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307 results for “Circadian rhythms”
Data from: Developmental exposure to PCB153 (2,2',4,4',5,5'-hexachlorobiphenyl) alters circadian rhythms and the expression of clock and metabolic genes
Polychlorinated biphenyls (PCBs) are highly persistent and ubiquitously distributed environmental pollutants. Based on their chemical structure, PCBs are classified into non-ortho-substituted and ortho-substituted congeners. Ortho-substituted PCBs are structurally similar to dioxin and their toxic effects and mode of action are well established. In contrast, very little is known about the effects of non-ortho-substituted PCBs, particularly during early development. The objective of this study is to investigate the effects of exposure to an environmentally prominent ortho-substituted PCB (2,2',4,4',5,5'-hexachlorobiphenyl; PCB153) on zebrafish embryos. We exposed zebrafish embryos to either DMSO or three different concentrations of PCB153 starting from 4 hours post-fertilization (hpf) to 120 hpf. We quantified gross morphological changes, behavioral phenotypes, gene expression changes and circadian behavior in the larvae. There were no developmental defects during the exposure period, but starting at 7 dpf, we observed spinal deformity in the 10 μM PCB153 treated group. A total of 633, 2227, and 3378 differentially expressed genes were observed in 0.1, 1 and 10 μM PCB153 treated embryos, respectively. Of these, 301 genes were common to all treatment groups. KEGG pathway analysis revealed enrichment of genes related to circadian rhythm, FoxO signaling and insulin resistance pathways. Behavioral analysis revealed that PCB153 exposure significantly alters circadian behavior. Disruption of circadian rhythms has been associated with the development of metabolic and neurological diseases. Thus, understanding the mechanisms of action on environmental chemicals in disrupting circadian regulation of metabolism is essential for preventing or mitigating chemical-induced metabolic disease.
Data from: Optimal sampling interval for characterisation of the circadian rhythm of body temperature in homeothermic animals using periodogram and cosinor analysis
<p>Core body temperature (T<sub>c</sub>) is a critical aspect of homeostasis in birds and mammals and is increasingly used as a biomarker of the fitness of an animal to its environment. Periodogram and cosinor analysis can be used to estimate the characteristics of the circadian rhythm of T<sub>c</sub> from data obtained on loggers that have limited memory capacity and battery life. This data set contains five days of core body temperature, measured by loggers implanted into the abdominal cavity, in nine species of birds and mammals.</p>
Characterizing the modern light environment and its influence on circadian rhythms
<p>Humans have largely supplanted natural light cycles with a variety of electric light sources and schedules misaligned with day-night cycles. Circadian disruption has been linked to a number of disease processes, but the extent of circadian disruption among the population is unknown. In this study, we measured light exposure and wrist temperature among residents of an urban area during each of the four seasons, as well as light illuminance in nearby outdoor locations. Daily light exposure was significantly lower for individuals, compared to outdoor light sensors, across all four seasons. There was also little seasonal variation in the realized photoperiod experienced by individuals, with the only significant difference occurring between winter and summer. We tested the hypothesis that differential light exposure impacts circadian phase timing, detected via the wrist temperature rhythm. To determine the influence of light exposure on circadian rhythms, we modeled the impact of morning and nighttime light exposure on the timing of the maximum wrist temperature. We found that morning and nighttime light exposure had significant but opposing impacts on maximum wrist temperature timing. Our results demonstrate that, within the range of exposure seen in everyday life, nighttime light can delay the onset of the maximum wrist temperature, while morning light can lead to earlier onset. Our results demonstrate that humans are minimizing natural seasonal differences in light exposure, and that circadian shifts and disruptions may be a more regular occurrence in the general population than is currently recognized.</p>
Arginine-vasopressin expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo
<p>The suprachiasmatic nucleus (SCN) is composed of functionally distinct subpopulations of GABAergic neurons which form a neural network responsible for synchronizing most physiological and behavioral circadian rhythms in mammals. To date, little is known regarding which aspects of SCN rhythmicity are generated by individual SCN neurons, and which aspects result from neuronal interaction within a network. Here, we utilize in vivo miniaturized microscopy to measure fluorescent GCaMP-reported calcium dynamics in arginine vasopressin (AVP)-expressing neurons in the intact SCN of awake, behaving mice. We report that SCN AVP neurons exhibit periodic, slow calcium waves which we demonstrate, using in vivo electrical recordings, likely reflect burst firing. Further, we observe substantial heterogeneity of function in that AVP neurons exhibit unstable rhythms and relatively weak rhythmicity at the population level. Network analysis reveals that correlated cellular behavior, or coherence, among neuron pairs also exhibited stochastic rhythms with about 33% of pairs rhythmic at any time. Unlike single-cell variables, coherence exhibited a strong rhythm at the population level with time of maximal coherence among AVP neuronal pairs at CT/ZT 6 and 9, coinciding with the timing of maximal neuronal activity for the SCN as a whole. These results demonstrate robust circadian variation in the coordination between stochastically rhythmic neurons and interactions between AVP neurons in the SCN may be more influential than single-cell activity in the regulation of circadian rhythms. Furthermore, they demonstrate that cells in this circuit, like those in many other circuits<span></span>, exhibit profound heterogenicity of function over time and space.</p>
Chemotherapy-induced Circadian Rhythm Disruption
ClinicalTrials.gov study NCT04364347. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessing Sleep and Circadian Rhythms in Primary Brain Tumors Patients
ClinicalTrials.gov study NCT04669574. IPD Sharing: YES. Countries: 1. Publications: 3.
Intra-individual Variability and Circadian Rhythm of VEGF Levels and Interaction With Biomarkers
ClinicalTrials.gov study NCT02325271. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study
ClinicalTrials.gov study NCT02853487. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Disruption of Circadian Rhythm and Healthcare-related Infection in Patients With Severe Trauma
ClinicalTrials.gov study NCT02307747. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Circadian Rhythm and Delirium in ICU
ClinicalTrials.gov study NCT05342987. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Circadian Rhythm in Critical Illness
ClinicalTrials.gov study NCT07063303. IPD Sharing: NO. Countries: 1. Publications: 16.
The Circadian Rhythm of Potassium and Cystatin C
ClinicalTrials.gov study NCT01318746. IPD Sharing: Not stated. Countries: 1. Publications: 1.
HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness
ClinicalTrials.gov study NCT05285124. IPD Sharing: NO. Countries: 1. Publications: 1.
The Circadian Rhythm of ICU Patients With Acute Myocardial Infraction and the Effect of Light Therapy
ClinicalTrials.gov study NCT04953767. IPD Sharing: NO. Countries: 1. Publications: 7.
The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
ClinicalTrials.gov study NCT04737200. IPD Sharing: NO. Countries: 1. Publications: 1.
Wearables-and Blood-based Biomarkers-incorporated Modernisation of Circadian Rhythm Disruption Management in People Living With Alzheimer's Dementia: A Stepwise Study From Digital Inclusivity, Digital
ClinicalTrials.gov study NCT07222449. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood
ClinicalTrials.gov study NCT05159141. IPD Sharing: NO. Countries: 1. Publications: 43.
DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR)
ClinicalTrials.gov study NCT04635098. IPD Sharing: YES. Countries: 1. Publications: 2.
The Effect of Nursing Care on Circadian Rhythm
ClinicalTrials.gov study NCT04934436. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Inspiratory Muscle Training Combined With Circadian Rhythm-based Running Programs in Children Male Football Players
ClinicalTrials.gov study NCT07170891. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.