [III]
GEO Series GSE226968. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Cellular microenvironment in inflammatory periapical tissue
GEO Series GSE197680. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and metabolic effect of immune checkpoint inhibitors on cellular components in renal cell tumor microenvironment and in Sunitinib resistant renal cell carcinoma
GEO Series GSE226969. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Molecular and cellular characterization of planarian stem cell microenvironments
GEO Series GSE199348. Schmidtea mediterranea. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and metabolic effect of immune checkpoint inhibitors on cellular components in renal cell tumor microenvironment and in Sunitinib resistant renal cell carcinoma [1]
GEO Series GSE226965. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Chemotherapy-induced dynamic remodeling of tumor microenvironment and cellular program in tongue squamous cell carcinoma
GEO Series GSE260953. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and metabolic effect of immune checkpoint inhibitors on cellular components in renal cell tumor microenvironment and in Sunitinib resistant renal cell carcinoma [II]
GEO Series GSE226967. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Dataset to submitted manuscript "Imaging Fluorescence Blinking of a Mitochondrial Localization Probe – a Strategy Combining Site-Specificity with Multi-Parametric Sensing of Cellular Microenvironments"
<p><strong>This folder contains all raw data underlying the results presented in a manuscript, submitted to <em>Small</em></strong><strong>, and entitled:</strong></p> <p> </p> <p><strong><em>Imaging Fluorescence Blinking of a Mitochondrial Localization Probe – a Strategy Combining Site-Specificity with Multi-Parametric Sensing of Cellular Microenvironments</em></strong></p> <p> </p> <p><strong>Authored by:</strong></p> <p>Zhixue Du<sup>a</sup><em>, </em>Joachim Piguet<sup>a,+</sup>, Gleb Baryshnikov<sup>b,+</sup>, Johan Tornmalm<sup>a</sup>, Baris Demirbay<sup>a</sup>, Hans Ågren<sup>b</sup>, Jerker Widengren<sup>a,*</sup></p> <p> </p> <p><sup>a</sup> Royal Institute of Technology (KTH), Experimental Biomolecular Physics, Dept. Applied Physics, Albanova Univ Center 106 91 Stockholm, Sweden</p> <p><sup>b</sup> Royal Institute of Technology (KTH), Dept Theroretical Chemistry and Biology, Albanova Univ Center 106 91 Stockholm, Sweden</p> <p><sup>+</sup> Contributed equally</p> <p>* Corresponding author: Email: <a href="mailto:jwideng@kth.se">jwideng@kth.se</a>, Phone: +46-8-7907813</p> <p> </p> <p><strong>The data files are grouped into the different techniques used to generate them, and refer to the figures/tables in the manuscript where the extracted results are presented. </strong></p> <p> </p> <p><strong>ABSTRACT</strong></p> <p>The local microenvironment of mitochondrial membranes directly influences cellular metabolic states but are difficult to follow locally. Here, we demonstrate a robust and straightforward strategy, transforming the widely used mitochondrial membrane localization fluorophore 10-Nonyl Acridine Orange (NAO) into a multi-functional probe of membrane microenvironments. By monitoring the blinking kinetics of NAO in small unilamellar vesicles, and by computational simulations, we found that NAO exhibits prominent reversible singlet-triplet state transitions and can act as a light-induced Lewis acid forming a red-emissive doublet radical. The resulting blinking kinetics are highly environment sensitive, specifically reflecting local membrane oxygen concentrations, redox conditions, membrane charge, fluidity and lipid compositions, and can also be imaged in live cells, in a spatially resolved manner. They also reflect hydroxyl ion dependent transitions to and from the fluorophore doublet radical, closely coupled to proton transfer events in the membranes, local pH, and two- and three-dimensional buffering properties on and above the membranes. Generally, by the demonstrated blinking imaging strategy existing fluorophore markers can be transformed into multi-parametric microenvironmental sensors. The strategy makes it possible to image local cellular conditions highly relevant to cancer, metabolic and infectious diseases, thereby providing a basis for cellular diagnostics and for fundamental membrane studies.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.